Simulation study of the second-generation MR-compatible SPECT system based on the inverted compound-eye gamma camera design.

abstract：:The UMC Utrecht is constructing a 1.5 T MRI scanner integrated with a linear accelerator (Lagendijk et al 2008 Radiother. Oncol. 86 25-9). The goal of this device is to facilitate soft-tissue contrast based image-guided radiotherapy, in order to escalate the dose to the tumour while sparing surrounding normal tissues....

journal_title：Physics in medicine and biology

authors： Meijsing I,Raaymakers BW,Raaijmakers AJ,Kok JG,Hogeweg L,Liu B,Lagendijk JJ

更新日期：2009-05-21 00:00:00

abstract：:This work presents a Monte Carlo model of Leksell Gamma Knife Perfexion as well as the main parameters of the dose distribution in the standard phantom obtained using this model. The model is developed in the Geant4 simulation toolkit in a modular way which enables its reuse in other Perfexion studies. Large phase spa...

journal_title：Physics in medicine and biology

authors： Pipek J,Novotný J,Novotný J,Kozubíková P

更新日期：2014-12-21 00:00:00

abstract：:This paper describes a neural network (NN) regression model for relative dose computation. The input signal of the NN model includes depths and field sizes and the output is the relative dose, for example, percentage depth dose (%DD) or tissue-air ratio (TAR) in this paper. After a functional link has been created, th...

journal_title：Physics in medicine and biology

authors： Wu X,Zhu Y

更新日期：2000-04-01 00:00:00

abstract：:Raman spectroscopy is a potentially important clinical tool for real-time diagnosis of disease and in situ evaluation of living tissue. The purpose of this article is to review the biological and physical basis of Raman spectroscopy of tissue, to assess the current status of the field and to explore future directions....

journal_title：Physics in medicine and biology

authors： Hanlon EB,Manoharan R,Koo TW,Shafer KE,Motz JT,Fitzmaurice M,Kramer JR,Itzkan I,Dasari RR,Feld MS

更新日期：2000-02-01 00:00:00

abstract：:The elastic and hyperelastic properties of biological soft tissues have been of interest to the medical community. There are several biomedical applications where parameters characterizing such properties are critical for a reliable clinical outcome. These applications include surgery planning, needle biopsy and brach...

journal_title：Physics in medicine and biology

authors： O'Hagan JJ,Samani A

更新日期：2009-04-21 00:00:00

abstract：:At the UMC Utrecht a prototype MR-linac has been installed. The system consists of an 8 MV Elekta linear accelerator and a 1.5 T Philips MRI system. This paper investigates the performance of the IC PROFILER™, a multi-axis ionization chamber array, in a 1.5 T magnetic field. The influence of the magnetic field on the ...

journal_title：Physics in medicine and biology

authors： Smit K,Kok JG,Lagendijk JJ,Raaymakers BW

更新日期：2014-04-07 00:00:00

abstract：:A system is described in which large superficial areas of tissue may be heated using a single plane ultrasonic transducer scanned in a raster fashion. The shape of the heated area is determined by the movement of a microswitch which is activated when it strikes the rigid edge of a hole of the required shape cut in a p...

journal_title：Physics in medicine and biology

authors： ter Haar G,Hopewell JW

更新日期：1985-12-01 00:00:00

abstract：:None of the existing protocols or codes of practice for high-energy electron dosimetry take any account of the accelerator-generated bremsstrahlung always present in electron beams. This results in a systematic error in the derivation of the absorbed dose. The purpose of this study is to draw attention to this omissio...

journal_title：Physics in medicine and biology

authors： Klevenhagen SC

更新日期：1994-07-01 00:00:00

abstract：:This study aims at investigating in real-time the structural and dynamical changes occurring in an ex vivo tissue during a microwave thermal ablation (MTA) procedure. The experimental set-up was based on ex vivo liver tissue inserted in a dedicated box, in which 3 fibre-optic (FO) temperature probes were introduced to...

journal_title：Physics in medicine and biology

authors： Strigari L,Minosse S,D'Alessio D,Farina L,Cavagnaro M,Cassano B,Pinto R,Vallati G,Lopresto V

更新日期：2019-05-31 00:00:00

abstract：:A function called Gx(L) was introduced by the International Commission on Radiation Units and Measurements (ICRU) Report-87 to facilitate measurement of cumulative dose for CT scans within long phantoms as recommended by the American Association of Physicists in Medicine (AAPM) TG-111. The Gx(L) function is equal to t...

journal_title：Physics in medicine and biology

authors： Abuhaimed A,Martin CJ,Sankaralingam M,Gentle DJ

更新日期：2015-07-21 00:00:00

abstract：:Monte Carlo simulation provides a valuable tool in performance assessment and optimization of system design parameters for PET scanners. SimSET is a popular Monte Carlo simulation toolkit that features fast simulation time, as well as variance reduction tools to further enhance computational efficiency. However, SimSE...

journal_title：Physics in medicine and biology

authors： Poon JK,Dahlbom ML,Casey ME,Qi J,Cherry SR,Badawi RD

更新日期：2015-02-07 00:00:00

abstract：:Two novel materials have been developed to simulate the dielectric properties of human muscle and fat at 1000 MHz. These materials, which are based on ethanediol set with gelatine, are easily made and have good mechanical properties. The complex permittivity, epsilon *, of each material was measured with an open-ended...

journal_title：Physics in medicine and biology

authors： Robinson MP,Richardson MJ,Green JL,Preece AW

更新日期：1991-12-01 00:00:00

abstract：:The origin of the differences in the refractive index observed between normal and tumor tissues using terahertz spectroscopy has been described quantitatively. To estimate water content differences in tissues, we prepared fresh and paraffin-embedded samples from rats. An approximately 5% increase of water content in t...

journal_title：Physics in medicine and biology

authors： Yamaguchi S,Fukushi Y,Kubota O,Itsuji T,Ouchi T,Yamamoto S

更新日期：2016-09-21 00:00:00

abstract：:For quantitative measurements of small animals such as mice or rats, a compact and high sensitivity continuous blood sampling detector is required because their blood sampling volume is limited. For this purpose we have developed and tested a new positron detector. The positron detector uses a pair of dual-layer thin ...

journal_title：Physics in medicine and biology

authors： Yamamoto S,Imaizumi M,Shimosegawa E,Kanai Y,Sakamoto Y,Minato K,Shimizu K,Senda M,Hatazawa J

更新日期：2010-07-07 00:00:00

abstract：:Simultaneous rest perfusion/fatty-acid metabolism studies have the potential to replace sequential rest/stress perfusion studies for the assessment of cardiac function. Simultaneous acquisition has the benefits of increased signal and lack of need for patient stress, but is complicated by cross-talk between the two ra...

journal_title：Physics in medicine and biology

authors： Trott CM,Ouyang J,El Fakhri G

更新日期：2010-11-21 00:00:00

abstract：:Radiotherapy treatment planning is associated with uncertainties. Examples are uncertainties in the tumour location due to organ movement or the inter/intra observer variability in target definition. Different approaches to incorporate uncertainties into IMRT optimization have been proposed. In this note, we point out...

journal_title：Physics in medicine and biology

authors： Unkelbach J,Oelfke U

更新日期：2006-12-07 00:00:00

abstract：:Average penetration depths and detour factors of 1-50 MeV electrons in water and plastic materials have been computed by means of analytical calculation, within the continuous-slowing-down approximation and including multiple scattering, and using the Monte Carlo codes ITS and PENELOPE. Results are compared to detour ...

journal_title：Physics in medicine and biology

authors： Fernández-Varea JM,Andreo P,Tabata T

更新日期：1996-07-01 00:00:00

abstract：:Treatment planning based on probability distribution function (PDF) of patient geometries has been shown a potential off-line strategy to incorporate organ motion, but the application of such approach highly depends upon the reproducibility of the PDF. In this paper, we investigated the dependences of the PDF reproduc...

journal_title：Physics in medicine and biology

authors： Cai J,Read PW,Altes TA,Molloy JA,Brookeman JR,Sheng K

更新日期：2007-01-21 00:00:00

abstract：:Dynamic SPECT is a relatively new technique that may potentially benefit many imaging applications. Though similar to dynamic PET, the accuracy and precision of dynamic SPECT parameter estimates are degraded by factors that differ from those encountered in PET. In this work we formulate a methodology for analytically ...

journal_title：Physics in medicine and biology

authors： Kadrmas DJ,DiBella EV,Huesman RH,Gullberg GT

更新日期：1999-08-01 00:00:00

abstract：:This work is a follow-up study for a recently-proposed 3D radiochromic gel dosimeter that contains a tetrazolium salt and a physical gel matrix made of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (Pluronic F-127). Several tetrazolium salts were examined in this work, including tetrazoli...

journal_title：Physics in medicine and biology

authors： Kwiatos K,Maras P,Kadlubowski S,Stempień Z,Dudek M,Kozicki M

更新日期：2018-05-04 00:00:00

abstract：:Experimental radiobiological investigations of fast neutron beams involve irradiation of thin cell layers. The irradiation of cells is done either in free air or with a material such as graphite, TE plastic or bone-equivalent plastic covering the cells. This paper discusses the computed dose distributions in LET at sh...

journal_title：Physics in medicine and biology

authors： Bhatia DP,Nagarajan PS

更新日期：1979-09-01 00:00:00

abstract：:The effect of the physical state (phase) of the absorbing medium and the energy straggling of the alpha particles on the calculation of the radiation dose due to the daughter products of radon deposited in the lung have been studied in detail. The stopping power data for alpha particles in water and water vapour have ...

journal_title：Physics in medicine and biology

authors： Haque AK,Al-affan IA

更新日期：1987-08-01 00:00:00

abstract：:Imaging technologies that allow non-radiative visualization and quantification of apoptosis have a great potential for assessing therapy response, early diagnosis, and disease monitoring. Magnetic particle imaging (MPI), the direct imaging of magnetic nanoparticles as positive contrast agent and sole signal source, en...

journal_title：Physics in medicine and biology

authors： Liang X,Wang K,Du J,Tian J,Zhang H

更新日期：2020-09-24 00:00:00

abstract：:A dynamic-contrast-enhanced magnetic resonance imaging (DCE-MRI) dataset consists of many imaging frames, often acquired both before and after contrast injection. Due to the length of time spent acquiring images, patient motion is likely and image re-alignment or registration is required before further analysis such a...

journal_title：Physics in medicine and biology

authors： Melbourne A,Hipwell J,Modat M,Mertzanidou T,Huisman H,Ourselin S,Hawkes DJ

更新日期：2011-12-21 00:00:00

abstract：:The purpose of this work is the clinical commissioning of a recently developed in vivo range verification system (IRVS) for treatment of prostate cancer by anterior and anterior oblique proton beams. The IRVS is designed to perform a complete workflow for pre-treatment range verification and adjustment. It contains sp...

journal_title：Physics in medicine and biology

authors： Hoesl M,Deepak S,Moteabbed M,Jassens G,Orban J,Park YK,Parodi K,Bentefour EH,Lu HM

更新日期：2016-04-21 00:00:00

abstract：:An original method for the analysis of oscillations of cutaneous blood flow has been developed, which makes use of laser Doppler flowmetry (LDF) data and is based on the continuous wavelet transform and adaptive wavelet theory. The potential of the method has been demonstrated in experiments with the response of micro...

journal_title：Physics in medicine and biology

authors： Tankanag A,Chemeris N

更新日期：2008-11-07 00:00:00

abstract：:Partial volume effects (PVEs) are consequences of the limited spatial resolution in emission tomography. They lead to a loss of signal in tissues of size similar to the point spread function and induce activity spillover between regions. Although PVE can be corrected for by using algorithms that provide the correct ra...

journal_title：Physics in medicine and biology

authors： Boussion N,Hatt M,Lamare F,Bizais Y,Turzo A,Cheze-Le Rest C,Visvikis D

更新日期：2006-04-07 00:00:00

abstract：:In carbon ion therapy treatment planning, the relative biological effectiveness (RBE) is accounted for by optimization of the RBE-weighted dose (biological dose). The RBE calculation methods currently applied clinically in carbon ion therapy are derived from the microdosimetric kinetic model (MKM) in Japan and the loc...

journal_title：Physics in medicine and biology

authors： Dahle TJ,Magro G,Ytre-Hauge KS,Stokkevåg CH,Choi K,Mairani A

更新日期：2018-11-12 00:00:00

abstract：:The imaging performance of a high-resolution preclinical micro-positron emission tomography (micro-PET) system employing liquid xenon (LXe) as the gamma-ray detection medium was simulated. The arrangement comprises a ring of detectors consisting of trapezoidal LXe time projection ionization chambers and two arrays of ...

journal_title：Physics in medicine and biology

authors： Miceli A,Glister J,Andreyev A,Bryman D,Kurchaninov L,Lu P,Muennich A,Retiere F,Sossi V

更新日期：2012-03-21 00:00:00

abstract：:Recently, the Task Group 103 of the International Commission on Radiological Protection (ICRP) has developed new mesh-type reference computational phantoms (MRCPs) for adult male and female. When compared to the current voxel-type reference computational phantoms in ICRP Publication 110, the MRCPs have several advanta...

journal_title：Physics in medicine and biology

authors： Lee H,Yeom YS,Nguyen TT,Choi C,Han H,Shin B,Zhang X,Kim CH,Chung BS,Zankl M

更新日期：2019-02-05 00:00:00