Abstract:
:Time-of-flight (TOF) positron emission tomography (PET) scanners offer the potential for significantly improved signal-to-noise ratio (SNR) and lesion detectability in clinical PET. However, fully 3D TOF PET image reconstruction is a challenging task due to the huge data size. One solution to this problem is to rebin TOF data into a lower dimensional format. We have recently developed Fourier rebinning methods for mapping TOF data into non-TOF formats that retain substantial SNR advantages relative to sinograms acquired without TOF information. However, mappings for rebinning into non-TOF formats are not unique and optimization of rebinning methods has not been widely investigated. In this paper we address the question of optimal rebinning in order to make full use of TOF information. We focus on FORET-3D, which approximately rebins 3D TOF data into 3D non-TOF sinogram formats without requiring a Fourier transform in the axial direction. We optimize the weighting for FORET-3D to minimize the variance, resulting in H(2)-weighted FORET-3D, which turns out to be the best linear unbiased estimator (BLUE) under reasonable approximations and furthermore the uniformly minimum variance unbiased (UMVU) estimator under Gaussian noise assumptions. This implies that any information loss due to optimal rebinning is as a result only of the approximations used in deriving the rebinning equation and developing the optimal weighting. We demonstrate using simulated and real phantom TOF data that the optimal rebinning method achieves variance reduction and contrast recovery improvement compared to nonoptimized rebinning weightings. In our preliminary study using a simplified simulation setup, the performance of the optimal rebinning method was comparable to that of fully 3D TOF MAP.
journal_name
IEEE Trans Med Imagingjournal_title
IEEE transactions on medical imagingauthors
Ahn S,Cho S,Li Q,Lin Y,Leahy RMdoi
10.1109/TMI.2011.2149537subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1808-18issue
10eissn
0278-0062issn
1558-254Xjournal_volume
30pub_type
杂志文章abstract::This paper addresses the long object problem in helical cone-beam computed tomography. We present the PHI-method, a new algorithm for the exact reconstruction of a region-of-interest (ROI) of a long object from axially truncated data extending only slightly beyond the ROI. The PHI-method is an extension of the Radon-m...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.870247
更新日期:2000-05-01 00:00:00
abstract::This paper presents a preconditioned Krasnoselskii-Mann (KM) algorithm with an improved EM preconditioner (IEM-PKMA) for higher-order total variation (HOTV) regularized positron emission tomography (PET) image reconstruction. The PET reconstruction problem can be formulated as a three-term convex optimization model co...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2019.2898271
更新日期:2019-09-01 00:00:00
abstract::The solution of impedance distribution in electrical impedance tomography is a nonlinear inverse problem that requires the use of a regularization method. The generalized Tikhonov regularization methods have been popular in the solution of many inverse problems. The regularization matrices that are usually used with t...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.700740
更新日期:1998-04-01 00:00:00
abstract::Advances in the area of digital chest radiography have resulted in the acquisition of high-quality images of the human chest. With these advances, there arises a genuine need for image processing algorithms specific to the chest, in order to fully exploit this digital technology. We have implemented the well-known tec...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.1987.4307791
更新日期:1987-01-01 00:00:00
abstract::This paper addresses the implementation of image processing and computer vision techniques to automate tracer flow extraction in images obtained by the photochromic dye technique. This task is important in modeled arterial blood flow studies. Currently, it is performed via manual application of B-spline curve fitting....
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.585762
更新日期:1997-06-01 00:00:00
abstract::We describe the efficient algebraic reconstruction (EAR) method, which applies to cone-beam tomographic reconstruction problems with a circular symmetry. Three independant steps/stages are presented, which use two symmetries and a factorization of the point spread functions (PSFs), each reducing computing times and ev...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2005.861707
更新日期:2006-02-01 00:00:00
abstract::The National Library of Medicine (NLM) is developing a digital chest X-ray (CXR) screening system for deployment in resource constrained communities and developing countries worldwide with a focus on early detection of tuberculosis. A critical component in the computer-aided diagnosis of digital CXRs is the automatic ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2013.2290491
更新日期:2014-02-01 00:00:00
abstract::We present a general wavelet-based denoising scheme for functional magnetic resonance imaging (fMRI) data and compare it to Gaussian smoothing, the traditional denoising method used in fMRI analysis. One-dimensional WaveLab thresholding routines were adapted to two-dimensional (2-D) images, and applied to 2-D wavelet ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2004.824234
更新日期:2004-03-01 00:00:00
abstract::Two-dimensional ultrasound sector scans of the left ventricle (LV) are commonly used to diagnose cardiac mechanical function. Present quantification procedures of wall motion by this technique entail inaccuracies, mainly due to relatively poor image quality and the absence of a definition of the relative position of t...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.1987.4307836
更新日期:1987-01-01 00:00:00
abstract::High peak RF amplitude and excessive specific absorption rate (SAR) are two critical concerns for hardware implementation and patient safety in scientific and clinical research for high field MRI using parallel transmissions (pTX). In this paper, we introduce a squeezing strategy to reduce peak RF amplitude and integr...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2018.2828112
更新日期:2018-08-01 00:00:00
abstract::Microcalcifications can be one of the earliest signs of breast cancer. Unfortunately, their appearance in mammograms can be mimicked by dust and dirt entering the imaging process and this has been shown previously to lead to false positives. We use a model of the imaging process and, in particular, the blurring functi...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.811313
更新日期:1999-10-01 00:00:00
abstract::Electromagnetic brain imaging is the reconstruction of brain activity from non-invasive recordings of the magnetic fields and electric potentials. An enduring challenge in this imaging modality is estimating the number, location, and time course of sources, especially for the reconstruction of distributed brain source...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2019.2932290
更新日期:2020-03-01 00:00:00
abstract::Monte Carlo (MC) simulation provides a flexible and robust framework to efficiently evaluate and optimize image processing methods in emission tomography. In this work we present Brain-VISET (Voxel-based Iterative Simulation for Emission Tomography), a method that aims to simulate realistic [ (99m) Tc]-SPECT and [ (18...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2014.2326041
更新日期:2014-10-01 00:00:00
abstract::A new graph-based approach for segmentation of luminal and external elastic lamina (EEL) surface of coronary vessels in gated 20 MHz intravascular ultrasound (IVUS) image sequences (volumes) is presented. The approach consists of a fully automated segmentation stage ("new automated" or NA) and a user-guided computer-a...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2013.2260763
更新日期:2013-08-01 00:00:00
abstract::The polymeric implant material poly(lactide-co-glycolide) (PLGA) degrades by a process of bulk degradation, which allows it to be used for the controlled release of therapeutic molecules from implants and microspheres. The temporal characterization of PLGA microsphere degradation has been limited by the need to destru...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2008.927356
更新日期:2009-01-01 00:00:00
abstract::Two methods of rejecting pileup events in 2-D array detectors used in positron emission tomography (PET) are investigated. Since the methods are based on different physical properties, they were investigated separately and in combination. Method one is based on the fact that valid events in the 2-D array detector occu...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.79481
更新日期:1991-01-01 00:00:00
abstract::The authors describe a technique to reduce truncation artifacts in chemical shift images taken for in vivo magnetic resonance spectroscopy by using boundary information available from anatomic images. In this approach, high spatial frequency components are extrapolated from the observed data by making use of the bound...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.97578
更新日期:1991-01-01 00:00:00
abstract::The mathematical basis of a new imaging modality, induced current electrical impedance tomography (EIT), is investigated, The ultimate aim of this technique is the reconstruction of conductivity distribution of the human body, from voltage measurements made between electrodes placed on the surface, when currents are i...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.293927
更新日期:1994-01-01 00:00:00
abstract::Iterative maximum likelihood (ML) transmission computed tomography algorithms have distinct advantages over Fourier-based reconstruction, but unfortunately require increased computation time. The convex algorithm [1] is a relatively fast iterative ML algorithm but it is nevertheless too slow for many applications. The...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.746730
更新日期:1998-12-01 00:00:00
abstract::We consider 3-D brain structures as continuous parameterized surfaces and present a metric for their comparisons that is invariant to the way they are parameterized. Past comparisons of such surfaces involve either volume deformations or nonrigid matching under fixed parameterizations of surfaces. We propose a new mat...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2010.2099130
更新日期:2011-03-01 00:00:00
abstract::Free-breathing cardiac diffusion tensor imaging (DTI) is a promising but challenging technique for the study of fiber structures of the human heart in vivo. This work proposes a clinically compatible and robust technique to provide three-dimensional (3-D) fiber architecture properties of the human heart. To this end, ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2014.2356792
更新日期:2015-01-01 00:00:00
abstract::The problem of automatic quantification of brain tissue by utilizing single-valued (single echo) magnetic resonance imaging (MRI) brain scans is addressed. It is shown that this problem can be solved without classification or segmentation, a method that may be particularly useful in quantifying white matter lesions wh...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.241885
更新日期:1993-01-01 00:00:00
abstract::We express the performance of the N-class "guessing" observer in terms of the N2-N conditional probabilities which make up an N-class receiver operating characteristic (ROC) space, in a formulation in which sensitivities are eliminated in constructing the ROC space (equivalent to using false-negative fraction and fals...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/tmi.2004.841227
更新日期:2005-03-01 00:00:00
abstract::In this paper, we present a two-stage algorithm for mammogram registration, the geometrical alignment of mammogram sequences. The rationale behind this paper stems from the intrinsic difficulties in comparing mammogram sequences. Mammogram comparison is a valuable tool in national breast screening programs as well as ...
journal_title:IEEE transactions on medical imaging
pub_type: 临床试验,杂志文章
doi:10.1109/TMI.2005.848374
更新日期:2005-06-01 00:00:00
abstract::X-ray computed tomography (CT) using sparse projection views is a recent approach to reduce the radiation dose. However, due to the insufficient projection views, an analytic reconstruction approach using the filtered back projection (FBP) produces severe streaking artifacts. Recently, deep learning approaches using l...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2018.2823768
更新日期:2018-06-01 00:00:00
abstract::After a brief discussion of the algebraic reconstruction techniques (ART), we introduce the attenuation problem in positron emission tomography (PET). We anticipate that a generalization of ART, the so-called cyclic subgradient projection (CSP) method, may be useful for solving this problem. This, however, has not bee...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.1982.4307567
更新日期:1982-01-01 00:00:00
abstract::Most benign breast tumors possess well-defined, sharp boundaries that delineate them from surrounding tissues, as opposed to malignant tumors. Computer techniques proposed to date for tumor analysis have concentrated on shape factors of tumor regions and texture measures. While shape measures based on contours of tumo...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.650876
更新日期:1997-12-01 00:00:00
abstract::Building a data-driven model to localize the origin of ventricular activation from 12-lead electrocardiograms (ECG) requires addressing the challenge of large anatomical and physiological variations across individuals. The alternative of a patient-specific model is, however, difficult to implement in clinical practice...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2018.2880092
更新日期:2019-05-01 00:00:00
abstract::In routine oncologic positron emission tomography (PET), dynamic information is discarded by time-averaging the signal to produce static images of the "standardised uptake value" (SUV). Defining functional volumes of interest (VOIs) in terms of SUV is flawed, as values are affected by confounding factors and the chose...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2012.2193896
更新日期:2012-08-01 00:00:00
abstract::This paper discusses image reconstruction with a tilted gantry in multislice computed tomography (CT) with helical (spiral) data acquisition. The reconstruction problem with gantry tilt is shown to be transformable into the problem of reconstructing a virtual object from multislice CT data with no gantry tilt, for whi...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2004.829337
更新日期:2004-09-01 00:00:00