Screening to Identify Multidrug Resistance-Associated Protein Inhibitors with Neuroblastoma-Selective Cytotoxicity.

abstract：:Several neurological disorders such as Alzheimer's and Parkinson's diseases have been attributed to gamma-aminobutyric acid (GABA) depletion in the brain. In order to provide a pharmacological basis for the neuroprotective actions of the enhanced accumulation of GABA in mulberry leaves (ML) against cerebral ischemia i...

journal_title：Biological & pharmaceutical bulletin

authors： Kang TH,Oh HR,Jung SM,Ryu JH,Park MW,Park YK,Kim SY

更新日期：2006-02-01 00:00:00

abstract：:We have previously proposed a novel deconvolution method, which can estimate first-pass metabolism of orally administered drugs. In the present study, we examined whether this deconvolution method is useful for evaluating oral dosage forms. The absorption and first-pass metabolism of orally administered aspirin formul...

journal_title：Biological & pharmaceutical bulletin

authors： Wu X,Yamashita F,Hashida M

更新日期：1999-11-01 00:00:00

abstract：:Oral tolerance is thought to have a role in preventing allergic responses and immune-mediated diseases. Modulation of this tolerance by drugs and chemicals can cause or suppress them. An improved model of oral tolerance to ovalbumin (OVA) in mice was developed to detect modulators of the tolerance and to apply it to s...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JH,Ohsawa M

更新日期：1995-06-01 00:00:00

abstract：:RNA interference (RNAi) is a technology that specifically inhibits gene expression and is carried out by small 21-27-nucleotide double-stranded small interfering RNA (siRNA) or short hairpin RNA (shRNA). RNAi has become a very promising technology for genetic research, however problems remain with the delivery of siRN...

journal_title：Biological & pharmaceutical bulletin

authors： Kawaguchi Y,Danjo K,Okuda T,Okamoto H

更新日期：2009-02-01 00:00:00

abstract：:We studied the protective effects of Echinacea purpurea against radiation by evaluating changes in the peripheral blood cell count and peripheral blood antioxidant activity. E. purpurea administration had a suppressive effect on radiation-induced leukopenia, especially on lymphocytes and monocytes, and resulted in a f...

journal_title：Biological & pharmaceutical bulletin

authors： Mishima S,Saito K,Maruyama H,Inoue M,Yamashita T,Ishida T,Gu Y

更新日期：2004-07-01 00:00:00

abstract：:Melatonin has been suggested to play important roles in lipid metabolism as well as circadian rhythm; however, very few studies explored the effects of ramelteon, a selective melatonin receptor agonist, on serum lipid profiles. In this study effects of ramelteon on serum lipid profiles were explored, comparing to thos...

journal_title：Biological & pharmaceutical bulletin

authors： Torii H,Shimizu R,Tanizaki Y,Omiya Y,Yamamoto M,Kamiike S,Yasuda D,Hiraoka Y,Hashida T,Kume N

更新日期：2018-01-01 00:00:00

abstract：:Previous studies show that the combined method using thrombolytic drugs and ultrasonic irradiation enhances the effect of thrombolysis in in vitro and in vivo experiments. However, the mechanism of the clot lysis was unclear. In previous studies the evaluation of the clot lysis effect was determined by the rate of dec...

journal_title：Biological & pharmaceutical bulletin

authors： Kimura M,Iijima S,Kobayashi K,Furuhata H

更新日期：1994-01-01 00:00:00

abstract：:The present study was designed to determine the effect of delta(9)-tetrahydrocannabinol (THC) on susceptibility to stress. We reported that THC significantly prolonged the immobility time during the forced swim-stress. The selective cannabinoid CB(1) receptor antagonist O-2050 significantly reduced the enhancement of ...

journal_title：Biological & pharmaceutical bulletin

authors： Sano K,Koushi E,Irie K,Higuchi S,Tsuchihashi R,Kinjo J,Egashira N,Oishi R,Uchida N,Nagai H,Nishimura R,Tanaka H,Morimoto S,Mishima K,Iwasaki K,Fujiwara M

更新日期：2009-12-01 00:00:00

abstract：:The hepatoprotecive effects of recombinant human epidermal growth factor (hEGF) on chemically and immunologically induced experimental liver injury models were examined. The hEGF clearly decreased serum transaminase levels in D-galactosamine (D-GalN) and D-GalN/lipopolysaccharide (LPS)-induced liver injury models unde...

journal_title：Biological & pharmaceutical bulletin

authors： Cho JY,Yeon JD,Kim JY,Yoo ES,Yu YH,Park MH

更新日期：2000-10-01 00:00:00

abstract：:The basal levels of extracellular Zn2+ are in the range of low nanomolar concentrations in the hippocampus and perhaps increase age-dependently. Extracellular Zn2+ dynamics is critical for cognitive activity and excess influx of extracellular Zn2+ into hippocampal neurons is a known cause of cognitive decline. The den...

journal_title：Biological & pharmaceutical bulletin

authors： Takeda A,Tamano H

更新日期：2018-01-01 00:00:00

abstract：:The present study was designed to evaluate skin permeation enhancement effect of essential oils from Ligusticum chuanxiong Hort (chuanxiong oil) in rabbits and to compare the in vivo absorption and in vitro permeation using flurbiprofen as a model drug. In vivo results demonstrated that chuanxiong oil showed a rapid a...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang LC,Hu JH,Li L,Gao LH,Zhu QG,Li Z,Wang ZZ,Su DF

更新日期：2006-06-01 00:00:00

abstract：:The medial prefrontal cortex (mPFC) plays critical roles in the development of cocaine addiction. Numerous studies have reported about the effects of cocaine on neuronal and synaptic activities in the nucleus accumbens and ventral tegmental area, which are brain regions associated with cocaine addiction; however, a li...

journal_title：Biological & pharmaceutical bulletin

authors： Sasase H,Izumi S,Deyama S,Hinoi E,Kaneda K

更新日期：2019-01-01 00:00:00

abstract：:Aconitine and higenamine are the major cardioactive compounds obtained from processed aconite. The chronotropic interaction between these two compounds was investigated in isolated right atria of mice. Both aconitine and higenamine potentiated the action of the other. Practolol (1 nM), a selective beta 1-adrenergic an...

journal_title：Biological & pharmaceutical bulletin

authors： Kimura I,Islam MA,Kimura M

更新日期：1996-08-01 00:00:00

abstract：:Physiological cell death is an essential event in normal development and maintenance of homeostasis. Recently, the morphological and pharmacological characteristics of programmed cell death, which are distinct from those of apoptosis under physiological and pathological conditions, have been reported. However, the mol...

journal_title：Biological & pharmaceutical bulletin

authors： Morimoto R,Obinata A

更新日期：2011-01-01 00:00:00

abstract：:A quantitative structure activity relationship, Hansch approach was applied on twenty compounds of chromene derivatives as Lanosterol 14alpha-demethylase inhibitory activity against eight fungal organisms. Various physicochemical descriptors and reported minimum inhibitory concentration values of different fungal orga...

journal_title：Biological & pharmaceutical bulletin

authors： Vasanthanathan P,Lakshmi M,Arockia Babu M,Kaskhedikar SG

更新日期：2006-06-01 00:00:00

abstract：:To develop potent paclitaxel (PTX) formulations for cancer chemotherapy, we formulated PTX into polymeric nanoparticles composed of polyethylene glycol (PEG) and polylactic acid (PLA) block copolymer (PN-PTX). First, the physicochemical properties of PN-PTX prepared were assessed; the mean particle size was around 80 ...

journal_title：Biological & pharmaceutical bulletin

authors： Araki T,Kono Y,Ogawara K,Watanabe T,Ono T,Kimura T,Higaki K

更新日期：2012-01-01 00:00:00

abstract：:The purpose of this study is to develop a new method of preparing salvianolic acid extracts (SAE) water-in-oil-in-water (W/O/W) multiple emulsion (ME). SAE injection is used in the treatment of brain infarct and promotion of blood circulation in China. However, the injection is not convenient, and the oral preparation...

journal_title：Biological & pharmaceutical bulletin

authors： Song Y,Gao H,Zhang S,Zhang Y,Jin X,Sun J

更新日期：2017-12-01 00:00:00

abstract：:A calcium-induced alginate gel bead (Alg-CS) containing chitosan (CS) and 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) was prepared. We then investigated (a) CMP release from Alg-CS, and (b) uptake of bile acid into the Alg-CS, within the gastrointestinal tract. Dried Alg-CS gradually swelled in taurocholate solut...

journal_title：Biological & pharmaceutical bulletin

authors： Murata Y,Hirai D,Kofuji K,Miyamoto E,Kawashima S

更新日期：2004-03-01 00:00:00

abstract：:In Japan, an increasing number of people suffer from pollenosis, a typical atopic disease. Japanese cedar (Cryptomeria japonica) pollen is the most common allergen that causes pollenosis. Although Cry j 1 and Cry j 2 are the common allergenic proteins contained in the pollen, there is a small population of patients wh...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumura D,Nabe T,Mizutani N,Fujii M,Kohno S

更新日期：2006-06-01 00:00:00

abstract：:The effects of alpha(1)-acid glycoprotein (AGP) on human erythrocyte membrane were examined in vitro. Bovine and dog AGP, in addition to human AGP or asialo human AGP were used, and the collected data were compared with that for human serum albumin (HSA). A new technique developed by Kikuchi was used to investigate er...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto K,Nishi K,Tokutomi Y,Irie T,Suenaga A,Otagiri M

更新日期：2003-01-01 00:00:00

abstract：:Costunolide, isolated from the stem bark of Magnolia sieboldii, is a sesquiterpene lactone that exhibits various biological and immunological actions. We investigated the induction mechanism of apoptosis by costunolide in a human B cell leukemia NALM-6 cell culture system. Costunolide (10 microM)-induced apoptosis tim...

journal_title：Biological & pharmaceutical bulletin

authors： Kanno S,Kitajima Y,Kakuta M,Osanai Y,Kurauchi K,Ujibe M,Ishikawa M

更新日期：2008-05-01 00:00:00

abstract：:We aimed to identify a novel flavonoid from the in-house natural products to suppress matrix metalloproteases (MMPs), which is responsible for degradation of collagen and other extracellular matrix proteins. Total eight natural products were screened for identification of a novel MMP-9 suppressor using MMP-9 reporter ...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JJ,Korm S,Kim WS,Kim OS,Lee JS,Min HG,Chin YW,Cha HJ

更新日期：2014-01-01 00:00:00

abstract：:The effect of Laennec, a hydrolyte of human placenta, on immune-mediated liver injury was investigated in vivo and in vitro in murine. Vena caudalis administration of concanavalin A (Con A) was employed to establish an in vivo liver-injury model, and in vitro hepatotoxicity was induced by 8 h interaction between Con A...

journal_title：Biological & pharmaceutical bulletin

authors： Wu J,Yang T,Wang C,Liu Q,Yao J,Sun H,Kaku T,Liu KX

更新日期：2008-11-01 00:00:00

abstract：:CC chemokine receptor 4 (CCR4) is generally recognized as a preferential marker for T helper 2 cells, and we have previously reported morpholine-derivative CCR4 antagonists, RS-1154 and RS-1269. Here, we investigate the pharmacological profiles of a novel pyrimidine-derivative CCR4 antagonist, 2-{4-[2-(diethylamino)et...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagami Y,Kawase Y,Yonekubo K,Nosaka E,Etori M,Takahashi S,Takagi N,Fukuda T,Kuribayashi T,Nara F,Yamashita M

更新日期：2010-01-01 00:00:00

abstract：:A fungus of Pestalotiopsis species produced an extracellular, water-soluble polysaccharide (PS-N). PS-N exhibited significant hypoglycemic activity in streptozotocin-induced diabetic mice following intraperitoneal administration and had an effect on oral glucose tolerance in normal mice following oral administration. ...

journal_title：Biological & pharmaceutical bulletin

authors： Kiho T,Itahashi S,Sakushima M,Matsunaga T,Usui S,Ukai S,Mori H,Sakamoto H,Ishiguro Y

更新日期：1997-02-01 00:00:00

abstract：:Among the calcium-binding proteins from chicken gizzard smooth muscle, smooth muscle calcium-binding protein 11 (SMCaBP 11), which is an EF-hand type calcium-binding protein, can prevent Ca2+ dependent histamine release from permeabilized rat peritoneal mast cells. This activity appears to be specific since other calc...

journal_title：Biological & pharmaceutical bulletin

authors： Fujii T,Kuzumaki N,Ogoma Y,Kondo Y

更新日期：1994-05-01 00:00:00

abstract：:Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by disabling fatigue of at least 6 months, in addition to symptoms such as muscle pain and muscle weakness. There is no treatment provides long-term benefits to most patients. Recently, clinical research suggested the involvement of pyruvate ...

journal_title：Biological & pharmaceutical bulletin

authors： Ohba T,Domoto S,Tanaka M,Nakamura S,Shimazawa M,Hara H

更新日期：2019-01-01 00:00:00

abstract：:As an attempt to find bioactive medicinal herbs exerting anti-asthmatic activity, the effects of an ethanol extract from the parts of Saururus chinensis were evaluated in both in vitro and in vivo. The ethanol extract of S. chinensis (ESC) inhibited generation of the cyclooxygenase-2 (COX-2) dependent phases of prosta...

journal_title：Biological & pharmaceutical bulletin

authors： Lee E,Haa K,Yook JM,Jin MH,Seo CS,Son KH,Kim HP,Bae KH,Kang SS,Son JK,Chang HW

更新日期：2006-02-01 00:00:00

abstract：:The bioavailability of morphine after rectal administration using three types of suppositories containing morphine hydrochloride (10 mg) in different added forms was evaluated in rabbits. Three types of suppositories were constructed with a base material (Witepsol H-15): a conventional suppository containing morphine ...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto Y,Watanabe Y,Yamamoto I,Matsumoto M

更新日期：1993-02-01 00:00:00

abstract：:The dopamine reuptake inhibitor bupropion and dopamine D2/3 receptor agonist pramipexole have been clinically proven to improve both depression and treatment-resistant depression. We examined its influence on the duration of immobility during the forced swim test in adrenocorticotropic hormone (ACTH)-treated rats and ...

journal_title：Biological & pharmaceutical bulletin

authors： Onoue Y,Kuwatsuka K,Miyazaki I,Asanuma M,Kitamura Y,Sendo T

更新日期：2014-01-01 00:00:00