Antiinflammatory activity of alpha-hederin methyl ester from the alkaline hydrolysate of the butanol fraction of Kalopanax pictus bark extract.

abstract：:The uptake of low molecular weight fractionated [3H]heparin (LMWFH: 7000 Da) was examined, for comparison with that of high molecular weight fractionated [3H]heparin (HMWFH:20000 Da), in a primary culture of rat hepatocytes. The uptake of LMWFH increased almost linearly with time up to 60 min (extended uptake), althou...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe J,Urano K,Muranishi H,Haba M,Yuasa H

更新日期：1995-03-01 00:00:00

abstract：:A calcium-induced alginate gel bead (Alg-CS) containing chitosan (CS) and 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) was prepared. We then investigated (a) CMP release from Alg-CS, and (b) uptake of bile acid into the Alg-CS, within the gastrointestinal tract. Dried Alg-CS gradually swelled in taurocholate solut...

journal_title：Biological & pharmaceutical bulletin

authors： Murata Y,Hirai D,Kofuji K,Miyamoto E,Kawashima S

更新日期：2004-03-01 00:00:00

abstract：:Temozolomide (TMZ) is currently the first-line drug used for clinical postoperative or non-surgical chemotherapy for glioma, but acquired and intrinsic resistance to TMZ limits its application. The anti-proliferative effect of formononetin on human glioma cells had been confirmed. To improve therapeutic effects of TMZ...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang X,Ni Q,Wang Y,Fan H,Li Y

更新日期：2018-08-01 00:00:00

abstract：:The accumulation of amyloid β(1-42) peptide (Aβ(1-42)) in retina is implicated in the development of retinal ganglion cell apoptosis and diabetic retinopathy. In this study we demonstrate that spontaneous diabetes mellitus Otsuka Long-Evans Tokushima Fatty (OLETF) rats can be used as an animal model in studies to iden...

journal_title：Biological & pharmaceutical bulletin

authors： Nagai N,Ito Y,Tanino T

更新日期：2015-01-01 00:00:00

abstract：:Deoxynybomycin was identified as an inducer of p21the/WAF1 gene following screening using a reporter, p21/luciferase. The present study examined its anti-proliferative effect on human tumor cell lines. Deoxynybomycin selectively inhibited growth of human osteoblastic sarcoma Saos-2, gastric cancer TMK-1, and monocytic...

journal_title：Biological & pharmaceutical bulletin

authors： Egawa K,Yamori T,Nosaka C,Kunimoto S,Takeuchi T,Nos K

更新日期：2000-09-01 00:00:00

abstract：:We previously isolated berberine from aqueous extracts of tsu-kan-gan, a Kampo formula used for the treatment of osteoporosis. Berberine caused an inhibitory effect on parathyroid hormone (PTH)-stimulated bone resorption in neonatal mouse bone. In this report we describe the inhibitory effect of berberine on the forma...

journal_title：Biological & pharmaceutical bulletin

authors： Li H,Miyahara T,Tezuka Y,Namba T,Suzuki T,Dowaki R,Watanabe M,Nemoto N,Tonami S,Seto H,Kadota S

更新日期：1999-04-01 00:00:00

abstract：:Mume fruit, the Japanese apricot (Prunus mume SIEB. et ZUCC.), is popular in Japan and is mostly consumed in the pickled form called umeboshi. This fruit is known to have anti-microbial properties, but the principal constituents responsible for the antimicrobial properties have not yet been elucidated. We investigated...

journal_title：Biological & pharmaceutical bulletin

authors： Mitani T,Ota K,Inaba N,Kishida K,Koyama HA

更新日期：2018-01-01 00:00:00

abstract：:This study aimed to investigate the mechanism by which the human lung cancer drug resistance-related gene BC006151 regulates chemosensitivity by down-regulating BC006151 expression via antisense gene transfer in H446/(C)DDP cells. A retroviral vector containing the antisense BC006151 sequence was constructed and trans...

journal_title：Biological & pharmaceutical bulletin

authors： Li S,Shi H,Ji F,Wang B,Feng Q,Feng X,Jia Z,Zhao Q,Qian G

更新日期：2010-01-01 00:00:00

abstract：:We examine the pharmacokinetic profile of cyclosporin A (CyA) after intravenous administration to rats prepared as models of various disease states found in patients who receive organ transplantations. After intravenous bolus administration to normal rats, the total blood clearance (CLt) of CyA showed a dose-dependent...

journal_title：Biological & pharmaceutical bulletin

authors： Shibata N,Shimakawa H,Minouchi T,Yamaji A

更新日期：1993-11-01 00:00:00

abstract：:Although hypokalemia is an adverse effect of Yokukansan preparation, especially in geriatric patients, its association with age is unclear. We investigated whether age is a risk factor for hypokalemia. This single-center retrospective cohort study, conducted at Tokyo Women's Medical University, Medical Center East bet...

journal_title：Biological & pharmaceutical bulletin

authors： Hirai T,Yamaga R,Kei M,Hosohata K,Itoh T

更新日期：2020-01-01 00:00:00

abstract：:Aberrant wound healing, either causing scarring or chronic wounds, is a significant cause of morbidity. There is therefore, considerable interest in agents which can modulate certain aspects of the wound healing process. Fucoidans, sulphated polyfucose polysaccharides which may be extracted from Fucus spp., have been ...

journal_title：Biological & pharmaceutical bulletin

authors： O'Leary R,Rerek M,Wood EJ

更新日期：2004-02-01 00:00:00

abstract：:Effects of ecabet sodium (TA-2711), a locally acting antiulcer agent, on prostanoid production and the morphology of the rat gastrointestinal mucosa were studied in comparison with sucralfate. Ecabet, at therapeutic doses (25 and 100 mg/kg, p.o.), dose-dependently increased the gastric mucosal level of prostaglandin E...

journal_title：Biological & pharmaceutical bulletin

authors： Kinoshita M,Iwasaki H,Yasoshima A,Tamaki H

更新日期：1993-12-01 00:00:00

abstract：:Hydroxylysylpyridinoline (HP), an intermolecular cross-linking amino acid, is present only in bone and cartilage collagen. We examined urinary HP levels in order to assess bone collagen metabolism using HPLC. Urinary HP excretion levels (nmol/mmol creatinine) of healthy control groups gradually increased with aging. U...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshihara K,Nemoto S,Nagata M

更新日期：1994-06-01 00:00:00

abstract：:The convulsant interaction between enoxacin (ENX), a new quinolone antibacterial agent (NQ), and felbinac (FLB), a non-steroidal anti-inflammatory drug (NSAID), in vivo was reproduced as the change of GABA-induced current response in Xenopus oocytes injected with mouse brain mRNA. GABA (10 microM) response was inhibit...

journal_title：Biological & pharmaceutical bulletin

authors： Kawakami J,Shimokawa M,Yamamoto K,Sawada Y,Asanuma A,Yanagisawa K,Iga T

更新日期：1993-07-01 00:00:00

abstract：:Nitrogen oxide, which is produced by activated macrophages, has been demonstrated to possess anti-tumor activity. We report herein the synergistic effect of sodium nitrite (NO2-) and/or sodium nitroprusside (SNP) on lysophospholipid (LysoPL)-mediated cytolysis. The incubation of 51Cr-labeled mouse melanoma (B16) cells...

journal_title：Biological & pharmaceutical bulletin

authors： Kanematsu M,Takagi K,Suketa Y

更新日期：1994-01-01 00:00:00

abstract：:Hepatoprotective effect of celosian, an acidic polysaccharide isolated from the water extract of the seed of Celosia argentea, was investigated using chemical and immunological liver injury models. Celosian inhibited the elevation of serum enzyme (GPT, GOT, LDH) and bilirubin levels on carbon tetrachloride (CC1(4))-in...

journal_title：Biological & pharmaceutical bulletin

authors： Hase K,Kadota S,Basnet P,Takahashi T,Namba T

更新日期：1996-04-01 00:00:00

abstract：:The effects of aged garlic extract (AGE) on longevity and learning and memory performances were studied in the senescence accelerated mouse (SAM). A solid diet containing 2% (w/w) AGE was given to SAM from 2 months of age. The survival ratio of SAM P8, senescence accelerated animals, treated with AGE was significantly...

journal_title：Biological & pharmaceutical bulletin

authors： Moriguchi T,Takashina K,Chu PJ,Saito H,Nishiyama N

更新日期：1994-12-01 00:00:00

abstract：:The effects of two saline cathartics (sodium chloride and sodium citrate) on the adsorptive capacity of activated charcoal (AC) for rifampicin were studied. Solutions of rifampicin alone and rifampicin with 7.5 mg/ml cathartic solution were vortex-mixed for 30 s with different quantities of AC. These were incubated fo...

journal_title：Biological & pharmaceutical bulletin

authors： Orisakwe OE,Afonne OJ,Agbasi PU,Ilondu NA,Ofoefule SI,Obi E

更新日期：2001-06-01 00:00:00

abstract：:The protective effect of sodium-L-ascorbyl-2 phosphate (As-2P), a stable form of ascorbic acid (AsA), against photodamage induced by a single dose of UVB exposure (290-320 nm, Max 312 nm) was investigated using cultured mouse skin. When the cultured skin was treated with various As-2P concentrations, the cutaneous AsA...

journal_title：Biological & pharmaceutical bulletin

authors： Nayama S,Takehana M,Kanke M,Itoh S,Ogata E,Kobayashi S

更新日期：1999-12-01 00:00:00

abstract：:High-resolution deep tissue imaging is possible with two-photon excitation microscopy. With the combined application of two-photon imaging and perfusion with a polar fluorescent tracer, we have established a method to detect exocytic events inside secretory tissues. This method displays the spatiotemporal distribution...

journal_title：Biological & pharmaceutical bulletin

authors： Takahashi N

更新日期：2015-01-01 00:00:00

abstract：:Nine alkaloid constituents in the root of Aconitum yesoense var. macroyesoense, as well as three acetylated derivatives, were examined for their peripheral vaso-activities by measuring laser-flowmetrically the cutaneous blood flow in the hind foot of mice after intravenous administration. The major constitutive delcos...

journal_title：Biological & pharmaceutical bulletin

authors： Wada K,Ishizuki S,Mori T,Bando H,Murayama M,Kawahara N

更新日期：1997-09-01 00:00:00

abstract：:Trimidox (3,4,5-trihydroxybenzamidoxime) is one of the most potent ribonucleotide reductase inhibitors, revealing an antitumor effect in several experimental studies. We have examined the effect of trimidox on the induction of cytotoxicity and apoptosis via oxidative stress by typical free radical inducers, hydrogen p...

journal_title：Biological & pharmaceutical bulletin

authors： Kanno S,Kakuta M,Kitajima Y,Osanai Y,Kurauchi K,Ohtake T,Ujibe M,Uwai K,Takeshita M,Ishikawa M

更新日期：2007-05-01 00:00:00

abstract：:We have found a new compound from thermophile extracts which inhibits antigen presentation on mouse macrophages. The substance inhibits the expression of the class II major histocompatibility molecule (Ia). It was extracted from Bacillus stearothermophilus UBT8038 and purified by silica gel column chromatography. The ...

journal_title：Biological & pharmaceutical bulletin

authors： Kohama Y,Itoh M,Tanaka K,Senba T,Itoh S,Mimura T

更新日期：1994-07-01 00:00:00

abstract：:The present paper proposes a new approach for fitting the plasma effect-site equilibrium rate constant (Ke0) of propofol to satisfy the condition that the effect-site concentration (Ce) is equal at the time of loss of consciousness (LOC) and recovery of consciousness (ROC). Forty patients receiving intravenous anesthe...

journal_title：Biological & pharmaceutical bulletin

authors： Wu Q,Sun B,Wang S,Zhao L,Qi F

更新日期：2013-01-01 00:00:00

abstract：:Cell-penetrating peptides (CPPs) have been highly anticipated as an efficient delivery system due to their ability to cross biological membranes and transport various cargoes into cells. In the present study, we have identified adenovirus-derived CPPs using various capsid-mutant adenovirus (Ad) vectors. First, we exam...

journal_title：Biological & pharmaceutical bulletin

authors： Hirai T,Yamagishi Y,Koizumi N,Nonaka M,Mochida R,Shida K,Nomura T,Fujii M,Sakurai F,Mizuguchi H,Watanabe Y,Utoguchi N

更新日期：2017-01-01 00:00:00

abstract：:R(-)-Apomorphine is a dopamine agonist used for rescue management of motor function impairment associated with levodopa therapy in Parkinson's disease patients. The aim of this study was to examine the role of proton-coupled organic cation antiporter in uptake of R(-)-apomorphine and its S-enantiomer in human brain, u...

journal_title：Biological & pharmaceutical bulletin

authors： Okura T,Higuchi K,Kitamura A,Deguchi Y

更新日期：2014-01-01 00:00:00

abstract：:Bryonolic acid was isolated in high yield from transformed hairy root cultures of Trichosanthes kirilowii var. Japonica. Bryonolic acid exhibited cytotoxic activity to various tumor cells in vitro, independent of cell type. Normal cells such as rat hepatocytes are less sensitive to bryonolic acid. The appearance of a ...

journal_title：Biological & pharmaceutical bulletin

authors： Kondo T,Inoue M,Mizukami H,Ogihara Y

更新日期：1995-05-01 00:00:00

abstract：:The effects of 70% methanol extract (EA-ext) from Evodiae Fructus (EA) consisting of dried fruits of Evodia rutaecarpa var. bodinieri (Rutaceae) on nociceptive responses were investigated. Oral administration of 50 or 200 mg/kg EA-ext had the same antinociceptive effect on writhing responses as induced by acetic acid....

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda H,Wu JX,Tanaka T,Iinuma M,Kubo M

更新日期：1997-03-01 00:00:00

abstract：:Over-expression of P-glycoprotein (P-gp) in lymphocytes is implicated in the failure of immunosuppressant therapy. We investigated P-gp function in peripheral-blood CD3+, CD4+, and CD8+ cells of 14 healthy subjects and 12 patients with systemic lupus erythematosus (SLE). P-gp function was estimated by the transporter ...

journal_title：Biological & pharmaceutical bulletin

authors： Henmi K,Yoshida M,Yoshikawa N,Hirano T

更新日期：2008-05-01 00:00:00

abstract：:A biologically active quinone that exhibits a growth-inhibitory effect on rat liver cancer cells was isolated from the nest of a social wasp, Vespa simillima (Vespinae, Vespidae). The structure was unambiguously determined by NMR and synthetic experiments and identified as being 7,8-seco-para-ferruginone. The syntheti...

journal_title：Biological & pharmaceutical bulletin

authors： Fujiwara Y,Mangetsu M,Yang P,Kofujita H,Suzuki K,Ohfune Y,Shinada T

更新日期：2008-04-01 00:00:00