Animal models of attention-deficit/hyperactivity disorder.

Abstract:

:Attention-deficit hyperactivity disorder (AD/HD) is a clinically heterogenous disorder including hyperactivity, impulsivity, and inattention. Both psychostimulant and non-psychostimulant drugs such as methylphenidate and atomoxetine, respectively, to modulate catecholeamine neurotransmission are used as current pharmacotherapies for AD/HD. Multiple lines of evidence suggest that genetic factors play major roles in the etiology of AD/HD. meta-Analyses and pooled data analyses have suggested associations between AD/HD and polymorphisms in genes encoding monoamine neurotransmission molecules. There has been considerable research on this disorder using genetic, pharmacological, and neuroimaging approaches, and several animal models of AD/HD such as spontaneously hypertensive rat (SHR), dopamine transporter (DAT) knockout mice, coloboma mutant mouse, and Grin1 mutant mouse have been reported. These animal models are valuable tools for investigating molecular, cellular, and behavioral mechanisms as well as the neural development and circuit mechanisms of AD/HD. Here, we review the recent literature on animal models of AD/HD and discuss their advantages and limitations.

journal_name

Biol Pharm Bull

authors

Arime Y,Kubo Y,Sora I

doi

10.1248/bpb.34.1373

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

1373-6

issue

9

eissn

0918-6158

issn

1347-5215

pii

JST.JSTAGE/bpb/34.1373

journal_volume

34

pub_type

杂志文章
  • Antihypertensive actions of methylripariochromene A from Orthosiphon aristatus, an Indonesian traditional medicinal plant.

    abstract::Methylripariochromene A (MRC) was isolated from the leaves of Orthosiphon aristatus (Lamiaceae) and subjected to the examination of several pharmacological actions related to antihypertensive activity. The following four findings were revealed from the present study: 1) MRC caused a continuous decrease in systolic blo...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.22.1083

    authors: Matsubara T,Bohgaki T,Watarai M,Suzuki H,Ohashi K,Shibuya H

    更新日期:1999-10-01 00:00:00

  • Utility decay rates of t(1)-weighted magnetic resonance imaging contrast based on redox-sensitive paramagnetic nitroxyl contrast agents.

    abstract::The availability and applicability of the combination of paramagnetic nitroxyl contrast agent and T(1)-weighted gradient echo (GE)-based dynamic magnetic resonance imaging (MRI) measurement for redox imaging are described. The time courses of T(1)-weighted GE MRI signal intensities according to first-order paramagneti...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.32.711

    authors: Matsumoto K

    更新日期:2009-04-01 00:00:00

  • Pharmacological characteristics of Ryokan-kyomi-shinge-nin-to, an antiallergic Kampo medicine.

    abstract::The pharmacological characteristics of Ryokan-kyomi-shinge-nin-to (RKS), a traditional oriental herbal (Kampo) medicine which has been used for the treatment of allergic asthma and rhinitis, were investigated. The number of sneezes by actively sensitized mice after a topical antigen challenge was significantly reduced...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.25.1562

    authors: Sakaguchi M,Ikeda Y,Kido T,Yuzurihara M,Kase Y,Yamamoto M,Ishige A,Sasaki H

    更新日期:2002-12-01 00:00:00

  • Molecular identification of "Chuanxiong" by nucleotide sequence and multiplex single base extension analysis on chloroplast trnK gene.

    abstract::Chloroplast trnK gene sequences of Cnidium officinale and Ligusticum chuanxiong were determined to establish an effective method for identifying Japanese Senkyu and Chinese Chuanxiong, the two which have the same drug name in Chinese characters, similar external feature, but different botanical origins. Three sites of...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.30.527

    authors: Zhu S,Fushimi H,Han G,Tsuchida T,Uno T,Takano A,Komatsu K

    更新日期:2007-03-01 00:00:00

  • Prevention of Atherosclerosis by the Induction of Microbial Polyamine Production in the Intestinal Lumen.

    abstract::Low molecular weight metabolites produced by the intestinal microbiome that have been associated with health and disease as metabolites need to be constantly absorbed from the intestinal lumen and transported to intestinal epithelial cells and blood. Polyamines, especially spermidine and spermine, are bioactive chemic...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章,评审

    doi:10.1248/bpb.b19-00855

    authors: Matsumoto M

    更新日期:2020-01-01 00:00:00

  • Lavandulyl flavonoids from Sophora flavescens suppress lipopolysaccharide-induced activation of nuclear factor-kappaB and mitogen-activated protein kinases in RAW264.7 cells.

    abstract::Oxidized low-density lipoprotein (oxLDL) and reactive oxygen species (ROS) play key roles in the early stage of atherosclerosis. Nitric oxide (NO) and ROS are responsible for regulation of the transcriptional pathways of nuclear Factor-kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK), key regulators of c...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.33.1019

    authors: Han JM,Jin YY,Kim HY,Park KH,Lee WS,Jeong TS

    更新日期:2010-01-01 00:00:00

  • Neural mechanisms of swallowing and effects of taste and other stimuli on swallow initiation.

    abstract::Swallowing involves several motor processes such as bolus formation and intraoral transport of a food bolus (oral stage) and a series of visceral events that occur in a relatively fixed timed sequence but are to some degree modifiable (pharyngeal stage or swallow reflex). Reflecting the progressive aging of society, p...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章,评审

    doi:10.1248/bpb.33.1786

    authors: Yamamura K,Kitagawa J,Kurose M,Sugino S,Takatsuji H,Mostafeezur RM,Zakir HM,Yamada Y

    更新日期:2010-01-01 00:00:00

  • Effect of insulin administration on bone formation is impaired in rats with skeletal unloading.

    abstract::The effect of insulin administration on bone formation was investigated in the femoral diaphysis of rats with skeletal unloading. When the femoral-diaphyseal tissues from normal rats were cultured in the presence of insulin (10(-9) and 10(-8) M) for 48 h, the hormone produced a significant increase of alkaline phospha...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.16.1179

    authors: Yamaguchi M,Kishi S,Hoshi T

    更新日期:1993-11-01 00:00:00

  • In a methotrexate-induced model of intestinal mucositis, olmesartan reduced inflammation and induced enteropathy characterized by severe diarrhea, weight loss, and reduced sucrose activity.

    abstract::The aim of this study was to evaluate the effect of olmesartan (OLME), an angiotensin II receptor antagonist, on an intestinal mucositis model. Briefly, daily intraperitoneal (i.p.) injections of methotrexate (MTX) 7 mg/kg were administered to rats on 3 consecutive days. A subset of these rats was also pretreated with...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b14-00847

    authors: de Araújo AA,Borba PB,de Souza FH,Nogueira AC,Saldanha TS,Araújo TE,da Silva AI,de Araújo Júnior RF

    更新日期:2015-01-01 00:00:00

  • Non-methylated CpG motif packaged into fusogenic liposomes enhance antigen-specific immunity in mice.

    abstract::DNA rich in non-methylated CG motifs (CpGs) enhances induction of immune responses against co-administered antigen encoding genes. CpGs are therefore among the promising adjuvants known to date. However, naked plasmid DNA, even which contains CpG motifs, are taken up by antigen presenting cells via the endocytosis pat...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.29.105

    authors: Yoshikawa T,Imazu S,Gao JQ,Hayashi K,Tsuda Y,Okada N,Tsutsumi Y,Akashi M,Mayumi T,Nakagawa S

    更新日期:2006-01-01 00:00:00

  • Nonenzymatic glycation of transferrin: decrease of iron-binding capacity and increase of oxygen radical production.

    abstract::The total iron-binding capacity (TIBC) and iron contents of diabetic rat serum, as well as the iron-binding capacity of glycated transferrin and oxygen radical production by the glycated proteins were examined. The TIBC and iron content of diabetic rat sera were found to be much lower than those of control rat sera. I...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.18.396

    authors: Fujimoto S,Kawakami N,Ohara A

    更新日期:1995-03-01 00:00:00

  • Site-directed mutagenesis of the serotonin 5-Hydroxytryptamine2c receptor: identification of amino acids responsible for sarpogrelate binding.

    abstract::Site-directed mutagenesis was used to investigate the molecular interactions involved in sarpogrelate binding to the human 5-Hydroxytryptamine(5-HT)2C receptor. Based on molecular modeling studies, Aspartic acid (Asp)155[3.32] in transmembrane region III and Serine(Ser)361[7.46] in transmembrane region VII of the 5-HT...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.29.1645

    authors: Muntasir HA,Takahashi J,Rashid M,Ahmed M,Komiyama T,Hossain M,Kawakami J,Nashimoto M,Nagatomo T

    更新日期:2006-08-01 00:00:00

  • Effectiveness of the Sleep Enhancement by Green Romaine Lettuce (Lactuca sativa) in a Rodent Model.

    abstract::This study was conducted to investigate the effects of the extracts of green romaine lettuce (GRE) on sleep enhancement. GRE contains 1071.7 and 199.2 µg/g of extracts of lactucin and lactucopicrin, respectively, known as sleep enhancement substances. When 100 mg/kg of GRE was administered orally, sleep latency and du...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b19-00454

    authors: Kim HW,Suh HJ,Choi HS,Hong KB,Jo K

    更新日期:2019-01-01 00:00:00

  • Neuroprotective effect of kaempferol against a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.

    abstract::In the present study, we investigated the neuroprotective effects of kaempferol in the mouse model of Parkinson's disease, which was induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We confirmed that MPTP led to behavioral deficits, depletion of dopamine and its metabolites, reduction in supe...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.34.1291

    authors: Li S,Pu XP

    更新日期:2011-01-01 00:00:00

  • Neuroprotective effects of phenylethanoid glycosides from Cistanches salsa against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity in C57 mice.

    abstract::The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been employed to create a Parkinson's disease-like model in both rodents and primates based primarily on its ability to create a striatal dopamine deficit due to the loss of dopaminergic neurons in the substantia nigra compacta. The present study w...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.27.797

    authors: Geng X,Song L,Pu X,Tu P

    更新日期:2004-06-01 00:00:00

  • Cell death mode switch from necrosis to apoptosis in brain.

    abstract::In brain ischemia, cell destructive necrosis occurs in the core, which in turn links to cell death expansion in the vicinity. Apoptosis, on the other hand, occurs in the surroundings of the core, called the penumbra, several days later. As cells showing apoptosis disappear by microglial phagocytosis in the brain, cell...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章,评审

    doi:10.1248/bpb.27.950

    authors: Ueda H,Fujita R

    更新日期:2004-07-01 00:00:00

  • Expression and Characterization of the Human Intestinal Bacterial Enzyme Which Cleaves the C-Glycosidic Bond in 3″-Oxo-puerarin.

    abstract::Puerarin (daidzein 8-C-glucoside) is an isoflavone C-glucoside contained in the roots of Pueraria lobata OHWI. We have previously isolated the human intestinal bacterium, strain PUE, which metabolizes puerarin to daidzein, though the enzyme which cleaves C-glycosidic bond has not been clarified. Here, we identified on...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b18-00729

    authors: Nakamura K,Zhu S,Komatsu K,Hattori M,Iwashima M

    更新日期:2019-03-01 00:00:00

  • Therapeutic Effect of Gypenosides on Nonalcoholic Steatohepatitis via Regulating Hepatic Lipogenesis and Fatty Acid Oxidation.

    abstract::Nonalcoholic steatohepatitis (NASH) is the most frequent cause of liver dysfunction and a common global problem. Gypenosides can decrease pathological modifications of high-fat diet-induced rat atherosclerosis; however, its effect and mechanism on NASH remain unclear. In this study, rats were randomly divided into nor...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b16-00942

    authors: Li H,Ying H,Hu A,Hu Y,Li D

    更新日期:2017-01-01 00:00:00

  • The Activity of Fungichromin against the Formation of Candida albicans Biofilm.

    abstract::The effect of fungichromin (FC) on the formation of Candida albicans biofilm was assessed using 2,3-bis(2-methoxy-4-nitro-5-sulfo-phenyl)-2H-tetrazolium-5-carboxanilide (XTT) reduction method, scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). Results showed that FC revealed an inhibitor...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b16-00380

    authors: An D,Wang X,Li J,Jiang S,Ma X,Zhang H,Shi H,Sun H,Ye L,Li J

    更新日期:2016-12-01 00:00:00

  • Neuroprotective properties of gallic acid from Sanguisorbae radix on amyloid beta protein (25--35)-induced toxicity in cultured rat cortical neurons.

    abstract::Our previous studies reported that methanol extract of Sanguisorbae radix from Sanguisorba officinalis L. (Rosaceae) prevented neuronal cell damage induced by Abeta (25-35) in vitro. The present study was carried out to investigate the effect of gallic acid isolated from Sanguisorbae radix on Abeta (25-35)-induced neu...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.31.149

    authors: Ban JY,Nguyen HT,Lee HJ,Cho SO,Ju HS,Kim JY,Bae K,Song KS,Seong YH

    更新日期:2008-01-01 00:00:00

  • Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats.

    abstract::Berberine is one of the main alkaloids of Rhizoma coptidis which has been used as a folk medicine to treat diabetes mellitus for more than 1400 years in China. To investigate the chronic effect of berberine on diabetic hyperlipidemic rats, fasted rats were intraperitoneally injected 35 mg/kg streptozotocin. Diabetic r...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.31.1169

    authors: Zhou JY,Zhou SW,Zhang KB,Tang JL,Guang LX,Ying Y,Xu Y,Zhang L,Li DD

    更新日期:2008-06-01 00:00:00

  • Potentiation by higenamine of the aconitine-induced positive chronotropic effect in isolated right atria of mice: the effects of cholera toxin, forskolin and pertussis toxin.

    abstract::Aconitine and higenamine are the major cardioactive compounds obtained from processed aconite. The chronotropic interaction between these two compounds was investigated in isolated right atria of mice. Both aconitine and higenamine potentiated the action of the other. Practolol (1 nM), a selective beta 1-adrenergic an...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.19.1032

    authors: Kimura I,Islam MA,Kimura M

    更新日期:1996-08-01 00:00:00

  • Effects of nefiracetam on cerebral adenylyl cyclase activity in rats with microsphere embolism-induced memory dysfunction.

    abstract::The effects of nefiracetam on the cerebral adenylyl cyclase (AC) activity of animals with microsphere embolism-induced memory dysfunction were examined. Sustained cerebral ischemia in the right cerebral hemisphere was induced by an injection of microspheres into the right internal carotid artery of rats. To examine le...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.26.318

    authors: Takeo S,Miyake-Takagi K,Kikuchi K,Ando T,Ichikawa T,Omino K,Kajihara H,Takagi N,Tanonaka K

    更新日期:2003-03-01 00:00:00

  • The role of OmpC and OmpF in acidic resistance in Escherichia coli.

    abstract::The roles of OmpC and OmpF in acidic resistance (AR) were examined. When ompC and ompF were deleted, AR was decreased. The decreased level of AR seen in the mutant that was deficient in ompC and ompF was elevated by the addition of glutamate, but not by the addition of arginine or lysine. The expression levels of adiA...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.34.330

    authors: Bekhit A,Fukamachi T,Saito H,Kobayashi H

    更新日期:2011-01-01 00:00:00

  • 2'-Fucosyllactose Attenuates Particulate Matter-Induced Inflammation via Inhibition of Hypoxia-Inducible Factor in Keratinocytes.

    abstract::2'-Fucosyllactose (2FL) is the most abundant component of the oligosaccharide content in human milk. It has been reported that 2FL has the ability to protect against infectious disease caused by bacterial pathogens. In this study, we investigated the protective effects of 2FL on particulate matter (PM)10-induced pro-i...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b18-00963

    authors: Lee KE,Ryu JJ,Jo YK,Yeo H,Kang S

    更新日期:2019-01-01 00:00:00

  • Inhibition of GABAA receptor-mediated current responses by enoxacin (new quinolone) and felbinac (non-steroidal anti-inflammatory drug) in Xenopus oocytes injected with mouse-brain messenger RNA.

    abstract::The convulsant interaction between enoxacin (ENX), a new quinolone antibacterial agent (NQ), and felbinac (FLB), a non-steroidal anti-inflammatory drug (NSAID), in vivo was reproduced as the change of GABA-induced current response in Xenopus oocytes injected with mouse brain mRNA. GABA (10 microM) response was inhibit...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.16.726

    authors: Kawakami J,Shimokawa M,Yamamoto K,Sawada Y,Asanuma A,Yanagisawa K,Iga T

    更新日期:1993-07-01 00:00:00

  • Glutathione-dependent cell cycle G1 arrest and apoptosis induction in human lung cancer A549 cells caused by methylseleninic acid: comparison with sodium selenite.

    abstract::The aim of the present study was to clarify the mechanism underlying the inhibition of cell proliferation in human lung cancer A549 cells by selenium (Se) compounds. Methylseleninic acid (CH3SeO2H, abbreviated as MSA), a synthetic Se compound, is a direct precursor of active methylselenol (CH3SeH) and is considered to...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b14-00453

    authors: Okuno T,Honda E,Arakawa T,Ogino H,Ueno H

    更新日期:2014-01-01 00:00:00

  • Nano-mechanical reinforcement in drug-resistant ovarian cancer cells.

    abstract::The mechanical properties of cells are considered promising biomarkers for the early detection of cancer and the testing of drug efficacy against it. Nevertheless, generalized correlations between drug resistance and the nano-mechanical properties of cancer cells are yet to be defined due to the lack of necessary stud...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b14-00604

    authors: Seo YH,Jo YN,Oh YJ,Park S

    更新日期:2015-01-01 00:00:00

  • Safe and effective delivery of small interfering RNA with polymer- and liposomes-based complexes.

    abstract::We developed binary and ternary complexes based on polymers and liposomes for safe and effective delivery of small interfering RNA (siRNA). Anti-luciferase siRNA was used as a model of nucleic acid medicine. The binary complexes of siRNA were prepared with cationic polymers and cationic liposomes such as polyethylenim...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b13-00054

    authors: Kodama Y,Harauchi S,Kawanabe S,Ichikawa N,Nakagawa H,Muro T,Higuchi N,Nakamura T,Kitahara T,Sasaki H

    更新日期:2013-01-01 00:00:00

  • Effects of Morinda citrifolia on Rheumatoid Arthritis in SKG Mice.

    abstract::Morinda citrifolia L., known as noni, originated from Indonesia exhibits various pharmacological activities including anti-inflammatory properties. However, the validity of noni fruit juice as a treatment for rheumatoid arthritis (RA), an autoimmune disorder, has not been confirmed yet. Therefore, the main purpose of ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章

    doi:10.1248/bpb.b18-00480

    authors: Kustiarini DA,Nishigaki T,Kanno H,To H

    更新日期:2019-01-01 00:00:00