Abstract:
:Biomedical applications such as cell tracking and angiography require the detection of low concentrations of superparamagnetic iron oxide nanoparticles (SPIOs) for imaging purposes. Magnetic particle imaging (MPI) is a new technology which enables the quantitative and time-resolved localization of SPIO distributions. However, the minimum concentration at which the SPIOs can be reconstructed with a suitable quality still remains to be investigated. In this work we examine the background signals in raw data that were measured without any SPIOs in the scanner tube. We show that a background subtraction in combination with a frequency cutoff for the dynamic part of the background signal lowers the detection limit for SPIOs in MPI up to a factor of ten. In-vivo mouse experiments show that for early time points from when the tracer enters the vena cava a reconstructed image of sufficient quality can only be obtained when a background subtraction is performed.
journal_name
IEEE Trans Med Imagingjournal_title
IEEE transactions on medical imagingauthors
Them K,Kaul MG,Jung C,Hofmann M,Mummert T,Werner F,Knopp Tdoi
10.1109/TMI.2015.2501462subject
Has Abstractpub_date
2016-03-01 00:00:00pages
893-900issue
3eissn
0278-0062issn
1558-254Xjournal_volume
35pub_type
杂志文章abstract::The polymeric implant material poly(lactide-co-glycolide) (PLGA) degrades by a process of bulk degradation, which allows it to be used for the controlled release of therapeutic molecules from implants and microspheres. The temporal characterization of PLGA microsphere degradation has been limited by the need to destru...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2008.927356
更新日期:2009-01-01 00:00:00
abstract::We propose an approach that combines an asymmetric fan-beam configuration and a new reconstruction algorithm to enhancing spatial resolution in computed tomography (CT). The asymmetric configuration can be achieved by changing the center of rotation (COR) from the conventional symmetric configuration. It does not, how...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/tmi.2004.840846
更新日期:2005-02-01 00:00:00
abstract::Cataract is the clouding of lens, which affects vision and it is the leading cause of blindness in the world's population. Accurate and convenient cataract detection and cataract severity evaluation will improve the situation. Automatic cataract detection and grading methods are proposed in this paper. With prior know...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2019.2928229
更新日期:2020-02-01 00:00:00
abstract::Identification of objective criteria to correctly diagnose ectatic diseases of the cornea or to detect early stages of corneal ectasia is of great interest in ophthalmology and optometry. Metrics for diagnosis typically employed are curvature maps (axial/sagittal, tangential); elevation map of the anterior surface of ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2018.2836304
更新日期:2018-11-01 00:00:00
abstract::Cardiac resynchronization therapy (CRT) has been shown to improve cardiovascular function in specific patients suffering from heart failure. This procedure still needs to be optimized to overcome the high rate of implanted patients that do not respond to this therapy. We propose in this work a better characterization ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2014.2311694
更新日期:2014-06-01 00:00:00
abstract::Magnetic resonance imaging (MRI) reconstruction techniques are often validated with signal-to-noise ratio (SNR), contrast-to-noise ratio, and mean-to-standard-deviation ratio measured on example images. We present human and model observers as a novel approach to evaluating reconstructions for low-SNR magnetic resonanc...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2006.881374
更新日期:2006-11-01 00:00:00
abstract::A reconstruction algorithm to simultaneously estimate the shape and location of three-dimensional breast cancer tumor is presented and its utility is analyzed. The approach is based on a spherical harmonic decomposition to capture the shape of the tumor. We combine a gradient descent optimization method with a direct ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/tmi.2006.881377
更新日期:2006-10-01 00:00:00
abstract::Ovarian ultrasound is an effective tool in infertility treatment. Repeated measurements of the size and shape of follicles over several days are the primary means of evaluation by physicians. Currently, follicle wall segmentation is achieved by manual tracing which is time consuming and susceptible to inter-operator v...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.746626
更新日期:1998-12-01 00:00:00
abstract::The authors describe a technique to reduce truncation artifacts in chemical shift images taken for in vivo magnetic resonance spectroscopy by using boundary information available from anatomic images. In this approach, high spatial frequency components are extrapolated from the observed data by making use of the bound...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.97578
更新日期:1991-01-01 00:00:00
abstract::Photon counting computed tomography (PCCT) has the ability to identify individual photons, resulting in quantitative material identification. Meanwhile, several technical challenges still exist in current PCCT imaging systems, including increased noise and suboptimal bin selection. These nonideal effects can substanti...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2020.3001616
更新日期:2020-11-01 00:00:00
abstract::The National Library of Medicine (NLM) is developing a digital chest X-ray (CXR) screening system for deployment in resource constrained communities and developing countries worldwide with a focus on early detection of tuberculosis. A critical component in the computer-aided diagnosis of digital CXRs is the automatic ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2013.2290491
更新日期:2014-02-01 00:00:00
abstract::After a brief discussion of the algebraic reconstruction techniques (ART), we introduce the attenuation problem in positron emission tomography (PET). We anticipate that a generalization of ART, the so-called cyclic subgradient projection (CSP) method, may be useful for solving this problem. This, however, has not bee...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.1982.4307567
更新日期:1982-01-01 00:00:00
abstract::The development and tests of an iterative reconstruction algorithm for emission tomography based on Bayesian statistical concepts are described. The algorithm uses the entropy of the generated image as a prior distribution, can be accelerated by the choice of an exponent, and converges uniformly to feasible images by ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.56340
更新日期:1990-01-01 00:00:00
abstract::In this paper, discrepancies and reference inaccuracies in the paper (Grana et al., 2003) are pointed out. Specifically, it is demonstrated that the definitions of "lesion gradient" and "skin lesion gradient," widely used in a number of medical papers on computer analysis of pigmented skin lesions, are unambiguous, an...
journal_title:IEEE transactions on medical imaging
pub_type: 评论,信件
doi:10.1109/tmi.2006.884205
更新日期:2006-12-01 00:00:00
abstract::Diffuse optical tomography (DOT) is a noninvasive technique which measures hemodynamic changes in the tissue with near infrared light, which has been increasingly used to study brain functions. Due to the nature of light propagation in the tissue, the reconstruction problem is severely ill-posed. For linearized DOT pr...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2014.2338214
更新日期:2014-12-01 00:00:00
abstract::Time-of-flight (TOF) positron emission tomography (PET) scanners offer the potential for significantly improved signal-to-noise ratio (SNR) and lesion detectability in clinical PET. However, fully 3D TOF PET image reconstruction is a challenging task due to the huge data size. One solution to this problem is to rebin ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2011.2149537
更新日期:2011-10-01 00:00:00
abstract::This paper describes the implementation of a novel and robust threshold energy calibration method for photon counting detectors using polychromatic X-ray tubes. Methods often used for such energy calibration may require re-orientation of the detector or introduce calibration errors that are flux and acquisition time-d...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2018.2875932
更新日期:2019-04-01 00:00:00
abstract::The theory and techniques of compressed sensing (CS) have shown their potential as a breakthrough in accelerating k-space data acquisition for parallel magnetic resonance imaging (pMRI). However, the performance of CS reconstruction models in pMRI has not been fully maximized, and CS recovery guarantees for pMRI are l...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2015.2474383
更新日期:2016-01-01 00:00:00
abstract::Magnetic resonance (MR) tagging has been shown to be a useful technique for noninvasively measuring the deformation of an in vivo heart. An important step in analyzing tagged images is the identification of tag lines in each image of a cine sequence. Most existing tag identification algorithms require user defined myo...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.768842
更新日期:1999-04-01 00:00:00
abstract::We compare different possible scanning geometries for prostate photoacoustic tomography (PAT) while considering a realistic reconstruction scenario in which the limited view of the prostate and the directivity effect of the transducer are considered. Simulations and experiments confirm that an intra-operative configur...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2018.2855166
更新日期:2019-01-01 00:00:00
abstract::A novel approach to correcting for intensity nonuniformity in magnetic resonance (MR) data is described that achieves high performance without requiring a model of the tissue classes present. The method has the advantage that it can be applied at an early stage in an automated data analysis, before a tissue model is a...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.668698
更新日期:1998-02-01 00:00:00
abstract::Magnetic resonance imaging (MRI) on patients with implanted deep brain stimulators (DBSs) can be hazardous because of the antenna-effect of leads exposed to the incident radio-frequency field. This study evaluated electromagnetic field and specific absorption rate (SAR) changes as a function of lead resistivity on an ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2010.2040624
更新日期:2010-04-01 00:00:00
abstract::Magnetic resonance (MR) fingerprinting is a technique for acquiring and processing MR data that simultaneously provides quantitative maps of different tissue parameters through a pattern recognition algorithm. A predefined dictionary models the possible signal evolutions simulated using the Bloch equations with differ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2014.2337321
更新日期:2014-12-01 00:00:00
abstract::An accurate diagnosis of burns and pressure ulcers in the early stages can be made by computerized image processing. This study describes a critical assessment of potential methodologies for noninvasive wound evaluation using a color imaging system. We also developed a method for quantifying histological readings and ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.552057
更新日期:1997-02-01 00:00:00
abstract::A method for fully automated morphological and topological quantification of microvascular structures in confocal laser scanning microscopy (CLSM) volume datasets is presented. Several characteristic morphological and topological quantities are calculated in a series of image-processing steps and can be used to compar...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2007.900379
更新日期:2007-08-01 00:00:00
abstract::Tomographic reconstruction from positron emission tomography (PET) data is an ill-posed problem that requires regularization. An attractive approach is to impose an l(1) -regularization constraint, which favors sparse solutions in the wavelet domain. This can be achieved quite efficiently thanks to the iterative algor...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2008.923698
更新日期:2008-01-01 00:00:00
abstract::Passive monitoring of the thermal noise variances of the channels of a receive array was shown to reveal respiratory motion of the underlying anatomy, a so called "noise navigator". There is, however, an inevitable trade off between the accuracy and temporal resolution of the noise navigator due to its passive nature....
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2018.2808699
更新日期:2018-08-01 00:00:00
abstract::Certain diseases cause permanent changes to the shapes and densities of nailfold capillaries and, therefore, nailfold capillaroscopy is important as a tool for diagnosing and monitoring these diseases. The first aim of the project is to resolve differences in terminology that have developed over the years in previous ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.921482
更新日期:2001-04-01 00:00:00
abstract::Segmentation of the wrist bones in CT images has been frequently used in different clinical applications including arthritis evaluation, bone age assessment and image-guided interventions. The major challenges include non-uniformity and spongy textures of the bone tissue as well as narrow inter-bone spaces. In this wo...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2016.2529500
更新日期:2016-08-01 00:00:00
abstract::This paper presents a preconditioned Krasnoselskii-Mann (KM) algorithm with an improved EM preconditioner (IEM-PKMA) for higher-order total variation (HOTV) regularized positron emission tomography (PET) image reconstruction. The PET reconstruction problem can be formulated as a three-term convex optimization model co...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2019.2898271
更新日期:2019-09-01 00:00:00