Inhibitory effects of 5-S-GAD on phosphorylation of V-SRC and BCR-ABL tyrosine kinase.

abstract：:Two fractions of neutral alpha-glucosidase were partially purified from the insoluble fraction of bovine lens. This is the first report of such an event to the best of our knowledge. The apparent native molecular weights of these fractions were 121 kDa (fraction-I) and 254 kDa (fraction-II). Both fractions contained t...

journal_title：Biological & pharmaceutical bulletin

authors： Kamei A,Fujiyama O

更新日期：1995-08-01 00:00:00

abstract：:A safe and effective delivery system with a submicron emulsion for puerarin was studied. Puerarin submicron emulsion was prepared by a novel complex-phase inversion-high press homogenization technology. The mechanism to reduce the hemolysis side effect of puerarin was studied by blood cell counts in rabbits. The avera...

journal_title：Biological & pharmaceutical bulletin

authors： Yue PF,Hai-Long Yuan HL,Zhu WF,Cong LB,Xie H,Liu ZG,Wang LJ,Xiao XH

更新日期：2008-01-01 00:00:00

abstract：:We elucidated the protective effect of 7,8-dihydroxyflavone against hydrogen peroxide (H(2)O(2))-induced DNA damage. We found that 7,8-dihydroxyflavone scavenges 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and intracellular reactive oxygen species (ROS). 7,8-Dihydroxyflavone with antioxidant effect prevented the H(2)...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang R,Kang KA,Piao MJ,Ko DO,Wang ZH,Chang WY,You HJ,Lee IK,Kim BJ,Kang SS,Hyun JW

更新日期：2009-02-01 00:00:00

abstract：:We examined whether adherence of enterohemorrhagic Escherichia coli (EHEC) O157:H7 to intestinal epithelial cells contributed to the induction of secretory immunoglobulin A (IgA) antibody production in mice. Wild-type EHEC O157:H7 and its mutants deficient in the espA, sepL, tir and eae genes, encoding adherent factor...

journal_title：Biological & pharmaceutical bulletin

authors： Nagano K,Taguchi K,Tokoro S,Tatsuno I,Mori H

更新日期：2014-01-01 00:00:00

abstract：:Since grape extract (GE) contains oligomeric proanthocyanidins and numerous polyphenols, dietary GE supplements may exert protective effects against various diseases. The present study investigated the pharmacological effects of GE derived from Chardonnay in vitro and in vivo. GE (100 µg/mL) completely inhibited tumor...

journal_title：Biological & pharmaceutical bulletin

authors： Ohkita M,Hayashi H,Ito K,Shigematsu N,Tanaka R,Tsutsui H,Matsumura Y

更新日期：2019-01-01 00:00:00

abstract：:HL-60 cells differentiate into granulocyte-like cells by all-trans retinoic acid (ATRA) treatment, and the cellular proliferation is markedly reduced during the differentiation. To elucidate the molecular mechanisms of the growth arrest during the cellular differentiation, we examined the regulated expression of the t...

journal_title：Biological & pharmaceutical bulletin

authors： Horie N,Komada Y,Ueta Y,Suzuki T,Nozawa R,Takeishi K

更新日期：2001-12-01 00:00:00

abstract：:Here, we confirmed that stable expression of B-cell lymphoma-xL (Bcl-xL) in N18TG neuroglioma cells could suppress c-Jun N-terminal protein kinase (JNK) activation, nuclear fragmentation, and cell death caused by etoposide treatment. Moreover, additional overexpression of JNK1 led to partially antagonize the antiapopt...

journal_title：Biological & pharmaceutical bulletin

authors： Jeong HS,Choi HY,Choi TW,Kim BW,Kim JH,Lee ER,Cho SG

更新日期：2008-09-01 00:00:00

abstract：:The dopamine reuptake inhibitor bupropion and dopamine D2/3 receptor agonist pramipexole have been clinically proven to improve both depression and treatment-resistant depression. We examined its influence on the duration of immobility during the forced swim test in adrenocorticotropic hormone (ACTH)-treated rats and ...

journal_title：Biological & pharmaceutical bulletin

authors： Onoue Y,Kuwatsuka K,Miyazaki I,Asanuma M,Kitamura Y,Sendo T

更新日期：2014-01-01 00:00:00

abstract：:We investigated the anti-allergic effect of tea-leaf saponin (TLS), which was a mixture of saponins separated from the leaves of Camellia sinensis var. sinensis, in guinea pigs and rats. TLS (20-100 mg/kg) dose-dependently inhibited experimentally-induced asthma, and ID50 was 61.7 mg/kg. TLS (20-100 mg/kg) dose-depend...

journal_title：Biological & pharmaceutical bulletin

authors： Akagi M,Fukuishi N,Kan T,Sagesaka YM,Akagi R

更新日期：1997-05-01 00:00:00

abstract：:Extracellular nucleotides have multiple biological actions in processes such as proliferation, differentiation, chemotaxis, and cytokine secretion through P2X receptors on the cell surface. To determine the biological activity of adenosine triphosphate (ATP) and the expression of P2 nucleotide receptors in murine bone...

journal_title：Biological & pharmaceutical bulletin

authors： Yoon MJ,Lee HJ,Lee YS,Kim JH,Park JK,Chang WK,Shin HC,Kim DK

更新日期：2007-04-01 00:00:00

abstract：:The nasal absorption of non-glycosylated recombinant human granulocyte colony-stimulating factor produced by Esherichia coli (E. coli-rhG-CSF) was studied in rats. We investigated the effects of the basic conditions of the dosing solution and the enhancing effects of various substances to find means to improve the nas...

journal_title：Biological & pharmaceutical bulletin

authors： Nomura H,Akamisaka S,Maruyama K

更新日期：1996-11-01 00:00:00

abstract：:To determine the mechanism involved, the incorporation rate (ICR) of drugs into hair was compared to melanin affinity, lipophilicity and membrane permeability. The following 20 drugs were tested; amphetamine, methamphetamine, p-hydroxyamphetamine, p-hydroxymethamphetamine, cocaine, benzoylecgonine, ecgonine methyl est...

journal_title：Biological & pharmaceutical bulletin

authors： Nakahara Y,Takahashi K,Kikura R

更新日期：1995-09-01 00:00:00

abstract：:Osthole, a main active constituent from Cnidium monnieri (L.) CUSSON, has been considered therapeutic agent in the treatment of ischemic stroke. This study was designed to investigate the effect of osthole on permanent middle cerebral artery occlusion (MCAO) in rats. Osthole was administrated by gavage to the normal a...

journal_title：Biological & pharmaceutical bulletin

authors： Li F,Gong Q,Wang L,Shi J

更新日期：2012-01-01 00:00:00

abstract：:Experimental rat models (5-week-old Sprague-Dawley rats) with hyperlipemia were prepared by feeding high-cholesterol feed containing sodium cholate and casein as a protein source. Dried maitake (Grifola frondosa) powder was mixed with the basic high-cholesterol feed and the serum lipids were periodically measured. Val...

journal_title：Biological & pharmaceutical bulletin

authors： Kubo K,Nanba H

更新日期：1997-07-01 00:00:00

abstract：:Rectal absorption of ozagrel (a selective thromboxane synthetase inhibitor) from suppositories was studied in rabbits. Two kinds of suppositories were prepared, one was from ozagrel powder (OPS, ozagrel powder suppository), and the other from ozagrel tablet (OTS, ozagrel tablet suppository). Ozagrel from OPS was absor...

journal_title：Biological & pharmaceutical bulletin

authors： Zheng NX,Adachi I,Horikoshi I,Kanamoto I

更新日期：1994-02-01 00:00:00

abstract：:The inhibitory effects of five angiotensin-converting enzyme (ACE) inhibitors on the uptake of an aminocephalosporin antibiotic, cefroxadine, by rabbit small intestinal brush-border membrane vesicles were examined in the presence of an inward H+ gradient. Dixon plot analysis showed that all these ACE inhibitors inhibi...

journal_title：Biological & pharmaceutical bulletin

authors： Kitagawa S,Takeda J,Sato S

更新日期：1999-07-01 00:00:00

abstract：:We have recently demonstrated that Bak Foong Pills (BFP), a well-known Chinese medicine widely used for treating gynecological disorders, stimulates human colonic epithelial anion secretion, which was mediated by intracellular cAMP and Ca(2+). The present study further investigated the effect of BFP on exocrine pancre...

journal_title：Biological & pharmaceutical bulletin

authors： Tang N,Zhu JX,Zhao WC,Xing Y,Gou YL,Rowlands DK,Chung YW,Chan HC

更新日期：2003-10-01 00:00:00

abstract：:Neuroinflammation has recently been implicated as an important mechanism responsible for the progression of neurodegenerative diseases. Activated microglia produce various proinflammatory cytokines and nitric oxide (NO) that are toxic to neurons. Thus, inhibition of microglial activation may alleviate neuroinflammator...

journal_title：Biological & pharmaceutical bulletin

authors： Ock J,Hong SH,Suk K

更新日期：2010-01-01 00:00:00

abstract：:The convulsant interaction between enoxacin (ENX), a new quinolone antibacterial agent (NQ), and felbinac (FLB), a non-steroidal anti-inflammatory drug (NSAID), in vivo was reproduced as the change of GABA-induced current response in Xenopus oocytes injected with mouse brain mRNA. GABA (10 microM) response was inhibit...

journal_title：Biological & pharmaceutical bulletin

authors： Kawakami J,Shimokawa M,Yamamoto K,Sawada Y,Asanuma A,Yanagisawa K,Iga T

更新日期：1993-07-01 00:00:00

abstract：:Manganese (Mn) plays an important role in the etiology of several neurobehavioral disorders, but there is a lack of data regarding its specific effects on neurotransduction, especially dopaminergic neurotransduction. We investigated the relationship between motor deficits and alterations in the expression of tyrosine ...

journal_title：Biological & pharmaceutical bulletin

authors： Nam J,Kim K

更新日期：2008-10-01 00:00:00

abstract：:An accumulating body of evidence indicates that inflammation plays a crucial role in the pathophysiology of myocardial infarction (MI). Nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome is an intracellular multiprotein complex that regulates caspase-1 a...

journal_title：Biological & pharmaceutical bulletin

authors： Takahashi M

更新日期：2019-01-01 00:00:00

abstract：:The uptake of low molecular weight fractionated [3H]heparin (LMWFH: 7000 Da) was examined, for comparison with that of high molecular weight fractionated [3H]heparin (HMWFH:20000 Da), in a primary culture of rat hepatocytes. The uptake of LMWFH increased almost linearly with time up to 60 min (extended uptake), althou...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe J,Urano K,Muranishi H,Haba M,Yuasa H

更新日期：1995-03-01 00:00:00

abstract：:Escherichia coli BM2506 produced macrolide 2'-phosphotransferase II [MPH (2') II]. A gene for MPH (2') II, designated mphB, is located on plasmids pTZ3721 and pTZ3723 in E. coli BM2506. In the present study, we determined the nucleotide sequence of the 6.5-kb EcoRI-PstI fragment containing mphB on pTZ3721. The DNA reg...

journal_title：Biological & pharmaceutical bulletin

authors： Katayama J,Noguchi N

更新日期：1999-02-01 00:00:00

abstract：:Echinacoside is a major compound of Cistanche Herb and has glutamate release-inhibiting activity in the brain. Given the involvement of excitotoxicity caused by massive glutamate in the pathophysiology of epilepsy, we explored the antiepileptic effect of echinacoside on kainic acid-induced seizures in rats. The rats w...

journal_title：Biological & pharmaceutical bulletin

authors： Lu CW,Hsieh HL,Lin TY,Hsieh TY,Huang SK,Wang SJ

更新日期：2018-11-01 00:00:00

abstract：:The purpose of this study was to investigate the characteristics of arachidonic acid-induced peripheral vascular disease in rats. Injecting arachidonic acid (2 mg/leg) into the femoral artery caused hind limb gangrene. Histopathological examination revealed occlusive thrombi and marked vascular injury, including denud...

journal_title：Biological & pharmaceutical bulletin

authors： Tanaka T,Takei M,Fukuta Y,Higashino R,Fukuda Y,Nomura Y,Ito S,Tamaki H,Kurimoto T,Suzuki Y

更新日期：1999-03-01 00:00:00

abstract：:Turnera ulmifolia is a plant belonging to the family Turneraceae, popularly known in Brazil as chanana. This species is distributed from Guyana to southern Brazil where it is considered a weed. The plant occurs in tropical rain forest, fields, and gardens. Chanana tea is used in Brazilian folk medicine for the treatme...

journal_title：Biological & pharmaceutical bulletin

authors： Gracioso Jde S,Vilegas W,Hiruma-Lima CA,Souza Brito AR

更新日期：2002-04-01 00:00:00

abstract：:2'-Fucosyllactose (2FL) is the most abundant component of the oligosaccharide content in human milk. It has been reported that 2FL has the ability to protect against infectious disease caused by bacterial pathogens. In this study, we investigated the protective effects of 2FL on particulate matter (PM)10-induced pro-i...

journal_title：Biological & pharmaceutical bulletin

authors： Lee KE,Ryu JJ,Jo YK,Yeo H,Kang S

更新日期：2019-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the accuracy of the recommended theophylline therapeutic range in the treatment of acute airway obstruction. Twenty seven patients (20 to 64 years) with acute asthma attack were given aminophylline intravenously to obtain a theophylline concentration between 10 and 20 microgra...

journal_title：Biological & pharmaceutical bulletin

authors： Nakahara Y,Murata M,Suzuki T,Ohtsu F,Nagasawa K

更新日期：1996-05-01 00:00:00

abstract：:We investigated a method for the simultaneous screening, identification, and quantitative determination of salicylic acid, acetaminophen, theophylline, barbiturates, and bromvalerylurea, drugs that frequently cause acute poisoning in Japan and therefore require rapid analysis for effective treatment in the clinical se...

journal_title：Biological & pharmaceutical bulletin

authors： Hori Y,Fujisawa M,Shimada K,Hirose Y,Yoshioka T

更新日期：2006-01-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-α) plays an important role in the developing process of inflammatory bowel disease. Tight junction protein zonula occludens-1 (ZO-1), one of epithelial junctional proteins, maintains the permeability of intestinal barrier. The objective of this study was to investigate the mechanism of...

journal_title：Biological & pharmaceutical bulletin

authors： Wang L,Zhang R,Chen J,Wu Q,Kuang Z

更新日期：2017-04-01 00:00:00