Abstract:
:Glomerulonephritis (GN) is a set of pathological conditions that result in the destruction of glomeruli and loss of renal function, commonly leading to the development of end-stage renal disease. Current pharmacotherapy is limited to immunosuppressive therapy. In the present study, we found a novel antinephritic effect of a tricaprylin emulsion in the anti-glomerular basement membrane (anti-GBM) GN rat model. We evaluated the treatment in vivo by comparing administration of the emulsion with administration of a casein kinase II (CK2) inhibitor in this rat model, and performed a gene ontology-based microarray analysis to reveal in silico the detailed mechanism of action. Our results showed that administration of the tricaprylin emulsion, or even tricaprylin alone, significantly ameliorated the anti-GBM antibody-induced renal dysfunction in these rats. We believe that tricaprylin is the key active antinephritic component of the emulsion and might be a promising drug for the effective treatment of nephritis. Moreover, with respect to microarray analysis, we developed a generally applicable and rapid method to compare gene expression profile data for multiple models of nephritis and clinical samples from a public domain microarray database.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Liu N,Shi J,Xiao Y,Yasue M,Takei Y,Sanefuji H,Tsujimoto G,Hirasawa Adoi
10.1248/bpb.b15-00124subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1175-84issue
8eissn
0918-6158issn
1347-5215journal_volume
38pub_type
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