Abstract：
:The polymeric implant material poly(lactide-co-glycolide) (PLGA) degrades by a process of bulk degradation, which allows it to be used for the controlled release of therapeutic molecules from implants and microspheres. The temporal characterization of PLGA microsphere degradation has been limited by the need to destructively monitor the samples at each time point. In this study, a noninvasive imaging technology, optical coherence tomography (OCT), was utilized to characterize the in situ degradation of PLGA microspheres suspended within photo-crosslinked hyaluronic acid (HA) hydrogels. Microspheres with differing degradation rates were loaded with bovine serum albumin (BSA) as a marker protein, and temporal release of protein was correlated with morphological changes observed during 3-D OCT imaging. As proof-of-principle, a microsphere-loaded hydrogel scaffold was implanted in a modified rat calvarial critical size defect model and imaged using OCT. This animal model presents the opportunity to monitor microsphere degradation over time in living animals.
journal_name
IEEE Trans Med Imagingjournal_title
IEEE transactions on medical imagingauthors
Patterson J,Stayton PS,Li Xdoi
10.1109/TMI.2008.927356subject
Has Abstractpub_date
2009-01-01 00:00:00pages
74-81issue
1eissn
0278-0062issn
1558-254Xjournal_volume
28pub_type
杂志文章abstract：PURPOSE:Demonstration of a technique for three-dimensional (3-D) assessment of tracheal-stenoses, regarding site, length and degree, based on spiral computed tomography (S-CT). PATIENTS AND METHODS:S-CT scanning and automated segmentation of the laryngo-tracheal tract (LTT) was followed by the extraction of the LTT me...
journal_title：IEEE transactions on medical imaging
pub_type： 临床试验,杂志文章
doi：10.1109/42.996344
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abstract：:Foreshortening of vessel segments in angiographic (biplane) projection images may cause misinterpretation of the extent and degree of coronary artery disease. The views in which the object of interest are visualized with minimum foreshortening are called optimal views. The authors present a complete approach to obtain...
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/42.750262
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
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journal_title：IEEE transactions on medical imaging
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journal_title：IEEE transactions on medical imaging
pub_type： 临床试验,杂志文章
doi：10.1109/tmi.2004.825601
更新日期：2004-05-01 00:00:00
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2007.909834
更新日期：2008-04-01 00:00:00
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/42.57771
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journal_title：IEEE transactions on medical imaging
pub_type： 临床试验,杂志文章
doi：10.1109/TMI.2002.806405
更新日期：2002-12-01 00:00:00
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2006.886810
更新日期：2007-04-01 00:00:00
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2017.2736423
更新日期：2018-02-01 00:00:00
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2018.2803681
更新日期：2018-06-01 00:00:00
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2018.2836304
更新日期：2018-11-01 00:00:00
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2012.2205586
更新日期：2012-09-01 00:00:00
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2016.2640180
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2017.2771504
更新日期：2018-02-01 00:00:00
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2012.2193896
更新日期：2012-08-01 00:00:00
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2009.2016337
更新日期：2009-09-01 00:00:00
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/42.97598
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journal_title：IEEE transactions on medical imaging
pub_type： 临床试验,杂志文章
doi：10.1109/TMI.2004.831221
更新日期：2004-08-01 00:00:00
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2016.2572641
更新日期：2016-11-01 00:00:00
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/tmi.2004.839359
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/42.7783
更新日期：1988-01-01 00:00:00
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2016.2559538
更新日期：2016-10-01 00:00:00
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journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2011.2182523
更新日期：2012-03-01 00:00:00
