Abstract:
:The present study selected and characterized a multidrug-resistant HL-60 human acute promyelocytic leukemia cell line, HL-60/RS, by exposure to stepwise incremental doses of doxorubicin. The drug-resistant HL-60/RS cells exhibited 85.68-fold resistance to doxorubicin and were cross-resistant to other chemotherapeutics, including cisplatin, daunorubicin, cytarabine, vincristine and etoposide. The cells over-expressed the transporters P-glycoprotein, multidrug-resistance-related protein 1 and breast-cancer-resistance protein, encoded by the adenosine triphosphate-binding cassette (ABC)B1, ABCC1 and ABCG2 genes, respectively. Unlike other recognized chemoresistant leukemia cell lines, HL-60/RS cells were also strongly cross-resistant to arsenic trioxide. The proportion of leukemia stem cells (LSCs) increased synchronously with increased of drug resistance in the doxorubicin-induced HL-60 cell population. The present study confirmed that doxorubicin-induced HL-60 cells exhibited multidrug-resistance and high arsenic-trioxide resistance. Drug-resistance in these cells may be due to surviving chemoresistant LSCs in the HL-60 population, which have been subjected to long and consecutive selection by doxorubicin.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Chen J,Wei H,Cheng J,Xie B,Wang B,Yi J,Tian B,Liu Z,Wang F,Zhang Zdoi
10.3892/ol.2017.7353subject
Has Abstractpub_date
2018-01-01 00:00:00pages
1255-1262issue
1eissn
1792-1074issn
1792-1082pii
OL-0-0-7353journal_volume
15pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, fast-growing, benign tumor originating from the neural crest. The tumor most often occurs during the first year of life. The predilection site of MNTI is the anterior maxilla, whereas lesions of the mandible are uncommon and account for only 6% of all cases....
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2665
更新日期:2015-01-01 00:00:00
abstract::Current endocrine therapies for females with estrogen receptor-positive breast cancer have facilitated substantial improvements in outcomes. The effectiveness of endocrine therapy is limited by either initial de novo resistance or acquired endocrine resistance. Multiple mechanisms responsible for endocrine resistance ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1405
更新日期:2013-08-01 00:00:00
abstract::Invasive breast carcinoma (BRCA) is a serious disease that threatens the survival time of those affected. Alternative splicing (AS) involved in BRCA pathogenesis may be a potential therapeutic target. However, to the best of our knowledge, a systematic analysis of survival-related alternative splicing events (SREs) ha...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11695
更新日期:2020-08-01 00:00:00
abstract::Previous studies have reported that basic fibroblast growth factor (bFGF) is associated with tumor genesis, growth and prognosis. The present study was conducted to detect the levels of bFGF expression in women with non-small cell lung cancer (NSCLC), colon cancer, breast cancer and melanoma, and analyze its associati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6335
更新日期:2017-08-01 00:00:00
abstract::The present study evaluated androgen deprivation methods to determine the approach that most improves the progression-free survival (PFS) of patients with metastatic prostate cancer. Patients had received continuous maximal androgen blockade (MAB) or monotherapy [luteinizing-hormone releasing hormone (LHRH) agonist or...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6056
更新日期:2017-06-01 00:00:00
abstract::The characteristics of the proliferation of B-cell activating factor (BAFF) and the proliferation-inducing ligand (APRIL) mRNA expression in mononuclear cell in multiple myeloma patients were detected, and the correlation was analyzed between the BAFF and APRIL concentrations in plasma and tumor burden parameters of m...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6528
更新日期:2017-09-01 00:00:00
abstract::In the present study, the function and mechanism of cytokine-induced killer cells (CIK) combined with dendritic cells (DC-CIK) were examined in Lewis lung cancer (LLC) cells. Co-culture of CIK dendritic cells (DC) in vitro was used to investigate their proliferation and the antitumor effects on LLC cells. DC and CIK c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8834
更新日期:2018-08-01 00:00:00
abstract::Acute lymphoblastic leukemia (ALL) accounts for 30% of all pediatric cancers. Currently available treatments exhibit toxicity and certain patients may develop resistance. Thus, less toxic and chemoresistance-reversal agents are required. In the present study, the potential effect of curcumin, a component of Curcuma lo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5217
更新日期:2016-11-01 00:00:00
abstract::Aberrant expression of microRNAs (miRNAs) contributes to the progression and outcomes of several types of tumor, while circulating miRNAs have been reported to act as biomarkers for several types of cancer. To identify specific circulating miRNAs associated with multiple myeloma (MM), a miRNA microarray analysis was u...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9128
更新日期:2018-09-01 00:00:00
abstract::Radical cystectomy, as the most common surgical treatment for patients with invasive bladder cancer (IBC) complicated by peritoneal metastasis, is usually accompanied by a urinary diversion procedure. In this study, we evaluated the improved tubeless cutaneous ureterostomy technique by comparing the resulting clinical...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.4045
更新日期:2016-02-01 00:00:00
abstract::Hepcidin and ferroportin, which are known as key iron regulators, may be used in future treatments of pancreatic ductal adenocarcinoma. Iron is essential for life support; it helps oxygen molecules bind to hemoglobin and acts as an important catalytic enzyme center. However, iron overload is a risk factor for cancer, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8357
更新日期:2018-05-01 00:00:00
abstract::Hedgehog (HH) and Wnt pathway activation have been implicated in poor prognosis of breast cancer. Crosstalk between these two pathways has been demonstrated to be important in breast cancer progression, however the association between these two pathways and breast cancer survival rate is unknown. The present study com...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6874
更新日期:2017-11-01 00:00:00
abstract::The traditional Chinese medicine Jinfukang (JFK) has been shown as a valuable drug to treat non-small cell lung cancer (NSCLC). Previously, it was reported that JFK-induced epigenetic alteration is involved in anti-lung cancer activity. In the present study, the effect of JFK on lung cancer cell lines was examined wit...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9149
更新日期:2018-10-01 00:00:00
abstract::Extragastrointestinal stromal tumors (EGISTs) are relatively rare soft tissue neoplasms arising from the extra gastrointestinal tract. The current study presents a case of primary EGIST of the prostate observed in a 55-year-old male. Imaging studies showed a 10×10.5×9.5-cm prostate mass. On histological observation, t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1968
更新日期:2014-06-01 00:00:00
abstract::The present study aimed to investigate the clinical characteristics, diagnosis and treatment of accessory breast cancer, and contribute valuable information regarding this rare tumour to the current literature, ultimately facilitating the development of improved treatment strategies. The present study reported the cas...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3388
更新日期:2015-09-01 00:00:00
abstract::The predominant characteristic of malignant glioma is the presence of invading tumor cells in the peritumoral zone. Distinguishing between tumor cells and normal cells in a peritumoral lesion is challenging. Therefore, the aim of the present study was to investigate the cell-cycle phase measurements of fixed paraffin-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4205
更新日期:2016-03-01 00:00:00
abstract::Physical activity offers a paradoxical hormetic effect and a health benefit to cancer survivors; however, the biochemical mechanisms have not been entirely elucidated. Despite the well-documented evidence implicating oxidative stress in breast cancer, the association between health benefits and redox status has not be...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5449
更新日期:2017-01-01 00:00:00
abstract::The radiological features of pulmonary sclerosing hemangioma (PSH) and pulmonary hamartoma are poorly specified. Thus, the present study aimed to compare and analyze the characteristics of fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in PSH versus pulmonary hamartoma. 18F-FDG PE...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8660
更新日期:2018-07-01 00:00:00
abstract::Glutathione S-transferases (GSTs) participate in the detoxification and elimination of electrophilic carcinogens by conjugating them to glutathione. Previous studies have reported a potential association between GSTM1 polymorphism and the risk of developing nasopharyngeal cancer (NPC). However, those findings remain c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3848
更新日期:2016-01-01 00:00:00
abstract::Osteosarcoma is the most common primary bone tumor and predominantly affects children and adolescents. The prognosis for patients with osteosarcoma is poor. Therefore, the development of novel treatments for osteosarcoma is required. Photodynamic therapy (PDT) is a disease site-specific treatment that utilizes a photo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9322
更新日期:2018-10-01 00:00:00
abstract::A nitroxide radical, Tempol (Tempol, TPL), is usually used as an antioxidative agent clinically, whereas the mechanism underlying its pro-oxidative effect has not been thoroughly investigated. The present study investigated the pro-oxidative effect of TPL on the inhibition of cellular proliferation and its role in enh...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9289
更新日期:2018-10-01 00:00:00
abstract::The present study aimed to explore the diagnostic and prognostic value of lncRNA maternally expressed 3 (MEG3) in cervical cancer. Eighty-four patients with cervical cancer from February 2013 to March 2014 were enrolled in the observation group (OG), and another 58 female subjects who underwent physical examination at...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12044
更新日期:2020-11-01 00:00:00
abstract::Primary mediastinal extraskeletal Ewing's sarcoma (EES) is quite rare. To the best of our knowledge, only five cases have been reported. Given the paucity of data, there is consequently no optimal treatment strategy available. The current study presents the case of a 51-year-old female with unresectable EES of the pos...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2788
更新日期:2015-02-01 00:00:00
abstract::Normal and cancerous cells are suggested to have differential utilization of fatty acids and ketone bodies, which could be exploited in cancer therapy. The present study examined the effect of 3-hydroxybutyric acid (3-HBA), which is a ketone body generating acetyl-CoA, and lauric acid (LAA, C12:0), which is a medium-c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6195
更新日期:2017-07-01 00:00:00
abstract::Exosomes derived from tumor cells are essential for processes involved in tumor progression, including angiogenesis, tumor cell proliferation and immunoregulation. In addition, exosome secretion may contribute to the mechanisms of hypoxia-induced angiogenesis and metastasis of tumors. In the present study, as it is on...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3841
更新日期:2016-01-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a common malignancy of the head and neck. The aim of the present study was to conduct an integrated bioinformatics analysis of differentially expressed genes (DEGs) and to explore the molecular mechanisms of NPC. Two profiling datasets, GSE12452 and GSE34573, were downloaded from the ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10382
更新日期:2019-07-01 00:00:00
abstract::MicroRNAs are proposed to serve vital functions in the regulation of tumor progression and invasion. However, the expression levels of miR-203 in non-small cell lung cancer (NSCLC) and its clinical significance remain unknown. In the present study, the association between B-cell-specific moloney murine leukemia virus ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3080
更新日期:2015-06-01 00:00:00
abstract::Aquaporin 5 (AQP5), a water channel protein, is highly expressed in non-small cell lung cancer (NSCLC) tissues compared with adjacent normal tissues. AQP5 expression in lung cancer tissues is associated with a poor prognosis. The present study aimed to analyze the expression of AQP5 and investigate its role in primary...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3108
更新日期:2015-06-01 00:00:00
abstract::We present the case of a patient with a solitary left frontoparietal brain metastasis of melanoma previously treated with surgery. Three months later, the patient was admitted to the emergency room in a confusional state with meningeal signs. A cerebrospinal fluid (CSF) test and magnetic resonance imaging findings sug...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2010.194
更新日期:2010-11-01 00:00:00
abstract::A 77-year-old female, with proptosis, reduced eye motility and diplopia which had developed over two to three months and a 69-year-old female with proptosis, oedema of the eyelid, reduced motility and ptosis, which had developed over three weeks, are presented in the present study. Computed tomography scans revealed i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3282
更新日期:2015-08-01 00:00:00