Abstract:
:Continuous oral administration of the acidic polysaccharide (TAP) solution (0.5 g/l) and the TAP-H (degradation products of TAP) solution (1.5 g/l) instead of water for 10 weeks were found to depress plasma glucose increases in diabetes using genetically non-insulin-dependent diabetic model (KK-Ay) mice. TAP and TAP-H significantly lowered levels of insulin, total-cholesterol and triglyceride in the blood of the mice. In excretion to feces, TAP and TAP-H significantly increased the total bile acid, while the cholesterol content of both groups was less than that of the control. Furthermore, TAP and TAP-H significantly decreased the plasma lipoperoxide level. The study shows that TAP and TAP-H have an antidiabetic effect on diabetes model mice.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Kiho T,Kochi M,Usui S,Hirano K,Aizawa K,Inakuma Tdoi
10.1248/bpb.24.1400subject
Has Abstractpub_date
2001-12-01 00:00:00pages
1400-3issue
12eissn
0918-6158issn
1347-5215journal_volume
24pub_type
杂志文章abstract::Ge-132 is a synthetic organic germanium that is used as a dietary supplement. The antioxidant activity of Ge-132 on cultured mammalian cells was investigated in this study. First, Ge-132 cytotoxicity on mammalian cultured cells was determined by measuring lactate dehydrogenase (LDH) levels. Ge-132 had no cytotoxic eff...
journal_title:Biological & pharmaceutical bulletin
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journal_title:Biological & pharmaceutical bulletin
pub_type: 杂志文章,评审
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更新日期:1996-03-01 00:00:00
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更新日期:1995-12-01 00:00:00
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