Central Nervous System Agent Classes and Fragility Fracture Risk among Elderly Japanese Individuals in a Nationwide Case-Crossover Design Study.

abstract：:When hot-water extracts of mushroom Agaricus brazei MURRILL fruiting bodies (Agaricus extracts) were administered orally into Meth A-bearing mice, tumor growth was significantly inhibited compared with controls given water orally. Treatment with Agaricus extracts for five successive days significantly increased natura...

journal_title：Biological & pharmaceutical bulletin

authors： Takimoto H,Wakita D,Kawaguchi K,Kumazawa Y

更新日期：2004-03-01 00:00:00

abstract：:Monoclonal antibodies are widely used for the treatment of various diseases, and because therapeutic monoclonal antibodies are stored in an aqueous solution or in a lyophilized state, the preparation of a stabilizing formulation that prevents their deterioration (degradation and aggregation) is crucial. Given the stru...

journal_title：Biological & pharmaceutical bulletin

authors： Ishikawa T,Ito T,Endo R,Nakagawa K,Sawa E,Wakamatsu K

更新日期：2010-01-01 00:00:00

abstract：:Cerebral ischemia causes the depletion of oxygen and nutrition from brain tissues, and when persistent, results in irreversible damage to the cell function and survival. The cellular response to ischemic conditions and its mechanisms have been investigated widely in in vivo and in vitro experimental models, yet no stu...

journal_title：Biological & pharmaceutical bulletin

authors： Ujita S,Mizunuma M,Matsuki N,Ikegaya Y

更新日期：2011-01-01 00:00:00

abstract：:We investigated a method for the simultaneous screening, identification, and quantitative determination of salicylic acid, acetaminophen, theophylline, barbiturates, and bromvalerylurea, drugs that frequently cause acute poisoning in Japan and therefore require rapid analysis for effective treatment in the clinical se...

journal_title：Biological & pharmaceutical bulletin

authors： Hori Y,Fujisawa M,Shimada K,Hirose Y,Yoshioka T

更新日期：2006-01-01 00:00:00

abstract：:Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is the principal source of reducing power in numerous processes of physiological importance. We examined the influence of oxidative stress on the relative amounts of NADPH in human red blood cells (RBCs). To determine the homeostasis of the NADPH existing in ...

journal_title：Biological & pharmaceutical bulletin

authors： Ogasawara Y,Funakoshi M,Ishii K

更新日期：2009-11-01 00:00:00

abstract：:The possibility of pharmacokinetic interactions between Sho-saiko-to extract powder (TJ-9), the most widely used traditional Chinese herbal (Kampo) medicine in Japan, and carbamazepine (CBZ), an important anti-epileptic drug, was examined in rats. There was no significant difference in the protein binding of CBZ in se...

journal_title：Biological & pharmaceutical bulletin

authors： Ohnishi N,Okada K,Yoshioka M,Kuroda K,Nagasawa K,Takara K,Yokoyama T

更新日期：2002-11-01 00:00:00

abstract：:Voltage-gated calcium channels (VGCCs) are classified into high-voltage-activated (HVA) channels and low-voltage-activated channels consisting of Cav3.1-3.3, known as T ("transient")-type VGCC. There is evidence that certain types of HVA channels are involved in neurogenic inflammation and inflammatory pain, in agreem...

journal_title：Biological & pharmaceutical bulletin

authors： Sekiguchi F,Tsubota M,Kawabata A

更新日期：2018-01-01 00:00:00

abstract：:Oral tolerance is thought to have a role in preventing allergic responses and immune-mediated diseases. Modulation of this tolerance by drugs and chemicals can cause or suppress them. An improved model of oral tolerance to ovalbumin (OVA) in mice was developed to detect modulators of the tolerance and to apply it to s...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JH,Ohsawa M

更新日期：1995-06-01 00:00:00

abstract：:A plasmid, pEP2104 (23.9 kilobase pairs), from Staphylococcus aureus carries a gene that specifies inducible resistance to 14-membered (erythromycin, EM, and oleandomycin, OL) and 16-membered macrolide (mycinamicin I and II), but not to all of the latter, and to streptogramin type B antibiotics (partial macrolide- and...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuoka M,Jánosi L,Endou K,Saitoh S,Hashimoto H,Nakajima Y

更新日期：1993-12-01 00:00:00

abstract：:Although hypokalemia is an adverse effect of Yokukansan preparation, especially in geriatric patients, its association with age is unclear. We investigated whether age is a risk factor for hypokalemia. This single-center retrospective cohort study, conducted at Tokyo Women's Medical University, Medical Center East bet...

journal_title：Biological & pharmaceutical bulletin

authors： Hirai T,Yamaga R,Kei M,Hosohata K,Itoh T

更新日期：2020-01-01 00:00:00

abstract：:The major physiologic effect of thyroid hormone is thought to be initiated by the binding of T3 to the DNA binding thyroid hormone receptor (TR). The aim of this study has been to characterize the organ specific expression of thyroid hormone receptor mRNA, as well as its protein distribution and molecular weight in ma...

journal_title：Biological & pharmaceutical bulletin

authors： Shahrara S,Drvota V,Sylvén C

更新日期：1999-10-01 00:00:00

abstract：:Reactive oxygen species (ROS) are produced in various cells and affect many biological processes. We previously reported that 2-methyl-1,4-naphtoquinone (menadione) inhibited Ca(2+) influx from the extracellular medium and exocytosis evoked by antigen stimulation in the mast cell line, RBL-2H3. Mast cells release vari...

journal_title：Biological & pharmaceutical bulletin

authors： Kawamura F,Nakanishi M,Hirashima N

更新日期：2010-01-01 00:00:00

abstract：:The immunoreactivity (specific binding) of three Gly(A1)-sulfobenzoxadiazole-labeled insulins which have different spacer groups, Gly(A1)-[3-(4-sulfobenzoxadiazol-7-ylthio)propanoyl]-insulin , Gly(A1)-[2-(4-sulfobenzoxadiazol-7-ylthio)acetyl]-insulin, Gly(A1)-[3-carboxy-2(or 3)-(4-sulfobenzoxadiazol-7-ylthio)propanoyl...

journal_title：Biological & pharmaceutical bulletin

authors： Nanami M,Zaitsu K,Ohkura Y

更新日期：1993-05-01 00:00:00

abstract：:Auditory neuropathy (AN) is a hearing disorder characterized by an abnormal auditory brainstem response (ABR). This study examined experimental AN model induced in mice following increased dosages of pyridoxine. Induced AN was examined for < or =10 weeks following the last pyridoxine treatment. To assess AN, we evalua...

journal_title：Biological & pharmaceutical bulletin

authors： Hong BN,Yi TH,Kim SY,Kang TH

更新日期：2009-04-01 00:00:00

abstract：:In a previous report, we had demonstrated the antioxidant activity of the sialic acid N-acetylneuraminic acid (Neu5Ac, NANA). This activity can counteract the cytotoxicity of hydrogen peroxide (H2O2), and the antitoxicity is a result of a direct chemical reaction, whereby NANA reduces H2O2 in the culture media. The in...

journal_title：Biological & pharmaceutical bulletin

authors： Iijima R,Takahashi H,Ikegami S,Yamazaki M

更新日期：2007-03-01 00:00:00

abstract：:Schwann cell injury is observed in diabetic neuropathy. It is speculated that glycolaldehyde (GA), a precursor of advanced glycation end products (AGEs), contributes to the pathogenesis and development of diabetic neuropathy. Here, we demonstrated for the first time that GA at near-physiological concentration decrease...

journal_title：Biological & pharmaceutical bulletin

authors： Sato K,Tatsunami R,Yama K,Tampo Y

更新日期：2013-01-01 00:00:00

abstract：:Formulations consisting of egg albumin, indomethacin (IND), and olive oil or fatty acids, were prepared by vigorous stirring using a high-speed homogenizer and subsequent freeze-drying. To confirm the anti-inflammatory properties and ulcerogenic effects of the formulations, we examined the action of the formulations o...

journal_title：Biological & pharmaceutical bulletin

authors： Tsuji Y,Kakegawa H,Miyataka H,Matsumoto H,Satoh T

更新日期：1993-07-01 00:00:00

abstract：:We studied nephrotoxicity following a single injection of cisplatin (CDDP) at low dose (1 mg/kg) in two groups of rats aged 52 weeks (adult, A group) and 9 weeks (young, Y group). Renal platinum (Pt) was detectable in both groups 3 h after the CDDP injection, and, from 6 h to 3 d after injection, its level in the A gr...

journal_title：Biological & pharmaceutical bulletin

authors： Namikawa K,Kinsoku A,Minami T,Okazaki Y,Kadota E,Teramura K,Hashimoto S

更新日期：1995-07-01 00:00:00

abstract：:The study revealed that high molecular polyvinyl sulfate (PVP) or sulfonate (PVS), and low molecular alkyldisulfonates (NaO3S(CH2)nSO3Na, n = 2--5: EDS, TDS, BDS and PDS) can alleviate acute toxicity of the herbicide, paraquat dichloride (PQ) in mice. Their activity as antidotes and the mode of the action varied depen...

journal_title：Biological & pharmaceutical bulletin

authors： Tsuchiya T,Yoshida T,Imaeda A,Kiho T,Ukai S

更新日期：1995-04-01 00:00:00

abstract：:Hydroxyoctadecadienoic acids (HODEs) are generated by oxidation of linoleic acid in vivo and thought to mediate various pathophysiological responses. In this study, we examined the effects of HODEs on EL4 mouse lymphoma cell growth and found that 9-(E,Z)-HODE inhibited EL4 cell growth in a dose-dependent manner, where...

journal_title：Biological & pharmaceutical bulletin

authors： Kodaka A,Hayakawa Y,AlSayegh RJ,Yasuhara T,Tomoda H,Oku T,Dan S,Tsuiji M,Tsuji T

更新日期：2019-01-01 00:00:00

abstract：:Coagulase-negative Staphylococcus (CNS) strains are frequently associated with bacteremia and hospital-acquired infections. 293 CNS strains were isolated from 744 samples from a dialysis center in S. M. de Tucumán, Argentina, from hemocultures, catheters and urine and identified as S. epidermidis, S. haemolyticus, S. ...

journal_title：Biological & pharmaceutical bulletin

authors： de Allori MC,Jure MA,Romero C,de Castillo ME

更新日期：2006-08-01 00:00:00

abstract：:Permeation enhancement of ketoprofen (KP) from supersaturated systems and the effects of antinucleant polymers on both stability and permeation of supersaturated KP were investigated using silicone membrane as a skin model. The supersaturation was prepared by the cosolvent technique with water and propylene glycol (PG...

journal_title：Biological & pharmaceutical bulletin

authors： Kumprakob U,Kawakami J,Adachi I

更新日期：2005-09-01 00:00:00

abstract：:The availability and applicability of the combination of paramagnetic nitroxyl contrast agent and T(1)-weighted gradient echo (GE)-based dynamic magnetic resonance imaging (MRI) measurement for redox imaging are described. The time courses of T(1)-weighted GE MRI signal intensities according to first-order paramagneti...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto K

更新日期：2009-04-01 00:00:00

abstract：:The present study assessed the safety/toxicity of Senecio scandens, a well-known Chinese herb that is used as an anti-inflammatory, antibiosis, and antipyretic drug. A 90-d subchronic oral toxicity study of S. scandens was performed in Wistar rats. The extract of S. scandens was administered orally to male and female ...

journal_title：Biological & pharmaceutical bulletin

authors： Wang XK,Zhao Y,Liu T,Yi Y,Li CY,Wang HJ,Wang CH,Wang ZT,Ye ZG,Liang AH

更新日期：2015-01-01 00:00:00

abstract：:Cisplatin-induced nephrotoxicity is related to an increase in lipid peroxidation and oxygen free radicals in a kidney. In the present study, we investigated the effect of the dietary antioxidants, capsaicin (Cap), against cisplatin-induced lipid peroxidation and nephrotoxicity in rats. Nephrotoxicity induced by treatm...

journal_title：Biological & pharmaceutical bulletin

authors： Shimeda Y,Hirotani Y,Akimoto Y,Shindou K,Ijiri Y,Nishihori T,Tanaka K

更新日期：2005-09-01 00:00:00

abstract：:The success of green tea as a cancer preventive is based on evidence that green tea contains tannins and antioxidants, does not show toxicity in humans and has long traditional use in Asia. In the light of this, herbal medicines are now also attracting attention as potential sources of cancer preventive agents. Using ...

journal_title：Biological & pharmaceutical bulletin

authors： Okabe S,Suganuma M,Imayoshi Y,Taniguchi S,Yoshida T,Fujiki H

更新日期：2001-10-01 00:00:00

abstract：:Butylbenzyl phthalate (BBzP) is used as a plasticizer to import flexibility to polyvinylchloride plastics. In this study, hydrolysis of BBzP to monobutyl phthalate (MBP) and monobenzyl phthalate (MBzP) in liver microsomes of humans, monkeys, dogs, rats and mice was examined. The kinetics for MBP formation by human, do...

journal_title：Biological & pharmaceutical bulletin

authors： Takahara Y,Kinashi Y,Takahara Y,Hichiya H,Okada K,Murata M,Shigeyama M,Hanioka N

更新日期：2014-01-01 00:00:00

abstract：:Nitric oxide (NO) and the partial pressure of oxygen (pO(2)) in the liver were simultaneously quantified in rats with partial hepatic ischemia/reperfusion injury (PHIRI). Real-time NO/pO(2) monitoring and immunohistochemical analysis for superoxide dismutase and inducible nitric oxide synthase (iNOS) and endothelial N...

journal_title：Biological & pharmaceutical bulletin

authors： Hataji K,Watanabe T,Oowada S,Nagaya M,Kamibayashi M,Murakami E,Kawakami H,Ishiuchi A,Kumai T,Nakano H,Kobayashi S,Otsubo T

更新日期：2010-01-01 00:00:00

abstract：:Fat specific protein 27 (FSP27) was originally isolated by screen for genes specifically expressed in fully differentiated mouse adipocytes. FSP27 and cell death-inducing DFF45-like effector C (CIDEC), the human homologue of FSP27, belong to the CIDE family. The FSP27 in adipocytes was recently reported to be a lipid ...

journal_title：Biological & pharmaceutical bulletin

authors： Matsusue K

更新日期：2010-01-01 00:00:00

abstract：:Depression and related mood disorders are among the world's greatest public health problems. Previous studies have demonstrated that astilbin (AST) has broad pharmacological functions which may modulate numerous pathways, such as antioxidant, scavenging free radicals, anti-inflammatory and so on, similarly to some of ...

journal_title：Biological & pharmaceutical bulletin

authors： Lv QQ,Wu WJ,Guo XL,Liu RL,Yang YP,Zhou DS,Zhang JX,Liu JY

更新日期：2014-01-01 00:00:00