Abstract:
:Simultaneous rest perfusion/fatty-acid metabolism studies have the potential to replace sequential rest/stress perfusion studies for the assessment of cardiac function. Simultaneous acquisition has the benefits of increased signal and lack of need for patient stress, but is complicated by cross-talk between the two radionuclide signals. We consider a simultaneous rest (99m)Tc-sestamibi/(123)I-BMIPP imaging protocol in place of the commonly used sequential rest/stress (99m)Tc-sestamibi protocol. The theoretical precision with which the severity of a cardiac defect and the transmural extent of infarct can be measured is computed for simultaneous and sequential SPECT imaging, and their performance is compared for discriminating (1) degrees of defect severity and (2) sub-endocardial from transmural defects. We consider cardiac infarcts for which reduced perfusion and metabolism are observed. From an information perspective, simultaneous imaging is found to yield comparable or improved performance compared with sequential imaging for discriminating both severity of defect and transmural extent of infarct, for three defects of differing location and size.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Trott CM,Ouyang J,El Fakhri Gdoi
10.1088/0031-9155/55/22/019subject
Has Abstractpub_date
2010-11-21 00:00:00pages
6897-910issue
22eissn
0031-9155issn
1361-6560pii
S0031-9155(10)54714-6journal_volume
55pub_type
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