A rapid, accurate image simulation strategy for mega-voltage cone-beam computed tomography.

Abstract:

:Intensive computation time is required to simulate images of electronic portal imaging device (EPID) using Monte Carlo (MC) technique, limiting the development of applications associated with EPID, such as mega-voltage cone-beam computed tomography (MV-CBCT). In this study, a fast, accurate simulation strategy for MV-CBCT utilizing the FastEPID technique has been developed and validated. During FastEPID simulation, photon detection was determined by pre-calculated photon energy deposition efficiency (η) and particle transport within the EPID was replaced with a pre-calculated optical photon spread function. This method is capable of reducing the time required for EPID image simulation by a factor of 90-140, without compromising image quality. MV-CBCT images reconstructed from the FastEPID simulated projections have been validated against measurement in terms of mean Hounsfield unit (HU), noise, and cupping artifact. These images were obtained with both a Catphan 604 phantom and an anthropomorphic pelvis phantom, under treatment beam energies of 2.5 MV, 6 MV, and 6 MV flattening filter free. The agreement between measurement and simulation was excellent in all cases. This novel strategy was capable of reducing the run time of a full scan simulation of MV-CBCT performed on a CPU cluster to a matter of hours, rather than weeks or months required by a conventional approach. Multiple applications associated with MV-CBCT (e.g. imager design optimization) are anticipated to gain from the implementation of this novel simulation strategy.

journal_name

Phys Med Biol

authors

Shi M,Myronakis M,Jacobson M,Lehmann M,Ferguson D,Baturin P,Huber P,Fueglistaller R,Harris T,Lozano IV,Williams C,Morf D,Berbeco RI

doi

10.1088/1361-6560/ab868a

subject

Has Abstract

pub_date

2020-07-06 00:00:00

pages

135004

issue

13

eissn

0031-9155

issn

1361-6560

journal_volume

65

pub_type

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