当前位置： SCI文献检索 > IEEE TRANSACTIONS ON MEDICAL IMAGING期刊下所有文献 > Gaussian process models of dynamic PET for functional volume definition in radiation oncology.

Gaussian process models of dynamic PET for functional volume definition in radiation oncology.

Abstract：

:In routine oncologic positron emission tomography (PET), dynamic information is discarded by time-averaging the signal to produce static images of the "standardised uptake value" (SUV). Defining functional volumes of interest (VOIs) in terms of SUV is flawed, as values are affected by confounding factors and the chosen time window, and SUV images are not sensitive to functional heterogeneity of pathological tissues. Also, SUV iso-contours are highly affected by the choice of threshold and no threshold, or other SUV-based segmentation method, is universally accepted for a given VOI type. Gaussian Process (GP) time series models describe macro-scale dynamic behavior arising from countless interacting micro-scale processes, as is the case for PET signals from heterogeneous tissue. We use GPs to model time-activity curves (TACs) from dynamic PET and to define functional volumes for PET oncology. Probabilistic methods of tissue discrimination are presented along with novel contouring methods for functional VOI segmentation. We demonstrate the value of GP models for voxel classification and VOI contouring of diseased and metastatic tissues with functional heterogeneity in prostate PET. Classification experiments reveal superior sensitivity and specificity over SUV calculation and a TAC-based method proposed in recent literature. Contouring experiments reveal differences in shape between gold-standard and GP VOIs and correlation with kinetic models shows that the novel VOIs contain extra clinically relevant information compared to SUVs alone. We conclude that the proposed models offer a principled data analysis technique that improves on SUVs for oncologic VOI definition. Continuing research will generalize GP models for different oncology tracers and imaging protocols with the ultimate goal of clinical use including treatment planning.

journal_name

IEEE Trans Med Imaging

journal_title

IEEE transactions on medical imaging

authors

Shepherd T,Owenius R

doi

10.1109/TMI.2012.2193896

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

1542-56

issue

8

eissn

0278-0062

issn

1558-254X

journal_volume

31

pub_type

杂志文章

相关文献

IEEE TRANSACTIONS ON MEDICAL IMAGING文献大全
  • Standing-wave and RF penetration artifacts caused by elliptic geometry: an electrodynamic analysis of MRI.

    abstract：:Motivated by the observation that the diagonal pattern of intensity nonuniformity usually associated with linearly polarized radio-frequency (RF) coils is often present in neurological scans using circularly polarized coils, a theoretical analysis has been conducted of the intensity nonuniformity inherent in imaging a...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/42.730409

    authors： Sled JG,Pike GB

    更新日期：1998-08-01 00:00:00

  • An Improved Method of Total Variation Superiorization Applied to Reconstruction in Proton Computed Tomography.

    abstract：:Previous work has shown that total variation superiorization (TVS) improves reconstructed image quality in proton computed tomography (pCT). The structure of the TVS algorithm has evolved since then and this paper investigated if this new algorithmic structure provides additional benefits to pCT image quality. Structu...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2019.2911482

    authors： Schultze B,Censor Y,Karbasi P,Schubert KE,Schulte RW

    更新日期：2020-02-01 00:00:00

  • Renal Segmentation From 3D Ultrasound via Fuzzy Appearance Models and Patient-Specific Alpha Shapes.

    abstract：:Ultrasound (US) imaging is the primary imaging modality for pediatric hydronephrosis, which manifests as the dilation of the renal collecting system (CS). In this paper, we present a new framework for the segmentation of renal structures, kidney and CS, from 3DUS scans. First, the kidney is segmented using an active s...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2016.2572641

    authors： Cerrolaza JJ,Safdar N,Biggs E,Jago J,Peters CA,Linguraru MG

    更新日期：2016-11-01 00:00:00

  • Automatic Stem Cell Detection in Microscopic Whole Mouse Cryo-Imaging.

    abstract：:With its single cell sensitivity over volumes as large as or larger than a mouse, cryo-imaging enables imaging of stem cell biodistribution, homing, engraftment, and molecular mechanisms. We developed and evaluated a highly automated software tool to detect fluorescently labeled stem cells within very large ( ∼ 200 GB...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2015.2497285

    authors： Wuttisarnwattana P,Gargesha M,van't Hof W,Cooke KR,Wilson DL

    更新日期：2016-03-01 00:00:00

  • Texture Feature Extraction and Analysis for Polyp Differentiation via Computed Tomography Colonography.

    abstract：:Image textures in computed tomography colonography (CTC) have great potential for differentiating non-neoplastic from neoplastic polyps and thus can advance the current CTC detection-only paradigm to a new level with diagnostic capability. However, image textures are frequently compromised, particularly in low-dose CT...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2016.2518958

    authors： Hu Y,Liang Z,Song B,Han H,Pickhardt PJ,Zhu W,Duan C,Zhang H,Barish MA,Lascarides CE

    更新日期：2016-06-01 00:00:00

  • Endoscopic video manifolds for targeted optical biopsy.

    abstract：:Gastro-intestinal (GI) endoscopy is a widely used clinical procedure for screening and surveillance of digestive tract diseases ranging from Barrett's Oesophagus to oesophageal cancer. Current surveillance protocol consists of periodic endoscopic examinations performed in 3-4 month intervals including expert's visual ...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2011.2174252

    authors： Atasoy S,Mateus D,Meining A,Yang GZ,Navab N

    更新日期：2012-03-01 00:00:00

  • Sparse patch-based label propagation for accurate prostate localization in CT images.

    abstract：:In this paper, we propose a new prostate computed tomography (CT) segmentation method for image guided radiation therapy. The main contributions of our method lie in the following aspects. 1) Instead of using voxel intensity information alone, patch-based representation in the discriminative feature space with logisti...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2012.2230018

    authors： Liao S,Gao Y,Lian J,Shen D

    更新日期：2013-02-01 00:00:00

  • A Generalized Correlation-Based Model for Out-of-Plane Motion Estimation in Freehand Ultrasound.

    abstract：:A big challenge in sensorless image-based ultrasound tracking is in the out-of-plane motion estimation. The correlation value of a specific model of speckle known as fully developed speckle (FDS) can be used to estimate the out-of-plane displacement. In real tissue, this kind of pattern is rare and the deviation of sp...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2013.2283969

    authors： Afsham N,Najafi M,Abolmaesumi P,Rohling R

    更新日期：2014-01-01 00:00:00

  • Automatic Segmentation and Quantification of White and Brown Adipose Tissues from PET/CT Scans.

    abstract：:In this paper, we investigate the automatic detection of white and brown adipose tissues using Positron Emission Tomography/Computed Tomography (PET/CT) scans, and develop methods for the quantification of these tissues at the whole-body and body-region levels. We propose a patient-specific automatic adiposity analysi...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2016.2636188

    authors： Hussein S,Green A,Watane A,Reiter D,Chen X,Papadakis GZ,Wood B,Cypess A,Osman M,Bagci U

    更新日期：2017-03-01 00:00:00

  • Toward Electrical Impedance Tomography Coupled Ultrasound Imaging for Assessing Muscle Health.

    abstract：:This paper establishes for the first time that a coupled ultrasound (US) and electrical impedance tomography (EIT) system can serve as a non-invasive, spatially localized approach to extract clinically relevant muscle properties. The US/EIT system represents a potential enhancement to electrical impedance myography (E...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2018.2886152

    authors： Murphy EK,Skinner J,Martucci M,Rutkove SB,Halter RJ

    更新日期：2019-06-01 00:00:00

  • The hypervolume under the ROC hypersurface of "near-guessing" and "near-perfect" observers in N-class classification tasks.

    abstract：:We express the performance of the N-class "guessing" observer in terms of the N2-N conditional probabilities which make up an N-class receiver operating characteristic (ROC) space, in a formulation in which sensitivities are eliminated in constructing the ROC space (equivalent to using false-negative fraction and fals...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/tmi.2004.841227

    authors： Edwards DC,Metz CE,Nishikawa RM

    更新日期：2005-03-01 00:00:00

  • Assessment of perfusion by dynamic contrast-enhanced imaging using a deconvolution approach based on regression and singular value decomposition.

    abstract：:The assessment of tissue perfusion by dynamic contrast-enhanced (DCE) imaging involves a deconvolution process. For analysis of DCE imaging data, we implemented a regression approach to select appropriate regularization parameters for deconvolution using the standard and generalized singular value decomposition method...

    journal_title：IEEE transactions on medical imaging

    pub_type： 临床试验,杂志文章

    doi：10.1109/TMI.2004.837355

    authors： Koh TS,Wu XY,Cheong LH,Lim CC

    更新日期：2004-12-01 00:00:00

  • Improved watershed transform for medical image segmentation using prior information.

    abstract：:The watershed transform has interesting properties that make it useful for many different image segmentation applications: it is simple and intuitive, can be parallelized, and always produces a complete division of the image. However, when applied to medical image analysis, it has important drawbacks (oversegmentation...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2004.824224

    authors： Grau V,Mewes AU,Alcañiz M,Kikinis R,Warfield SK

    更新日期：2004-04-01 00:00:00

  • Quantitative analysis of cardiac tissue including fibroblasts using three-dimensional confocal microscopy and image reconstruction: towards a basis for electrophysiological modeling.

    abstract：:Electrophysiological modeling of cardiac tissue is commonly based on functional and structural properties measured in experiments. Our knowledge of these properties is incomplete, in particular their remodeling in disease. Here, we introduce a methodology for quantitative tissue characterization based on fluorescent l...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2013.2240693

    authors： Schwab BC,Seemann G,Lasher RA,Torres NS,Wulfers EM,Arp M,Carruth ED,Bridge JH,Sachse FB

    更新日期：2013-05-01 00:00:00

  • Simultaneous Quantitative Imaging of Electrical Properties and Proton Density From B1 Maps Using MRI.

    abstract：:Electrical conductivity and permittivity of biological tissues are important diagnostic parameters and are useful for calculating subject-specific specific absorption rate distribution. On the other hand, water proton density also has clinical relevance for diagnosis purposes. These two kinds of tissue properties are ...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2016.2547988

    authors： Jiaen Liu,Van de Moortele PF,Xiaotong Zhang,Yicun Wang,Bin He

    更新日期：2016-09-01 00:00:00

  • Imaging the distribution of magnetic nanoparticles with ultrasound.

    abstract：:Magnetic nanoparticles can be caused to oscillate under the influence of an incident ultrasonic wave. If the particles are momentarily aligned with a magnetizing pulse creating a macroscopic magnetization, this oscillation will result in a time-varying magnetic moment which should be detectable as an induced voltage i...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2007.895476

    authors： Norton SJ,Vo-Dinh T

    更新日期：2007-05-01 00:00:00

  • Intrathoracic airway trees: segmentation and airway morphology analysis from low-dose CT scans.

    abstract：:The segmentation of the human airway tree from volumetric computed tomography (CT) images builds an important step for many clinical applications and for physiological studies. Previously proposed algorithms suffer from one or several problems: leaking into the surrounding lung parenchyma, the need for the user to man...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2005.857654

    authors： Tschirren J,Hoffman EA,McLennan G,Sonka M

    更新日期：2005-12-01 00:00:00

  • A fast iterated conditional modes algorithm for water-fat decomposition in MRI.

    abstract：:Decomposition of water and fat in magnetic resonance imaging (MRI) is important for biomedical research and clinical applications. In this paper, we propose a two-phased approach for the three-point water-fat decomposition problem. Our contribution consists of two components: 1) a background-masked Markov random field...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2011.2125980

    authors： Huang F,Narayan S,Wilson D,Johnson D,Zhang GQ

    更新日期：2011-08-01 00:00:00

  • Simultaneous Photoacoustic Imaging and Cavitation Mapping in Shockwave Lithotripsy.

    abstract：:Kidney stone disease is a major health problem worldwide. Shockwave lithotripsy (SWL), which uses high-energy shockwave pulses to break up kidney stones, is extensively used in clinic. However, despite its noninvasiveness, SWL can produce cavitation in vivo. The rapid expansion and violent collapse of cavitation bubbl...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2019.2928740

    authors： Li M,Lan B,Sankin G,Zhou Y,Liu W,Xia J,Wang D,Trahey G,Zhong P,Yao J

    更新日期：2020-02-01 00:00:00

  • A geometry-driven optical flow warping for spatial normalization of cortical surfaces.

    abstract：:Spatial normalization is frequently used to map data to a standard coordinate system by removing intersubject morphological differences, thereby allowing for group analysis to be carried out. The work presented in this paper is motivated by the need for an automated cortical surface normalization technique that will a...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2008.925080

    authors： Tosun D,Prince JL

    更新日期：2008-12-01 00:00:00

  • Multimodal registration and data fusion for cardiac resynchronization therapy optimization.

    abstract：:Cardiac resynchronization therapy (CRT) has been shown to improve cardiovascular function in specific patients suffering from heart failure. This procedure still needs to be optimized to overcome the high rate of implanted patients that do not respond to this therapy. We propose in this work a better characterization ...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2014.2311694

    authors： Tavard F,Simon A,Leclercq C,Donal E,Hernández AI,Garreau M

    更新日期：2014-06-01 00:00:00

  • Accurate event-driven motion compensation in high-resolution PET incorporating scattered and random events.

    abstract：:With continuing improvements in spatial resolution of positron emission tomography (PET) scanners, small patient movements during PET imaging become a significant source of resolution degradation. This work develops and investigates a comprehensive formalism for accurate motion-compensated reconstruction which at the ...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2008.917248

    authors： Rahmim A,Dinelle K,Cheng JC,Shilov MA,Segars WP,Lidstone SC,Blinder S,Rousset OG,Vajihollahi H,Tsui BM,Wong DF,Sossi V

    更新日期：2008-08-01 00:00:00

  • Electrical impedance spectroscopy of the breast: clinical imaging results in 26 subjects.

    abstract：:Electrical impedance spectroscopy (EIS) is a potential, noninvasive technique to image women for breast cancer. Studies have shown characteristic frequency dispersions in the electrical conductivity and permittivity of malignant versus normal tissue. Using a multifrequency EIS system, we imaged the breasts of 26 women...

    journal_title：IEEE transactions on medical imaging

    pub_type： 临床试验,杂志文章

    doi：10.1109/tmi.2002.800606

    authors： Kerner TE,Paulsen KD,Hartov A,Soho SK,Poplack SP

    更新日期：2002-06-01 00:00:00

  • Novel scatter compensation of list-mode PET data using spatial and energy dependent corrections.

    abstract：:With the widespread use of positron emission tomography (PET) crystals with greatly improved energy resolution (e.g., 11.5% with LYSO as compared to 20% with BGO) and of list-mode acquisitions, the use of the energy of individual events in scatter correction schemes becomes feasible. We propose a novel scatter approac...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2010.2095025

    authors： Guérin B,El Fakhri G

    更新日期：2011-03-01 00:00:00

  • A multiple active contour model for cardiac boundary detection on echocardiographic sequences.

    abstract：:Tracing of left-ventricular epicardial and endocardial borders on echocardiographic sequences is essential for quantification of cardiac function. The authors designed a method based on an extension of active contour models to detect both epicardial and endocardial borders on short-axis cardiac sequences spanning the ...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/42.500138

    authors： Chalana V,Linker DT,Haynor DR,Kim Y

    更新日期：1996-01-01 00:00:00

  • Dynamic Cell Imaging in PET With Optimal Transport Regularization.

    abstract：:We propose a novel dynamic image reconstruction method from PET listmode data that could be particularly suited to tracking single or small numbers of cells. In contrast to conventional PET reconstruction our method combines the information from all detected events not only to reconstruct the dynamic evolution of the ...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2019.2953773

    authors： Schmitzer B,Schafers KP,Wirth B

    更新日期：2020-05-01 00:00:00

  • Spatio-temporal nonrigid registration for ultrasound cardiac motion estimation.

    abstract：:We propose a new spatio-temporal elastic registration algorithm for motion reconstruction from a series of images. The specific application is to estimate displacement fields from two-dimensional ultrasound sequences of the heart. The basic idea is to find a spatio-temporal deformation field that effectively compensat...

    journal_title：IEEE transactions on medical imaging

    pub_type： 临床试验,杂志文章

    doi：10.1109/TMI.2005.852050

    authors： Ledesma-Carbayo MJ,Kybic J,Desco M,Santos A,Sühling M,Hunziker P,Unser M

    更新日期：2005-09-01 00:00:00

  • Bayesian approach for a robust speed-of-sound reconstruction using pulse-echo ultrasound.

    abstract：:Computed ultrasound tomography in echo mode (CUTE) is a promising ultrasound (US) based multi-modal technique that allows to image the spatial distribution of speed of sound (SoS) inside tissue using hand-held pulse-echo US. It is based on measuring the phase shift of echoes when detected under varying steering angles...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/TMI.2020.3029286

    authors： Stahli PS,Frenz M,Jaeger M

    更新日期：2020-10-07 00:00:00

  • Pubic arch detection in transrectal ultrasound guided prostate cancer therapy.

    abstract：:New biopsy techniques, increased life expectancy, and prostate-specific antigen (PSA) screening have contributed to an increase in the reported incidence of prostate cancer. Among several treatment options available to the patients, transperineal prostate brachytherapy has emerged as a medically successful, cost-effec...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/42.736032

    authors： Pathak SD,Grimm PD,Chalana V,Kim Y

    更新日期：1998-10-01 00:00:00

  • A methodology for evaluation of boundary detection algorithms on medical images.

    abstract：:Image segmentation is the partition of an image into a set of nonoverlapping regions whose union is the entire image. The image is decomposed into meaningful parts which are uniform with respect to certain characteristics, such as gray level or texture. In this paper, we propose a methodology for evaluating medical im...

    journal_title：IEEE transactions on medical imaging

    pub_type： 杂志文章

    doi：10.1109/42.640755

    authors： Chalana V,Kim Y

    更新日期：1997-10-01 00:00:00