Abstract:
:The current study aimed to explore whether the efficiency of the standard International Prognostic Index (S-IPI), revised-IPI (R-IPI) and enhanced-IPI (NCCN-IPI) in evaluating the prognosis of patients with diffuse large B-cell lymphoma (DLBCL) may be improved by interim 18F-FDG PET/CT. A total of 185 patients with newly diagnosed DLBCL were enrolled in the current study. All patients underwent interim PET/CT following the 4th cycle of chemotherapy. Patients were divided into different risk groups using S-IPI, R-IPI and NCCN-IPI and further subdivided into risk groups using interim PET/CT. Interpretations were evaluated for 2-year progression-free survival (PFS) and overall survival (OS). With a median follow-up time of 44 months, the 2-year PFS and OS were 60% [95% confidence interval (CI) 53-67%] and 81% (95% CI 74-86%), respectively. Analysis of S-IPI and NCCN-IPI identified no significant difference in PFS and OS between high intermediate and high risk groups. However, there were significant differences in the PFS and OS between the low and low intermediate risk groups (P<0.01). Interim PET/CT was used to redistribute patients in the higher risk group into PET negative and positive groups (P<0.01) and arallel results were observed in the lower risk group. In R-IPI, interim PET/CT identified a significant difference between PFS and OS in the good and poor risk groups but not in the very good risk group. Therefore, the results of the current study indicate that S-IPI, R-IPI and NCCN-IPI are three clinically useful prognostic indexes for patients with DLBCL. Interim PET/CT may improve the prognostic value of S-IPI, R-IPI and NCCN-IPI in predicting 2-year PFS and OS, particularly in patients with a high IPI score.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Jiang M,Chen P,Ruan X,Ye X,Pan Y,Zhang J,Huang Q,Zhou W,Wu H,Wang Qdoi
10.3892/ol.2017.7093subject
Has Abstractpub_date
2017-12-01 00:00:00pages
6715-6723issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-7093journal_volume
14pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::The present study aimed to screen the regulatory mechanism of microRNA (miR/miRNA) typing on gastric cancer cells in gastric cancer tissues. In total, 46 patients who underwent gastric resection in Xiangya Hospital of Central-South University (Changsha, Hunan, China) between January and December 2012 were selected. Ga...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2232
更新日期:2014-08-01 00:00:00
abstract::Retroperitoneal liposarcoma is a rare tumor with an incidence of 2.5 per million individuals. Early diagnosis is difficult as there is an absence of specific clinical presentations. The present case study reports a patient diagnosed with retroperitoneal liposarcoma who was treated by complete surgical resection and re...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3193
更新日期:2015-07-01 00:00:00
abstract::Lung cancer is one of the most common cancers, which is the leading cause of cancer-related death among various cancers worldwide. Flavokawain A (FKA), a chalcone found in the kava plant, exerts potent anticancer activity. However, the activity and mechanisms of FKA in inhibiting the viability of paclitaxel (PTX)-resi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11069
更新日期:2020-01-01 00:00:00
abstract::The histological subtype of non-small-cell lung cancer (NSCLC) is a significant factor when selecting treatment strategies. However, cases are occasionally encountered that are diagnosed as 'not otherwise specified' (NOS) prior to surgery, due to an uncertain histological subtype. The present study investigated the pr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2302
更新日期:2014-09-01 00:00:00
abstract::The occurrence of primary carcinoma of the ureteral stump following radical nephrectomy for renal cell carcinoma is extremely rare; 7 patients with the disease have been reported previously. All these patients were males with transitional cell carcinoma. The current study reports the case of a 61-year-old woman, who p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4426
更新日期:2016-05-01 00:00:00
abstract::DJ-1 and HSP90α play a significant role in the progression of various types of cancer and are known to be associated with phosphatase and tensin homolog deleted on chromosome 10 (PTEN), PI3K-p110α and pAkt, the signaling molecule proteins from the phosphatidylinositol 3-kinase (PI3K) pathway. However, the expression o...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.522
更新日期:2012-03-01 00:00:00
abstract::Sigma-1 receptor (sigma-1R), a 25-kDa integral membrane protein, is expressed at a high density in various tumor cell lines and its ligands mediate tumor cell proliferation. However, the effect of this receptor on proliferation and the associated intracellular molecules in tumors remains unclear. The present study aim...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9448
更新日期:2018-11-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a common tumor in south China. Kinesin family member 2A (KIF2A) belongs to the kinesin-13 family and is associated with the growth and invasion of a number of different types of human cancer, including ovarian, breast and prostate cancer. The aim of the present study was to evaluate t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10597
更新日期:2019-09-01 00:00:00
abstract::The elbow is an uncommon site for malignant bone tumors. Surgical options for the reconstruction of the elbow joint are limited and technically challenging. In this study, we describe a patient with osteosarcoma of the proximal ulna treated by wide resection and reconstruction with a combined use of free vascularised ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000024
更新日期:2010-01-01 00:00:00
abstract::The clinical significance of the proteasome inhibitor MG132 has been examined in numerous human cancer types; however, its influence on the metastasis and progression of pancreatic cancer is yet to be determined. In the present study, the effect of MG132 treatment on pancreatic ductal adenocarcinoma (PDAC) cell lines ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11157
更新日期:2020-01-01 00:00:00
abstract::Gastric cancer (GC) is a malignant tumor that negatively impacts human health, which typically presents in the advanced stages of disease in the majority of patients. Despite the development of combination chemotherapy, only a modest survival advantage is gained in patients with GC treated by this method. Recently, ca...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2019.10935
更新日期:2019-12-01 00:00:00
abstract::Inflammatory myofibroblastic tumor (IMT) is a rare type of mesenchymal tumor, which may affect various organs. The preferential site for IMT in the genitourinary system is the urinary bladder, while the presence of IMT in the kidney, and particularly in the renal pelvis, is rare. In the present report, the case of a 4...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3767
更新日期:2015-12-01 00:00:00
abstract::A 77-year-old female, with proptosis, reduced eye motility and diplopia which had developed over two to three months and a 69-year-old female with proptosis, oedema of the eyelid, reduced motility and ptosis, which had developed over three weeks, are presented in the present study. Computed tomography scans revealed i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3282
更新日期:2015-08-01 00:00:00
abstract::The role of tumor-infiltrating lymphocytes (TILs) suggests that cancer is a disease with not only a genetic, but also an immunological basis. Additionally, immune cell infiltration is an important feature of oral cancer. C-X-C motif chemokine ligand 12 (CXCL12) serves an important role in immune suppression in the tum...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10415
更新日期:2019-08-01 00:00:00
abstract::5,7-dihydroxy-3',4',6-trimethoxyflavone, commonly known as eupatilin, is a traditional Asian medicinal plant, which is mainly used for the treatment of gastritis, as well as its use as an anti-inflammatory agent. Eupatilin is a bioactive compound; however, its effects on osteosarcoma (OS) have remained to be elucidate...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3563
更新日期:2015-10-01 00:00:00
abstract::Traditional Chinese medicine, based on theories developed and practiced for >2,000 years, is one of the most common complementary and alternative types of medicine currently used in the treatment of patients with breast cancer. Ruanjian Sanjie (RJSJ) decoction, is composed of four herbs, including Ban xia (Pinellia te...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5832
更新日期:2017-05-01 00:00:00
abstract::Non-steroidal nuclear receptors play a major role in breast cancer development. A correlation among, and possible prognostic function of, the members of the nuclear receptor superfamily has been discussed controversially over the years. Hence, we conducted a quantification of the different expression levels of the thy...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.799
更新日期:2012-10-01 00:00:00
abstract::Colon cancer is the second most common type of cancer in females and the third in males, worldwide. The most common sites of colon cancer metastasis are the regional lymph nodes, liver, lung, bone and brain. In this study, an extremely rare case of colon adenocarcinoma with extensive metastasis to the mediastinal lymp...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2426
更新日期:2014-11-01 00:00:00
abstract::Abnormal glucose metabolism is critical in colorectal cancer (CRC) development. Expression of the pyruvate kinase (PK) M2 isoform, rather than the PKM1 isoform, serves important functions in reprogramming the glucose metabolism of cancer cells. Preferential expression of PKM2 is primarily driven by alternative splicin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7085
更新日期:2017-12-01 00:00:00
abstract::microRNAs (miRNAs) have been hypothesized to function as oncogenes or tumor suppressors by targeting specific cancer-related genes. Previous studies have reported that miR-223 may serve as a tumor suppressor in a number of cancer types, however, knowledge of its targets in non-small cell lung cancer (NSCLC) remains li...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1375
更新日期:2013-08-01 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC), one of the most common malignant tumors, endangers human health. Recently, the incidence of HNSCC has kept increasing: However, its prognosis has not significantly improved. Understanding the molecular mechanism underlying HNSCC development will therefore provide new stra...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10920
更新日期:2019-12-01 00:00:00
abstract::Intramuscular myxoma (IM) is a benign intramuscular neoplasm composed of fibroblasts and abundant myxoid stroma. IMs most commonly affect larger skeletal muscles, while those affecting the oral and maxillofacial regions are rare, with a small number of documented cases in the available literature. The aim of the prese...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1955
更新日期:2014-05-01 00:00:00
abstract::Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related protein (DC-SIGNR) is a type II transmembrane protein that has been reported to bind to various pathogens and participate in immunoregulation and tumorigenesis. However, further research is required to investigate whether the level ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6508
更新日期:2017-09-01 00:00:00
abstract::Voltage-dependent anion channels (VDACs) are situated in the outer membrane of the mitochondria and serve as gatekeepers that control metabolite and ion exchange between the cytosol and mitochondria. VDAC1 is one of the most studied members of the VDAC protein family and is overexpressed in multiple types of cancer. H...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10534
更新日期:2019-09-01 00:00:00
abstract::A 54-year-old female presented with a large pancreatic tumor of the tail during a regular physical examination. The patient underwent surgical intervention and the surgeon identified that the tumor originated from the retroperitoneal region. Markedly severe hemodynamic fluctuations occurred during the manipulation of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1447
更新日期:2013-09-01 00:00:00
abstract::Hyperparathyroidism is characterized by the oversecretion of parathyroid hormone biochemically and increased cell proliferation histologically. Primary and secondary hyperparathyroidism exhibit distinct pathophysiology but share certain common microscopic features. The present study performed the first genome-wide exp...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4623
更新日期:2016-07-01 00:00:00
abstract::Cluster of differentiation 44 (CD44), a marker for cancer stem cells, has been reported to be associated with poor prognosis in non-small cell lung cancer (NSCLC), but its involvement in tumor growth has not fully been elucidated. The present study explored the associations between CD44 expression and clinicopathologi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8051
更新日期:2018-04-01 00:00:00
abstract::The epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal transition (EMT)-assoc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5406
更新日期:2017-01-01 00:00:00
abstract::Patients with renal medullary carcinoma (RMC) have a poor prognosis, usually due to late diagnosis. Computed tomography (CT) analysis may aid the differentiation between RMC and other types of renal cell carcinoma, in order to establish an accurate early diagnosis. There is a limited number of reports in the literatur...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3891
更新日期:2016-01-01 00:00:00
abstract::As a member of the tripartite motif family, tripartite motif-containing protein 59 (TRIM59) serves as an E3 ubiquitin ligase in various cellular processes, including intracellular signaling, development, apoptosis, protein quality control, innate immunity, autophagy and carcinogenesis. The present study aimed to inves...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11199
更新日期:2020-02-01 00:00:00