Abstract:
:The biological mechanisms of platelet destruction must be correctly identified before platelet survival curves can be interpreted. This report develops a theory of platelet destruction which is compared with experiments performed on platelets labelled with the radioactive isotope 51Cr. Platelet destruction rate is a complicated function of platelet number and the thrombokinetic destruction state of the body. A linear approximation of this function shows that destruction is dominated by constant and random consumption. A second order non-linear approximation shows the effect of 'platelet crowding'. This theoretical study explains the difference between predicting the complete platelet survival curve from only two experimental points (in the linear approximation) and the methods of curve fitting currently recommended by the International Committee for Standardization in Haematology. It indicates that the curve fitting of known functional forms to experimental data usually results in an under interpretation of the observations and dilutes the diagnostic potential of the platelet survival curve.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Trowbridge EA,Martin JFdoi
10.1088/0031-9155/28/12/001subject
Has Abstractpub_date
1983-12-01 00:00:00pages
1349-68issue
12eissn
0031-9155issn
1361-6560journal_volume
28pub_type
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