Hsa_circ_0002060 Knockdown Ameliorates Osteoporosis by Targeting MiR-198-5p.

abstract：:Stressors with a physical factor such as immobilization, electric foot shock, cold swim, etc., have been shown to produce oxidative damage to membrane lipids in the brain. In this study, we investigated the effect of protracted social isolation stress on lipid peroxidation activity in the mouse brain and elucidated th...

journal_title：Biological & pharmaceutical bulletin

authors： Huong NT,Murakami Y,Tohda M,Watanabe H,Matsumoto K

更新日期：2005-08-01 00:00:00

abstract：:Plasma hyaluronan-binding protein (PHBP), a serine protease that can activate coagulation factor VII and prourokinase, circulates in a single-chain form (pro-PHBP) and autoproteolytically converts to an active two-chain form with the aid of an effector such as spermidine and heparin. It has been postulated that PHBP p...

journal_title：Biological & pharmaceutical bulletin

authors： Yamamoto E,Nishimura N,Okada K,Sekido C,Yamamichi S,Hasumi K

更新日期：2011-01-01 00:00:00

abstract：:Orally disintegrating tablets (ODTs) are formulated to disintegrate upon contact with saliva, allowing administration without water. Olopatadine hydrochloride, a second-generation antihistamine, is widely used for treating allergic rhinitis. However, it has a bitter taste; therefore, the development of taste-masked ol...

journal_title：Biological & pharmaceutical bulletin

authors： Sotoyama M,Uchida S,Tanaka S,Hakamata A,Odagiri K,Inui N,Watanabe H,Namiki N

更新日期：2017-01-01 00:00:00

abstract：:A possible evaluation technique was devised for examing timely cholesterol synthetic activity in the rat liver. The principle of the technique is to measure the incorporation rate of 14C atoms into a few target metabolites excreted in bile with time after an intraportal injection of [1,2-14C] acetate to the conscious ...

journal_title：Biological & pharmaceutical bulletin

authors： Okuyama M,Tsunogai M,Watanabe N,Asakura Y,Shigematsu A

更新日期：1995-11-01 00:00:00

abstract：:We investigated the properties of honokiol, a natural rexinoid, as a regulator of retinoid X receptor (RXR) heterodimers with various partner nuclear receptors (NRs), in comparison with those of the synthetic rexinoid bexarotene. Honokiol alone was hardly capable of activating peroxisome proliferator-activated recepto...

journal_title：Biological & pharmaceutical bulletin

authors： Kotani H,Tanabe H,Mizukami H,Amagaya S,Inoue M

更新日期：2012-01-01 00:00:00

abstract：:The genome sequencing project revealed presence of two active chalcone synthase (CHS) homologues (At1g02050 and At4g34850) in the model plant Arabidopsis thaliana. We report herein the two genes encode closely related novel plant-specific type III polyketide synthases (PKSs) that produces long-chain alkyl alpha-pyrone...

journal_title：Biological & pharmaceutical bulletin

authors： Mizuuchi Y,Shimokawa Y,Wanibuchi K,Noguchi H,Abe I

更新日期：2008-12-01 00:00:00

abstract：:Berberine has a wide range of biochemical and pharmacologic effects, including antitumor activity, but the mechanisms involved in berberine-induced apoptosis remain unclear. The purpose of the present study was to investigate the changes in oxidative stress and endoplasmic reticulum (ER)-related molecules, which are c...

journal_title：Biological & pharmaceutical bulletin

authors： Eom KS,Kim HJ,So HS,Park R,Kim TY

更新日期：2010-01-01 00:00:00

abstract：:Liver regeneration is a very complex process and is regulated by several cytokines and growth factors. It is also known that liver transplantation and the regeneration process cause massive oxidative stress, which interferes with liver regeneration. The placenta is known to contain various physiologically active ingre...

journal_title：Biological & pharmaceutical bulletin

authors： Lee TH,Park DS,Jang JY,Lee I,Kim JM,Choi GS,Oh CT,Kim JY,Han HJ,Han BS,Joh JW

更新日期：2019-01-01 00:00:00

abstract：:Previous reports have indicated that isosteviol sodium (STVNa) has neuroprotective effects against acute focal cerebral ischemia in rats; however, the exact underlying mechanisms and ideal treatment paradigm are not known. To find a reasonable method for STVNa administration and to determine its possible therapeutic m...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang H,Sun X,Xie Y,Tian F,Hu H,Tan W

更新日期：2018-01-01 00:00:00

abstract：:Onset of cancer and neurodegenerative disease occurs by abnormal cell growth and neuronal cell death, respectively, and the number of patients with both diseases has been increasing in parallel with an increase in mean lifetime, especially in developed countries. Although both diseases are sporadic, about 10% of the d...

journal_title：Biological & pharmaceutical bulletin

authors： Ariga H

更新日期：2015-01-01 00:00:00

abstract：:Pharmacokinetic research in China on the use of voriconazole in critically ill adult patients with different pulmonary diseases remains to be explored. This study evaluated the population pharmacokinetics of the use of voriconazole (VRC) in critically ill patients to determine covariate effects on VRC pharmacokinetics...

journal_title：Biological & pharmaceutical bulletin

authors： Chen W,Xie H,Liang F,Meng D,Rui J,Yin X,Zhang T,Xiao X,Cai S,Liu X,Li Y

更新日期：2015-01-01 00:00:00

abstract：:Splenic marginal zone macrophages expressing macrophage receptor with collagenous structure (MARCO) contribute to the clearance of blood-borne pathogens. We determined a splenic adherent cell fraction abundantly containing cells expressing a higher level of MARCO by flow cytometry, and examined the effects of daily ad...

journal_title：Biological & pharmaceutical bulletin

authors： Shirato K,Sato S,Sato M,Hashizume Y,Tachiyashiki K,Imaizumi K

更新日期：2013-01-01 00:00:00

abstract：:Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with Parkinson's disease. LRRK2 is a large protein with multiple functional domains, including a guanosine 5'-triphosphate (GTP)-binding domain and a protein kinase domain. Recent studies indicated that the members of the Rab GTPase family, Rab8...

journal_title：Biological & pharmaceutical bulletin

authors： Imai M,Kawakami F,Kubo M,Kanzaki M,Maruyama H,Kawashima R,Maekawa T,Kurosaki Y,Kojima F,Ichikawa T

更新日期：2020-01-01 00:00:00

abstract：:Acute pancreatitis (AP) is one kind of acute surgical abdominal disease in the world. It causes intestinal damage with subsequent bacterial migration, endotoxemia and secondary pancreatic infections. In this investigation, we determined that edaravone (EDA) reduces pancreatic and intestinal injury after AP in mice. Th...

journal_title：Biological & pharmaceutical bulletin

authors： Wang B,Lin W

更新日期：2020-01-01 00:00:00

abstract：:We investigated the changes (increase or decrease in peak intensity) in the expression of plasma proteins in spontaneously diabetic WBN/Kob rats that were with complicated diabetic nephropathy, to determine multiple biomarkers in the plasma of diabetic rats. The present study using surface enhanced laser desorption/io...

journal_title：Biological & pharmaceutical bulletin

authors： Kiga C,Nakagawa T,Koizumi K,Sakurai H,Shibagaki Y,Ogawa K,Goto H,Saiki I

更新日期：2005-06-01 00:00:00

abstract：:Four lavandulyl flavanones, (2S)-2'-methoxykurarinone (1), sophoraflavanone G (2), leachianone A (3), and (-)-kurarinone (4), which are isolated from the roots of Sophora flavescens have been tested for in vitro antimalarial activity against Plasmodium falciparum. Compounds 1-3 showed moderate antimalarial activities ...

journal_title：Biological & pharmaceutical bulletin

authors： Kim YC,Kim HS,Wataya Y,Sohn DH,Kang TH,Kim MS,Kim YM,Lee GM,Chang JD,Park H

更新日期：2004-05-01 00:00:00

abstract：:To determine the mechanism involved, the incorporation rate (ICR) of drugs into hair was compared to melanin affinity, lipophilicity and membrane permeability. The following 20 drugs were tested; amphetamine, methamphetamine, p-hydroxyamphetamine, p-hydroxymethamphetamine, cocaine, benzoylecgonine, ecgonine methyl est...

journal_title：Biological & pharmaceutical bulletin

authors： Nakahara Y,Takahashi K,Kikura R

更新日期：1995-09-01 00:00:00

abstract：:We examined the feasibility of using submicron-sized liposomes (ssLips) for retinal delivery of hydrophilic compounds, which would also have a wide range of applications. To evaluate the uptake into conjunctival cell line and the intraocular behavior of hydrophilic compound-containing ssLips after eyedrop application,...

journal_title：Biological & pharmaceutical bulletin

authors： Hironaka K,Fujisawa T,Sasaki H,Tozuka Y,Tsuruma K,Shimazawa M,Hara H,Takeuchi H

更新日期：2011-01-01 00:00:00

abstract：:Glucocorticoids have multiple systemic effects that may influence bone metabolism but also directly affect osteoblasts by decreasing their proliferation. Using human osteoblastic SaM-1 cells, we examined whether the effects of hydrocortisone on cellular proliferation are mediated by hepatocyte growth factor (HGF). Hum...

journal_title：Biological & pharmaceutical bulletin

authors： Tsunashima Y,Kondo A,Matsuda T,Togari A

更新日期：2011-01-01 00:00:00

abstract：:Echinacoside is a major compound of Cistanche Herb and has glutamate release-inhibiting activity in the brain. Given the involvement of excitotoxicity caused by massive glutamate in the pathophysiology of epilepsy, we explored the antiepileptic effect of echinacoside on kainic acid-induced seizures in rats. The rats w...

journal_title：Biological & pharmaceutical bulletin

authors： Lu CW,Hsieh HL,Lin TY,Hsieh TY,Huang SK,Wang SJ

更新日期：2018-11-01 00:00:00

abstract：:The estimation of metallothionein (MT) levels in a biological sample is required to study the physiological role or the induction of MT, which is a multifunctional protein. MT contains 61 amino acids with 20 homologous cysteines. The high selectivity, sensitivity and stability of N-[4-(dimethylamino-2-benzofuranyl)phe...

journal_title：Biological & pharmaceutical bulletin

authors： Shinogi M,Nishinaga K,Yokoyama I

更新日期：1996-07-01 00:00:00

abstract：:The present study investigated whether or not Sho-saiko-to (crude powder extract, TJ-9) can suppress nitric oxide (NO) generation by endotoxin-activated J774A.1 cells in order to study the preventive mechanism of Sho-saiko-to against endotoxemia. In this experiment, we estimated the NO2- in the murine macrophage cell ...

journal_title：Biological & pharmaceutical bulletin

authors： Sakaguchi S,Furusawa S,Yokota K,Sasaki K,Takayanagi Y

更新日期：1995-04-01 00:00:00

abstract：:Melanogenesis inhibitory and free radical scavenging activities of nine cyclic (1-9) and one acyclic diarylheptanoids (10), and two phenolic compounds, (+)-rhododendrol (11) and (+)-catechin (12), isolated from the ethyl acetate-soluble fraction of the MeOH extract of the bark of Acer nikoense MAXIM. (Aceraceae) were ...

journal_title：Biological & pharmaceutical bulletin

authors： Akazawa H,Akihisa T,Taguchi Y,Banno N,Yoneima R,Yasukawa K

更新日期：2006-09-01 00:00:00

abstract：:To develop an external vehicle for skin hydration and enhanced dermal drug delivery, a hydrogel-based ultra-moisturizing cream (HUMC) was successfully formulated with carbopol 934P, urea, Tinocare GL, grape seed oil, and other excipients. The HUMC showed plastic flow behavior due to a gel structure with a cream base. ...

journal_title：Biological & pharmaceutical bulletin

authors： Lee SG,Kim SR,Cho HI,Kang MH,Yeom DW,Lee SH,Lee S,Choi YW

更新日期：2014-01-01 00:00:00

abstract：:Formulations consisting of egg albumin, indomethacin (IND), and olive oil or fatty acids, were prepared by vigorous stirring using a high-speed homogenizer and subsequent freeze-drying. To confirm the anti-inflammatory properties and ulcerogenic effects of the formulations, we examined the action of the formulations o...

journal_title：Biological & pharmaceutical bulletin

authors： Tsuji Y,Kakegawa H,Miyataka H,Matsumoto H,Satoh T

更新日期：1993-07-01 00:00:00

abstract：:Compound K (CK) is a major intestinal metabolite of ginsenosides derived from ginseng radix. In our preliminary studies, CK has shown to exhibit anti-hyperglycemic effect through its insulin-secreting action, similar to that of insulin secretagogue sulfonylureas. Metformin, a biguanide, improves insulin resistance by ...

journal_title：Biological & pharmaceutical bulletin

authors： Yoon SH,Han EJ,Sung JH,Chung SH

更新日期：2007-11-01 00:00:00

abstract：:While the use of in vitro-transcribed mRNA (IVT-mRNA) in therapeutics is a rapidly expanding area, the transfection of the exogenous IVT-mRNA is accompanied by a risk of immune activation. This immunological defense mechanism suppresses cellular translation process and can reduce transfection efficiency to a considera...

journal_title：Biological & pharmaceutical bulletin

authors： Ohto T,Konishi M,Tanaka H,Onomoto K,Yoneyama M,Nakai Y,Tange K,Yoshioka H,Akita H

更新日期：2019-01-01 00:00:00

abstract：:Analgesic activities of Randia siamensis CRAIB (R. siamensis) extract and pseudoginsenoside-RP1, a constituent of the extract, were examined in the writhing test, hot plate test and Randall-Selitto test. Oral administration of R. siamensis extract dose-dependently decreased the number of writhings and stretchings indu...

journal_title：Biological & pharmaceutical bulletin

authors： Reanmongkol W,Matsumoto K,Itharat A,Watanabe H

更新日期：1994-09-01 00:00:00

abstract：:In the present study, we showed the inhibition of motility by trifluoromethyl ketone (TF) derivatives (1-8) in Proteus vulgaris (P. vulgaris) cultures. Among them, 1-(2-benzoxazoyl)-3,3,3-trifluoro-2-propanone (1) showed a much stronger inhibitory effect on the motility of P. vulgaris than other TF compounds at 10% MI...

journal_title：Biological & pharmaceutical bulletin

authors： Wolfart K,Molnar A,Kawase M,Motohashi N,Molnar J

更新日期：2004-09-01 00:00:00

abstract：:Hydroxyoctadecadienoic acids (HODEs) are generated by oxidation of linoleic acid in vivo and thought to mediate various pathophysiological responses. In this study, we examined the effects of HODEs on EL4 mouse lymphoma cell growth and found that 9-(E,Z)-HODE inhibited EL4 cell growth in a dose-dependent manner, where...

journal_title：Biological & pharmaceutical bulletin

authors： Kodaka A,Hayakawa Y,AlSayegh RJ,Yasuhara T,Tomoda H,Oku T,Dan S,Tsuiji M,Tsuji T

更新日期：2019-01-01 00:00:00