Abstract：
:Magnetic nanoparticles can be caused to oscillate under the influence of an incident ultrasonic wave. If the particles are momentarily aligned with a magnetizing pulse creating a macroscopic magnetization, this oscillation will result in a time-varying magnetic moment which should be detectable as an induced voltage in a nearby pickup coil. In this way, focused ultrasound can be used to map, or image, the spatial distribution of the magnetic particles after these particles have been introduced into the body. The magnetic particles could be antibody-labeled to target tumor cells or used as a cardiovascular contrast agent, among other applications. The magnitude of the induced signal is estimated for one micron particles with a Fe/tissue volume fraction of 10(-6), which is about the limit of detectability for MRI superparamagnetic contrast agents consisting of single domain iron-oxide particles. One advantage of this method compared to conventional MRI is potentially greater sensitivity due to the absence of a large background signal.
journal_name
IEEE Trans Med Imagingjournal_title
IEEE transactions on medical imagingauthors
Norton SJ,Vo-Dinh Tdoi
10.1109/TMI.2007.895476subject
Has Abstractpub_date
2007-05-01 00:00:00pages
660-5issue
5eissn
0278-0062issn
1558-254Xjournal_volume
26pub_type
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