Neuroprotective properties of gallic acid from Sanguisorbae radix on amyloid beta protein (25--35)-induced toxicity in cultured rat cortical neurons.

abstract：:An increase in the number of glucocorticoid-induced tumor necrosis factor receptor-family related gene/protein (GITR)+CD25- (or fork-head box protein 3: Foxp3-) CD4+ T cells, after treating a mouse model of arthritis with fingolimod (FTY720), and a pathogenic antigen may play a key role in the establishment of immune ...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshida Y,Mikami N,Nakanishi Y,Saimoto M,Nagaike A,Shimono H,Nakano S,Tsuji T,Kohno T

更新日期：2021-01-26 00:00:00

abstract：:For the accurate identification of medicinal licorice species, nucleotide sequences of four types of DNA regions were researched for 205 specimens, including three species used as licorice: Glycyrrhiza uralensis, Glycyrrhiza glabra, and Glycyrrhiza inflata. The four DNA regions were the internal transcribed spacer (IT...

journal_title：Biological & pharmaceutical bulletin

authors： Kondo K,Shiba M,Yamaji H,Morota T,Zhengmin C,Huixia P,Shoyama Y

更新日期：2007-08-01 00:00:00

abstract：:The aim of the present study was to clarify the mechanism underlying the inhibition of cell proliferation in human lung cancer A549 cells by selenium (Se) compounds. Methylseleninic acid (CH3SeO2H, abbreviated as MSA), a synthetic Se compound, is a direct precursor of active methylselenol (CH3SeH) and is considered to...

journal_title：Biological & pharmaceutical bulletin

authors： Okuno T,Honda E,Arakawa T,Ogino H,Ueno H

更新日期：2014-01-01 00:00:00

abstract：:Beta-D-Xylosidase (EC 3.2.1.37) has been purified from ginsenoside Ra-metabolizing Bifidobacterium breve K-110, which was isolated from human intestinal microflora. beta-D-Xylosidase was purified to apparent homogeneity by a combination of ammonium sulfate precipitation, QAE-cellulose, butyl-toyopearl, hydroxyapatit a...

journal_title：Biological & pharmaceutical bulletin

authors： Shin HY,Lee JH,Lee JY,Han YO,Han MJ,Kim DH

更新日期：2003-08-01 00:00:00

abstract：:The degradation of 125I-endothelin-1 (125I-ET-1) was examined on cultured porcine aortic endothelial cell (EC) and rat vascular smooth muscle cell (SMC) by HPLC analysis. The degradation of ET-1 was observed on SMC and was slightly observed on EC. Membrane fractions of SMC had a strong potency for the degradation of E...

journal_title：Biological & pharmaceutical bulletin

authors： Edano T,Arai K,Koshi T,Torii T,Ohshima T,Hirata M,Ohkuchi M,Okabe T

更新日期：1994-03-01 00:00:00

abstract：:We investigated the effect of components in grapefruit juice (GFJ) on the transport of vinblastine, a substrate of P-glycoprotein (P-gp), across Caco-2 cells. The apical to basolateral flux of [3H]vinblastine was increased in the presence of GFJ extracts. The steady-state uptake of [3H]vinblastine from the apical side...

journal_title：Biological & pharmaceutical bulletin

authors： Takanaga H,Ohnishi A,Matsuo H,Sawada Y

更新日期：1998-10-01 00:00:00

abstract：:Among the calcium-binding proteins from chicken gizzard smooth muscle, smooth muscle calcium-binding protein 11 (SMCaBP 11), which is an EF-hand type calcium-binding protein, can prevent Ca2+ dependent histamine release from permeabilized rat peritoneal mast cells. This activity appears to be specific since other calc...

journal_title：Biological & pharmaceutical bulletin

authors： Fujii T,Kuzumaki N,Ogoma Y,Kondo Y

更新日期：1994-05-01 00:00:00

abstract：:Tetrandrine (TET), a bis-benzylisoquinoline alkaloid isolated from the dried root of hang-fang-chi (Stephania tetrandra S. Moore), is traditionally used in China for treating inflammation, hypertension and silicosis. In this study, our aim was to examine the anti-inflammatory mechanism of TET through measuring the ind...

journal_title：Biological & pharmaceutical bulletin

authors： Wu SJ,Ng LT

更新日期：2007-01-01 00:00:00

abstract：:The usefulness of the urine protein : creatine ratio (UPCR) in management of molecular targeted therapy and immunotherapy has not been studied, although urine protein dipstick testing (uPr) is widely used in the clinical setting. The aim of this study was to investigate the usefulness of UPCR as compared to uPr in pat...

journal_title：Biological & pharmaceutical bulletin

authors： Nakamura K,Tanaka T,Masumori N,Miyamoto A,Hirano T

更新日期：2020-01-01 00:00:00

abstract：:The phylogenetic relationship of Cistanche deserticola, C. salsa and C. tubulosa was analyzed by comparing the nucleotide sequences of the plastid rps2 gene and the intergenic spacer region between rpl16 and rpl14. By comparison of sequence data, the Cistanche samples were distinguishable from each other. The results ...

journal_title：Biological & pharmaceutical bulletin

authors： Tomari N,Ishizuka Y,Moriya A,Kojima S,Deyama T,Mizukami H,Tu P

更新日期：2002-02-01 00:00:00

abstract：:Sesamin is a major lignan in sesame seeds, and a recent meta-analysis of controlled trials indicated that sesamin intake decreases blood pressure. The antihypertensive effect of sesamin has been suggested to be due to sesamin-mediated suppression of 20-hydroxyeicosatetraenoic acid production catalyzed by CYP4F2. Howev...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe H,Yamaori S,Kamijo S,Aikawa K,Ohmori S

更新日期：2020-01-01 00:00:00

abstract：:An alkaloid piperine isolated from the Piper Nigrum was found to inhibit lipid droplet accumulation in mouse macrophages, and especially inhibited cholesteryl ester (CE) synthesis (IC50: 25 microM). The metabolism of cholesterol from lysosome to lipid droplet was inhibited with a similar IC50 (18 microM), indicating t...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda D,Ohte S,Ohshiro T,Jiang W,Rudel L,Hong B,Si S,Tomoda H

更新日期：2008-06-01 00:00:00

abstract：:In addition to regulation of normal cell functions, hepatocyte growth factor (HGF) has also been shown to be involved in malignant cell transformation and in growth, invasion and metastasis in cancer cells. Inhibitors of HGF production have a potential for interfering with malignant cell transformation and progression...

journal_title：Biological & pharmaceutical bulletin

authors： Motoki T,Takami Y,Yagi Y,Tai A,Yamamoto I,Gohda E

更新日期：2005-02-01 00:00:00

abstract：:The purpose of this study is to develop a new method of preparing salvianolic acid extracts (SAE) water-in-oil-in-water (W/O/W) multiple emulsion (ME). SAE injection is used in the treatment of brain infarct and promotion of blood circulation in China. However, the injection is not convenient, and the oral preparation...

journal_title：Biological & pharmaceutical bulletin

authors： Song Y,Gao H,Zhang S,Zhang Y,Jin X,Sun J

更新日期：2017-12-01 00:00:00

abstract：:Glomerulonephritis (GN) is a set of pathological conditions that result in the destruction of glomeruli and loss of renal function, commonly leading to the development of end-stage renal disease. Current pharmacotherapy is limited to immunosuppressive therapy. In the present study, we found a novel antinephritic effec...

journal_title：Biological & pharmaceutical bulletin

authors： Liu N,Shi J,Xiao Y,Yasue M,Takei Y,Sanefuji H,Tsujimoto G,Hirasawa A

更新日期：2015-01-01 00:00:00

abstract：:Small interfering RNAs (siRNAs) are expected to offer a means of treating rheumatoid arthritis (RA) because they allow the specific silencing of genes related to RA pathogenesis. In our previous study, we reported that the siRNA targeted against RelA (anti-RelA siRNA), an important nuclear factor-kappaB (NF-κB) subdom...

journal_title：Biological & pharmaceutical bulletin

authors： Kanazawa T,Tamano K,Sogabe K,Endo T,Ibaraki H,Takashima Y,Seta Y

更新日期：2017-01-01 00:00:00

abstract：:Diosgenyl saponins are the most abundant steroid saponins, and exert a large variety of biological functions. In a previous report, we showed that dioscin was able to induce cytotoxicity and apoptosis in human myeloblast leukemia HL-60 cells. This study further investigated the action mechanisms underlying this effect...

journal_title：Biological & pharmaceutical bulletin

authors： Liu MJ,Wang Z,Ju Y,Zhou JB,Wang Y,Wong RN

更新日期：2004-07-01 00:00:00

abstract：:Bupleuri Radix (Chai-hu in Chinese and Saiko in Japanese) is one of the most important traditional Chinese crude drugs for treating hepatitis malaria and intermittent fever. B. kaoi is one of the Bupleurum spp. families locally found in Taiwan. The effects of saponin-enriched fraction (SEF) from Bupleurum Kaoi in huma...

journal_title：Biological & pharmaceutical bulletin

authors： Hsu YL,Kuo PL,Weng TC,Yen MH,Chiang LC,Lin CC

更新日期：2004-07-01 00:00:00

abstract：:Isofatty acid-containing phosphatidylglycerol (Fr. 7-C), isolated from Bacillus stearothermophilus UBT8038, enhances the induction of concanavalin A (Con A)-activated suppressor T (Ts) cells in a dose dependent manner (0.01-1 microgram/ml). Its further biological properties on mouse mixed lymphocyte reaction (MLR) has...

journal_title：Biological & pharmaceutical bulletin

authors： Kohama Y,Semba T,Tanaka K,Iida K,Moriyama K,Suda T,Tone H,Itoh S,Mimura T

更新日期：1994-11-01 00:00:00

abstract：:In this paper we investigated the vascular activity and possible mechanism of Orientin, from bamboo leaves (Phyllostachys nigra), in isolated thoracic aortic rings from New Zealand rabbit. Among the four compounds, studied, only Orientin relaxed phenylephrine-induced contractions with an IC50 value of 2.28 microM in t...

journal_title：Biological & pharmaceutical bulletin

authors： Fu XC,Wang MW,Li SP,Zhang Y,Wang HL

更新日期：2005-01-01 00:00:00

abstract：:We synthesized a new quaternary ammonium salt, N-alkyl-N-2-hydroxyethyl-N, N-dimethylammonium butyl phosphate (ABP) that does not precipitate in the presence of anionic surfactants by incorporating a paired butyl phosphate anion into cationic surfactants. ABP showed much greater bactericidal activities and antirusting...

journal_title：Biological & pharmaceutical bulletin

authors： Ohta S,Makino M,Nagai K,Zenda H

更新日期：1996-02-01 00:00:00

abstract：:A lower serum cholesterol level was recently shown to be one of the causes of stroke in an epidemiological study. Spontaneously hypertensive rats stroke-prone (SHRSP) have lower serum cholesterol levels than normotensive Wistar-Kyoto rats (WKY). To elucidate the mechanisms responsible for the lower serum cholesterol l...

journal_title：Biological & pharmaceutical bulletin

authors： Michihara A,Mido M,Matsuoka H,Mizutani Y

更新日期：2015-01-01 00:00:00

abstract：:Thiazolidinediones (TZDs) are known as peroxisome proliferator-activated receptor γ (PPARγ) activators, and are used in the treatment of diabetes. Although the usefulness of TZDs has been demonstrated, some of their side effects are becoming an obstacle to their clinical applicability; edema is known to be evoked by t...

journal_title：Biological & pharmaceutical bulletin

authors： Okazaki H,Takeda S,Ishii H,Takemoto Y,Fujita S,Suyama M,Matsumoto K,Shindo M,Aramaki H

更新日期：2017-01-01 00:00:00

abstract：:Telekin, a eudesmane-type sesquiterpene lactone compound isolated from Chinese folk medicine Carpesium divaricatum, has been reported to strongly inhibit the proliferation of cancer cells. In this study, the involvement of a mitochondria-mediated pathway in the pro-apoptotic action of telekin was investigated in human...

journal_title：Biological & pharmaceutical bulletin

authors： Zheng B,Wu L,Ma L,Liu S,Li L,Xie W,Li X

更新日期：2013-01-01 00:00:00

abstract：:Hairy roots of interspecific hybrid ginseng (Panax ginseng x P. quinquefolium), induced by Agrobacterium rhizogenes ATCC 15834, grew well in B5 liquid media supplemented with 2.5 microM auxins (3-indole butyric acid (IBA), 1-naphtaleneacetic acid (NAA) and 3-indoleacetic acid (IAA)). The hairy roots cultured in B5 liq...

journal_title：Biological & pharmaceutical bulletin

authors： Washida D,Shimomura K,Takido M,Kitanaka S

更新日期：2004-05-01 00:00:00

abstract：:The current study reports several post-translational modifications of alphaB-crystallin in normal human lenses. The isoforms of post-translational modified alphaB-crystallin were isolated from the normal human lenses of >70-age group by ion exchange chromatography and sodium dodecyl sulfate-polyacrylamide gel electrop...

journal_title：Biological & pharmaceutical bulletin

authors： Kamei A,Hamaguchi T,Matsuura N,Iwase H,Masuda K

更新日期：2000-02-01 00:00:00

abstract：:We investigated the relationship between noradrenaline (NAd)-induced contractions, endothelial function, and hypertension in femoral arteries isolated from spontaneously hypertensive rats (SHR). In the femoral arteries of SHR, vs. age-matched control Wistar Kyoto (WKY) rats, contractions induced by NAd were increased....

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto T,Watanabe S,Iguchi M,Ando M,Oda M,Nagata M,Yamada K,Taguchi K,Kobayashi T

更新日期：2016-01-01 00:00:00

abstract：:Chitooligosaccharides, the oligomers made up of beta-1,4-linked D-glucosamine, are obtained by partial hydrolysis of chitosan, a deacetylation product of chitin. The antioxidant activity of various chitooligosaccharides was tested in vitro with aminoguanidine, pyridoxamine, and Trolox as reference compounds. Hydroxyla...

journal_title：Biological & pharmaceutical bulletin

authors： Chen AS,Taguchi T,Sakai K,Kikuchi K,Wang MW,Miwa I

更新日期：2003-09-01 00:00:00

abstract：:The quantification of tenofovir, a nucleoside reverse transcriptase inhibitor prescribed once daily, in human plasma is important due to a recent increase in its use. HPLC, however, can not easily detect and quantify tenofovir because of interfering peaks. Therefore, we developed a rapid and conventional LC-MS method,...

journal_title：Biological & pharmaceutical bulletin

authors： Takahashi M,Kudaka Y,Okumura N,Hirano A,Banno K,Kaneda T

更新日期：2007-09-01 00:00:00

abstract：:The success of green tea as a cancer preventive is based on evidence that green tea contains tannins and antioxidants, does not show toxicity in humans and has long traditional use in Asia. In the light of this, herbal medicines are now also attracting attention as potential sources of cancer preventive agents. Using ...

journal_title：Biological & pharmaceutical bulletin

authors： Okabe S,Suganuma M,Imayoshi Y,Taniguchi S,Yoshida T,Fujiki H

更新日期：2001-10-01 00:00:00