Abstract:
:This study was conducted to determine the beneficial effects of treating digestive disorders of (6E,12E)-tetradecadiene-8,10-diyne-1,3-diol diacetate (TDEYA) detected in the plasma in hydrolyzed form: (6E,12E)-tetradecadiene-8,10-diyne-1,3-diol (TDEY), following the oral administration of a decoction of Atractylodes rhizome to rats. Assessment was also made of the efficacy of TDEYA in experimental gastric disorder models. Oral administration of TDEYA at doses of 300 to 500 mg/kg suppressed the formation of gastric lesions induced by indometacin in a dose-dependent manner. TDEYA at a dose of 200 mg/kg suppressed gastric lesions induced by an ischemia-reperfusion injury model. TDEYA at doses of 100 to 300 mg/kg did not show suppressive effects on water immersion stress-induced gastric lesions. TDEYA showed no active oxygen species scavenging action, nor did it have any effect on superoxide dismutase activity in the stomach tissue. TDEYA at doses of 200 to 500 mg/kg significantly suppressed xanthine oxidase (XO) activity in the stomach tissue following its oral administration. The suppressive effects of TDEYA on lesion formation induced by indometacin and ischemia-reperfusion injury models would thus appear to be due in part to the inhibition of XO activity in the stomach tissue.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Sakurai T,Sugawara H,Saito K,Kano Ydoi
10.1248/bpb.17.1364subject
Has Abstractpub_date
1994-10-01 00:00:00pages
1364-8issue
10eissn
0918-6158issn
1347-5215journal_volume
17pub_type
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journal_title:Biological & pharmaceutical bulletin
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journal_title:Biological & pharmaceutical bulletin
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Biological & pharmaceutical bulletin
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journal_title:Biological & pharmaceutical bulletin
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更新日期:1995-05-01 00:00:00
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更新日期:2001-10-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
pub_type: 杂志文章
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journal_title:Biological & pharmaceutical bulletin
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更新日期:2014-01-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
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更新日期:2016-05-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
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更新日期:1994-11-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
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更新日期:2009-10-01 00:00:00
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更新日期:2011-01-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
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更新日期:2015-01-01 00:00:00
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更新日期:2014-01-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
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更新日期:2013-01-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
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更新日期:2004-10-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
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更新日期:2018-01-01 00:00:00