Evaluation of the reproducibility of lung motion probability distribution function (PDF) using dynamic MRI.

Abstract:

:Treatment planning based on probability distribution function (PDF) of patient geometries has been shown a potential off-line strategy to incorporate organ motion, but the application of such approach highly depends upon the reproducibility of the PDF. In this paper, we investigated the dependences of the PDF reproducibility on the imaging acquisition parameters, specifically the scan time and the frame rate. Three healthy subjects underwent a continuous 5 min magnetic resonance (MR) scan in the sagittal plane with a frame rate of approximately 10 f s-1, and the experiments were repeated with an interval of 2 to 3 weeks. A total of nine pulmonary vessels from different lung regions (upper, middle and lower) were tracked and the dependences of their displacement PDF reproducibility were evaluated as a function of scan time and frame rate. As results, the PDF reproducibility error decreased with prolonged scans and appeared to approach equilibrium state in subjects 2 and 3 within the 5 min scan. The PDF accuracy increased in the power function with the increase of frame rate; however, the PDF reproducibility showed less sensitivity to frame rate presumably due to the randomness of breathing which dominates the effects. As the key component of the PDF-based treatment planning, the reproducibility of the PDF affects the dosimetric accuracy substantially. This study provides a reference for acquiring MR-based PDF of structures in the lung.

journal_name

Phys Med Biol

authors

Cai J,Read PW,Altes TA,Molloy JA,Brookeman JR,Sheng K

doi

10.1088/0031-9155/52/2/004

subject

Has Abstract

pub_date

2007-01-21 00:00:00

pages

365-73

issue

2

eissn

0031-9155

issn

1361-6560

pii

S0031-9155(07)30845-2

journal_volume

52

pub_type

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