Enzymatic sulfation of glycosides and their corresponding aglycones by arylsulfate sulfotransferase from a human intestinal bacterium.

Abstract:

:A novel type of arylsulfate sulfotransferase (ASST) from a predominant human intestinal bacterium catalyzes the stoichiometric transfer of a sulfate group from phenolic sulfate esters to phenols. We clarified that polyphenols were better substrates of this enzyme than the corresponding glycosides. Additionally, a coumarin derivative, esculetin, was sulfated by ASST at the 6-position to give 6-monosulfate. Therefore, ASST is more useful for the preparation of sulfated polyphenols at their specific hydroxyl groups and would play an important role in the metabolism of phenolic compounds in vegetable food and traditional medicines.

journal_name

Biol Pharm Bull

authors

Konishi-Imamura L,Sato M,Dohi K,Kadota S,Namba T,Kobashi K

doi

10.1248/bpb.17.1018

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

1018-22

issue

8

eissn

0918-6158

issn

1347-5215

journal_volume

17

pub_type

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