Lower Squalene Epoxidase and Higher Scavenger Receptor Class B Type 1 Protein Levels Are Involved in Reduced Serum Cholesterol Levels in Stroke-Prone Spontaneously Hypertensive Rats.

Abstract:

:A lower serum cholesterol level was recently shown to be one of the causes of stroke in an epidemiological study. Spontaneously hypertensive rats stroke-prone (SHRSP) have lower serum cholesterol levels than normotensive Wistar-Kyoto rats (WKY). To elucidate the mechanisms responsible for the lower serum cholesterol levels in SHRSP, we determined whether the amounts of cholesterol biosynthetic enzymes or the receptor and transporter involved in cholesterol uptake and efflux in the liver were altered in SHRSP. When the mRNA levels of seven cholesterol biosynthetic enzymes were measured using real-time polymerase chain reaction (PCR), farnesyl pyrophosphate synthase and squalene epoxidase (SQE) levels in the liver of SHRSP were significantly lower than those in WKY. SQE protein levels were significantly reduced in tissues other than the brain of SHRSP. No significant differences were observed in low-density lipoprotein (LDL) receptor (uptake of serum LDL-cholesterol) or ATP-binding cassette transporter A1 (efflux of cholesterol from the liver/formation of high-density lipoprotein (HDL)) protein levels in the liver and testis between SHRSP and WKY, whereas scavenger receptor class B type 1 (SRB1: uptake of serum HDL-cholesterol) protein levels were higher in the livers of SHRSP. These results indicated that the lower protein levels of SQE and higher protein levels of SRB1 in the liver were involved in the reduced serum cholesterol levels in SHRSP.

journal_name

Biol Pharm Bull

authors

Michihara A,Mido M,Matsuoka H,Mizutani Y

doi

10.1248/bpb.b15-00450

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

1879-90

issue

12

eissn

0918-6158

issn

1347-5215

journal_volume

38

pub_type

杂志文章
  • Influence of thermodynamic parameter in Lanosterol 14alpha-demethylase inhibitory activity as antifungal agents: a QSAR approach.

    abstract::A quantitative structure activity relationship, Hansch approach was applied on twenty compounds of chromene derivatives as Lanosterol 14alpha-demethylase inhibitory activity against eight fungal organisms. Various physicochemical descriptors and reported minimum inhibitory concentration values of different fungal orga...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.29.1262

    authors: Vasanthanathan P,Lakshmi M,Arockia Babu M,Kaskhedikar SG

    更新日期:2006-06-01 00:00:00

  • Determination of uric acid in scalp hair for non-invasive evaluation of uricemic controls in hyperuricemia.

    abstract::The uric acid concentration in blood has been widely accepted as a diagnostic indicator of hyperuricemia and gout, and its assay method is well established. In the present study, we developed a simple and rapid method for the determination of uric acid in hair, which can be obtained non-invasively. The concentration (...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 临床试验,杂志文章

    doi:10.1248/bpb.21.398

    authors: Kobayashi K,Morioka Y,Isaka Y,Tozawa T

    更新日期:1998-04-01 00:00:00

  • Social isolation stress-induced oxidative damage in mouse brain and its modulation by majonoside-R2, a Vietnamese ginseng saponin.

    abstract::Stressors with a physical factor such as immobilization, electric foot shock, cold swim, etc., have been shown to produce oxidative damage to membrane lipids in the brain. In this study, we investigated the effect of protracted social isolation stress on lipid peroxidation activity in the mouse brain and elucidated th...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.28.1389

    authors: Huong NT,Murakami Y,Tohda M,Watanabe H,Matsumoto K

    更新日期:2005-08-01 00:00:00

  • Low density lipoprotein (LDL)-antioxidant flavonoids from roots of Sophora flavescens.

    abstract::Oxidation of low density lipoprotein (LDL) is strongly implicated as a key process in the onset of atherosclerosis. In this study, nine alkylated (C10-C5) flavonoids from Sophora flavescens were examined for their inhibitory effects on copper-induced LDL oxidation. Of the flavonoids tested, sophoraflavanone G (1), kur...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.31.2097

    authors: Jeong TS,Ryu YB,Kim HY,Curtis-Long MJ,An S,Lee JH,Lee WS,Park KH

    更新日期:2008-11-01 00:00:00

  • Pharmacokinetic analysis program based on tank-in-series model, MULTI(TIS), for evaluation of capacity-limited local disposition.

    abstract::A pharmacokinetic analysis program based on a tank-in-series model, MULTI(TIS), was developed for the evaluation of dose-dependency in the local disposition of a drug. The program written in FORTRAN was constructed by expanding MULTI(RUNGE). The reliability of MULTI(TIS) was verified by analyzing the experimental data...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.21.1338

    authors: Fukumura K,Yamaoka K,Higashimori M,Nakagawa T

    更新日期:1998-12-01 00:00:00

  • Topology of Surface Ligands on Liposomes: Characterization Based on the Terms, Incorporation Ratio, Surface Anchor Density, and Reaction Yield.

    abstract::The surface topology of ligands on liposomes is an important factor in active targeting in drug delivery systems. Accurately evaluating the density of anchors and bioactive functional ligands on a liposomal surface is critical for ensuring the efficient delivery of liposomes. For evaluating surface ligand density, it ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b16-00462

    authors: Lee SH,Sato Y,Hyodo M,Harashima H

    更新日期:2016-01-01 00:00:00

  • Evaluation of predictability for vancomycin dosage regimens by the Bayesian method with Japanese population pharmacokinetic parameters.

    abstract::The predictability of serum vancomycin (VCM) concentrations by means of the Bayesian method was evaluated to establish whether the method can be used to select safe and effective VCM treatment regimens for individual patients. Serum VCM concentrations at the trough and 2 h after the end of infusion (peak) were measure...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.25.1333

    authors: Teramachi H,Hatakeyama H,Matsushita R,Imai Y,Miyamoto K,Tsuji A

    更新日期:2002-10-01 00:00:00

  • Human Placenta Hydrolysate Promotes Liver Regeneration via Activation of the Cytokine/Growth Factor-Mediated Pathway and Anti-oxidative Effect.

    abstract::Liver regeneration is a very complex process and is regulated by several cytokines and growth factors. It is also known that liver transplantation and the regeneration process cause massive oxidative stress, which interferes with liver regeneration. The placenta is known to contain various physiologically active ingre...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b18-00712

    authors: Lee TH,Park DS,Jang JY,Lee I,Kim JM,Choi GS,Oh CT,Kim JY,Han HJ,Han BS,Joh JW

    更新日期:2019-01-01 00:00:00

  • Study of the pharmacological effect of the bile salt, sodium scymnol sulfate, from Rhizoprionodon acutus. III. Protective effect of scymnol against vascular endothelial cell damage in a rat peripheral arterial occlusion model.

    abstract::The prophylactic action of scymnol in a rat peripheral arterial occlusion model, involving injection of 5% lactic acid into the femoral artery, was investigated. Increases in serum lactate dehydrogenase (LDH), glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) activities and in plasma leve...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.22.822

    authors: Ishida H,Nakayasu H,Nukaya H,Tsuji K

    更新日期:1999-08-01 00:00:00

  • Enzymatic sulfation of glycosides and their corresponding aglycones by arylsulfate sulfotransferase from a human intestinal bacterium.

    abstract::A novel type of arylsulfate sulfotransferase (ASST) from a predominant human intestinal bacterium catalyzes the stoichiometric transfer of a sulfate group from phenolic sulfate esters to phenols. We clarified that polyphenols were better substrates of this enzyme than the corresponding glycosides. Additionally, a coum...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.17.1018

    authors: Konishi-Imamura L,Sato M,Dohi K,Kadota S,Namba T,Kobashi K

    更新日期:1994-08-01 00:00:00

  • Comparison of the blood clearance of triple- and single-helical schizophyllan in mice.

    abstract::(1-->3)-beta-D-Glucans exhibit a variety of biological and immunopharmacological activities, and the degree of these activities depends on the nature of the individual glucans e.q. molecular weight, degree of branching and conformation. Based on the generally accepted evidence that the conformation of Sonifilan (SPG) ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.18.185

    authors: Miura NN,Ohno N,Adachi Y,Aketagawa J,Tamura H,Tanaka S,Yadomae T

    更新日期:1995-01-01 00:00:00

  • Antidepressant effects of apocynum venetum leaves in a forced swimming test.

    abstract::An extract of the leaves of Apocynum venetum L. (Apocynaceae) markedly shortened the immobility time of male rats in a forced swimming test (FST) in a dose range of 30-125 mg/kg, indicating a possible antidepressant activity. This effect was comparable to that of the tricyclic antidepressant imipramine (20 mg/kg). Nei...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.24.848

    authors: Butterweck V,Nishibe S,Sasaki T,Uchida M

    更新日期:2001-07-01 00:00:00

  • Application of a non-linear dispersion model to analysis of the renal handling of p-aminohippurate in isolated perfused rat kidney.

    abstract::To analyze the renal handling of therapeutic compounds observed as a non-linear process with a diffusion phenomenon, we employed a non-linear dispersion model described with a partial differential equation and solved it by using the finite difference method with an implicit scheme in a model dependent analysis. In thi...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.22.633

    authors: Aiba T,Kubota S,Koizumi T

    更新日期:1999-06-01 00:00:00

  • Involvement of c-Met- and phosphatidylinositol 3-kinase dependent pathways in arsenite-induced downregulation of catalase in hepatoma cells.

    abstract::Catalase protects cells from reactive oxygen species-induced damage by catalyzing the breakdown of hydrogen peroxide to oxygen and water. Arsenite decreases catalase activity; it activates phosphatidylinositol 3-kinase (PI3K) and its key downstream effector Akt in a variety of cells. The PI3K pathway is known to inhib...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.34.1748

    authors: Kim S,Lee SH,Kang S,Lee L,Park JD,Ryu DY

    更新日期:2011-01-01 00:00:00

  • Yokukansan inhibits social isolation-induced aggression and methamphetamine-induced hyperlocomotion in rodents.

    abstract::Behavioral and psychological symptoms of dementia (BPSD) are commonly seen in patients with Alzheimer's disease (AD) and other forms of senile dementia. BPSD have a serious impact on the quality of life of dementia patients, as well as on that of their caregivers. However, effective drug therapy for BPSD has not been ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.32.372

    authors: Uchida N,Egashira N,Iwasaki K,Ishibashi A,Tashiro R,Nogami A,Manome N,Abe M,Takasaki K,Mishima K,Takata J,Oishi R,Nishimura R,Fujiwara M

    更新日期:2009-03-01 00:00:00

  • Differential Development of Facial and Hind Paw Allodynia in a Nitroglycerin-Induced Mouse Model of Chronic Migraine: Role of Capsaicin Sensitive Primary Afferents.

    abstract::Despite the relatively high prevalence of migraine or headache, the pathophysiological mechanisms triggering headache-associated peripheral hypersensitivities, are unknown. Since nitric oxide (NO) is well known as a causative factor in the pathogenesis of migraine or migraine-associated hypersensitivities, a mouse mod...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b17-00589

    authors: Kim SJ,Yeo JH,Yoon SY,Kwon SG,Lee JH,Beitz AJ,Roh DH

    更新日期:2018-02-01 00:00:00

  • Molecular and sugar-binding heterogeneity of C-type lectins from Osmerus (Spirinchus) lanceolatus eggs.

    abstract::Two C-type lectins (OLLafs and OLLafl) were isolated from Osmerus (Spirinchus) lanceolatus eggs using asialofetuin-Sepharose column. OLLafs and OLLafl were eluted with 0.2 M sucrose and 0.2 M lactose from the same column, respectively. OLLafl has been estimated to be a heterodimeric protein composed of H- and L-subuni...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.28.791

    authors: Sugawara S,Hosono M,Ogawa Y,Takayanagi M,Nitta K

    更新日期:2005-05-01 00:00:00

  • Mechanism of decreased susceptibility for Gram-negative bacteria and synergistic effect with ampicillin of indole-3-carbinol.

    abstract::Indole-3-carbinol (I3C) is a natural compound found in a wide variety of plant food substances including members of the family Cruciferae with antioxidant and potential chemopreventive properties. In a previous study, I3C exhibited broad spectrum antibacterial activities. Particularly, it showed a more potent antibact...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.31.1798

    authors: Sung WS,Lee DG

    更新日期:2008-09-01 00:00:00

  • Common mechanisms of onset of cancer and neurodegenerative diseases.

    abstract::Onset of cancer and neurodegenerative disease occurs by abnormal cell growth and neuronal cell death, respectively, and the number of patients with both diseases has been increasing in parallel with an increase in mean lifetime, especially in developed countries. Although both diseases are sporadic, about 10% of the d...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章,评审

    doi:10.1248/bpb.b15-00125

    authors: Ariga H

    更新日期:2015-01-01 00:00:00

  • The effect of zaldaride maleate, an antidiarrheal compound, on acetylcholine-induced intestinal electrolyte secretion.

    abstract::The effect of zaldaride on acetylcholine-induced colonic electrolyte secretion was examined. The short-circuit current response to acetylcholine was partially reduced by tetrodotoxin, a neuronal blocker, and was completely inhibited by atropine, an acetylcholine M receptor antagonist, in the rat colonic preparations. ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.23.1377

    authors: Aikawa N,Kishibayashi N,Karasawa A,Ohmori K

    更新日期:2000-11-01 00:00:00

  • Depressive effect of a traditional Chinese medicine (sho-saiko-to) on endotoxin-induced nitric oxide formation in activated murine macrophage J774A.1 cells.

    abstract::The present study investigated whether or not Sho-saiko-to (crude powder extract, TJ-9) can suppress nitric oxide (NO) generation by endotoxin-activated J774A.1 cells in order to study the preventive mechanism of Sho-saiko-to against endotoxemia. In this experiment, we estimated the NO2- in the murine macrophage cell ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.18.621

    authors: Sakaguchi S,Furusawa S,Yokota K,Sasaki K,Takayanagi Y

    更新日期:1995-04-01 00:00:00

  • Genetic engineering of transgenic tobacco for enhanced uptake and bioaccumulation of mercury.

    abstract::To further enhance the efficiency and potential of plants for phytoremediation of mercury pollution, a genetically engineered tobacco to simultaneously express mercury transporter, mercury transporter (MerT) and mercury chelator, polyphosphate (polyP) was constructed by integrating bacterial merT gene in polyphosphate...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.32.1491

    authors: Nagata T,Nakamura A,Akizawa T,Pan-Hou H

    更新日期:2009-09-01 00:00:00

  • Citric Acid Suppresses the Bitter Taste of Olopatadine Hydrochloride Orally Disintegrating Tablets.

    abstract::Orally disintegrating tablets (ODTs) are formulated to disintegrate upon contact with saliva, allowing administration without water. Olopatadine hydrochloride, a second-generation antihistamine, is widely used for treating allergic rhinitis. However, it has a bitter taste; therefore, the development of taste-masked ol...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b16-00828

    authors: Sotoyama M,Uchida S,Tanaka S,Hakamata A,Odagiri K,Inui N,Watanabe H,Namiki N

    更新日期:2017-01-01 00:00:00

  • Relaxin Ameliorates Renal Fibrosis and Expression of Endothelial Cell Transition Markers in Rats of Isoproterenol-Induced Heart Failure.

    abstract::There may be cardio-renal interactions in rats of isoproterenol-induced heart failure, which may be associated with renal fibrosis and endothelial-to-mesenchymal transition (EndMT). Since its discovery, relaxin (RLX) which was regarded as a reproductive hormone for a long time, is recently considered an effective anti...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b16-00882

    authors: Zheng G,Cai J,Chen X,Chen L,Ge W,Zhou X,Zhou H

    更新日期:2017-01-01 00:00:00

  • A tale of early response genes.

    abstract::Immediate early genes (IEG) are rapidly but transiently induced directly by intracellular signaling cascades to alter patterns of gene expression. It has been proposed that histone modifications could be the key to the quick alteration of chromatin structure, as this spread occurs too rapidly to be the consequence of ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章,评审

    doi:10.1248/bpb.27.606

    authors: Sng JC,Taniura H,Yoneda Y

    更新日期:2004-05-01 00:00:00

  • Osthole reverses beta-amyloid peptide cytotoxicity on neural cells by enhancing cyclic AMP response element-binding protein phosphorylation.

    abstract::Accumulation of β-amyloid peptide (Aβ) in the brain plays an important role in the pathogenesis of Alzheimer’s disease (AD). Previous studies have demonstrated the neuroprotective role of osthole against oxygen and glucose deprivation in cortical neurons. However, the effects of osthole on Aβ-induced neurotoxicity in ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b13-00561

    authors: Hu Y,Wen Q,Liang W,Kang T,Ren L,Zhang N,Zhao D,Sun D,Yang J

    更新日期:2013-01-01 00:00:00

  • Fucoidan modulates the effect of transforming growth factor (TGF)-beta1 on fibroblast proliferation and wound repopulation in in vitro models of dermal wound repair.

    abstract::Aberrant wound healing, either causing scarring or chronic wounds, is a significant cause of morbidity. There is therefore, considerable interest in agents which can modulate certain aspects of the wound healing process. Fucoidans, sulphated polyfucose polysaccharides which may be extracted from Fucus spp., have been ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.27.266

    authors: O'Leary R,Rerek M,Wood EJ

    更新日期:2004-02-01 00:00:00

  • Reversal effect of arsenic sensitivity in human leukemia cell line K562 and K562/ADM using realgar transforming solution.

    abstract::The success of arsenic trioxide (ATO) in treatment of acute promyelocytic leukemia (APL) attracts a great deal of attention to researchers to explore its activity of anti-leukemia. However, ATO has unavailable effect on chronic myeloid leukemia (CML), especially multidrug resistant (MDR)-CML, unless using high concent...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b12-01015

    authors: Wang X,Zhang X,Xu Z,Wang Z,Yue X,Li H

    更新日期:2013-01-01 00:00:00

  • Synergistic enhancement of nitrite on lysophospholipid-mediated cytolysis.

    abstract::Nitrogen oxide, which is produced by activated macrophages, has been demonstrated to possess anti-tumor activity. We report herein the synergistic effect of sodium nitrite (NO2-) and/or sodium nitroprusside (SNP) on lysophospholipid (LysoPL)-mediated cytolysis. The incubation of 51Cr-labeled mouse melanoma (B16) cells...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.17.78

    authors: Kanematsu M,Takagi K,Suketa Y

    更新日期:1994-01-01 00:00:00

  • A rat model of early sepsis: relationships between gentamicin pharmacokinetics and systemic and renal effects of bacterial lipopolysaccharide combined with interleukin-2.

    abstract::A rat model of early sepsis induced by lipopolysaccharide (LPS) combined with interleukin-2 (IL-2) was developed. The primary aim was to assess the pharmacokinetics of gentamicin and sepsis-induced pathophysiological changes. Moreover, the effects on the glomerular filtration rate and tubular function were studied in ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b12-00205

    authors: Studena S,Martinkova J,Slizova D,Krs O,Senkerik M,Springer D,Chládek J

    更新日期:2012-01-01 00:00:00