Abstract:
:The effects of various absorption promoters on the pulmonary absorption of drugs with different molecular weights were examined in rats. Phenol red and fluorescein isothiocyanate-labeled dextrans (FDs) with various molecular weights were used as model drugs and the absorption promoters used in this study were sodium glycocholate, sodium salicylate, ethylenediaminetetraacetic acid disodium salt (Na2-EDTA) and sodium caprate, all at a concentration of 1%. Of these absorption promoters, sodium glycocholate and sodium caprate appeared to be more effective for enhancing the pulmonary absorption of these drugs than sodium salicylate and Na2-EDTA. Furthermore, it was indicated that there is the optimal molecular weight to which each absorption promoter gives the largest enhancing effect on the pulmonary absorption of drugs.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Morita T,Yamamoto A,Hashida M,Sezaki Hdoi
10.1248/bpb.16.259subject
Has Abstractpub_date
1993-03-01 00:00:00pages
259-62issue
3eissn
0918-6158issn
1347-5215journal_volume
16pub_type
杂志文章abstract::The aim of the present study was to determine the effect of sulfaphenazole (SP) on the pharmacokinetics of ampiroxicam (AM) which is metabolized by cytochrome P-450 (CYP) 2C9, since SP is a potent inhibitor of CYP 2C9, and so a dramatic pharmacokinetic drug interaction between both drugs is assumed after dosing. Singl...
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journal_title:Biological & pharmaceutical bulletin
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journal_title:Biological & pharmaceutical bulletin
pub_type: 杂志文章
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journal_title:Biological & pharmaceutical bulletin
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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更新日期:2014-01-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
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journal_title:Biological & pharmaceutical bulletin
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journal_title:Biological & pharmaceutical bulletin
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更新日期:2017-01-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
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journal_title:Biological & pharmaceutical bulletin
pub_type: 杂志文章
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更新日期:1999-06-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
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journal_title:Biological & pharmaceutical bulletin
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更新日期:2015-01-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
pub_type: 杂志文章
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更新日期:1999-04-01 00:00:00
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更新日期:2006-06-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
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journal_title:Biological & pharmaceutical bulletin
pub_type: 杂志文章
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journal_title:Biological & pharmaceutical bulletin
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更新日期:2000-06-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
pub_type: 杂志文章,评审
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abstract::3',4'-Diisovalerylkhellactone diester (PJ-1) is a coumarin derivative purified from the medicinal herb Peucedanum japonicum Thunb. We examined its in vitro effects on various aspects of platelet reactivity. PJ-1 inhibited the aggregation and ATP release of rabbit platelets induced by PAF (platelet-activating factor) a...
journal_title:Biological & pharmaceutical bulletin
pub_type: 杂志文章
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更新日期:1998-07-01 00:00:00