FR901724, a novel anti-human immunodeficiency virus (HIV) peptide produced by Streptomyces, shows synergistic antiviral activities with HIV protease inhibitor and 2',3'-dideoxynucleosides.

abstract：:The effects of exogenously applied gibberellic acid (GA(3)) or brassinolide (BL) on the H(+)-pumps and aquaporin in the vacuolar membrane of rice seedling leaf sheath were investigated. Antibodies against mung bean H(+)-PPase, the B subunit of V-ATPase, and radish tonoplast intrinsic protein (TIP) cross-reacted with t...

journal_title：Biological & pharmaceutical bulletin

authors： Yang S,Maeshima M,Tanaka Y,Komatsu S

更新日期：2003-01-01 00:00:00

abstract：:We determined the effects of psychotropic drugs on the cytochrome P450 2D (CYP2D)-mediated 21-hydroxylation of progesterone (PROG) and allopregnanolone (ALLO) with the goal of clarifying whether neurosteroid levels are affected by psychotropic drugs in the brain. PROG or ALLO was incubated with rat CYP2D4 or human CYP...

journal_title：Biological & pharmaceutical bulletin

authors： Niwa T,Okada K,Hiroi T,Imaoka S,Narimatsu S,Funae Y

更新日期：2008-03-01 00:00:00

abstract：:The mechanical properties of cells are considered promising biomarkers for the early detection of cancer and the testing of drug efficacy against it. Nevertheless, generalized correlations between drug resistance and the nano-mechanical properties of cancer cells are yet to be defined due to the lack of necessary stud...

journal_title：Biological & pharmaceutical bulletin

authors： Seo YH,Jo YN,Oh YJ,Park S

更新日期：2015-01-01 00:00:00

abstract：:We determined the binding affinity of tamsulosin, a selective α(1)-adrenoceptor antagonist, for human α(1)-adrenoceptor subtypes in comparison with those of other α(1)-adrenoceptor antagonists including silodosin, prazosin, 5-methylurapidil, terazosin, alfuzosin, nafopidil, urapidil and BMY7378. The association and di...

journal_title：Biological & pharmaceutical bulletin

authors： Sato S,Hatanaka T,Yuyama H,Ukai M,Noguchi Y,Ohtake A,Taguchi K,Sasamata M,Miyata K

更新日期：2012-01-01 00:00:00

abstract：:Glomerulonephritis (GN) is a set of pathological conditions that result in the destruction of glomeruli and loss of renal function, commonly leading to the development of end-stage renal disease. Current pharmacotherapy is limited to immunosuppressive therapy. In the present study, we found a novel antinephritic effec...

journal_title：Biological & pharmaceutical bulletin

authors： Liu N,Shi J,Xiao Y,Yasue M,Takei Y,Sanefuji H,Tsujimoto G,Hirasawa A

更新日期：2015-01-01 00:00:00

abstract：:We have found a new compound from thermophile extracts which inhibits antigen presentation on mouse macrophages. The substance inhibits the expression of the class II major histocompatibility molecule (Ia). It was extracted from Bacillus stearothermophilus UBT8038 and purified by silica gel column chromatography. The ...

journal_title：Biological & pharmaceutical bulletin

authors： Kohama Y,Itoh M,Tanaka K,Senba T,Itoh S,Mimura T

更新日期：1994-07-01 00:00:00

abstract：:Tubeimoside I (TBMS I), an extract from Chinese herbal medicine Bolbostemma paniculatum (MAXIM.) FRANQUET (Cucurbitaceae) has been shown as a potent anti-tumor agent for a variety of human cancers, but yet to be evaluated for hepatoma that is highly prevalent in Eastern Asian countries including China. Here, we examin...

journal_title：Biological & pharmaceutical bulletin

authors： Wang Y,Deng L,Zhong H,Wang Y,Jiang X,Chen J

更新日期：2011-01-01 00:00:00

abstract：:Using a validated high-performance liquid chromatographic (HPLC) method, the pharmacokinetics of multi-constituents in Huangqin-Tang decoction were simultaneously studied both in the compound prescription and in each single herb decoction. At different intervals (0, 1, 2, 4, 8, 12, 24, 36, 48 h) after oral administrat...

journal_title：Biological & pharmaceutical bulletin

authors： Zuo F,Zhou ZM,Zhang Q,Mao D,Xiong YL,Wang YL,Yan MZ,Liu ML

更新日期：2003-07-01 00:00:00

abstract：:The transdermal therapeutic systems (TTS) usually achieve constant plasma concentration for an extended period of time. This is because a sufficient drug stored in the device can keep the constant concentration on the surface of the stratum corneum during the system application. When the drug molecules are not enough ...

journal_title：Biological & pharmaceutical bulletin

authors： Kawamata H,Tojo K

更新日期：2002-03-01 00:00:00

abstract：:Imbalance between oxidative stress and antioxidative defence system is generally known as one of mechanisms causing an oxidative stress-medieated neuropathogenesis. Peroxiredoxins (Prxs), a family of antioxidative enzymes neutralizing cellular hydroperoxides, was characterized recently, but their distributions and rol...

journal_title：Biological & pharmaceutical bulletin

authors： Kim SU,Hwang CN,Sun HN,Jin MH,Han YH,Lee H,Kim JM,Kim SK,Yu DY,Lee DS,Lee SH

更新日期：2008-05-01 00:00:00

abstract：:As an attempt to identify bioactive natural products with anti-inflammatory activity, we evaluated the effects of the methanol extract of the semen of Xanthium strumarium L. (MEXS) on lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E2 (PGE2) and tumor necrosis factor-alpha (TNF-alpha) production in R...

journal_title：Biological & pharmaceutical bulletin

authors： Kim IT,Park YM,Won JH,Jung HJ,Park HJ,Choi JW,Lee KT

更新日期：2005-01-01 00:00:00

abstract：:Westernization of dietary habits leads to an increase in lipid intake and is thought to be responsible for an increase in patients with dyslipidemia. It is a well-known fact that the impaired cholesterol homeostasis is closely related to the development of various lifestyle-related diseases such as fatty liver, diabet...

journal_title：Biological & pharmaceutical bulletin

authors： Yamanashi Y,Takada T,Suzuki H

更新日期：2018-01-01 00:00:00

abstract：:The effect of the hypothyroidism induced by thiamazole on toxic interactions between propranolol and disopyramide were studied in chick embryos. Fertilized eggs of White Leghorns were incubated and investigated. 1.2 mg/0.2 ml/egg of thiamazole was injected into the albumen of fertilized eggs on the 9th day of incubati...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshiyama Y,Kanke M

更新日期：2005-10-01 00:00:00

abstract：:A high performance liquid chromatography (HPLC) method was developed for the first time to quantify simultaneously the six major active ingredients in Acanthopanax senticosus (Rupr. et Maxim.) Harms, namely protocatechuic acid, syringin, chlorogenic acid, caffeic acid, liriodendrin and isofraxidin. The analysis was pe...

journal_title：Biological & pharmaceutical bulletin

authors： Li Q,Jia Y,Xu L,Wang X,Shen Z,Liu Y,Bi K

更新日期：2006-03-01 00:00:00

abstract：:This study was designed to test the efficacy of eugenol, a compound obtained from the essential oil of cloves (Syzygium aromaticum) in collagen-induced arthritis (CIA), a well characterized murine model of rheumatoid arthritis. Macroscopic clinical evidence of CIA manifests first as periarticular erythema and edema in...

journal_title：Biological & pharmaceutical bulletin

authors： Grespan R,Paludo M,Lemos Hde P,Barbosa CP,Bersani-Amado CA,Dalalio MM,Cuman RK

更新日期：2012-01-01 00:00:00

abstract：:Apoptosis is the main form of β-cell death in diabetes. Ginseng has been used as an anti-diabetic herb for several thousand years in Asia with ginsenoside Rg1 and ginsenoside Rb1 as important active ingredients. In this study, we demonstrated ginsenoside Rg1 and Rb1 protect β-cells from high glucose/cytokine-induced p...

journal_title：Biological & pharmaceutical bulletin

authors： Chen F,Chen Y,Kang X,Zhou Z,Zhang Z,Liu D

更新日期：2012-01-01 00:00:00

abstract：:Microsomal enzyme inducers are known to influence the expression of many transporter proteins and mRNA. In this study, we examined the effects of microsomal enzyme inducers on the mRNA expression of Breast Cancer Resistance Protein (BCRP) and Multidrug Resistance Associated Protein 2 (MRP2) in BALB/c mice. mRNA expres...

journal_title：Biological & pharmaceutical bulletin

authors： Han Y,Sugiyama Y

更新日期：2006-05-01 00:00:00

abstract：:We measured the activity and stability of three mannosyltransferases to ascertain the mechanisms of changes in the antigenicity and the mannan structure of Candida albicans cells cultured at high temperature (37 degrees C) under acidic (pH 2.0) conditions in a liquid medium. The alpha-1,6-mannosyltransferase (alpha-1,...

journal_title：Biological & pharmaceutical bulletin

authors： Goto K,Okawa Y

更新日期：2008-07-01 00:00:00

abstract：:The pharmacokinetics of ketotifen fumarate (KF) was examined after administration in rabbits through four different routes (intravenous, intranasal, oral and rectal). The time-course of the plasma concentration of KF after intravenous administration (1 mg/kg dose) fitted a two-compartment open model. KF was rapidly ab...

journal_title：Biological & pharmaceutical bulletin

authors： Yagi N,Taniuchi Y,Hamada K,Sudo J,Sekikawa H

更新日期：2002-12-01 00:00:00

abstract：:The effects of different combinations of ciprofloxacin (CIP) and norfloxacin (NOR) against Escherichia coli and Staphylococcus aureus were studied using checkerboard, fractional inhibitory concentration (FIC) and time-kill analysis methods. Results obtained by the checkerboard method showed that the more effectives co...

journal_title：Biological & pharmaceutical bulletin

authors： Vitorino GP,Becerra MC,Barrera GD,Caira MR,Mazzieri MR

更新日期：2017-01-01 00:00:00

abstract：:Sixteen flavonoids including quercetin and kaempferol and their relatives were examined for their ability to promote DNA degradation induced by the bleomycin (BLM)-Fe complex. Three hydroxyl groups in the flavonoidal nucleus were proposed as a crucial structural requirement for effectively promoting DNA degradation: 1...

journal_title：Biological & pharmaceutical bulletin

authors： Sugihara N,Kaneko A,Furuno K

更新日期：2003-08-01 00:00:00

abstract：:Irsogladine maleate (2,4-diamino-6-[2,5-dichlorophenyl]-s-triazine maleate; IM), an anti-peptic ulcer drug, may have a protective effect on the gastrointestinal mucosa. This study investigated the effects of IM on spontaneous colitis in interleukin-10 gene-deficient (IL-10(-/-)) mice. Five-week-old IL-10(-/-) mice wer...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagawa T,Katsuno T,Noguchi Y,Mandai Y,Yoshihama S,Saito K,Maruoka D,Matsumura T,Arai M,Yokosuka O

更新日期：2015-01-01 00:00:00

abstract：:Diosgenyl saponins are the most abundant steroid saponins, and exert a large variety of biological functions. In a previous report, we showed that dioscin was able to induce cytotoxicity and apoptosis in human myeloblast leukemia HL-60 cells. This study further investigated the action mechanisms underlying this effect...

journal_title：Biological & pharmaceutical bulletin

authors： Liu MJ,Wang Z,Ju Y,Zhou JB,Wang Y,Wong RN

更新日期：2004-07-01 00:00:00

abstract：:To analyze the renal handling of therapeutic compounds observed as a non-linear process with a diffusion phenomenon, we employed a non-linear dispersion model described with a partial differential equation and solved it by using the finite difference method with an implicit scheme in a model dependent analysis. In thi...

journal_title：Biological & pharmaceutical bulletin

authors： Aiba T,Kubota S,Koizumi T

更新日期：1999-06-01 00:00:00

abstract：:Stevens-Johnson syndrome (SJS) was diagnosed in a 39-year-old woman, treated with ampicillin (4000-8000 mg daily), phenytoin (250 mg daily), and furosemide (20-40 mg daily) for 25, 21, and 20 d, respectively, before the appearance of the eruption. The lymphocyte stimulation test with the MTT [3-(4,5-dimethyl thiazol-2...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshimura T,Hamaguchi E,Usami E,Nakashima K,Kawaguchi M,Suzuki N,Okamoto Y,Nakao T,Yamazaki F

更新日期：2004-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is pathologically characterized by accumulation of amyloid β (Aβ) and hyperphosphorylated tau, and thereby induction of neuronal cell death. The Aβ-induced neuronal cell death has been shown to occur by several modes, such as apoptosis, necrosis, and necroptosis. Interestingly, in AD patients,...

journal_title：Biological & pharmaceutical bulletin

authors： Tagai N,Tanaka A,Sato A,Uchiumi F,Tanuma SI

更新日期：2020-01-01 00:00:00

abstract：:Silymarin is a polyphenolic flavonoid from milk thistle (Silybum marianum), which has anti-inflammatory, cytoprotective, and anticarcinogenic effects. In this study, we assessed the effect of silibinin (Fig. 1), the major active compound in silymarin, on ultraviolet light (UV)-induced cell apoptosis in HaCaT cells, a ...

journal_title：Biological & pharmaceutical bulletin

authors： Li LH,Wu LJ,Tashiro S,Onodera S,Uchiumi F,Ikejima T

更新日期：2006-06-01 00:00:00

abstract：:Ty2 retrotransposons are the mobile genetic elements of the yeast Saccharomyces cerevisiae. Transcriptional regulation of Ty2-917 requires a complex set of cis acting elements which are located both upstream and downstream of the transcription initiation site. Previously, the glycolysis regulatory protein Gcr1p has be...

journal_title：Biological & pharmaceutical bulletin

authors： Türkel S

更新日期：2002-09-01 00:00:00

abstract：:Rats stressed by specific alternation of rhythm in temperature (SART) show various symptoms of disautonomia, increased pulse rates, continuous hypotension, and severe orthostatic hypotension (OH) when they are subjected to postural change. The OH symptoms are improved by muscarinic M2-receptor blockers. In the present...

journal_title：Biological & pharmaceutical bulletin

authors： Funakami Y,Hata T,Itoh E,Itano S

更新日期：2007-02-01 00:00:00

abstract：:Thyroid hormone, thyroxine (T4) binding to glycosylated human serum albumin (G-HSA), and native human serum albumin (HSA) were studied as a function of pH using the fluorescence method. T4 binding affinity for G-HSA was remarkably reduced in an alkaline pH as compared with the native HSA. The thermodynamic parameters ...

journal_title：Biological & pharmaceutical bulletin

authors： Okabe N,Yoshida S

更新日期：1995-01-01 00:00:00