Kinetic characterization of carrier-mediated transport systems for D-glucose and taurocholate in the everted sacs of the rat colon.

abstract：:The present study was designed to examine whether the methanol extract of Sorbus commixta cortex (MSC) could prevent the development of atherosclerosis through regulating the vascular nitric oxide (NO) and endothelin-1 (ET-1) systems in atherogenic-diet rats. Our findings show that aortic NO production as well as endo...

journal_title：Biological & pharmaceutical bulletin

authors： Sohn EJ,Kang DG,Mun YJ,Woo WH,Lee HS

更新日期：2005-08-01 00:00:00

abstract：:Central nervous system (CNS) agents cause fractures among the elderly, but fracture risks of a wide range of CNS agent classes have not been analyzed in a study with the same population and definitions of variables. This study aimed to estimate the degree of fragility fracture risk of a wide range of CNS agent classes...

journal_title：Biological & pharmaceutical bulletin

authors： Ohara E,Bando Y,Yoshida T,Ohara M,Kirino Y,Iihara N

更新日期：2020-01-01 00:00:00

abstract：:The hepatoprotecive effects of recombinant human epidermal growth factor (hEGF) on chemically and immunologically induced experimental liver injury models were examined. The hEGF clearly decreased serum transaminase levels in D-galactosamine (D-GalN) and D-GalN/lipopolysaccharide (LPS)-induced liver injury models unde...

journal_title：Biological & pharmaceutical bulletin

authors： Cho JY,Yeon JD,Kim JY,Yoo ES,Yu YH,Park MH

更新日期：2000-10-01 00:00:00

abstract：:A conditioned medium (CM) was prepared by culturing human sperm at 3.0 x 10(6) sperm/ml for 12 h. The fusion index increased significantly when the sperm penetration assay (SPA) was performed with CM (0.6 without CM to 2.0 with CM). The conditioned medium was also effective on the sperm from 11 patients who showed a l...

journal_title：Biological & pharmaceutical bulletin

authors： Ikawa M,Ying X,Tanaka K,Ohashi K,Saji F,Okabe M

更新日期：1995-01-01 00:00:00

abstract：:Aerobic glycolysis is an established hallmark of cancer. Neoplastic cells display increased glucose consumption and a corresponding increase in lactate production compared to the normal cells. Aerobic glycolysis is regulated by the phosphatidylinositol-3-kinase (PI3K)/Akt/ mammalian target of rapamycin (mTOR) signalin...

journal_title：Biological & pharmaceutical bulletin

authors： Parajuli P,Tiwari RV,Sylvester PW

更新日期：2015-01-01 00:00:00

abstract：:The degradation of 125I-endothelin-1 (125I-ET-1) was examined on cultured porcine aortic endothelial cell (EC) and rat vascular smooth muscle cell (SMC) by HPLC analysis. The degradation of ET-1 was observed on SMC and was slightly observed on EC. Membrane fractions of SMC had a strong potency for the degradation of E...

journal_title：Biological & pharmaceutical bulletin

authors： Edano T,Arai K,Koshi T,Torii T,Ohshima T,Hirata M,Ohkuchi M,Okabe T

更新日期：1994-03-01 00:00:00

abstract：:We demonstrate that glycyrrhizin (GL) enhanced Fas-mediated apoptotic body formation and DNA fragmentation in T cell lines although GL alone did not induce apoptosis. The enhancement effect of Fas-mediated apoptosis by GL was dose-dependent above 0.3 microM. Time course study revealed that simultaneous co-treatment of...

journal_title：Biological & pharmaceutical bulletin

authors： Ishiwata S,Nakashita K,Ozawa Y,Niizeki M,Nozaki S,Tomioka Y,Mizugaki M

更新日期：1999-11-01 00:00:00

abstract：:Polyethylenimine (PEI) is widely used for non-viral transfection in vitro and in vivo. Hepatectomy is an interesting and considerable factor modifying PEI-mediated gene expression. We investigated the gene expression in mice over time following partial hepatectomy after an intravenous injection of PEI/plasmid DNA (pDN...

journal_title：Biological & pharmaceutical bulletin

authors： Tada Y,Kitahara T,Yoshioka T,Nakamura T,Ichikawa N,Nakashima M,Nishida K,Nakamura J,Sasaki H

更新日期：2006-08-01 00:00:00

abstract：:The intestinal expression of the CYP3A subfamily was investigated in female rats, and the intestinal metabolism of two CYP3A substrates, testosterone and rifabutin, was examined and compared between males and females. CYP3A1/23 and CYP3A2 intestinal expression was barely detected in male and female rats. Although CYP3...

journal_title：Biological & pharmaceutical bulletin

authors： Aiba T,Yoshinaga M,Ishida K,Takehara Y,Hashimoto Y

更新日期：2005-02-01 00:00:00

abstract：:The inhibitory effects of tetrandrine (an alkaloid isolated from the Chinese medicine Stephania tetrandrae S. Moore) were investigated in terms of the angiogenesis in an adjuvant-induced chronic inflammation model of mouse and tube formation of rat vascular endothelial cells (EC). Tetrandrine (7.5-30 mg/kg) reduced th...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi S,Inaba K,Kimura I,Kimura M

更新日期：1998-04-01 00:00:00

abstract：:Recently, Banhabackchulchunmatang (HMC05) has been implicated as a preventive and/or therapeutic candidate for cardiovascular diseases due to its inhibition of atherosclerosis lesions and its reduction of neointima formation. Knowledge of the mechanism of HMC05 in smooth muscle cells (SMC) is limited. However, SMC may...

journal_title：Biological & pharmaceutical bulletin

authors： Gum SI,Shin HM,Cho MK

更新日期：2014-01-01 00:00:00

abstract：:The induction of lymphangiogenesis is an important process to promote cancer growth and cancer metastasis via the lymphatic system. Identifying the compounds that can prevent lymphangiogenesis for cancer therapy is urgently required. Chrysin, 5,7-dihydroxyflavone, a natural flavone extracted from Thai propolis, was us...

journal_title：Biological & pharmaceutical bulletin

authors： Prangsaengtong O,Athikomkulchai S,Xu J,Koizumi K,Inujima A,Shibahara N,Shimada Y,Tadtong S,Awale S

更新日期：2016-01-01 00:00:00

abstract：:It has been recently reported that the consumption of a high-fat diet during pregnancy exerts various effects on fetuses and newborn mice. The purpose of this study was to determine the effects of a high-fat diet during pregnancy on the expression of cytochrome P450 (CYP) in the livers of offspring. Mouse dams were fe...

journal_title：Biological & pharmaceutical bulletin

authors： Tajima M,Ikarashi N,Okaniwa T,Imahori Y,Saruta K,Toda T,Ishii M,Tanaka Y,Machida Y,Ochiai W,Yamada H,Sugiyama K

更新日期：2013-01-01 00:00:00

abstract：:CC chemokine receptor 4 (CCR4) is generally recognized as a preferential marker for T helper 2 cells, and we have previously reported morpholine-derivative CCR4 antagonists, RS-1154 and RS-1269. Here, we investigate the pharmacological profiles of a novel pyrimidine-derivative CCR4 antagonist, 2-{4-[2-(diethylamino)et...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagami Y,Kawase Y,Yonekubo K,Nosaka E,Etori M,Takahashi S,Takagi N,Fukuda T,Kuribayashi T,Nara F,Yamashita M

更新日期：2010-01-01 00:00:00

abstract：:The fat-specific protein 27 (Fsp27) gene belongs to the cell death-inducing DNA fragmentation factor 45-like effector family. Fsp27 is highly expressed in adipose tissue as well as the fatty liver of ob/ob mice. Fsp27 is directly regulated by the peroxisome proliferator-activated receptor γ (PPARγ) in livers of geneti...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuo K,Matsusue K,Aibara D,Takiguchi S,Gonzalez FJ,Yamano S

更新日期：2017-01-01 00:00:00

abstract：:Caesalpinia ferrea MART. (Leguminosae) called as Juca is one of the medicinal plants in Brazil used for diabetes. From the fruits of this plant, ellagic acid (EA) and 2-(2,3,6-trihydroxy-4-carboxyphenyl)ellagic acid (TEA) have been recently isolated as aldose reductase (AR) inhibitors. In this study, we examined to pr...

journal_title：Biological & pharmaceutical bulletin

authors： Ueda H,Kawanishi K,Moriyasu M

更新日期：2004-10-01 00:00:00

abstract：:Calprotectin is a calcium- and zinc-binding protein complex that is abundant in cytosol of neutrophils. The concentration of calprotectin in extracellular fluids is greatly increased under various inflammatory conditions in vivo. We recently demonstrated that calprotectin inhibited cell growth and induced apoptosis of...

journal_title：Biological & pharmaceutical bulletin

authors： Mikami M,Kitahara M,Kitano M,Ariki Y,Mimaki Y,Sashida Y,Yamazaki M,Yui S

更新日期：1999-07-01 00:00:00

abstract：:Povidone-iodine (PVP-I), an antibacterial medicine, was infiltrated in sepiolite (SPL). The available iodine content in this new pharmaceutical product, a sepiolite preparation containing povidone-iodine (PVP-I-SPL), was retained at 98.9 and 98.3% during storage at 40 degrees C for 3 and 6 months, respectively. The ef...

journal_title：Biological & pharmaceutical bulletin

authors： Ohta S,Nagai K,Maruyama M,Inoue H,Katsuyama Y,Atobe O,Ogata H,Yamato S,Tachikawa E,Zenda H

更新日期：1999-01-01 00:00:00

abstract：:Cannabinoids are the active ingredients in marijuana, which is among the most widely used addictive drugs despite the well-documented harmfulness related to its abuse. The mechanism underlying cannabinoid addiction remains unclear, which is attributed partially to the difficulty in behavioral testing of high-dose cann...

journal_title：Biological & pharmaceutical bulletin

authors： Liu T,Zheng Q,Qian Z,Wang H,Liu Z,Ren W,Zhang X,Han J

更新日期：2016-05-01 00:00:00

abstract：:Glomerulonephritis (GN) is a set of pathological conditions that result in the destruction of glomeruli and loss of renal function, commonly leading to the development of end-stage renal disease. Current pharmacotherapy is limited to immunosuppressive therapy. In the present study, we found a novel antinephritic effec...

journal_title：Biological & pharmaceutical bulletin

authors： Liu N,Shi J,Xiao Y,Yasue M,Takei Y,Sanefuji H,Tsujimoto G,Hirasawa A

更新日期：2015-01-01 00:00:00

abstract：:The in vitro percutaneous permeation of diclofenac from various vehicles was examined using rat abdominal skin as a model membrane. The oleaginous vehicles used in this study consisted of three components: i.e. fatty acid, fatty acid ester and nonpolar oil. The solubilities of sodium diclofenac in formulated vehicles ...

journal_title：Biological & pharmaceutical bulletin

authors： Takahashi K,Suzuki T,Sakano H,Mizuno N

更新日期：1995-04-01 00:00:00

abstract：:Markedly inhibitory effects of Ca(2+) on the growth of human tumor cells were attained through the induction of apoptosis in vitro. On the other hand, a good correlation between the growth inhibition effects of Ca(2+) and the amounts of phosphatidylserines (PS) in the cell membranes (plasma membranes) was obtained. Fu...

journal_title：Biological & pharmaceutical bulletin

authors： Goto K,Tatsumi K,Nagata T,Komizu Y,Ueoka R

更新日期：2011-01-01 00:00:00

abstract：:The nasal absorption of non-glycosylated recombinant human granulocyte colony-stimulating factor produced by Esherichia coli (E. coli-rhG-CSF) was studied in rats. We investigated the effects of the basic conditions of the dosing solution and the enhancing effects of various substances to find means to improve the nas...

journal_title：Biological & pharmaceutical bulletin

authors： Nomura H,Akamisaka S,Maruyama K

更新日期：1996-11-01 00:00:00

abstract：:The complete molecule or the ligand-binding domain-containing region of each of the three subtypes of human retinoic acid receptors (hRAR alpha, hRAR beta and hRAR gamma) was expressed in Escherichia coli. The expressed recombinant RARs (rRARs: rRAR alpha/E, rRAR beta/E and rRAR gamma) showed nearly the same magnitude...

journal_title：Biological & pharmaceutical bulletin

authors： Fukasawa H,Iijima T,Kagechika H,Hashimoto Y,Shudo K

更新日期：1993-04-01 00:00:00

abstract：:The effects of the angiotensin II type 1 receptor antagonist YM358 on blood pressure were compared to those of the angiotensin converting enzyme inhibitor enalapril in one-kidney, one-clip renal hypertensive rats (1K1C RHR), two-kidney, one-clip renal hypertensive rats (2K1C RHR) and normotensive rats (NTR). Additiona...

journal_title：Biological & pharmaceutical bulletin

authors： Tokioka T,Shibasaki M,Fujimori A,Matsuda-Satoh Y,Uchida W,Inagaki O,Yanagisawa I

更新日期：2000-02-01 00:00:00

abstract：:Acute biliary pancreatitis (ABP) with a high mortality rate is an incurable digestive system disease induced by abnormal bile acid regurgitation due to the biliary obstruction. Dehydrocholic acid (DA) alleviates the severity of cholestatic hepatitis related to biliary inflammation, suggesting DA is potential to develo...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang X,Xin G,Li S,Wei Z,Ming Y,Yuan J,Wen E,Xing Z,Yu K,Li Y,Zhang J,Zhang B,Niu H,Huang W

更新日期：2020-01-01 00:00:00

abstract：:Hinokitiol (beta-thujaplicin), beta-dolabrin and gamma-thujaplicin isolated from Thujopsis dolabrata SIEB. et ZUCC var hondai MAKINO showed antifungal activities against all of the wood-rotting fungi examined. The antifungal activity of three compounds on Daedalea dickinsii IFO-4979 was especially strong, their minimu...

journal_title：Biological & pharmaceutical bulletin

authors： Inamori Y,Sakagami Y,Morita Y,Shibata M,Sugiura M,Kumeda Y,Okabe T,Tsujibo H,Ishida N

更新日期：2000-08-01 00:00:00

abstract：:The medial prefrontal cortex (mPFC) plays critical roles in the development of cocaine addiction. Numerous studies have reported about the effects of cocaine on neuronal and synaptic activities in the nucleus accumbens and ventral tegmental area, which are brain regions associated with cocaine addiction; however, a li...

journal_title：Biological & pharmaceutical bulletin

authors： Sasase H,Izumi S,Deyama S,Hinoi E,Kaneda K

更新日期：2019-01-01 00:00:00

abstract：:Plasma hyaluronan biding protein (PHBP) is a novel serine protease, which has an amino acid sequence homology to that of hepatocyte growth factor activator (HGFA), and has a similar domain structure to that of urinary plasminogen activator (u-PA), found in human plasma. We searched the PHBP substrate in human plasma b...

journal_title：Biological & pharmaceutical bulletin

authors： Choi-Miura NH,Yoda M,Saito K,Takahashi K,Tomita M

更新日期：2001-02-01 00:00:00

abstract：:The inducibility of chromosomal aberration was studied using five mammalian topoisomerase inhibitors in Chinese hamster lung fibroblastic cells (CHL) in two protocols involving 6 and 24 h treatment, with respect to the mechanism of chromosomal aberration. In the 6 h treatment plus 18 h recovery culture (6 h treatment)...

journal_title：Biological & pharmaceutical bulletin

authors： Suzuki H,Nakane S

更新日期：1994-02-01 00:00:00