Expression of cyclooxygenase-2 and pro-inflammatory cytokines induced by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) in human mast cells requires NF-kappa B activation.

abstract：:In the present study, we showed the inhibition of motility by trifluoromethyl ketone (TF) derivatives (1-8) in Proteus vulgaris (P. vulgaris) cultures. Among them, 1-(2-benzoxazoyl)-3,3,3-trifluoro-2-propanone (1) showed a much stronger inhibitory effect on the motility of P. vulgaris than other TF compounds at 10% MI...

journal_title：Biological & pharmaceutical bulletin

authors： Wolfart K,Molnar A,Kawase M,Motohashi N,Molnar J

更新日期：2004-09-01 00:00:00

abstract：:It has been suggested that imbalances in gut microbiota are related to diseases associated with metabolism, the central nervous system, etc. Therefore, analysis of short-chain fatty acids (SCFAs) produced by gut microbiota is very important as an indicator of causation, demonstrating the effects on the host due to cha...

journal_title：Biological & pharmaceutical bulletin

authors： Inoue H,Takayama K,Takahara C,Tabuchi N,Okamura N,Narahara N,Kojima E,Date Y,Tsuruta Y

更新日期：2019-01-01 00:00:00

abstract：:A novel type of arylsulfate sulfotransferase (ASST) from a predominant human intestinal bacterium catalyzes the stoichiometric transfer of a sulfate group from phenolic sulfate esters to phenols. We clarified that polyphenols were better substrates of this enzyme than the corresponding glycosides. Additionally, a coum...

journal_title：Biological & pharmaceutical bulletin

authors： Konishi-Imamura L,Sato M,Dohi K,Kadota S,Namba T,Kobashi K

更新日期：1994-08-01 00:00:00

abstract：:In Japan, an increasing number of people suffer from pollenosis, a typical atopic disease. Japanese cedar (Cryptomeria japonica) pollen is the most common allergen that causes pollenosis. Although Cry j 1 and Cry j 2 are the common allergenic proteins contained in the pollen, there is a small population of patients wh...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumura D,Nabe T,Mizutani N,Fujii M,Kohno S

更新日期：2006-06-01 00:00:00

abstract：:A safe and effective delivery system with a submicron emulsion for puerarin was studied. Puerarin submicron emulsion was prepared by a novel complex-phase inversion-high press homogenization technology. The mechanism to reduce the hemolysis side effect of puerarin was studied by blood cell counts in rabbits. The avera...

journal_title：Biological & pharmaceutical bulletin

authors： Yue PF,Hai-Long Yuan HL,Zhu WF,Cong LB,Xie H,Liu ZG,Wang LJ,Xiao XH

更新日期：2008-01-01 00:00:00

abstract：:The possibility of pharmacokinetic interactions between Sho-saiko-to extract powder (TJ-9), the most widely used traditional Chinese herbal (Kampo) medicine in Japan, and carbamazepine (CBZ), an important anti-epileptic drug, was examined in rats. There was no significant difference in the protein binding of CBZ in se...

journal_title：Biological & pharmaceutical bulletin

authors： Ohnishi N,Okada K,Yoshioka M,Kuroda K,Nagasawa K,Takara K,Yokoyama T

更新日期：2002-11-01 00:00:00

abstract：:The sialic acid binding lectin from bullfrog Rana catesbeiana oocyte (cSBL) is known to have anti-tumor activity. In order to investigate the relationship between the net charge of cSBL and its anti-tumor effect, cSBL was modified with a water-soluble carbodiimide (EDC) in the presence of three kinds of nucleophiles, ...

journal_title：Biological & pharmaceutical bulletin

authors： Iwama M,Ogawa Y,Sasaki N,Nitta K,Takayanagi Y,Ohgi K,Tsuji T,Irie M

更新日期：2001-09-01 00:00:00

abstract：:The antiemetic effect of a potent and selective neurokinin-1 (NK1) receptor antagonist, FK886 ([3,5-bis(trifluoromethyl)phenyl][(2R)-2-(3-hydroxy-4-methylbenzyl)-4-{2-[(2S)-2-(methoxymethyl)morpholin-4-yl]ethyl}piperazin-1-yl]methanone dihydrochloride), on cisplatin-induced acute and delayed emesis in ferrets was stud...

journal_title：Biological & pharmaceutical bulletin

authors： Furukawa TY,Nakayama H,Imazumi K,Yamakuni H,Takeshita K,Matsuo M,Manda T,Uchida W

更新日期：2014-01-01 00:00:00

abstract：:The effects of Eurycoma longifolia JACK were studied on the orientation activities of sexually experienced male rats towards receptive females (mounting, licking, anogenital sniffing), environment (exploration, raring, climbing), themselves (genital grooming, non-genital grooming) and mobility (unrestricted, restricte...

journal_title：Biological & pharmaceutical bulletin

authors： Ang HH,Sim MK

更新日期：1998-02-01 00:00:00

abstract：:Nine murine monoclonal antibodies (MAbs) raised against recombinant soluble intercellular adhesion molecule-1 (sICAM-1) were evaluated by means of ELISAs, and their neutralizing activity was investigated in two bioassays employing Raji cells activated with phorbol myristate acetate. Three of the MAbs inhibited autoagg...

journal_title：Biological & pharmaceutical bulletin

authors： Inuzuka H,Seita T,Okamoto K,Iida K,Ogawa Y,Iwasa S

更新日期：1995-08-01 00:00:00

abstract：:The effect of permeation enhancers on the percutaneous absorption of pentazocine (PTZ) was investigated in excised hairless mice using Franz diffusion cells in vitro. The enhancing effect on the percutaneous absorption of PTZ from the isopropyl myristate (IPM) solution system was improved with glyceryl monocaprylate (...

journal_title：Biological & pharmaceutical bulletin

authors： Furuishi T,Oda S,Saito H,Fukami T,Suzuki T,Tomono K

更新日期：2007-07-01 00:00:00

abstract：:Preparation of the fatty alcohol propylene glycol (FAPG) ointment base plays an important role in controlling the physicochemical properties of ointments. These essay investigates the effects of preparative conditions such as cooling rate and stirring rate on the percutaneous absorption of norfloxacin from FAPG ointme...

journal_title：Biological & pharmaceutical bulletin

authors： Lin HH,Hsu LR,Wu PC,Tsai YH

更新日期：1995-11-01 00:00:00

abstract：:Lectin-like receptors natural killer group 2D (NKG2D) and CD94 on natural killer (NK) cells bind to α2,3-NeuAc-containing N-glycans and heparin/heparan sulfate (HS). Using recombinant glutathione S-transferase-fused extracellular lectin-like domains of NKG2D (rGST-NKG2Dlec) and CD94 (rGST-CD94lec), we evaluated their ...

journal_title：Biological & pharmaceutical bulletin

authors： Higai K,Suzuki C,Imaizumi Y,Xin X,Azuma Y,Matsumoto K

更新日期：2011-01-01 00:00:00

abstract：:Plant phenolic compounds isolated from a 70% aqueous acetone extract of the leaves of Malus doumeri A. CHEV. var. formosana (KAWAK. & KOIDZ.) S. S. YING, a type of Taiwanese indigenous plant, were evaluated for potential application in the field of skin care. A phytochemical investigation of the active fractions resul...

journal_title：Biological & pharmaceutical bulletin

authors： Leu SJ,Lin YP,Lin RD,Wen CL,Cheng KT,Hsu FL,Lee MH

更新日期：2006-04-01 00:00:00

abstract：:The purpose of this study was to reveal the effectiveness of the polymer coated liposomes as a carrier of the anticancer drug doxorubicin in intravenous administration. The size controlled doxorubicin-loaded liposomes (egg phosphatidylcholine : cholesterol = 1:1 in molar ratio) were coated with hydrophilic polymers (p...

journal_title：Biological & pharmaceutical bulletin

authors： Takeuchi H,Kojima H,Yamamoto H,Kawashima Y

更新日期：2001-07-01 00:00:00

abstract：:Effects of a traditional Chinese medicine, Shimotsu-to (a combined prescription of cnidium rhizome, peony root, angelica root and rehmannia root), and its included crude fractions were investigated on an adjuvant-induced chronic inflammation model of mice. The aqueous extract (30, 100 and 300 mg/kg, i.p.) of Shimotsu-...

journal_title：Biological & pharmaceutical bulletin

authors： Kojima S,Inaba K,Kobayashi S,Kimura M

更新日期：1996-01-01 00:00:00

abstract：:Hairy roots of interspecific hybrid ginseng (Panax ginseng x P. quinquefolium), induced by Agrobacterium rhizogenes ATCC 15834, grew well in B5 liquid media supplemented with 2.5 microM auxins (3-indole butyric acid (IBA), 1-naphtaleneacetic acid (NAA) and 3-indoleacetic acid (IAA)). The hairy roots cultured in B5 liq...

journal_title：Biological & pharmaceutical bulletin

authors： Washida D,Shimomura K,Takido M,Kitanaka S

更新日期：2004-05-01 00:00:00

abstract：:Mouse thioglycollate-induced peritoneal macrophages effectively, in the absence of serum, recognized mouse polymorphonuclear leukocytes (PMNs) mildly oxidized with diamide, superoxide (hypoxanthine/xanthine oxidase) or t-butyhydroperoxide, or modified with N-ethylmaleimide (NEM). The recognition reached a maximum when...

journal_title：Biological & pharmaceutical bulletin

authors： Beppu M,Yokoyama N,Motohashi M,Kikugawa K

更新日期：2001-01-01 00:00:00

abstract：:In vitro release behavior and cytotoxic activity, and in vivo plasma disposition of newly synthesized macromolecular derivatives of cisplatin (CDDP) were investigated and compared with CDDP. The derivatives included oxidized dextran conjugate of CDDP (OX-Dex/CDDP) and dicarboxymethylated dextran conjugate of CDDP (DCM...

journal_title：Biological & pharmaceutical bulletin

authors： Nakashima M,Ichinose K,Kanematsu T,Masunaga T,Ohya Y,Ouchi T,Tomiyama N,Sasaki H,Ichikawa M

更新日期：1999-07-01 00:00:00

abstract：:The present study provides the first evidence that stilbene oxide and styrene oxide are reductively metabolized to the corresponding olefins in rats. When cis- or trans-stilbene oxide was given orally to rats, both cis- and trans-stilbene were isolated from the urine and feces. Styrene was also isolated from the urine...

journal_title：Biological & pharmaceutical bulletin

authors： Kitamura S,Shiraishi Y,Mita M,Sueki H,Maeda C,Tatsumi K

更新日期：2000-02-01 00:00:00

abstract：:Five rabbit aldo-keto reductases (AKRs) that participate in the reduction of drug ketones and endogenous ketosteroids have recently been cloned and characterized. Among them, AKR1C30 and AKR1C31 show the highest amino acid sequence identity of 91%, but markedly differ in their substrate specificity and inhibitor sensi...

journal_title：Biological & pharmaceutical bulletin

authors： Endo S,Arai Y,Matsunaga T,Ikari A,El-Kabbani O,Hara A,Kitade Y

更新日期：2014-01-01 00:00:00

abstract：:Formulations consisting of egg albumin, indomethacin (IND), and olive oil or fatty acids, were prepared by vigorous stirring using a high-speed homogenizer and subsequent freeze-drying. To confirm the anti-inflammatory properties and ulcerogenic effects of the formulations, we examined the action of the formulations o...

journal_title：Biological & pharmaceutical bulletin

authors： Tsuji Y,Kakegawa H,Miyataka H,Matsumoto H,Satoh T

更新日期：1993-07-01 00:00:00

abstract：:Among the eight inbred mouse strains employed in our preceding report, 12-O-tetradecanoylphorbol 13-acetate (TPA) painting alone induced CD4+ regulatory T (Tr) cells in four strains (e.g., C3H/He) at 6-8 weeks of age, but not in the remaining strains (e.g., C57BL/6, BALB/c). In the present study, the effect of growth ...

journal_title：Biological & pharmaceutical bulletin

authors： Negoro T,Satoh K,Iinuma F,Tobe T,Watanabe M

更新日期：2002-02-01 00:00:00

abstract：:Immediate early genes (IEG) are rapidly but transiently induced directly by intracellular signaling cascades to alter patterns of gene expression. It has been proposed that histone modifications could be the key to the quick alteration of chromatin structure, as this spread occurs too rapidly to be the consequence of ...

journal_title：Biological & pharmaceutical bulletin

authors： Sng JC,Taniura H,Yoneda Y

更新日期：2004-05-01 00:00:00

abstract：:We examined the transport mechanisms of daunorubicin (DNR) and doxorubicin (ADR) in HL60 and HL60/THP cells which were the non-P-glycoprotein-mediated resistant clone of the parent HL60 cells and showed a low degree of resistance, and compared them with those of pirarubicin (THP). In both lines, it appeared that the u...

journal_title：Biological & pharmaceutical bulletin

authors： Nagasawa K,Natazuka T,Nomiyama M,Ohnishi N,Yokoyama T

更新日期：1996-01-01 00:00:00

abstract：:Oral tolerance is thought to have a role in preventing allergic responses and immune-mediated diseases. Modulation of this tolerance by drugs and chemicals can cause or suppress them. An improved model of oral tolerance to ovalbumin (OVA) in mice was developed to detect modulators of the tolerance and to apply it to s...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JH,Ohsawa M

更新日期：1995-06-01 00:00:00

abstract：:Fragility fractures associated with age-related bone loss are of urgent concern worldwide because they reduce QOL and pose financial burdens for health care services. Currently, national data in Japan are limited. This study provides quantitative data for older patients throughout Japan who, although otherwise relativ...

journal_title：Biological & pharmaceutical bulletin

authors： Iihara N,Ohara E,Bando Y,Yoshida T,Ohara M,Kirino Y

更新日期：2019-01-01 00:00:00

abstract：:An accumulating body of evidence indicates that inflammation plays a crucial role in the pathophysiology of myocardial infarction (MI). Nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome is an intracellular multiprotein complex that regulates caspase-1 a...

journal_title：Biological & pharmaceutical bulletin

authors： Takahashi M

更新日期：2019-01-01 00:00:00

abstract：:Oxidized low-density lipoprotein (oxLDL) and reactive oxygen species (ROS) play key roles in the early stage of atherosclerosis. Nitric oxide (NO) and ROS are responsible for regulation of the transcriptional pathways of nuclear Factor-kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK), key regulators of c...

journal_title：Biological & pharmaceutical bulletin

authors： Han JM,Jin YY,Kim HY,Park KH,Lee WS,Jeong TS

更新日期：2010-01-01 00:00:00

abstract：:This study was designed to evaluate the protective effect of kolaviron (KV), a biflavonoid from Garcinia kola seeds, against gamma-radiation (5 Gy)-induced oxidative stress in brain of Wistar rats. Vitamin C (VC) served as standard antioxidant. Forty-four rats were divided into 4 groups of 11 animals each. One group w...

journal_title：Biological & pharmaceutical bulletin

authors： Adaramoye OA

更新日期：2010-01-01 00:00:00