Abstract:
:Coenzyme Q10 (Co-Q10) is a vitamin-like supplement which appears to be safe, with minimal side effects and low drug interaction potential. Co-Q10 is used in the treatment of a variety of disorders related primarily to suboptimal cellular energy metabolism and oxidative injury. Studies supporting the efficacy of Co-Q10 appear most promising for a variety of diseases, including ulcerative colitis (UC). The present investigation aims to elucidate the possible protective effects of Co-Q10 against UC, as induced by the administration of iodoacetamide to adult male albino rats. In our study, Co-Q10 showed potent anti-oxidant and anti-inflammatory activities through a significant increase in catalase activity and glutathione content. In addition, it significantly decreased myeloperoxidase activity, malondialdehyde content and nitrate/nitrite production. These results suggest that Co-Q10 protects against UC in rats via anti-oxidant and anti-inflammatory potentials, and therefore seems promising for use in further clinical trials.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Ewees MG,Messiha BA,Abo-Saif AA,Abd El-Latif HAdoi
10.1248/bpb.b16-00124subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1159-66issue
7eissn
0918-6158issn
1347-5215journal_volume
39pub_type
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