Molecular identification of "Chuanxiong" by nucleotide sequence and multiplex single base extension analysis on chloroplast trnK gene.

abstract：:Human pluripotent stem cells (hPSCs), i.e. human embryonic stem cells and human induced pluripotent stem cells, are able to self-renew and differentiate into multiple cell types. Because of these abilities, numerous attempts have been made to utilize hPSCs in regenerative medicine/cell therapy. hPSCs are, however, als...

journal_title：Biological & pharmaceutical bulletin

authors： Kuroda T,Yasuda S,Sato Y

更新日期：2013-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the essential oils from sweet basil (Ocimum basilicum, OB) as skin permeation enhancers to promote the percutaneous absorption of drugs. The in vitro and in vivo irritancy of the essential oils was also examined. Terpenes with various carbon numbers (mono-, sesqui-, di-, and t...

journal_title：Biological & pharmaceutical bulletin

authors： Fang JY,Leu YL,Hwang TL,Cheng HC

更新日期：2004-11-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor plays a key role in learning and memory. Our recent studies have shown that nobiletin from citrus peels activates the cAMP response element-binding protein (CREB) signaling pathway and ameliorates NMDA receptor antagonist-induced learning impairment by activating extracellular ...

journal_title：Biological & pharmaceutical bulletin

authors： Kimura J,Nemoto K,Degawa M,Yokosuka A,Mimaki Y,Shimizu K,Oku N,Ohizumi Y

更新日期：2014-01-01 00:00:00

abstract：:Cry j 1 is one of the major allergens in Japanese cedar pollen. We attempt high throughput analysis and comprehensive identification of the linear IgE epitopes of Cry j 1. A series of overlapping synthetic Cry j 1 peptides chemically spotted on cellulose membrane was probed with sera from patients in Japan and United ...

journal_title：Biological & pharmaceutical bulletin

authors： Takagi K,Teshima R,Sawada J

更新日期：2005-08-01 00:00:00

abstract：:2'-Fucosyllactose (2FL) is the most abundant component of the oligosaccharide content in human milk. It has been reported that 2FL has the ability to protect against infectious disease caused by bacterial pathogens. In this study, we investigated the protective effects of 2FL on particulate matter (PM)10-induced pro-i...

journal_title：Biological & pharmaceutical bulletin

authors： Lee KE,Ryu JJ,Jo YK,Yeo H,Kang S

更新日期：2019-01-01 00:00:00

abstract：:A traditional Chinese herbal medicine, Qizhu Tang (QZT) was studied for its in vitro antioxidant activity and the effect on cerebral oxidative damage after forebrain ischemia followed by reperfusion in rats. The QZT decoction was shown to have strong hydroxyl radical (*OH) scavenging activity (approx. 0.1 mM as Trolox...

journal_title：Biological & pharmaceutical bulletin

authors： Xuejiang W,Ichikawa H,Konishi T

更新日期：2001-05-01 00:00:00

abstract：:Liposomes have been artificially made into membranous vesicles composed essentially of naturally occurring phospholipids and have been found to serve as a carrier of drugs and an immunological adjuvant. After being intravenously injected, they are quickly removed from the blood circulation and trapped by Kupffer cells...

journal_title：Biological & pharmaceutical bulletin

authors： Aramaki Y

更新日期：2000-11-01 00:00:00

abstract：:Essential elements (Ca, Mg, Zn, Cu, Fe, Cr, Mn and V) and non-essential elements (As, Cd, Hg and Pb) were measured in scalp hair samples of 45 diabetic subjects and 59 control subjects in Japan using inductively coupled plasma mass spectrometry. All diabetic subjects took insulin and/or antidiabetic agents, with glyca...

journal_title：Biological & pharmaceutical bulletin

authors： Hotta Y,Fujino R,Kimura O,Endo T

更新日期：2018-01-01 00:00:00

abstract：:Alzheimer's beta-amyloid protein (A beta) is the main component of senile plaques, which are characteristic hallmarks of the Alzheimer's disease brain. Recently, there have been several reports that A beta has toxic effects on both cultured neurons and in the brain. We confirmed the neurotoxicity of A beta in vitro an...

journal_title：Biological & pharmaceutical bulletin

authors： Hasegawa Y,Sugimoto E,Endo T,Ogawa K,Aratake H,Morikawa A,Kitaguchi N

更新日期：1995-12-01 00:00:00

abstract：:The effect of fungichromin (FC) on the formation of Candida albicans biofilm was assessed using 2,3-bis(2-methoxy-4-nitro-5-sulfo-phenyl)-2H-tetrazolium-5-carboxanilide (XTT) reduction method, scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). Results showed that FC revealed an inhibitor...

journal_title：Biological & pharmaceutical bulletin

authors： An D,Wang X,Li J,Jiang S,Ma X,Zhang H,Shi H,Sun H,Ye L,Li J

更新日期：2016-12-01 00:00:00

abstract：:The effect of permeation enhancers on the percutaneous absorption of pentazocine (PTZ) was investigated in excised hairless mice using Franz diffusion cells in vitro. The enhancing effect on the percutaneous absorption of PTZ from the isopropyl myristate (IPM) solution system was improved with glyceryl monocaprylate (...

journal_title：Biological & pharmaceutical bulletin

authors： Furuishi T,Oda S,Saito H,Fukami T,Suzuki T,Tomono K

更新日期：2007-07-01 00:00:00

abstract：:The aim of this study was to determine the stimulatory effects of Maillard reaction, a non-enzymatic browning reaction on the expression of pro-inflammatory cytokines and phagocytic activity induced by whey protein concentrate (WPC). Glycated WPC (G-WPC) was prepared by a reaction between WPC and the lactose it contai...

journal_title：Biological & pharmaceutical bulletin

authors： Chun SH,Lee HA,Lee KB,Kim SH,Park KY,Lee KW

更新日期：2016-01-01 00:00:00

abstract：:The protective effect of sodium-L-ascorbyl-2 phosphate (As-2P), a stable form of ascorbic acid (AsA), against photodamage induced by a single dose of UVB exposure (290-320 nm, Max 312 nm) was investigated using cultured mouse skin. When the cultured skin was treated with various As-2P concentrations, the cutaneous AsA...

journal_title：Biological & pharmaceutical bulletin

authors： Nayama S,Takehana M,Kanke M,Itoh S,Ogata E,Kobayashi S

更新日期：1999-12-01 00:00:00

abstract：:The present study assessed the safety/toxicity of Senecio scandens, a well-known Chinese herb that is used as an anti-inflammatory, antibiosis, and antipyretic drug. A 90-d subchronic oral toxicity study of S. scandens was performed in Wistar rats. The extract of S. scandens was administered orally to male and female ...

journal_title：Biological & pharmaceutical bulletin

authors： Wang XK,Zhao Y,Liu T,Yi Y,Li CY,Wang HJ,Wang CH,Wang ZT,Ye ZG,Liang AH

更新日期：2015-01-01 00:00:00

abstract：:Hepatoprotective effect of celosian, an acidic polysaccharide isolated from the water extract of the seed of Celosia argentea, was investigated using chemical and immunological liver injury models. Celosian inhibited the elevation of serum enzyme (GPT, GOT, LDH) and bilirubin levels on carbon tetrachloride (CC1(4))-in...

journal_title：Biological & pharmaceutical bulletin

authors： Hase K,Kadota S,Basnet P,Takahashi T,Namba T

更新日期：1996-04-01 00:00:00

abstract：:The extract of Ongael [leaves of Phaleria cumingii (MEISN.) F. VILL.], a Palauan medicinal herb, enhanced an in vitro phagocytic activity of mouse macrophages RAW 264.7 cells (RAW 264.7). Activity-guided fractionation of the Ongael extract by the in vitro phagocytosis assay using RAW 264.7 led to the isolation of a mi...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda H,Tokunaga M,Iwahashi H,Naruto S,Yagi H,Masuko T,Kubo M

更新日期：2005-05-01 00:00:00

abstract：:The tumor suppressor phosphatase and tensin homolog (PTEN) functions as a phosphoinositide 3-phosphatase, that antagonizes phosphatidylinositol 3-kinase action, and negatively regulates cell proliferation and survival signals. Inactivation of PTEN by loss-of-function mutations gives rise to deregulated hyperproliferat...

journal_title：Biological & pharmaceutical bulletin

authors： Maehama T

更新日期：2007-09-01 00:00:00

abstract：:Two carboxylesterases with pI 6.0 and 6.2 derived from rat liver microsomes were purified. The two isozymes were remarkably different in substrate specificity, but they had equal enzymatic activity for alpha-naphthyl acetate and were inhibited equally by phenylmethylsulfonyl fluoride (PMSF) and bis-(4-nitrophenyl) pho...

journal_title：Biological & pharmaceutical bulletin

authors： Luan L,Sugiyama T,Takai S,Usami Y,Adachi T,Katagiri Y,Hirano K

更新日期：1997-01-01 00:00:00

abstract：:We investigated the anti-allergic effect of tea-leaf saponin (TLS), which was a mixture of saponins separated from the leaves of Camellia sinensis var. sinensis, in guinea pigs and rats. TLS (20-100 mg/kg) dose-dependently inhibited experimentally-induced asthma, and ID50 was 61.7 mg/kg. TLS (20-100 mg/kg) dose-depend...

journal_title：Biological & pharmaceutical bulletin

authors： Akagi M,Fukuishi N,Kan T,Sagesaka YM,Akagi R

更新日期：1997-05-01 00:00:00

abstract：:Tulobuterol patches are long-acting bronchodilators for percutaneous absorption including the β(2)-adrenoreceptor agonist tulobuterol, as a main ingredient, used for long-term management of pediatric asthma. Since patients who have pediatric asthma often also have atopic dermatitis in which the skin barrier is impaire...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshihara S,Fukuda H,Abe T,Arisaka O

更新日期：2010-01-01 00:00:00

abstract：:The present study describes the activity of Ca(2+)-ATPase in liver plasma membrane and cytosolic-free Ca2+ concentration ([Ca2+]i) in an individual vital cell in mouse liver 18 h after endotoxin administration. Ca(2+)-ATPase activity in liver plasma membrane in the poisoned mice was markedly decreased to 28% of that i...

journal_title：Biological & pharmaceutical bulletin

authors： Sakaguchi S,Tsutsumi E,Yokota K

更新日期：1993-08-01 00:00:00

abstract：:Penicillin binding proteins (PBPs) are penicillin-sensitive DD-peptidases catalyzing the terminal stages of bacterial cell wall assembly. We identified a Dictyostelium discoideum gene that encodes a protein of 522 amino acids showing similarity to Escherichia coli PBP4. The D. discoideum protein conserves three consen...

journal_title：Biological & pharmaceutical bulletin

authors： Yasukawa H,Kuroita T,Tamura K,Yamaguchi K

更新日期：2003-07-01 00:00:00

abstract：:We determined the binding affinity of tamsulosin, a selective α(1)-adrenoceptor antagonist, for human α(1)-adrenoceptor subtypes in comparison with those of other α(1)-adrenoceptor antagonists including silodosin, prazosin, 5-methylurapidil, terazosin, alfuzosin, nafopidil, urapidil and BMY7378. The association and di...

journal_title：Biological & pharmaceutical bulletin

authors： Sato S,Hatanaka T,Yuyama H,Ukai M,Noguchi Y,Ohtake A,Taguchi K,Sasamata M,Miyata K

更新日期：2012-01-01 00:00:00

abstract：:The radioprotective effects of propolis and polyphenolic compounds from propolis on the radiation-induced mortality of mice exposed to 9 Gy of gamma-irradiation were studied. Intraperitoneal (i.p.) treatment of mice at doses of 100 mg kg(-1) body weight of propolis (water or ethanolic extract; WSDP or EEP) or its poly...

journal_title：Biological & pharmaceutical bulletin

authors： Orsolić N,Benković V,Horvat-Knezević A,Kopjar N,Kosalec I,Bakmaz M,Mihaljević Z,Bendelja K,Basić I

更新日期：2007-05-01 00:00:00

abstract：:The surface topology of ligands on liposomes is an important factor in active targeting in drug delivery systems. Accurately evaluating the density of anchors and bioactive functional ligands on a liposomal surface is critical for ensuring the efficient delivery of liposomes. For evaluating surface ligand density, it ...

journal_title：Biological & pharmaceutical bulletin

authors： Lee SH,Sato Y,Hyodo M,Harashima H

更新日期：2016-01-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) pathway is a major determinant in the control of diverse cellular processes such as proliferation, survival, and motility. This pathway is often upregulated in human cancers and as such represents an attractive target for mechanism-based approaches to cancer treatment. H...

journal_title：Biological & pharmaceutical bulletin

authors： Kohno M,Tanimura S,Ozaki K

更新日期：2011-01-01 00:00:00

abstract：:Povidone-iodine (PVP-I), an antibacterial medicine, was infiltrated in sepiolite (SPL). The available iodine content in this new pharmaceutical product, a sepiolite preparation containing povidone-iodine (PVP-I-SPL), was retained at 98.9 and 98.3% during storage at 40 degrees C for 3 and 6 months, respectively. The ef...

journal_title：Biological & pharmaceutical bulletin

authors： Ohta S,Nagai K,Maruyama M,Inoue H,Katsuyama Y,Atobe O,Ogata H,Yamato S,Tachikawa E,Zenda H

更新日期：1999-01-01 00:00:00

abstract：:Continuous oral administration of the acidic polysaccharide (TAP) solution (0.5 g/l) and the TAP-H (degradation products of TAP) solution (1.5 g/l) instead of water for 10 weeks were found to depress plasma glucose increases in diabetes using genetically non-insulin-dependent diabetic model (KK-Ay) mice. TAP and TAP-H...

journal_title：Biological & pharmaceutical bulletin

authors： Kiho T,Kochi M,Usui S,Hirano K,Aizawa K,Inakuma T

更新日期：2001-12-01 00:00:00

abstract：:Attention-deficit hyperactivity disorder (AD/HD) is a clinically heterogenous disorder including hyperactivity, impulsivity, and inattention. Both psychostimulant and non-psychostimulant drugs such as methylphenidate and atomoxetine, respectively, to modulate catecholeamine neurotransmission are used as current pharma...

journal_title：Biological & pharmaceutical bulletin

authors： Arime Y,Kubo Y,Sora I

更新日期：2011-01-01 00:00:00

abstract：:Candida albicans is the most important human fungal pathogen. Amphotericin (AmB) is a gold standard of antifungal treatment for fungi, but the severe side effect of this drug restricts its clinical application. In this study, the interaction of AmB and baicalein (BE) was investigated against thirty clinical isolates o...

journal_title：Biological & pharmaceutical bulletin

authors： Fu Z,Lu H,Zhu Z,Yan L,Jiang Y,Cao Y

更新日期：2011-01-01 00:00:00