Depressive effect of a traditional Chinese medicine (sho-saiko-to) on endotoxin-induced nitric oxide formation in activated murine macrophage J774A.1 cells.

abstract：:Salt-sensitive hypertension induces renal injury via decreased blood flow in the renal artery (RA), and ion channel dysfunction in RA myocytes (RAMs) may be involved in the higher renal vascular resistance. We examined the effects of several voltage-gated K+ (KV) channel blockers on the resting tension in endothelium-...

journal_title：Biological & pharmaceutical bulletin

authors： Ogiwara K,Ohya S,Suzuki Y,Yamamura H,Imaizumi Y

更新日期：2017-01-01 00:00:00

abstract：:The anti-herpes simplex virus type 1 (HSV-1) activity of 15 oleanan-type triterpenoides including glycyrrhizin and its sapogenol was examined and their structure-activity relationships were discussed. Although glycyrrhizin which exhibited in vivo efficacy against HSV-1 replication showed moderate in vitro anti-HSV-1 a...

journal_title：Biological & pharmaceutical bulletin

authors： Ikeda T,Yokomizo K,Okawa M,Tsuchihashi R,Kinjo J,Nohara T,Uyeda M

更新日期：2005-09-01 00:00:00

abstract：:The purpose of this study was to investigate the absorption behavior of an ophthalmic drug injected in rabbit periocular tissues. After intracapsular, retrobulbar and palpebral conjunctival injections of 150 microl and 50 microl fluorescein isothiocyanate dextran (FITC-dextran, average molecular weight 11000), leakage...

journal_title：Biological & pharmaceutical bulletin

authors： Sasaki H,Kashiwagi S,Mukai T,Nishida K,Nakamura J,Nakashima M,Ichikawa M

更新日期：1999-09-01 00:00:00

abstract：:The genome sequencing project revealed presence of two active chalcone synthase (CHS) homologues (At1g02050 and At4g34850) in the model plant Arabidopsis thaliana. We report herein the two genes encode closely related novel plant-specific type III polyketide synthases (PKSs) that produces long-chain alkyl alpha-pyrone...

journal_title：Biological & pharmaceutical bulletin

authors： Mizuuchi Y,Shimokawa Y,Wanibuchi K,Noguchi H,Abe I

更新日期：2008-12-01 00:00:00

abstract：:Recently, a silent polymorphism of C3435T of the MDR1 gene, encoding the multidrug resistant transporter MDR1/P-glycoprotein, has been found to be associated with susceptibility to ulcerative colitis (UC), but this remains controversial. This study was conducted to find a possible reason for the discrepancies, and it ...

journal_title：Biological & pharmaceutical bulletin

authors： Osuga T,Sakaeda T,Nakamura T,Yamada T,Koyama T,Tamura T,Aoyama N,Okamura N,Kasuga M,Okumura K

更新日期：2006-02-01 00:00:00

abstract：:The prostacyclin I1 (PGI1) analogue, SM-10906 and its methyl ester, SM-10902, have been compared with the PGI2 analogue, iloprost, with respect to binding to the PGI2 receptor, stimulation of adenylate cyclase activity and inhibition of thrombin-induced Ca2+ mobilization in mastocytoma P-815 cells. SM-10906 displaced ...

journal_title：Biological & pharmaceutical bulletin

authors： Oka M,Negishi M,Yamamoto T,Satoh K,Hirohashi T,Ichikawa A

更新日期：1994-01-01 00:00:00

abstract：:Only a few biosynthetic pathways in fungal cells have been used as antifungal targets. Therefore, the number of antifungals has been limited, and a cross-drug resistance among them has emerged in the therapy of mycoses. Under such circumstances, the identification of an antifungal with a new mode of action is highly d...

journal_title：Biological & pharmaceutical bulletin

authors： Aoki Y,Kamiyama T,Fujii T,Yamamoto M,Ohwada J,Arisawa M

更新日期：1995-09-01 00:00:00

abstract：:Metallothioneins (MTs) occur throughout the animal kingdom and they are induced in vivo by metals, hormones, cytotoxic agents, and some kind of stress. It is well known that various stresses such as starvation and immobilization can induce MT synthesis in animal tissues, but the influence of dietary restriction is unk...

journal_title：Biological & pharmaceutical bulletin

authors： Shinogi M,Sakaridani M,Yokoyama I

更新日期：1999-02-01 00:00:00

abstract：:We investigated the cytotoxicity of eight vitamin K3 (VK3) analogs against neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, and SK-N-SH) and normal cell lines (human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)) using a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) a...

journal_title：Biological & pharmaceutical bulletin

authors： Kitano T,Yoda H,Tabata K,Miura M,Toriyama M,Motohashi S,Suzuki T

更新日期：2012-01-01 00:00:00

abstract：:In vivo reducing capacity and cytosolic glutathione peroxidase (GSH-Px) activity in liver homogenate were evaluated in 6 weeks old Se-deficient and normal rats. GSH-Px was significantly lower in Se-deficient rats than in normal rats. In vivo reducing capacity in head and liver parts, estimated from in vivo signal deca...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto K,Endo K,Utsumi H

更新日期：2000-05-01 00:00:00

abstract：:The gastric mucus is an important factor in the gastric mucosal protection from acid, pepsin and various reagents (alcohol, aspirin, etc.). MUC5AC is the mucin secreted from surface mucous cells, and belongs to the gel-forming mucin. We examined the regulation of rat MUC5AC (rMUC5AC) mRNA by glucocorticoid in vivo and...

journal_title：Biological & pharmaceutical bulletin

authors： Tanaka T,Kobayashi T,Sunaga K,Tani S

更新日期：2001-06-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor plays a key role in learning and memory. Our recent studies have shown that nobiletin from citrus peels activates the cAMP response element-binding protein (CREB) signaling pathway and ameliorates NMDA receptor antagonist-induced learning impairment by activating extracellular ...

journal_title：Biological & pharmaceutical bulletin

authors： Kimura J,Nemoto K,Degawa M,Yokosuka A,Mimaki Y,Shimizu K,Oku N,Ohizumi Y

更新日期：2014-01-01 00:00:00

abstract：:We examined the action mechanism of oleanolic acid 3-O-monodesmoside, momordin Ic (1), and oleanolic acid 3-O-glucuronide (2) for the inhibitory effect on the increase in serum glucose levels in oral glucose-loaded rats. Although 1 and 2 dose-dependently inhibited the increase in serum glucose levels in oral glucose-l...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda H,Murakami T,Shimada H,Matsumura N,Yoshikawa M,Yamahara J

更新日期：1997-06-01 00:00:00

abstract：:We previously isolated berberine from aqueous extracts of tsu-kan-gan, a Kampo formula used for the treatment of osteoporosis. Berberine caused an inhibitory effect on parathyroid hormone (PTH)-stimulated bone resorption in neonatal mouse bone. In this report we describe the inhibitory effect of berberine on the forma...

journal_title：Biological & pharmaceutical bulletin

authors： Li H,Miyahara T,Tezuka Y,Namba T,Suzuki T,Dowaki R,Watanabe M,Nemoto N,Tonami S,Seto H,Kadota S

更新日期：1999-04-01 00:00:00

abstract：:Potent ligands of peroxisome proliferator-activated receptor γ (PPARγ) such as thiazolidinediones (pioglitazone, troglitazone, etc.) improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Several constituents from medicinal...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda H,Nakamura S,Yoshikawa M

更新日期：2014-01-01 00:00:00

abstract：:The effect of the hypothyroidism induced by thiamazole on toxic interactions between propranolol and disopyramide were studied in chick embryos. Fertilized eggs of White Leghorns were incubated and investigated. 1.2 mg/0.2 ml/egg of thiamazole was injected into the albumen of fertilized eggs on the 9th day of incubati...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshiyama Y,Kanke M

更新日期：2005-10-01 00:00:00

abstract：:Chemoprevention has emerged as a very effective preventive measure against carcinogenesis. Several bioactive compounds present in fruits and vegetables have revealed their cancer curative potential on benzo(a)pyrene (B(a)P) induced carcinogenesis. In the present study, the efficacy of quercetin on the level of lipid p...

journal_title：Biological & pharmaceutical bulletin

authors： Kamaraj S,Vinodhkumar R,Anandakumar P,Jagan S,Ramakrishnan G,Devaki T

更新日期：2007-12-01 00:00:00

abstract：:Alpha1-adrenoceptor antagonists are clinically useful for the improvement of urinary obstruction due to benign prostatic hyperplasia (BPH), and their therapeutic effects are mediated through the blockade of prostatic alpha(1)-adrenoceptors. The present study was undertaken to predict the magnitude and duration of alph...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada S,Kato Y,Okura T,Kagawa Y,Kawabe K

更新日期：2007-07-01 00:00:00

abstract：:Deoxynybomycin was identified as an inducer of p21the/WAF1 gene following screening using a reporter, p21/luciferase. The present study examined its anti-proliferative effect on human tumor cell lines. Deoxynybomycin selectively inhibited growth of human osteoblastic sarcoma Saos-2, gastric cancer TMK-1, and monocytic...

journal_title：Biological & pharmaceutical bulletin

authors： Egawa K,Yamori T,Nosaka C,Kunimoto S,Takeuchi T,Nos K

更新日期：2000-09-01 00:00:00

abstract：:Two subclones (K562-L and -H) were previously isolated from K562 human leukemic cells according to hemoglobin production: K562-L was expressed in less than 5% and K562-H in more than 90% of dianisidine positive cells. 12-O-Tetradecanoylphorbol-13- acetate (TPA) suppressed the expression of the erythrocytic (glycophori...

journal_title：Biological & pharmaceutical bulletin

authors： Sasaki D,Kosunago S,Mikami T,Matsumoto T,Suzuki M

更新日期：1993-10-01 00:00:00

abstract：:L-2,4-Diaminobutyrate decarboxylase (DABA DC) is a novel enzyme yielding 1,3-diaminopropane (DAP) from DABA, which has previously been purified from strains of the genera Vibrio and Acinetobacter. In this study, we also detected DABA DC activity in the species of Enterobacteriaceae: E. aerogenes, E. cloacae, E. agglom...

journal_title：Biological & pharmaceutical bulletin

authors： Yamamoto S,Mutoh N,Ikai H,Nagasaka M

更新日期：1996-10-01 00:00:00

abstract：:Protein purification is a key technique for the identification of novel sensory nerve-specific proteins. A 35 kDa protein, the sensory neuronal specific protein, was isolated and purified from rabbit spinal ganglia and sensory fibers by homogenizing and deriving soluble extracts, followed by ion exchange chromatograph...

journal_title：Biological & pharmaceutical bulletin

authors： Ping XP,Wang JZ

更新日期：2000-05-01 00:00:00

abstract：:Continuous oral administration of the acidic polysaccharide (TAP) solution (0.5 g/l) and the TAP-H (degradation products of TAP) solution (1.5 g/l) instead of water for 10 weeks were found to depress plasma glucose increases in diabetes using genetically non-insulin-dependent diabetic model (KK-Ay) mice. TAP and TAP-H...

journal_title：Biological & pharmaceutical bulletin

authors： Kiho T,Kochi M,Usui S,Hirano K,Aizawa K,Inakuma T

更新日期：2001-12-01 00:00:00

abstract：:Lectin-like receptors natural killer group 2D (NKG2D) and CD94 on natural killer (NK) cells bind to α2,3-NeuAc-containing N-glycans and heparin/heparan sulfate (HS). Using recombinant glutathione S-transferase-fused extracellular lectin-like domains of NKG2D (rGST-NKG2Dlec) and CD94 (rGST-CD94lec), we evaluated their ...

journal_title：Biological & pharmaceutical bulletin

authors： Higai K,Suzuki C,Imaizumi Y,Xin X,Azuma Y,Matsumoto K

更新日期：2011-01-01 00:00:00

abstract：:We showed previously that transdifferentiation of skin epidermis to mucous epithelium can be induced by treatment with 20 µM retinol for 1 d followed by culture for 4 d without retinol in chick embryonic tarsometatarsal skin. In mouse epidermal cells, 3 µM retinoic acid (an active metabolite of retinol) inhibits epide...

journal_title：Biological & pharmaceutical bulletin

authors： Obinata A,Akimoto Y

更新日期：2011-01-01 00:00:00

abstract：:The aim of this work is to investigate the therapeutic efficacy of VP-343 ((N-[4-[[(2S,3aR)-2-hydroxy-2,3,3a,4-tetrahydropyrrolo[1,2-a]qunoxalin-5(1H)-yl]phenyl]-4'-methyl[1,1'-biphenyl]-2-carboxamide), a selective vasopressin V2 receptor antagonist, using the experimental SIADH (syndrome of inappropriate secretion of...

journal_title：Biological & pharmaceutical bulletin

authors： Naito A,Hasegawa H,Kurasawa T,Ohtake Y,Matsukawa H,Ezure Y,Tsuriya Y,Koike K,Shigenobu K

更新日期：2000-11-01 00:00:00

abstract：:Phenolic compounds are numerous and ubiquitous in the plant kingdom, being particularly present in health-promoting foods. Epidemiological evidences suggest that the consumption of polyphenol-rich foods reduces the incidence of cancer, coronary heart disease and inflammation. Chlorogenic acid (CGA) is one of the most ...

journal_title：Biological & pharmaceutical bulletin

authors： dos Santos MD,Almeida MC,Lopes NP,de Souza GE

更新日期：2006-11-01 00:00:00

abstract：:The blood clearance, tissue uptake and antitumor efficacy against liver metastasis of M5076 reticulosarcoma in mice and against primary liver cancer in rats of doxorubicin (DOX) encapsulated in two types of liposomes, with and without a soYbean-derived sterylglucoside mixture (SG), were examined. Liposomes entrapping ...

journal_title：Biological & pharmaceutical bulletin

authors： Shimizu K,Qi XR,Maitani Y,Yoshii M,Kawano K,Takayama K,Nagai T

更新日期：1998-07-01 00:00:00

abstract：:Coenzyme Q10 (Co-Q10) is a vitamin-like supplement which appears to be safe, with minimal side effects and low drug interaction potential. Co-Q10 is used in the treatment of a variety of disorders related primarily to suboptimal cellular energy metabolism and oxidative injury. Studies supporting the efficacy of Co-Q10...

journal_title：Biological & pharmaceutical bulletin

authors： Ewees MG,Messiha BA,Abo-Saif AA,Abd El-Latif HA

更新日期：2016-01-01 00:00:00

abstract：:When carbohydrate metabolism is impaired, fatty acid metabolism is activated. Excess acetyl-coenzyme A (CoA) is generated from fatty acids by β-oxidation and is used for the formation of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) and subsequently for acetoacetate. High levels of secreted ketone bodies (acetoacetate and ...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagawa S,Kojima Y,Sekino K,Yamato S

更新日期：2013-01-01 00:00:00