An optimized leaf-setting algorithm for beam intensity modulation using dynamic multileaf collimators.

abstract：:The beam quality correction factor k Q for megavoltage photon beams has been calculated for eight PTW (Freiburg, Germany) ionization chambers (Farmer chambers PTW30010, PTW30011, PTW30012, and PTW30013, Semiflex 3D chambers PTW31021, PTW31010, and PTW31013, and the PinPoint 3D chamber PTW31016). Simulations performed ...

journal_title：Physics in medicine and biology

authors： Giménez-Alventosa V,Giménez V,Ballester F,Vijande J,Andreo P

更新日期：2020-10-07 00:00:00

abstract：:Several applications in nuclear medicine require absolute activity quantification of single photon emission computed tomography images. Obtaining a repeatable calibration factor that converts voxel values to activity units is essential for these applications. Because source preparation and measurement of the source ac...

journal_title：Physics in medicine and biology

authors： Anizan N,Wang H,Zhou XC,Wahl RL,Frey EC

更新日期：2015-02-07 00:00:00

abstract：:Radiotherapy and particle therapy treatment planning require accurate knowledge of the electron density and elemental composition of the tissues in the beam path to predict the local dose deposition. We describe a method for the analysis of dual energy computed tomography (DECT) images that provides the electron densi...

journal_title：Physics in medicine and biology

authors： van Abbema JK,van Goethem MJ,Greuter MJ,van der Schaaf A,Brandenburg S,van der Graaf ER

更新日期：2015-05-07 00:00:00

abstract：:The problem of fluorescence diffuse optical tomography consists in localizing fluorescent markers from near-infrared light measurements. Among the different available acquisition modalities, the time-resolved modality is expected to provide measurements of richer information content. To extract this information, the m...

journal_title：Physics in medicine and biology

authors： Ducros N,Hervé L,Da Silva A,Dinten JM,Peyrin F

更新日期：2009-12-07 00:00:00

abstract：:The dielectric constant and conductivity of muscle, liver, spleen and kidney of cats in vivo and in situ immediately following the animal's death were measured at frequencies from 10 kHz to 100 MHz. A novel multi-ring capacitive sensor and a computer-controlled automatic network analyser (ANA) were employed. The resul...

journal_title：Physics in medicine and biology

authors： Surowiec A,Stuchly SS,Keaney M,Swarup A

更新日期：1986-08-01 00:00:00

abstract：:Quantifying the retention or washout of (99m)Tc-Sestamibi (MIBI) in breast tumours in vivo may provide a basis for predicting the chemotherapy response. The aim of this study is to investigate the variations and limitations of the different methods used to quantify these parameters. A phantom was developed that allowe...

journal_title：Physics in medicine and biology

authors： Marshall C,Griffiths PA

更新日期：2005-05-07 00:00:00

abstract：:State of the art point-spread function (PSF) corrections implemented in positron emission tomography/computed tomography (PET/CT) reconstruction improved image quality and diagnostic performance but caused an increase in the standardized uptake value (SUV) compared to a conventional OSEM reconstruction system. The EAN...

journal_title：Physics in medicine and biology

authors： Ferretti A,Chondrogiannis S,Rampin L,Bellan E,Marzola MC,Grassetto G,Gusella S,Maffione AM,Gava M,Rubello D

更新日期：2018-11-26 00:00:00

abstract：:The basic principles of x-ray image formation in radiology have remained essentially unchanged since Röntgen first discovered x-rays over a hundred years ago. The conventional approach relies on x-ray attenuation as the sole source of contrast and draws exclusively on ray or geometrical optics to describe and interpre...

journal_title：Physics in medicine and biology

authors： Bech M,Bunk O,Donath T,Feidenhans'l R,David C,Pfeiffer F

更新日期：2010-09-21 00:00:00

abstract：:The 'EXACT3D' positron tomograph, which is now in routine clinical research use, was developed with the aim of achieving unprecedented sensitivity, high spatial and temporal resolution and simplicity of design using proven detector technology. It consists of six rings of standard detector blocks (CTI/Siemens EXACT HR+...

journal_title：Physics in medicine and biology

authors： Spinks TJ,Jones T,Bloomfield PM,Bailey DL,Miller M,Hogg D,Jones WF,Vaigneur K,Reed J,Young J,Newport D,Moyers C,Casey ME,Nutt R

更新日期：2000-09-01 00:00:00

abstract：:We propose and evaluate the performance of an improved preclinical positron emission tomography (PET) scanner design, referred to as Polaroid-PET, consisting of a detector equipped with a layer of horizontal Polaroid to filter scintillation photons with vertical polarization. This makes it possible to improve the spat...

journal_title：Physics in medicine and biology

authors： Sanaat A,Ashrafi-Belgabad A,Zaidi H

更新日期：2020-12-02 00:00:00

abstract：:Many models exist for predicting toxicities based on dose-volume histograms (DVHs) or dose-surface histograms (DSHs). This approach has several drawbacks as firstly the reduction of the dose distribution to a histogram results in the loss of spatial information and secondly the bins of the histograms are highly correl...

journal_title：Physics in medicine and biology

authors： Buettner F,Gulliford SL,Webb S,Partridge M

更新日期：2011-04-07 00:00:00

abstract：:Determining a multidimensional velocity field within microscale opaque fluid flows is needed in areas such as microfluidic devices, biofluid mechanics and hemodynamics research in animal studies. The ultrasonic particle image velocimetry (EchoPIV) technique is appropriate for measuring opaque flows by taking advantage...

journal_title：Physics in medicine and biology

authors： Qian M,Niu L,Wang Y,Jiang B,Jin Q,Jiang C,Zheng H

更新日期：2010-10-21 00:00:00

abstract：:Modern effort in radiotherapy to address the challenges of tumor localization and motion has led to the development of MRI guided radiotherapy technologies. Accurate dose calculations must properly account for the effects of the MRI magnetic fields. Previous work has investigated the accuracy of a deterministic linear...

journal_title：Physics in medicine and biology

authors： Zelyak O,Fallone BG,St-Aubin J

更新日期：2017-12-14 00:00:00

abstract：:This paper describes the development and characterization of a fully automated in vitro cell irradiator using an electronic brachytherapy source to perform radiation sensitivity bioassays. This novel irradiator allows complex variable dose and dose rate schemes to be delivered to multiple wells of 96-well culture plat...

journal_title：Physics in medicine and biology

authors： Fowler TL,Fulkerson RK,Micka JA,Kimple RJ,Bednarz BP

更新日期：2014-03-21 00:00:00

abstract：:Absorption and emission optical projection tomography (OPT), alternatively referred to as optical computed tomography (optical-CT) and optical-emission computed tomography (optical-ECT), are recently developed three-dimensional imaging techniques with value for developmental biology and ex vivo gene expression studies...

journal_title：Physics in medicine and biology

authors： Fumene Feruglio P,Vinegoni C,Gros J,Sbarbati A,Weissleder R

更新日期：2010-09-21 00:00:00

abstract：:A motorized electron multileaf collimator (eMLC) was developed as an add-on device to the Varian linac for delivery of advanced electron beam therapy. It has previously been shown that electron beams collimated by an eMLC have very similar penumbra to those collimated by applicators and cutouts. Thus, manufacturing pa...

journal_title：Physics in medicine and biology

authors： Eldib A,Jin L,Li J,Ma CM

更新日期：2013-08-21 00:00:00

abstract：:We investigate the effect of multiple scattering on the optical coherence tomography (OCT) signal and the Doppler OCT signal of flowing blood. Doppler OCT measurements at 1300 nm are performed on flowing diluted porcine blood with hematocrit ranging between 0% and 15%. Measured blood hematocrit and mean red blood cell...

journal_title：Physics in medicine and biology

authors： Kalkman J,Bykov AV,Streekstra GJ,van Leeuwen TG

更新日期：2012-04-07 00:00:00

abstract：:In nonlinear optimisation, using exact Hessian computations (full-Newton) hold superior convergence properties over quasi-Newton methods or gradient-based methods. However, for medium-scale problems, computing the Hessian can be computationally expensive and thus time-consuming. For solvers dedicated to a specific pro...

journal_title：Physics in medicine and biology

authors： van Haveren R,Breedveld S

更新日期：2019-08-14 00:00:00

abstract：:Cylindrical homogenous phantoms for magnetic resonance (MR) elastography in biomedical research provide one way to validate an imaging systems performance, but the simplified geometry and boundary conditions can cloak complexity arising at tissue interfaces. In an effort to develop a more realistic gel tissue phantom ...

journal_title：Physics in medicine and biology

authors： Schwartz BL,Yin Z,Magin RL

更新日期：2016-09-21 00:00:00

abstract：:By means of a transonic gas jet, gene guns ballistically deliver microparticle formulations of drugs and vaccines to the outer layers of the skin or mucosal tissue to induce unique physiological responses for the treatment of a range of conditions. Reported high-speed imaging experiments show that the mucosa deforms s...

journal_title：Physics in medicine and biology

authors： Hardy MP,Kendall MA

更新日期：2005-10-07 00:00:00

abstract：:Catheter-based ultrasound devices provide a method to deliver 3D conformable heating integrated with HDR brachytherapy delivery. Theoretical characterization of heating patterns was performed to identify implant strategies for these devices which can best be used to apply hyperthermia to cervical cancer. A constrained...

journal_title：Physics in medicine and biology

authors： Wootton JH,Prakash P,Hsu IC,Diederich CJ

更新日期：2011-07-07 00:00:00

abstract：:We propose a completely automated algorithm for the detection of the spinal centreline and the centres of vertebral bodies and intervertebral discs in images acquired by computed tomography (CT) and magnetic resonance (MR) imaging. The developed methods are based on the analysis of the geometry of spinal structures an...

journal_title：Physics in medicine and biology

authors： Stern D,Likar B,Pernus F,Vrtovec T

更新日期：2010-01-07 00:00:00

abstract：:Fractional flow reserve (FFR) provides an objective physiological evaluation of stenosis severity. A technique that can measure FFR using only angiographic images would be a valuable tool in the cardiac catheterization laboratory. To perform this, the diseased blood flow can be measured with a first pass distribution ...

journal_title：Physics in medicine and biology

authors： Wong JT,Molloi S

更新日期：2008-07-21 00:00:00

abstract：:A general theory is presented for minimizing noise in linear dimension reduction of sequences of medical images when the factors and the covariance matrix and mean of the noise are given. A dimension reduction is optimal when all diagonal elements in the covariance matrix of the noise in the signal (factor) space are ...

journal_title：Physics in medicine and biology

authors： Hermansen F,Lammertsma AA

更新日期：1995-11-01 00:00:00

abstract：:Two complementary approaches to the noise suppression problem in on-line portal imaging have been analysed. Temporal filtering by image summation can substantially reduce the amount of noise in an image. In many cases, however, movements of the patient or the radiation source limit the time period over which the avera...

journal_title：Physics in medicine and biology

authors： Leszczynski KW,Shalev S,Cosby NS

更新日期：1990-03-01 00:00:00

abstract：:Ultrasound Doppler (UD) velocity measurements are commonly used to quantify blood flow velocities in vivo. The aim of our work was to investigate the accuracy of in vivo spectral Doppler measurements of velocity waveforms. Waveforms were derived from spectral Doppler signals and corrected for intrinsic spectral broade...

journal_title：Physics in medicine and biology

authors： Jiang J,Strother C,Johnson K,Baker S,Consigny D,Wieben O,Zagzebski J

更新日期：2011-03-21 00:00:00

abstract：:In this paper we present a novel method of reducing the dosimetric effects of the finite leaf width of a multileaf collimator (MLC) in conformal and intensity modulated radiotherapy (IMRT). This is achieved by decomposing the required high-resolution fluence distribution into two orthogonal components, which are deliv...

journal_title：Physics in medicine and biology

authors： Evans PM,Partridge M

更新日期：2000-03-01 00:00:00

abstract：:This work applies a previously developed analytical algorithm to the reconstruction problem in a rotating multi-segment slant-hole (RMSSH) SPECT system. The RMSSH collimator has greater detection efficiency than the parallel-hole collimator with comparable spatial resolution at the expense of limited common volume-of-...

journal_title：Physics in medicine and biology

authors： Huang Q,Xu J,Tsui BM,Gullberg GT

更新日期：2009-07-07 00:00:00

abstract：:For the first time the absolute photon mass energy-absorption coefficient of air in the energy range of 10 to 60 keV has been measured with relative standard uncertainties below 1%, considerably smaller than those of up to 2% assumed for calculated data. For monochromatized synchrotron radiation from the electron stor...

journal_title：Physics in medicine and biology

authors： Buhr H,Büermann L,Gerlach M,Krumrey M,Rabus H

更新日期：2012-12-21 00:00:00

abstract：:We present a novel linear programming (LP) based approach for efficiently solving the intensity modulated radiation therapy (IMRT) fluence-map optimization (FMO) problem to global optimality. Our model overcomes the apparent limitations of a linear-programming approach by approximating any convex objective function by...

journal_title：Physics in medicine and biology

authors： Romeijn HE,Ahuja RK,Dempsey JF,Kumar A,Li JG

更新日期：2003-11-07 00:00:00