Protective effects of berberine on doxorubicin-induced hepatotoxicity in mice.

abstract：:The success of green tea as a cancer preventive is based on evidence that green tea contains tannins and antioxidants, does not show toxicity in humans and has long traditional use in Asia. In the light of this, herbal medicines are now also attracting attention as potential sources of cancer preventive agents. Using ...

journal_title：Biological & pharmaceutical bulletin

authors： Okabe S,Suganuma M,Imayoshi Y,Taniguchi S,Yoshida T,Fujiki H

更新日期：2001-10-01 00:00:00

abstract：:Temozolomide (TMZ) is currently the first-line drug used for clinical postoperative or non-surgical chemotherapy for glioma, but acquired and intrinsic resistance to TMZ limits its application. The anti-proliferative effect of formononetin on human glioma cells had been confirmed. To improve therapeutic effects of TMZ...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang X,Ni Q,Wang Y,Fan H,Li Y

更新日期：2018-08-01 00:00:00

abstract：:The involvement of the peripheral serotonin2A (5-HT2A) receptor in alpha-methyl-5-HT-induced hyperglycemia was examined in rats. The 5-HT2A receptor antagonist, ketanserin, significantly inhibited alpha-methyl-5-HT-elicited hyperglycemia. Taken together with a previous report that 5-HT-induced hyperglycemia was preven...

journal_title：Biological & pharmaceutical bulletin

authors： Sugimoto Y,Yamada J,Yoshikawa T,Horisaka K

更新日期：1996-10-01 00:00:00

abstract：:In the present study, we showed the inhibition of motility by trifluoromethyl ketone (TF) derivatives (1-8) in Proteus vulgaris (P. vulgaris) cultures. Among them, 1-(2-benzoxazoyl)-3,3,3-trifluoro-2-propanone (1) showed a much stronger inhibitory effect on the motility of P. vulgaris than other TF compounds at 10% MI...

journal_title：Biological & pharmaceutical bulletin

authors： Wolfart K,Molnar A,Kawase M,Motohashi N,Molnar J

更新日期：2004-09-01 00:00:00

abstract：:Madecassoside (MA), one of the principle terpenoids in Centella asiatica, has shown protect effect on isolated rat hearts and isolated cardiomyocytes against reperfusion injury in our previous studies. The aim of this study is to investigate if MA also protected against myocardial ischemia-reperfusion injury in vivo. ...

journal_title：Biological & pharmaceutical bulletin

authors： Bian GX,Li GG,Yang Y,Liu RT,Ren JP,Wen LQ,Guo SM,Lu QJ

更新日期：2008-03-01 00:00:00

abstract：:New lipid derivatives of polyethyleneglycol (PEG) have been synthesized and tested for the ability to allow liposomes to evade uptake by the reticuloendothelial system (RES) and to prolong the circulation time of liposomes in mice. Liposomes were prepared from distearoylphosphatidylcholine (DSPC) and cholesterol (CH) ...

journal_title：Biological & pharmaceutical bulletin

authors： Yuda T,Maruyama K,Iwatsuru M

更新日期：1996-10-01 00:00:00

abstract：:The genome sequencing project revealed presence of two active chalcone synthase (CHS) homologues (At1g02050 and At4g34850) in the model plant Arabidopsis thaliana. We report herein the two genes encode closely related novel plant-specific type III polyketide synthases (PKSs) that produces long-chain alkyl alpha-pyrone...

journal_title：Biological & pharmaceutical bulletin

authors： Mizuuchi Y,Shimokawa Y,Wanibuchi K,Noguchi H,Abe I

更新日期：2008-12-01 00:00:00

abstract：:Metallothioneins (MTs) occur throughout the animal kingdom and they are induced in vivo by metals, hormones, cytotoxic agents, and some kind of stress. It is well known that various stresses such as starvation and immobilization can induce MT synthesis in animal tissues, but the influence of dietary restriction is unk...

journal_title：Biological & pharmaceutical bulletin

authors： Shinogi M,Sakaridani M,Yokoyama I

更新日期：1999-02-01 00:00:00

abstract：:The antiemetic effect of a potent and selective neurokinin-1 (NK1) receptor antagonist, FK886 ([3,5-bis(trifluoromethyl)phenyl][(2R)-2-(3-hydroxy-4-methylbenzyl)-4-{2-[(2S)-2-(methoxymethyl)morpholin-4-yl]ethyl}piperazin-1-yl]methanone dihydrochloride), on cisplatin-induced acute and delayed emesis in ferrets was stud...

journal_title：Biological & pharmaceutical bulletin

authors： Furukawa TY,Nakayama H,Imazumi K,Yamakuni H,Takeshita K,Matsuo M,Manda T,Uchida W

更新日期：2014-01-01 00:00:00

abstract：:To further enhance the efficiency and potential of plants for phytoremediation of mercury pollution, a genetically engineered tobacco to simultaneously express mercury transporter, mercury transporter (MerT) and mercury chelator, polyphosphate (polyP) was constructed by integrating bacterial merT gene in polyphosphate...

journal_title：Biological & pharmaceutical bulletin

authors： Nagata T,Nakamura A,Akizawa T,Pan-Hou H

更新日期：2009-09-01 00:00:00

abstract：:Neuroinflammation has recently been implicated as an important mechanism responsible for the progression of neurodegenerative diseases. Activated microglia produce various proinflammatory cytokines and nitric oxide (NO) that are toxic to neurons. Thus, inhibition of microglial activation may alleviate neuroinflammator...

journal_title：Biological & pharmaceutical bulletin

authors： Ock J,Hong SH,Suk K

更新日期：2010-01-01 00:00:00

abstract：:The effect of the hypothyroidism induced by thiamazole on toxic interactions between propranolol and disopyramide were studied in chick embryos. Fertilized eggs of White Leghorns were incubated and investigated. 1.2 mg/0.2 ml/egg of thiamazole was injected into the albumen of fertilized eggs on the 9th day of incubati...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshiyama Y,Kanke M

更新日期：2005-10-01 00:00:00

abstract：:The effects of Ginkgo biloba leaf extract (GBE), one of the most widely used herbal dietary supplements in Japan and the United States, on the pharmacokinetics of nifedipine (NFP), a typical probe of P450 (CYP) 3A, but not a substrate of the multidrug transporter P-glycoprotein (P-gp), were studied using rats. Simulta...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshioka M,Ohnishi N,Sone N,Egami S,Takara K,Yokoyama T,Kuroda K

更新日期：2004-12-01 00:00:00

abstract：:The weights of prostate and seminal vesicle were decreased by treatment with 3,6-dimethylpyrazine-2-thiol(3,6-DMP-SH) but the weights of testes and the plasma testosterone levels were not changed. The recovery of the weight of prostate and seminal vesicles of testosterone-treated orchidectomized rats were inhibited by...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada K,Komatsu H,Ohta A

更新日期：1996-03-01 00:00:00

abstract：:Two acidic polysaccharides, called ginsenan S-IA and ginsenan S-IIA, were isolated from the root of Panax ginseng C. A. Meyer. They were homogeneous on electrophoresis and gel chromatography, and their molecular masses were estimated to be 5.6 x 10(4) and 1.0 x 10(5), respectively. Ginsenan S-IA is composed of L-arabi...

journal_title：Biological & pharmaceutical bulletin

authors： Tomoda M,Hirabayashi K,Shimizu N,Gonda R,Ohara N,Takada K

更新日期：1993-11-01 00:00:00

abstract：:Methylmercury (MeHg) is a causative agent of Minamata disease and an environmental pollutant that comprises a large portion of organically occurring mercury. Many aspects of the biological defense mechanisms against MeHg toxicity remain unclear. Recently, nuclear factor-E2-related factor 2 (Nrf2), heat shock factor pr...

journal_title：Biological & pharmaceutical bulletin

authors： Hwang GW

更新日期：2012-01-01 00:00:00

abstract：:We investigated the genotypic status of thiopurine methyltransferase (TPMT) polymorphism to evaluate the possible risk of the toxicity of azathioprine (AZA) in 68 patients with systemic lupus erythematosus (SLE). The allele frequency of TPMT mutation in the SLE group (2.9%) was higher than that in 174 Japanese healthy...

journal_title：Biological & pharmaceutical bulletin

authors： Okada Y,Nakamura K,Kodama T,Ueki K,Tsukada Y,Maezawa A,Tsukamoto N,Nojima Y,Ishizaki T,Horiuchi R,Yamamoto K

更新日期：2005-11-01 00:00:00

abstract：:Ty2 retrotransposons are the mobile genetic elements of the yeast Saccharomyces cerevisiae. Transcriptional regulation of Ty2-917 requires a complex set of cis acting elements which are located both upstream and downstream of the transcription initiation site. Previously, the glycolysis regulatory protein Gcr1p has be...

journal_title：Biological & pharmaceutical bulletin

authors： Türkel S

更新日期：2002-09-01 00:00:00

abstract：:Periodontitis is initiated by accumulation of microbial plaque and activation of gingival inflammation through overexpression of matrix metalloproteinases (MMPs), leading to tissue destruction. Natural MMP inhibitors may be developed as therapeutic agents against periodontitis. In this study, panduratin A, a natural b...

journal_title：Biological & pharmaceutical bulletin

authors： Yanti,Oh HI,Anggakusuma,Hwang JK

更新日期：2009-01-01 00:00:00

abstract：:The variable region of heavy chain [V(H)] of human rheumatoid factor (hRF) IgM was connected with the variable region of light chain [V(L)] with the peptide-linker (GGGSGGGSGGGS) by genetic engineering method and the single-chain Fv (scFv) was expressed in E. coli. On design, scFv and scFv (tag) were planned; the latt...

journal_title：Biological & pharmaceutical bulletin

authors： Hashimoto Y,Ikenaga T,Tanigawa K,Ueda T,Ezak I,Imoto T

更新日期：2000-08-01 00:00:00

abstract：:The effects of various surfactants and protease inhibitors on the nasal absorption of recombinant human granulocyte colony-stimulating factor (rhG-CSF) were examined in rats. No effects of bile salts and acids such as sodium glycocholate or taurocholic acid, amphoteric surfactants such as lauryldimethyl betaine, or an...

journal_title：Biological & pharmaceutical bulletin

authors： Machida M,Sano K,Arakawa M,Hayashi M,Awazu S

更新日期：1994-10-01 00:00:00

abstract：:When kalopanaxsaponin K (KPK) from Kalopanax pictus was incubated for 24 h at 37 degrees C with human intestinal microflora, KPK was mainly metabolized to kalopanaxsaponin I (KPI) via kalopanaxsaponin H (KPH) rather than via kalopanaxsaponin J (KPJ), and then transformed to kalopanaxsaponin A (KPA) and hederagenin. Ba...

journal_title：Biological & pharmaceutical bulletin

authors： Kim DH,Bae EA,Han MJ,Park HJ,Choi JW

更新日期：2002-01-01 00:00:00

abstract：:The relation between degranulation and rapid metabolic responses (acidification rate changes) in RBL-2H3 cells was studied using a cytosensor microphysiometer, a silicon-based biosensor system. The metabolic responses in RBL-2H3 cells by antigen stimulation were compared with those by inhibitors of Ca2+ -ATPase. The f...

journal_title：Biological & pharmaceutical bulletin

authors： Furuno T,Ohyama N,Nakanishi M

更新日期：1999-03-01 00:00:00

abstract：:Corneal transplantation has been used to treat severe eye disease for decades, but the therapeutic effect of the operation is highly compromised by immunological allograft rejection. To improve the success rate of corneal transplantation, we studied the protective effects of cyclosporine nanomicelle eye drops (CNED) o...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang H,Wang L,Zhang L

更新日期：2015-01-01 00:00:00

abstract：:The current study reports several post-translational modifications of alphaB-crystallin in normal human lenses. The isoforms of post-translational modified alphaB-crystallin were isolated from the normal human lenses of >70-age group by ion exchange chromatography and sodium dodecyl sulfate-polyacrylamide gel electrop...

journal_title：Biological & pharmaceutical bulletin

authors： Kamei A,Hamaguchi T,Matsuura N,Iwase H,Masuda K

更新日期：2000-02-01 00:00:00

abstract：:The present study investigated the effect of 4[(5,6,7,8-tetrahydro-5,5,8,8,-tetramethyl-2-naphthalenyl)carbamoyl] benzoic acid (Am-80), a synthetic retinoid, on spinal cord injury (SCI) in rats. Treatment with Am-80 (orally and subcutaneously) significantly promoted recovery from SCI-induced motor dysfunction. On day ...

journal_title：Biological & pharmaceutical bulletin

authors： Takenaga M,Ohta Y,Tokura Y,Hamaguchi A,Shudo K,Okano H,Igarashi R

更新日期：2009-02-01 00:00:00

abstract：:The aim of the present study was to evaluate the effect of the aqueous extract of seeds of two varieties, namely a country and hybrid variety of Momordica charantia (MCSEt1 and MCSEt2) on oxidative stress in plasma and pancreas of streptozotocin (STZ) induced diabetic rats. Oral administration of each of the seed extr...

journal_title：Biological & pharmaceutical bulletin

authors： Sathishsekar D,Subramanian S

更新日期：2005-06-01 00:00:00

abstract：:The radioprotective effects of propolis and polyphenolic compounds from propolis on the radiation-induced mortality of mice exposed to 9 Gy of gamma-irradiation were studied. Intraperitoneal (i.p.) treatment of mice at doses of 100 mg kg(-1) body weight of propolis (water or ethanolic extract; WSDP or EEP) or its poly...

journal_title：Biological & pharmaceutical bulletin

authors： Orsolić N,Benković V,Horvat-Knezević A,Kopjar N,Kosalec I,Bakmaz M,Mihaljević Z,Bendelja K,Basić I

更新日期：2007-05-01 00:00:00

abstract：:Direct detection of nitric oxide (NO) is essential for understanding the precise mechanism of its production from endothelial cells. Previously, we developed an NO detection system based on the chemiluminescence reaction between NO and luminol-H2O2. Here, we have applied this system to cultured endothelial cells for t...

journal_title：Biological & pharmaceutical bulletin

authors： Kurumatani H,Kikuchi K,Nagano T,Hirobe M,Yamazaki J,Nagao T

更新日期：1998-12-01 00:00:00

abstract：:It has been well known that Vibrio cholerae inhabit in environmental water. As many patients infected with cholera toxin-producing V. cholerae O1 (toxigenic V. cholerae O1) emerge in Kolkata, India, it has been thought that toxigenic V. cholerae O1 is easily detected in environmental water in Kolkata. However, we coul...

journal_title：Biological & pharmaceutical bulletin

authors： Paul SS,Takahashi E,Chowdhury G,Miyoshi SI,Mizuno T,Mukhopadhyay AK,Dutta S,Okamoto K

更新日期：2020-08-01 00:00:00