Abstract:
:Computed ultrasound tomography in echo mode (CUTE) is a promising ultrasound (US) based multi-modal technique that allows to image the spatial distribution of speed of sound (SoS) inside tissue using hand-held pulse-echo US. It is based on measuring the phase shift of echoes when detected under varying steering angles. The SoS is then reconstructed using a regularized inversion of a forward model that describes the relation between the SoS and echo phase shift. Promising results were obtained in phantoms when using a Tikhonov-type regularization of the spatial gradient (SG) of SoS. In-vivo, however, clutter and aberration lead to an increased phase noise. In many subjects, this phase noise causes strong artifacts in the SoS image when using the SG regularization. To solve this shortcoming, we propose to use a Bayesian framework for the inverse calculation, which includes a priori statistical properties of the spatial distribution of the SoS to avoid noise-related artifacts in the SoS images. In this study, the a priori model is based on segmenting the B-Mode image. We show in a simulation and phantom study that this approach leads to SoS images that are much more stable against phase noise compared to the SG regularization. In a preliminary in-vivo study, a reproducibility in the range of 10 ms-1 was achieved when imaging the SoS of a volunteer's liver from different scanning locations. These results demonstrate the diagnostic potential of CUTE for example for the staging of fatty liver disease.
journal_name
IEEE Trans Med Imagingjournal_title
IEEE transactions on medical imagingauthors
Stahli PS,Frenz M,Jaeger Mdoi
10.1109/TMI.2020.3029286subject
Has Abstractpub_date
2020-10-07 00:00:00eissn
0278-0062issn
1558-254Xjournal_volume
PPpub_type
杂志文章abstract::The magnetic particle imaging (MPI) method directly images the magnetization of super-paramagnetic iron oxide (SPIO) nanoparticles, which are contrast agents commonly used in magnetic resonance imaging (MRI). MPI, as originally envisioned, requires a high-bandwidth receiver coil and preamplifier, which are difficult t...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2009.2013849
更新日期:2009-08-01 00:00:00
abstract::Automatic computer-based methods are well suited for the image analysis of the different components in atherosclerotic plaques. Although several groups work on such analysis some of the methods used are oversimplified and require improvements when used within a computational framework for predicting meaningful stress ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2006.870485
更新日期:2006-03-01 00:00:00
abstract::Cardiac single photon emission computed tomography (SPECT) images are known to suffer from both cardiac and respiratory motion blur. In this paper, we investigate a 4-D reconstruction approach to suppress the effect of respiratory motion in gated cardiac SPECT imaging. In this approach, the sequence of cardiac gated i...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2017.2690819
更新日期:2017-08-01 00:00:00
abstract::A system for digital flashing tomosynthesis (DFTS) consists of four ECG-gated simultaneously flashed X-ray tubes, a 14-in image intensifier, a unit for digital subtraction angiography (DSA), a PC-hosted transputer network for three-dimensional (3-D) reconstruction as well as for quantitative coronary angiography and v...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.232261
更新日期:1993-01-01 00:00:00
abstract::A special-purpose hardware architecture is proposed to implement the expectation-maximization algorithm to compute, in clinically useful times, the maximum-likelihood estimate of a radionuclide distribution for a positron-emission tomogram from time-of-flight measurements. Two-dimensional convolutions required for for...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.14510
更新日期:1988-01-01 00:00:00
abstract::Iterative maximum likelihood (ML) transmission computed tomography algorithms have distinct advantages over Fourier-based reconstruction, but unfortunately require increased computation time. The convex algorithm [1] is a relatively fast iterative ML algorithm but it is nevertheless too slow for many applications. The...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.746730
更新日期:1998-12-01 00:00:00
abstract::Magnetic resonance imaging (MRI) pulse sequence consoles typically employ closed proprietary hardware, software, and interfaces, making difficult any adaptation for innovative experimental technology. Yet MRI systems research is trending to higher channel count receivers, transmitters, gradient/shims, and unique inter...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2011.2169681
更新日期:2012-02-01 00:00:00
abstract::Percutaneous coronary intervention (PCI) is the prevalent treatment for coronary artery disease, with hundreds of thousands of stents implanted annually. Computational studies have demonstrated the role of biomechanics in the failure of vascular stents, but clinical studies is this area are limited by a lack of unders...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2018.2870714
更新日期:2019-03-01 00:00:00
abstract::Ultrasound (US) imaging is the primary imaging modality for pediatric hydronephrosis, which manifests as the dilation of the renal collecting system (CS). In this paper, we present a new framework for the segmentation of renal structures, kidney and CS, from 3DUS scans. First, the kidney is segmented using an active s...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2016.2572641
更新日期:2016-11-01 00:00:00
abstract::This paper presents a new approach to characterize subtle diffuse changes in multiple sclerosis (MS) using histograms derived from magnetization transfer ratio (MTR) images. Two major parts dominate our histogram analysis; 1) Classification of MTR histograms into control and MS subgroups; 2) Correlation with current d...
journal_title:IEEE transactions on medical imaging
pub_type: 临床试验,杂志文章
doi:10.1109/TMI.2002.1000256
更新日期:2002-04-01 00:00:00
abstract::Optical Diffusion Tomography (ODT) is a modern non-invasive medical imaging modality which requires mathematical modelling of near-infrared light propagation in tissue. Solving the ODT forward problem equation accurately and efficiently is crucial. Typically, the forward problem is represented by a Diffusion PDE and i...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2016.2641500
更新日期:2017-04-01 00:00:00
abstract::Simulations provide a way of generating data where ground truth is known, enabling quantitative testing of image processing methods. In this paper, we present the construction of 20 realistic digital brain phantoms that can be used to simulate medical imaging data. The phantoms are made from 20 normal adults to take i...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2006.883453
更新日期:2006-11-01 00:00:00
abstract::Determining the susceptibility distribution from the magnetic field measured in a magnetic resonance (MR) scanner is an ill-posed inverse problem, because of the presence of zeroes in the convolution kernel in the forward problem. An algorithm called morphology enabled dipole inversion (MEDI), which incorporates spati...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2011.2182523
更新日期:2012-03-01 00:00:00
abstract::Spectral computed tomography (CT) provides information on material characterization and quantification because of its ability to separate different basis materials. Dual-energy (DE) CT provides two sets of measurements at two different source energies. In principle, two materials can be accurately decomposed from DECT...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2014.2320284
更新日期:2014-08-01 00:00:00
abstract::A general approach that the authors proposed elsewhere reveals the intrinsic relationship among methods for inversion of the 2-D exponential Radon transform described by Bellini et al. (1979), by Tretiak and Metz (1980), by Hawkins et al. (1988), and by Inouye et al. (1989). Moreover, the authors' approach provides an...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.476107
更新日期:1995-01-01 00:00:00
abstract::A fully automated 2-D+time myocardial segmentation framework is proposed for cardiac magnetic resonance (CMR) blood-oxygen-level-dependent (BOLD) data sets. Ischemia detection with CINE BOLD CMR relies on spatio-temporal patterns in myocardial intensity, but these patterns also trouble supervised segmentation methods,...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2017.2726112
更新日期:2017-11-01 00:00:00
abstract::Transmembrane voltage-sensitive fluorescent dyes are used to study electrical activity in hearts. Green and red fluorescence emissions from di-4-ANEPPS excited with 488 nm light indicate both transmembrane voltage changes and heart movement. We have previously shown that the ratio, green fluorescence divided by red fl...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2005.861019
更新日期:2006-01-01 00:00:00
abstract::We show that electrical impedance tomography (EIT) image reconstruction algorithms with regularization based on the total variation (TV) functional are suitable for in vivo imaging of physiological data. This reconstruction approach helps to preserve discontinuities in reconstructed profiles, such as step changes in e...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2009.2022540
更新日期:2010-01-01 00:00:00
abstract::The purpose of this study is to develop and test a new computerized model for predicting near-term breast cancer risk based on quantitative assessment of bilateral mammographic image feature variations in a series of negative full-field digital mammography (FFDM) images. The retrospective dataset included series of fo...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2016.2527619
更新日期:2016-07-01 00:00:00
abstract::The development of an automatic telemedicine system for computer-aided screening and grading of diabetic retinopathy depends on reliable detection of retinal lesions in fundus images. In this paper, a novel method for automatic detection of both microaneurysms and hemorrhages in color fundus images is described and va...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2015.2509785
更新日期:2016-04-01 00:00:00
abstract::The performance of a classifier is largely dependent on the size and representativeness of data used for its training. In circumstances where accumulation and/or labeling of training samples is difficult or expensive, such as medical applications, data augmentation can potentially be used to alleviate the limitations ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2016.2640180
更新日期:2017-04-01 00:00:00
abstract::The response characteristics of two tomographic systems were compared for imaging of positron emitters: a) a SPECT system with a 3/8 in crystal and 511 keV detector shielding, equipped with a specially designed 511 keV collimator, and b) a PET V system using coincidence detection. SPECT transverse plane resolution was...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.1986.4307776
更新日期:1986-01-01 00:00:00
abstract::Advances in the area of digital chest radiography have resulted in the acquisition of high-quality images of the human chest. With these advances, there arises a genuine need for image processing algorithms specific to the chest, in order to fully exploit this digital technology. We have implemented the well-known tec...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.1987.4307791
更新日期:1987-01-01 00:00:00
abstract::A major issue in telepathology is the extremely large and growing size of digitized "virtual" slides, which can require several gigabytes of storage and cause significant delays in data transmission for remote image interpretation and interactive visualization by pathologists. Compression can reduce this massive amoun...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2010.2077308
更新日期:2011-02-01 00:00:00
abstract::We describe a new approach to the problem of collimator optimization in nuclear medicine; our methodology is illustrated for the challenging case of gallium-67 imaging. Collimator-design methods based on empirical rules, such as specification of an allowable level of single-septal penetration (SSP) at a fixed energy, ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2005.857211
更新日期:2005-10-01 00:00:00
abstract::Most strain imaging techniques follow a pipeline strategy: in the first step, tissue displacement is estimated from radio-frequency (RF) frames, and in the second step, a spatial derivative operation is applied. There are two main issues that arise from this framework. First, the gradient operation amplifies noise, an...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2017.2685522
更新日期:2017-06-01 00:00:00
abstract::Ultrafast ultrasound imaging using plane or diverging waves, instead of focused beams, has advanced greatly the development of novel ultrasound imaging methods for evaluating tissue functions beyond anatomical information. However, the sonographic signal-to-noise ratio (SNR) of ultrafast imaging remains limited due to...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2017.2781261
更新日期:2018-04-01 00:00:00
abstract::In this paper, we propose the use of multiscale amplitude-modulation-frequency-modulation (AM-FM) methods for discriminating between normal and pathological retinal images. The method presented in this paper is tested using standard images from the early treatment diabetic retinopathy study. We use 120 regions of 40 x...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2009.2037146
更新日期:2010-02-01 00:00:00
abstract::In the PET system a block detector, which is a position-sensitive photomultiplier (PMT) tube coupled to four arrays of 1.7-mm-wide BGO crystals, is utilized. Fifteen block detectors are positioned to form a 35-cm-diameter ring, with four BGO arrays coupled to each PMT. This provides four detector rings, giving the sys...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.192694
更新日期:1992-01-01 00:00:00
abstract::In waveform design for magnetic resonance applications, periodic continuous-wave excitation offers potential advantages that remain largely unexplored because of a lack of understanding of the Bloch equation with periodic continuous-wave excitations. Using harmonic balancing techniques the steady state solutions of th...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2015.2423313
更新日期:2015-10-01 00:00:00