Comparison of simultaneous and sequential SPECT imaging for discrimination tasks in assessment of cardiac defects.

Abstract:

:Simultaneous rest perfusion/fatty-acid metabolism studies have the potential to replace sequential rest/stress perfusion studies for the assessment of cardiac function. Simultaneous acquisition has the benefits of increased signal and lack of need for patient stress, but is complicated by cross-talk between the two radionuclide signals. We consider a simultaneous rest (99m)Tc-sestamibi/(123)I-BMIPP imaging protocol in place of the commonly used sequential rest/stress (99m)Tc-sestamibi protocol. The theoretical precision with which the severity of a cardiac defect and the transmural extent of infarct can be measured is computed for simultaneous and sequential SPECT imaging, and their performance is compared for discriminating (1) degrees of defect severity and (2) sub-endocardial from transmural defects. We consider cardiac infarcts for which reduced perfusion and metabolism are observed. From an information perspective, simultaneous imaging is found to yield comparable or improved performance compared with sequential imaging for discriminating both severity of defect and transmural extent of infarct, for three defects of differing location and size.

journal_name

Phys Med Biol

authors

Trott CM,Ouyang J,El Fakhri G

doi

10.1088/0031-9155/55/22/019

subject

Has Abstract

pub_date

2010-11-21 00:00:00

pages

6897-910

issue

22

eissn

0031-9155

issn

1361-6560

pii

S0031-9155(10)54714-6

journal_volume

55

pub_type

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