Structural and practical identifiability of dual-input kinetic modeling in dynamic PET of liver inflammation.

abstract：:The silicon photomultiplier (Si-PM) is a promising photo-detector for PET for use in magnetic resonance imaging (MRI) systems because it has high gain and is insensitive to static magnetic fields. Recently we developed a Si-PM-based depth-of-interaction PET system for small animals and performed simultaneous measureme...

journal_title：Physics in medicine and biology

authors： Yamamoto S,Watabe T,Watabe H,Aoki M,Sugiyama E,Imaizumi M,Kanai Y,Shimosegawa E,Hatazawa J

更新日期：2012-01-21 00:00:00

abstract：:The 'monoenergetic' electron loss model was derived in a previous work to account for pathlength straggling in the Fermi-Eyges pencil beam problem. In this paper, we extend this model to account for energy-loss straggling and secondary knock-on electron transport in order to adequately predict a depth dose curve. To m...

journal_title：Physics in medicine and biology

authors： Chvetsov AV,Sandison GA,Yeboah C

更新日期：2000-10-01 00:00:00

abstract：:Respiratory-correlated 4D-MRI can characterize respiratory-induced motion of tumors and organs-at-risk for radiotherapy treatment planning and is a necessity for image guidance of moving tumors treated on an MRI-linac. Essential for 4D-MRI generation is a robust respiratory surrogate signal. We investigated the feasib...

journal_title：Physics in medicine and biology

authors： Navest RJM,Mandija S,Bruijnen T,Stemkens B,Tijssen RHN,Andreychenko A,Lagendijk JJW,van den Berg CAT

更新日期：2020-01-13 00:00:00

abstract：:Methods based on magnetic resonance imaging for the measurement of three-dimensional distributions of radiation dose are highly developed. However, relatively little work has been done on optical computed tomography (OCT). This paper describes a new OCT scanner based on a broad beam light source and a two-dimensional ...

journal_title：Physics in medicine and biology

authors： Doran SJ,Koerkamp KK,Bero MA,Jenneson P,Morton EJ,Gilboy WB

更新日期：2001-12-01 00:00:00

abstract：:As the use of radiofrequency (RF) electromagnetic (EM) fields has increased along with increased use of wireless communication, the possible related health risks have also been widely discussed. One safety aspect is the interaction of medical implants and RF devices like mobile phones. In the literature, effects on ac...

journal_title：Physics in medicine and biology

authors： Virtanen H,Keshvari J,Lappalainen R

更新日期：2007-03-07 00:00:00

abstract：:Users of nuclear and atomic data for biomedical purposes often have difficulty in identifying the most up-to-date and appropriate sources of such data. The biomedical Subcommittee of the UK Nuclear Data Committee have prepared a list of recommended data sources available at the beginning of 1978 on radioactive decay s...

journal_title：Physics in medicine and biology

authors： Holt PD

更新日期：1979-01-01 00:00:00

abstract：:The purpose of this study was the evaluation of the impact of a variable relative biological effectiveness (RBE) compared to a constant RBE value of 1.1 in proton therapy prostate trials due to uncertainties in α/β ratio. Twenty patients receiving passive scattered proton therapy (PSPT) and fifteen patients receiving ...

journal_title：Physics in medicine and biology

authors： Marteinsdottir M,Paganetti H

更新日期：2019-06-05 00:00:00

abstract：:We propose a novel scintillation detector design for positron emission tomography (PET), which has depth of interaction (DOI) capability and uses a single-ended readout scheme. The DOI detector contains a pair of crystal bars segmented using sub-surface laser engraving (SSLE). The two crystal bars are optically couple...

journal_title：Physics in medicine and biology

authors： Uchida H,Sakai T,Yamauchi H,Hakamata K,Shimizu K,Yamashita T

更新日期：2016-09-21 00:00:00

abstract：:Finite element (FE) modeling provides a useful tool to understand the mechanical behavior of complex tissues, such as cancers, in a variety of testing conditions. Although a number of numerical and analytical models for cancerous tumors are retrievable in the literature, none of these models is capable of completely d...

journal_title：Physics in medicine and biology

authors： Islam MT,Reddy JN,Righetti R

更新日期：2018-10-24 00:00:00

abstract：:Many models exist for predicting toxicities based on dose-volume histograms (DVHs) or dose-surface histograms (DSHs). This approach has several drawbacks as firstly the reduction of the dose distribution to a histogram results in the loss of spatial information and secondly the bins of the histograms are highly correl...

journal_title：Physics in medicine and biology

authors： Buettner F,Gulliford SL,Webb S,Partridge M

更新日期：2011-04-07 00:00:00

abstract：:An inverse radiation treatment planning algorithm for Sensus Healthcare's SculpturaTM electronic brachytherapy system has been designed. The algorithm makes use of simulated annealing to optimize the conformation number of the treatment plan. The highly anisotropic dose distributions produced by the SculpturaTM x-ray ...

journal_title：Physics in medicine and biology

authors： Badali DS,Vainer Y,Ellenor CW,Mitchell CR,Fishman K,Soro N,Price R,Funk T

更新日期：2021-01-11 00:00:00

abstract：:A single photon absorptiometry method to measure the arterial concentration of injected iodinated contrast agent was developed. A prototype absorptiometry unit was built which consists of either a square or circular cross section acrylic (polymethylmethacrylate) cuvette connected to an arterial catheter at one end and...

journal_title：Physics in medicine and biology

authors： Yeung WT,Lee TY,Del Maestro RF,Kozak R,Bennett JD,Brown T

更新日期：1992-09-01 00:00:00

abstract：:Intensive computation time is required to simulate images of electronic portal imaging device (EPID) using Monte Carlo (MC) technique, limiting the development of applications associated with EPID, such as mega-voltage cone-beam computed tomography (MV-CBCT). In this study, a fast, accurate simulation strategy for MV-...

journal_title：Physics in medicine and biology

authors： Shi M,Myronakis M,Jacobson M,Lehmann M,Ferguson D,Baturin P,Huber P,Fueglistaller R,Harris T,Lozano IV,Williams C,Morf D,Berbeco RI

更新日期：2020-07-06 00:00:00

abstract：:The S-value is a standard measure in cellular dosimetry. S-values are calculated by applying analytical methods or by Monte Carlo simulation. In Monte Carlo simulation, particles are either tracked individually event-by-event or close events are condensed and processed collectively in different steps. Both of these me...

journal_title：Physics in medicine and biology

authors： Tajik-Mansoury MA,Rajabi H,Mozdarani H

更新日期：2017-03-07 00:00:00

abstract：:Proton computed tomography (pCT) promises to reduce or even eliminate range uncertainties inherent in the conversion of Hounsfield units into relative stopping power (RSP) for proton therapy treatment planning. This is of particular interest for proton irradiation studies in animal models due to the high precision req...

journal_title：Physics in medicine and biology

authors： Meyer S,Bortfeldt J,Lämmer P,Englbrecht FS,Pinto M,Schnürle K,Würl M,Parodi K

更新日期：2020-08-13 00:00:00

abstract：:A reader study was conducted to tune the parameters of an observer model used to predict the detectability index (dʹ ) of test objects as a task-based quality control (QC) metric for digital mammography. A simple test phantom was imaged to measure the model parameters, namely, noise power spectrum,modulation transfer ...

journal_title：Physics in medicine and biology

authors： Bloomquist AK,Mainprize JG,Mawdsley GE,Yaffe MJ

更新日期：2014-11-07 00:00:00

abstract：:For low-energy (up to 150 kV) x-rays, the ratio of mass-energy absorption coefficients for water to air, (mu(en)/rho)w.air, and the backscatter factor B are used in the conversion of air kerma, measured free-in-air, to water kerma on the surface of a water phantom. For clinical radiotherapy, similar conversion factors...

journal_title：Physics in medicine and biology

authors： Ma CM,Seuntjens JP

更新日期：1999-01-01 00:00:00

abstract：:In order to measure in vivo resistivity of tissues in the thorax, the possibility of combining anatomical data extracted from high-resolution images with multiple-electrode impedance measurements, a priori knowledge of the range of tissue resistivities, and a priori data on the instrumentation noise is assessed in thi...

journal_title：Physics in medicine and biology

authors： Eyüboğlu BM,Pilkington TC,Wolf PD

更新日期：1994-01-01 00:00:00

abstract：:Magnetic Resonance Electrical Impedance Tomography (MREIT) is an MRI method that enables mapping of internal conductivity and/or current density via measurements of magnetic flux density signals. The MREIT measures only the z-component of the induced magnetic flux density B = (Bx, By, Bz) by external current injection...

journal_title：Physics in medicine and biology

authors： Jeong WC,Chauhan M,Sajib SZ,Kim HJ,Serša I,Kwon OI,Woo EJ

更新日期：2014-09-07 00:00:00

abstract：:Respiratory gating based on external surrogates is performed in many clinics. We have developed a new technique for treatment verification using an electronic portal imaging device (EPID) in cine mode for gated 3D conformal therapy. Implanted radiopaque fiducial markers inside or near the target are required for this ...

journal_title：Physics in medicine and biology

authors： Berbeco RI,Neicu T,Rietzel E,Chen GT,Jiang SB

更新日期：2005-08-21 00:00:00

abstract：:In this paper we describe measurements of the contrast transfer function, modulation transfer function and point-spread function of an optical coherence tomography (OCT) imaging system through scattering layers having a dimension-less scattering depth over the range 0.2-6.9. The results were found to be insensitive to...

journal_title：Physics in medicine and biology

authors： Woolliams PD,Tomlins PH

更新日期：2011-05-07 00:00:00

abstract：:Most solid-state detectors, including 3D dosimeters, show lower signal in the Bragg peak than expected, a process termed quenching. The purpose of this study was to investigate how variation in chemical composition of a recently developed radiochromic, silicone-based 3D dosimeter influences the observed quenching in p...

journal_title：Physics in medicine and biology

authors： Høye EM,Skyt PS,Balling P,Muren LP,Taasti VT,Swakoń J,Mierzwińska G,Rydygier M,Bassler N,Petersen JB

更新日期：2017-02-21 00:00:00

abstract：:An iterative Bayesian reconstruction algorithm for limited view angle tomography, or ectomography, based on the three-dimensional total variation (TV) norm has been developed. The TV norm has been described in the literature as a method for reducing noise in two-dimensional images while preserving edges, without intro...

journal_title：Physics in medicine and biology

authors： Persson M,Bone D,Elmqvist H

更新日期：2001-03-01 00:00:00

abstract：:Near-infrared fluorescence optical imaging has the unique opportunity of differentiating diseased lesions from normal lesions based upon environmentally indicated changes in the lifetime of a fluorescent imaging agent. In this paper, we demonstrate three-dimensional lifetime tomography using the gradient-based penalty...

journal_title：Physics in medicine and biology

authors： Roy R,Godavarty A,Sevick-Muraca EM

更新日期：2007-07-21 00:00:00

abstract：:The analysis of (x-ray) mammograms remains qualitative, relying on the judgement of clinicians. We present a novel method to compute a quantitative, normalized measure of tissue radiodensity traversed by the primary beam incident on each pixel of a mammogram, a measure we term the standard attenuation rate (SAR). SAR ...

journal_title：Physics in medicine and biology

authors： Tromans CE,Cocker MR,Brady SM

更新日期：2012-10-21 00:00:00

abstract：:Artifacts caused by patient breathing and movement during PET data acquisition affect image quality. Respiratory gating is commonly used to gate the list-mode PET data into multiple bins over a respiratory cycle. Non-rigid registration of respiratory-gated PET images can reduce motion artifacts and preserve count stat...

journal_title：Physics in medicine and biology

authors： Li T,Zhang M,Qi W,Asma E,Qi J

更新日期：2020-07-30 00:00:00

abstract：:We present a new method for automated characterization of atherosclerotic plaque composition in ex vivo MRI. It uses MRI intensities as well as four other types of features: smoothed, gradient magnitude and Laplacian images at several scales, and the distances to the lumen and outer vessel wall. The ground truth for f...

journal_title：Physics in medicine and biology

authors： van Engelen A,Niessen WJ,Klein S,Groen HC,Verhagen HJ,Wentzel JJ,van der Lugt A,de Bruijne M

更新日期：2012-01-07 00:00:00

abstract：:Andreo and Benmakhlouf (2017 Phys. Med. Biol. 62 1518-32) have disputed a finding of Scott et al (2012 Phys. Med. Biol. 57 4461-76) that the variation with field-size of the response of small ion chambers and solid-state dosimeters in small megavoltage photon radiation fields can largely be attributed to density. Furt...

journal_title：Physics in medicine and biology

authors： Fenwick JD,Georgiou G,Rowbottom CG,Underwood TSA,Kumar S

更新日期：2018-10-03 00:00:00

abstract：:The biological mechanisms of platelet destruction must be correctly identified before platelet survival curves can be interpreted. This report develops a theory of platelet destruction which is compared with experiments performed on platelets labelled with the radioactive isotope 51Cr. Platelet destruction rate is a c...

journal_title：Physics in medicine and biology

authors： Trowbridge EA,Martin JF

更新日期：1983-12-01 00:00:00

abstract：:Recent studies have demonstrated the feasibility of transcranial high-intensity focused ultrasound (HIFU) therapy in the brain using adaptive focusing techniques. However, the complexity of the procedures imposes provision of accurate targeting, monitoring and control of this emerging therapeutic modality in order to ...

journal_title：Physics in medicine and biology

authors： Larrat B,Pernot M,Aubry JF,Dervishi E,Sinkus R,Seilhean D,Marie Y,Boch AL,Fink M,Tanter M

更新日期：2010-01-21 00:00:00