Effectiveness of the Sleep Enhancement by Green Romaine Lettuce (Lactuca sativa) in a Rodent Model.

abstract：:Rheumatoid arthritis (RA) is an inflammatory disease with joint dysfunction following cartilage degradation. The level of lysophosphatidic acid (LPA) has been reported to be augmented in human synovial fluid from patients with RA. However, it remains to be elucidated whether LPA participates in cartilage destruction. ...

journal_title：Biological & pharmaceutical bulletin

authors： Mizuno K,Komiya M,Okuyama K,Imada K,Sato T

更新日期：2021-01-01 00:00:00

abstract：:Feast/famine regulatory proteins (FFRPs) comprise a single group of transcription factors systematically distributed throughout archaea and eubacteria. In the eubacterial domain in Escherichia coli, autotrophic pathways are activated and heterotrophic pathways are repressed by an FFRP, the leucine-responsive regulator...

journal_title：Biological & pharmaceutical bulletin

authors： Kawashima T,Aramaki H,Oyamada T,Makino K,Yamada M,Okamura H,Yokoyama K,Ishijima SA,Suzuki M

更新日期：2008-02-01 00:00:00

abstract：:Effects of epidermal growth factor (EGF) on the expression of alpha(2)-adrenergic responses were examined in primary cultures of adult rat hepatocytes. The alpha(2)-responses were assessed by the inhibition of the rate of forskolin-stimulated cAMP formation by the selective alpha(2)-adrenergic agonists, oxymetazoline ...

journal_title：Biological & pharmaceutical bulletin

authors： Ogihara M

更新日期：1996-04-01 00:00:00

abstract：:Physiological cell death is an essential event in normal development and maintenance of homeostasis. Recently, the morphological and pharmacological characteristics of programmed cell death, which are distinct from those of apoptosis under physiological and pathological conditions, have been reported. However, the mol...

journal_title：Biological & pharmaceutical bulletin

authors： Morimoto R,Obinata A

更新日期：2011-01-01 00:00:00

abstract：:Fat specific protein 27 (FSP27) was originally isolated by screen for genes specifically expressed in fully differentiated mouse adipocytes. FSP27 and cell death-inducing DFF45-like effector C (CIDEC), the human homologue of FSP27, belong to the CIDE family. The FSP27 in adipocytes was recently reported to be a lipid ...

journal_title：Biological & pharmaceutical bulletin

authors： Matsusue K

更新日期：2010-01-01 00:00:00

abstract：:The purpose of this research is improvement of therapeutic treatment for periodontitis by using lipophilic and/or hydrophilic zinc materials. The sample suspension injections were prepared from zinc octanate (C8Zn), zinc stearate (C18Zn), zinc sulfate hepta-hydrate (ZnSO4) and tricalcium phosphate (ZnTCP) containing 6...

journal_title：Biological & pharmaceutical bulletin

authors： Tokudome Y,Otsuka M

更新日期：2012-01-01 00:00:00

abstract：:Aerobic glycolysis is an established hallmark of cancer. Neoplastic cells display increased glucose consumption and a corresponding increase in lactate production compared to the normal cells. Aerobic glycolysis is regulated by the phosphatidylinositol-3-kinase (PI3K)/Akt/ mammalian target of rapamycin (mTOR) signalin...

journal_title：Biological & pharmaceutical bulletin

authors： Parajuli P,Tiwari RV,Sylvester PW

更新日期：2015-01-01 00:00:00

abstract：:Central nervous system (CNS) agents cause fractures among the elderly, but fracture risks of a wide range of CNS agent classes have not been analyzed in a study with the same population and definitions of variables. This study aimed to estimate the degree of fragility fracture risk of a wide range of CNS agent classes...

journal_title：Biological & pharmaceutical bulletin

authors： Ohara E,Bando Y,Yoshida T,Ohara M,Kirino Y,Iihara N

更新日期：2020-01-01 00:00:00

abstract：:The present study assessed the safety/toxicity of Senecio scandens, a well-known Chinese herb that is used as an anti-inflammatory, antibiosis, and antipyretic drug. A 90-d subchronic oral toxicity study of S. scandens was performed in Wistar rats. The extract of S. scandens was administered orally to male and female ...

journal_title：Biological & pharmaceutical bulletin

authors： Wang XK,Zhao Y,Liu T,Yi Y,Li CY,Wang HJ,Wang CH,Wang ZT,Ye ZG,Liang AH

更新日期：2015-01-01 00:00:00

abstract：:Our previous study using apoptosis analysis suggested that Ca(2+) release through inositol 1,4,5-trisphosphate (IP3) receptors and the subsequent Ca(2+) influx through store-operated channels (SOCs) constitute a triggering signal for H2O2-induced β-cell apoptosis. In the present study, we further examined the obligato...

journal_title：Biological & pharmaceutical bulletin

authors： Sato T,Kaneko YK,Sawatani T,Noguchi A,Ishikawa T

更新日期：2015-01-01 00:00:00

abstract：:Attention-deficit hyperactivity disorder (AD/HD) is a clinically heterogenous disorder including hyperactivity, impulsivity, and inattention. Both psychostimulant and non-psychostimulant drugs such as methylphenidate and atomoxetine, respectively, to modulate catecholeamine neurotransmission are used as current pharma...

journal_title：Biological & pharmaceutical bulletin

authors： Arime Y,Kubo Y,Sora I

更新日期：2011-01-01 00:00:00

abstract：:Among the calcium-binding proteins from chicken gizzard smooth muscle, smooth muscle calcium-binding protein 11 (SMCaBP 11), which is an EF-hand type calcium-binding protein, can prevent Ca2+ dependent histamine release from permeabilized rat peritoneal mast cells. This activity appears to be specific since other calc...

journal_title：Biological & pharmaceutical bulletin

authors： Fujii T,Kuzumaki N,Ogoma Y,Kondo Y

更新日期：1994-05-01 00:00:00

abstract：:The effects of ketoconazole (KCZ) on secretion of progesterone and cAMP in Leydig cells were investigated in vitro. MA-10 mouse Leydig tumor cells were used to conduct the experiments. KCZ significantly inhibited the progesterone production from MA-10 cells in a dose dependent fashion between 2 and 20 microM among 1, ...

journal_title：Biological & pharmaceutical bulletin

authors： Chang CL,Fung HP

更新日期：2002-06-01 00:00:00

abstract：:To develop an isoelectric focusing apparatus using a cellulose acetate membrane (Separax EF), we have designed a thermoelectric cooling isoelectric apparatus. This apparatus has two characteristics. Firstly, the cooling system was switched to a thermoelectric cooling system from an ice-cooling system. Secondly, the ch...

journal_title：Biological & pharmaceutical bulletin

authors： Shiba K,Toda T,Iijima S,Inoue J,Yoshida T,Cho H,Kimura M

更新日期：1994-10-01 00:00:00

abstract：:We examined the feasibility of using submicron-sized liposomes (ssLips) for retinal delivery of hydrophilic compounds, which would also have a wide range of applications. To evaluate the uptake into conjunctival cell line and the intraocular behavior of hydrophilic compound-containing ssLips after eyedrop application,...

journal_title：Biological & pharmaceutical bulletin

authors： Hironaka K,Fujisawa T,Sasaki H,Tozuka Y,Tsuruma K,Shimazawa M,Hara H,Takeuchi H

更新日期：2011-01-01 00:00:00

abstract：:A simple and efficient method for the separation of phosphatidylinositol 4-phosphate (PI 4-P) from phosphatidylinositol (PI) and phosphatidylserine (PS) is described. A mixture of PI, PI 4-P and PS was injected onto a Sep-Pak C18 cartridge. PI and PS were flushed through the cartridge with solvent 1 [methanol-chlorofo...

journal_title：Biological & pharmaceutical bulletin

authors： Morisaki N,Masaoka M,Shirai R,Hashimoto Y

更新日期：2000-09-01 00:00:00

abstract：:The present study investigated whether or not Sho-saiko-to (crude powder extract, TJ-9) can suppress nitric oxide (NO) generation by endotoxin-activated J774A.1 cells in order to study the preventive mechanism of Sho-saiko-to against endotoxemia. In this experiment, we estimated the NO2- in the murine macrophage cell ...

journal_title：Biological & pharmaceutical bulletin

authors： Sakaguchi S,Furusawa S,Yokota K,Sasaki K,Takayanagi Y

更新日期：1995-04-01 00:00:00

abstract：:Aromatase is a cytochrome P-450 enzyme complex that catalyzes the conversion of androst-4-ene-3,17-dione (AD) to estrone through three sequential oxygenations of the 19-methyl group. To gain insight into the ability of AD isomers, 4-en-6-one 1a, 5-en-4-one 2a, and 5-en-7-one 3a, competitive inhibitors of aromatase wit...

journal_title：Biological & pharmaceutical bulletin

authors： Numazawa M,Yamada K,Nagaoka M

更新日期：2001-04-01 00:00:00

abstract：:Neuroprotective effects of estrogen and estrogen-like chemicals on neurodegenerative diseases, especially Parkinson's disease, have been well established. In the present study, we compared the effects of Bak Foong Pill (BFP), a well-known gynaecological tonic in China, and 17beta-estradiol, on dopamine transporter (DA...

journal_title：Biological & pharmaceutical bulletin

authors： Liu B,Xie JX,Rowlands DK,Gou YL,Leung CC,Chung YW,Chan HC

更新日期：2004-08-01 00:00:00

abstract：:We investigated the genotypic status of thiopurine methyltransferase (TPMT) polymorphism to evaluate the possible risk of the toxicity of azathioprine (AZA) in 68 patients with systemic lupus erythematosus (SLE). The allele frequency of TPMT mutation in the SLE group (2.9%) was higher than that in 174 Japanese healthy...

journal_title：Biological & pharmaceutical bulletin

authors： Okada Y,Nakamura K,Kodama T,Ueki K,Tsukada Y,Maezawa A,Tsukamoto N,Nojima Y,Ishizaki T,Horiuchi R,Yamamoto K

更新日期：2005-11-01 00:00:00

abstract：:Essential elements (Ca, Mg, Zn, Cu, Fe, Cr, Mn and V) and non-essential elements (As, Cd, Hg and Pb) were measured in scalp hair samples of 45 diabetic subjects and 59 control subjects in Japan using inductively coupled plasma mass spectrometry. All diabetic subjects took insulin and/or antidiabetic agents, with glyca...

journal_title：Biological & pharmaceutical bulletin

authors： Hotta Y,Fujino R,Kimura O,Endo T

更新日期：2018-01-01 00:00:00

abstract：:Four lavandulyl flavanones, (2S)-2'-methoxykurarinone (1), sophoraflavanone G (2), leachianone A (3), and (-)-kurarinone (4), which are isolated from the roots of Sophora flavescens have been tested for in vitro antimalarial activity against Plasmodium falciparum. Compounds 1-3 showed moderate antimalarial activities ...

journal_title：Biological & pharmaceutical bulletin

authors： Kim YC,Kim HS,Wataya Y,Sohn DH,Kang TH,Kim MS,Kim YM,Lee GM,Chang JD,Park H

更新日期：2004-05-01 00:00:00

abstract：:Methylmercury (MeHg) is a causative agent of Minamata disease and an environmental pollutant that comprises a large portion of organically occurring mercury. Many aspects of the biological defense mechanisms against MeHg toxicity remain unclear. Recently, nuclear factor-E2-related factor 2 (Nrf2), heat shock factor pr...

journal_title：Biological & pharmaceutical bulletin

authors： Hwang GW

更新日期：2012-01-01 00:00:00

abstract：:The constituents of the leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense were investigated based on their trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent of Chagas' disease. As the active components, the polyisoprenylated benzophenone derivative guttiferone A...

journal_title：Biological & pharmaceutical bulletin

authors： Abe F,Nagafuji S,Okabe H,Akahane H,Estrada-Muñiz E,Huerta-Reyes M,Reyes-Chilpa R

更新日期：2004-01-01 00:00:00

abstract：:The effects of various disinfectants and hot water on planktonic cells and biofilm cells of Burkholderia cepacia were investigated. The survival rate of viable B. cepacia cells in suspension decreased to 0.001% or lower within 15 s of exposure to 0.5% benzalkonium chloride, within 30 s of exposure to 0.5% alkyldiamino...

journal_title：Biological & pharmaceutical bulletin

authors： Miyano N,Oie S,Kamiya A

更新日期：2003-05-01 00:00:00

abstract：:The transdermal therapeutic systems (TTS) usually achieve constant plasma concentration for an extended period of time. This is because a sufficient drug stored in the device can keep the constant concentration on the surface of the stratum corneum during the system application. When the drug molecules are not enough ...

journal_title：Biological & pharmaceutical bulletin

authors： Kawamata H,Tojo K

更新日期：2002-03-01 00:00:00

abstract：:Uridine 5'-diphosphate-glucuronosyltransferase (UGT) catalyzes a major phase II reaction in a drug-metabolizing enzyme system. Although the UGT1A subfamily is expressed mainly in the liver, it is also expressed in the brain. The purpose of the present study was to elucidate the effect of β-naphthoflavone (BNF), one of...

journal_title：Biological & pharmaceutical bulletin

authors： Sakakibara Y,Katoh M,Kondo Y,Nadai M

更新日期：2016-01-01 00:00:00

abstract：:There are many important considerations in the interactions among the herbal constituents in a prescription of traditional Chinese medicine (TCM). Ephedra Herb [Chinese characters: see text] (Eph) is described a warm and acrid agent in TCM. The combination of Eph and Gypsum [Chinese characters: see text] (Eph-Gyp) sho...

journal_title：Biological & pharmaceutical bulletin

authors： Yuan D,Sunouchi H,Sakurai T,Saito K,Kano Y

更新日期：2002-07-01 00:00:00

abstract：:Consuming food at uncommon times during the day might be associated with obesity in experimental animals and humans. We previously reported that mice become obese and their metabolism becomes disrupted when they consume food during the daytime (sleep phase feeding; SPF), but not during the nighttime (active phase feed...

journal_title：Biological & pharmaceutical bulletin

authors： Oishi K,Okauchi H

更新日期：2019-01-01 00:00:00

abstract：:The dopamine reuptake inhibitor bupropion and dopamine D2/3 receptor agonist pramipexole have been clinically proven to improve both depression and treatment-resistant depression. We examined its influence on the duration of immobility during the forced swim test in adrenocorticotropic hormone (ACTH)-treated rats and ...

journal_title：Biological & pharmaceutical bulletin

authors： Onoue Y,Kuwatsuka K,Miyazaki I,Asanuma M,Kitamura Y,Sendo T

更新日期：2014-01-01 00:00:00