Hepatic steatosis with relation to increased expression of peroxisome proliferator-activated receptor-γ in insulin resistant mice.

abstract：:We established a highly sensitive method for evaluating P-glycoprotein activity in Caco-2 cells. Using time-lapse confocal laser-scanning microscopy, we measured the change in fluorescence of residual rhodamine 123 in Caco-2 cells. Horizontal fluorescence images of rhodamine 123 in the apical and central parts of thes...

journal_title：Biological & pharmaceutical bulletin

authors： Wakuda H,Nejime N,Tada Y,Kagota S,Umegaki K,Yamada S,Shinozuka K

更新日期：2010-01-01 00:00:00

abstract：:Daiokanzoto (DKT), a Kampo medicine that includes the combination of two crude drugs (rhubarb and glycyrrhiza), is clinically effective for constipation. The aim of this study is to clarify the influence of glycyrrhiza, three glycyrrhiza constituents (glycyrrhizin, liquiritin, and liquiritin apioside), and eight antib...

journal_title：Biological & pharmaceutical bulletin

authors： Matsui E,Takayama K,Sato E,Okamura N

更新日期：2011-01-01 00:00:00

abstract：:The effects of 70% methanol extract (EA-ext) from Evodiae Fructus (EA) consisting of dried fruits of Evodia rutaecarpa var. bodinieri (Rutaceae) on nociceptive responses were investigated. Oral administration of 50 or 200 mg/kg EA-ext had the same antinociceptive effect on writhing responses as induced by acetic acid....

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda H,Wu JX,Tanaka T,Iinuma M,Kubo M

更新日期：1997-03-01 00:00:00

abstract：:The oligopeptide transporter PEPT1 (SLC15A1) is responsible for absorption of peptidic nutrients in the small intestine. Although the L-diastereomer of the beta-lactam antibiotic cephalexin (L-cephalexin) is likely to be transported by PEPT1, there has been no direct demonstration of PEPT1-mediated L-cephalexin transp...

journal_title：Biological & pharmaceutical bulletin

authors： Mitsuoka K,Tamai I,Morohashi Y,Kubo Y,Saitoh R,Tsuji A,Kato Y

更新日期：2009-08-01 00:00:00

abstract：:2-Thiophenecarboxylic acid (I) exhibited growth-inhibitory activity in five kinds of plants. In particular, I strongly inhibited the growth of the roots of Lactuca sativa L. var. longifolia LAM and Echinochloa utilis OHWI et YABUNO, even at the low concentration of 5.0 x 10(-3) M. Furthermore, all of the I-related com...

journal_title：Biological & pharmaceutical bulletin

authors： Inamori Y,Muro C,Funakoshi Y,Usami Y,Tsujibo H,Numata A

更新日期：1994-01-01 00:00:00

abstract：:Eight new diterpenoids (1-8) have been isolated from the wood of Excoecaria agallocha (Euphorbiaceae) and their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) in Raji cells were examined to search for potent anti-tumor-promoters from natural resources. Of these compounds, the secolabd...

journal_title：Biological & pharmaceutical bulletin

authors： Konoshima T,Konishi T,Takasaki M,Yamazoe K,Tokuda H

更新日期：2001-12-01 00:00:00

abstract：:The induction of a mutant DnaA protein (DnaA E204Q) with decreased intrinsic ATPase activity in cells causes a lethal phenotype. Based on our results that the decreased ATPase activity of DnaA E204Q is activated to the level of a wild-type protein in the presence of partially purified stimulating factors for DnaA ATPa...

journal_title：Biological & pharmaceutical bulletin

authors： Makise M,Sakamoto K,Tsuchiya T,Mizushima T

更新日期：1999-09-01 00:00:00

abstract：:Chinese medicinal prescriptions were screened for their effects on alpha-amylase activity in mouse plasma. Daio-kanzo-to, Hange-koboku-to, Saiko-ka-ryukotsu-borei-to, Saiko-keishi-kankyo-to and Mao-to changed the activity in isolated mouse plasma greatly and concentration dependently. However, no prescription influenc...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi K,Funayama N,Suzuki R,Yoshizaki F

更新日期：2002-08-01 00:00:00

abstract：:The effects of a liquid nutritive and tonic drug (NTD) selected from a modification of the "Kai-xin-shou-yu-shen-qi-wan" prescription, on scopolamine-induced amnesia in mice were investigated using the passive avoidance and water-maze tasks. A popular NTD in Japan that contains 17 crude (natural) drug extracts togethe...

journal_title：Biological & pharmaceutical bulletin

authors： Sakata Y,Chida R,Ishige K,Edagawa Y,Tadano T,Ito Y

更新日期：2005-10-01 00:00:00

abstract：:Tyrosinase is a key enzyme in the synthesis of melanin and is widely distributed in animals, plants, and microorganisms. As excessive melanin production causes not only hyperpigmenting effects on human skin but also melanosis in various foods, an inhibitor of tyrosinase has become of interest lately from a practical p...

journal_title：Biological & pharmaceutical bulletin

authors： Tsuchiya T,Yamada K,Minoura K,Miyamoto K,Usami Y,Kobayashi T,Hamada-Sato N,Imada C,Tsujibo H

更新日期：2008-08-01 00:00:00

abstract：:We investigated the properties of honokiol, a natural rexinoid, as a regulator of retinoid X receptor (RXR) heterodimers with various partner nuclear receptors (NRs), in comparison with those of the synthetic rexinoid bexarotene. Honokiol alone was hardly capable of activating peroxisome proliferator-activated recepto...

journal_title：Biological & pharmaceutical bulletin

authors： Kotani H,Tanabe H,Mizukami H,Amagaya S,Inoue M

更新日期：2012-01-01 00:00:00

abstract：:We previously reported that kiwi fruit is rich in polyphenols and has immunostimulatory activity. Polyphenols are widely known for having anti-oxidant effects. We also revealed potential anti-oxidant effects of kiwi fruit in vivo by oral administration to mice. Here, we compared the anti-oxidant effects of kiwi fruit ...

journal_title：Biological & pharmaceutical bulletin

authors： Iwasawa H,Morita E,Yui S,Yamazaki M

更新日期：2011-01-01 00:00:00

abstract：:CCl(4) (0.5 ml/kg as CCl(4)) was orally administered to rats. Twelve hours after administration of CCl(4), plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, indicators of liver necrosis, were significantly higher than those in the control group showing that active liver necrosis took p...

journal_title：Biological & pharmaceutical bulletin

authors： Washino Y,Koga E,Kitamura Y,Kamikawa C,Kobayashi K,Nakagawa T,Nakazaki C,Ichi I,Kojo S

更新日期：2010-01-01 00:00:00

abstract：:The weights of prostate and seminal vesicle were decreased by treatment with 3,6-dimethylpyrazine-2-thiol(3,6-DMP-SH) but the weights of testes and the plasma testosterone levels were not changed. The recovery of the weight of prostate and seminal vesicles of testosterone-treated orchidectomized rats were inhibited by...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada K,Komatsu H,Ohta A

更新日期：1996-03-01 00:00:00

abstract：:The effects of hop extracts (Humulus lupulus L.) on histamine release from rat peritoneal mast cells and human basophilic KU812 cells were studied. Hop water extract (HWE) and XAD-4 50% methanol fraction of HWE (MFH) inhibited histamine release from rat mast cells induced by compound 48/80 at concentrations of 100 and...

journal_title：Biological & pharmaceutical bulletin

authors： Takubo M,Inoue T,Jiang S,Tsumuro T,Ueda Y,Yatsuzuka R,Segawa S,Watari J,Kamei C

更新日期：2006-04-01 00:00:00

abstract：:To study the role of asarinin on collagen-induced arthritis (CIA) and its treatment mechanism on dendritic cells (DCs) and T cells. Before the onset of arthritis, asarinin were given orally to CIA mouse. Macroscopic scoring and micrometer caliper measurement were used to assess arthritis. The occurrence of cartilage d...

journal_title：Biological & pharmaceutical bulletin

authors： Dai Q,Wang M,Li Y,Li J

更新日期：2019-07-01 00:00:00

abstract：:To elucidate drug interaction between human immunodeficiency virus (HIV) protease inhibitors (PIs), the effect of indinavir (IDV) on the intestinal exsorption of other HIV PIs, amprenavir (APV), saquinavir (SQV) and nelfinavir (NFV) was investigated in rats using an in situ single perfusion method. IDV in the intestin...

journal_title：Biological & pharmaceutical bulletin

authors： Gao W,Kageyama M,Inoue Y,Tadano J,Fukumoto K,Fukushima K,Yamasaki D,Nishimura A,Yoshikawa Y,Shibata N,Takada K

更新日期：2003-02-01 00:00:00

abstract：:DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate), a calmodulin antagonist, provides protection against Ca(2+) overload-associated cytotoxicity and brain injury after cerebral ischemia in rats. In this study, we assessed the e...

journal_title：Biological & pharmaceutical bulletin

authors： Sugimura M,Takamori H,Fukushi H,Kitano Y,Kanazawa Y,Shirasaki Y

更新日期：2005-04-01 00:00:00

abstract：:Glucocorticoids are effective drugs for the treatment of allergic skin diseases. In the present study, we observed the effects of prednisolone on the cutaneous reaction and skin barrier function in mice treated with a hapten, 2,4-dinitrofluorobenzene. Repeated hapten application onto the mouse ear resulted in a potent...

journal_title：Biological & pharmaceutical bulletin

authors： Ueda Y,Sone T,Inagaki N,Nagai H

更新日期：2003-05-01 00:00:00

abstract：:Alpha1-adrenoceptor antagonists are clinically useful for the improvement of urinary obstruction due to benign prostatic hyperplasia (BPH), and their therapeutic effects are mediated through the blockade of prostatic alpha(1)-adrenoceptors. The present study was undertaken to predict the magnitude and duration of alph...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada S,Kato Y,Okura T,Kagawa Y,Kawabe K

更新日期：2007-07-01 00:00:00

abstract：:High-resolution deep tissue imaging is possible with two-photon excitation microscopy. With the combined application of two-photon imaging and perfusion with a polar fluorescent tracer, we have established a method to detect exocytic events inside secretory tissues. This method displays the spatiotemporal distribution...

journal_title：Biological & pharmaceutical bulletin

authors： Takahashi N

更新日期：2015-01-01 00:00:00

abstract：:The free radical scavenging activities of Panax ginseng C.A. MEYER are known to increase by heat processing. Phenolic acids and Maillard reaction products (MRPs) have been suggested as active free radical scavenging components from our previous research, but heat processing-induced chemical and activity changes of gin...

journal_title：Biological & pharmaceutical bulletin

authors： Kang KS,Kim HY,Baek SH,Yoo HH,Park JH,Yokozawa T

更新日期：2007-04-01 00:00:00

abstract：:Meiosis activating sterol (MAS), the intermediate of cholesterol biosynthesis, is an important substance to stimulate oocytes maturation in FSH-induced signal transduction pathway. Lanosterol 14alpha-demethylase (CYP51) converts lanosterol to MAS. Although MAS is firstly isolated from bovine testis, the information ab...

journal_title：Biological & pharmaceutical bulletin

authors： Wang F,Shen Y,Song X,Xia G,Chen X,Zhou B,Lei L

更新日期：2006-03-01 00:00:00

abstract：:Solifenacin succinate is a novel muscarinic receptor antagonist used for the treatment of overactive bladder (OAB). We investigated the effects of solifenacin by oral and intravenous administration on carbachol (CCh)-induced intravesical pressure (IVP) elevation and compared its efficacy with that on CCh-induced saliv...

journal_title：Biological & pharmaceutical bulletin

authors： Okutsu H,Noguchi Y,Ohtake A,Suzuki M,Sato S,Sasamata M

更新日期：2007-12-01 00:00:00

abstract：:This study aims to determine the potential renal protective effects of Opuntia ficus-indica (L.) Miller (OFI) fruits against cisplatin-induced nephrotoxicity in mice. The antioxidant activity of OFI methanol extract was calculated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulfo...

journal_title：Biological & pharmaceutical bulletin

authors： Okur ME,Ayla Ş,Karadağ AE,Çiçek Polat D,Demirci S,Seçkin İ

更新日期：2020-01-01 00:00:00

abstract：:We investigated the changes (increase or decrease in peak intensity) in the expression of plasma proteins in spontaneously diabetic WBN/Kob rats that were with complicated diabetic nephropathy, to determine multiple biomarkers in the plasma of diabetic rats. The present study using surface enhanced laser desorption/io...

journal_title：Biological & pharmaceutical bulletin

authors： Kiga C,Nakagawa T,Koizumi K,Sakurai H,Shibagaki Y,Ogawa K,Goto H,Saiki I

更新日期：2005-06-01 00:00:00

abstract：:Recent development in carbohydrate markers and functions are described. Identification of carbohydrate epitope for cancer-specific antibody is introduced. This novel approach involves the key glycosyltransferases that synthesize tumor-associated carbohydrate-antigens and elucidate the biosynthetic pathways. This is th...

journal_title：Biological & pharmaceutical bulletin

authors： Fukuda M

更新日期：2012-01-01 00:00:00

abstract：:Since grape extract (GE) contains oligomeric proanthocyanidins and numerous polyphenols, dietary GE supplements may exert protective effects against various diseases. The present study investigated the pharmacological effects of GE derived from Chardonnay in vitro and in vivo. GE (100 µg/mL) completely inhibited tumor...

journal_title：Biological & pharmaceutical bulletin

authors： Ohkita M,Hayashi H,Ito K,Shigematsu N,Tanaka R,Tsutsui H,Matsumura Y

更新日期：2019-01-01 00:00:00

abstract：:Topiramate pharmacokinetics is influenced by individual factors such as patient age, renal function and co-treatment. The aim of this study was to develop a population pharmacokinetic model of topiramate to assist dosage adjustments in individual patients. Steady-state topiramate plasma concentrations in patients with...

journal_title：Biological & pharmaceutical bulletin

authors： Vovk T,Jakovljević MB,Kos MK,Janković SM,Mrhar A,Grabnar I

更新日期：2010-01-01 00:00:00

abstract：:Hairy roots of interspecific hybrid ginseng (Panax ginseng x P. quinquefolium), induced by Agrobacterium rhizogenes ATCC 15834, grew well in B5 liquid media supplemented with 2.5 microM auxins (3-indole butyric acid (IBA), 1-naphtaleneacetic acid (NAA) and 3-indoleacetic acid (IAA)). The hairy roots cultured in B5 liq...

journal_title：Biological & pharmaceutical bulletin

authors： Washida D,Shimomura K,Takido M,Kitanaka S

更新日期：2004-05-01 00:00:00