Abstract：
:Photon counting computed tomography (PCCT) has the ability to identify individual photons, resulting in quantitative material identification. Meanwhile, several technical challenges still exist in current PCCT imaging systems, including increased noise and suboptimal bin selection. These nonideal effects can substantially degrade the reconstruction performance and material estimation accuracy. To address these issues, in this work, we present a novel system for high-performance spectral PCCT imaging, which is a combination of multiple dynamic modulations, interpolation-based measurements processing strategy and advanced reconstruction method. For simplicity, this new PCCT imaging system is referred to as "MDM-PCCT". Specifically, the multiple dynamic modulations consist of dynamic kVp modulation, dynamic spectrum modulation and dynamic energy threshold modulation. In the dynamic kVp modulation, three kVp values, i.e., 80, 110 and 140, are included, and the tube voltage waveform follows a sinusoidal curve which is more practical than the rectangular curve in the fast kV switching mode. In the dynamic spectrum modulation, the X-ray spectra are processed by selective spatial-spectral filters to balance the X-ray fluxes and increase the spectral separation. In the dynamic energy threshold modulation, the energy threshold is adaptively changed to determine the optimal bin selection. Furthermore, we propose an energy threshold determination method and interpolation-based measurements processing strategy to address the issue of non-uniform and sparse-view PCCT measurements, respectively. In addition, by considering the intrinsic characteristics of the MDM-PCCT images, we utilize an enhanced total variation regularized model for images reconstruction. Finally, numerical and preclinical studies demonstrate that the presented MDM-PCCT imaging system is capable of yielding uniform and high-fidelity PCCT measurements with noise consistency, and the presented reconstruction method further improves the image quality and material decomposition accuracy.
journal_name
IEEE Trans Med Imagingjournal_title
IEEE transactions on medical imagingauthors
Li D,Zeng D,Li S,Ge Y,Bian Z,Huang J,Ma Jdoi
10.1109/TMI.2020.3001616subject
Has Abstractpub_date
2020-11-01 00:00:00pages
3630-3642issue
11eissn
0278-0062issn
1558-254Xjournal_volume
39pub_type
杂志文章abstract：:Cone beam X-ray luminescence computed tomography (CB-XLCT) is a promising imaging technique in studying the physiological and pathological processes in small animals. However, the dynamic bio-distributions of probes in small animal, especially in adjacent targets are still hard to be captured directly from dynamic CB-...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2019.2917026
更新日期：2019-12-01 00:00:00
abstract：:Reconstructing images of large high-contrast objects with microwave methods has proved difficult. Successful images have generally been obtained by using a priori information to constrain the image reconstruction to recover the correct electromagnetic property distribution. In these situations, the measured electric f...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/42.913177
更新日期：2001-02-01 00:00:00
abstract：:This paper presents two new methods for robust parameter estimation of mixtures in the context of magnetic resonance (MR) data segmentation. The head is constituted of different types of tissue that can be modeled by a finite mixture of multivariate Gaussian distributions. Our goal is to estimate accurately the statis...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/42.700730
更新日期：1998-04-01 00:00:00
abstract：:Radiofrequency ablation (RFA) is an established treatment for liver cancer when resection is not possible. Yet, its optimal delivery is challenged by the presence of large blood vessels and the time-varying thermal conductivity of biological tissue. Incomplete treatment and an increased risk of recurrence are therefor...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2015.2406575
更新日期：2015-07-01 00:00:00
abstract：:Synthesizing a CT image from an available MR image has recently emerged as a key goal in radiotherapy treatment planning for cancer patients. CycleGANs have achieved promising results on unsupervised MR-to-CT image synthesis; however, because they have no direct constraints between input and synthetic images, cycleGAN...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2020.3015379
更新日期：2020-12-01 00:00:00
abstract：:In magnetic resonance imaging, spatial localization is usually achieved using Fourier encoding which is realized by applying a magnetic field gradient along the dimension of interest to create a linear correspondence between the resonance frequency and spatial location following the Larmor equation. In the presence of...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/42.712126
更新日期：1998-06-01 00:00:00
abstract：:During the last two decades, various Doppler methods have been successfully used to screen patients with significant cerebral and peripheral vascular disease. In general terms, the principal advantages of Doppler ultrasound techniques in the evaluation of atherosclerotic lesions are that they: 1) are noninvasive, 2) a...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.1982.4307550
更新日期：1982-01-01 00:00:00
abstract：:We are presenting data from the largest clinical trial on optical tomographic imaging of finger joints to date. Overall we evaluated 99 fingers of patients affected by rheumatoid arthritis (RA) and 120 fingers from healthy volunteers. Using frequency-domain imaging techniques we show that sensitivities and specificiti...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2011.2135374
更新日期：2011-10-01 00:00:00
abstract：:Fluorescence loss in photobleaching (FLIP) is a method to study compartment connectivity in living cells. A FLIP sequence is obtained by alternatively bleaching a spot in a cell and acquiring an image of the complete cell. Connectivity is estimated by comparing fluorescence signal attenuation in different cell parts. ...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2011.2171497
更新日期：2012-02-01 00:00:00
abstract：:This paper presents a learning-based method for deformable registration of magnetic resonance (MR) brain images. There are two novelties in the proposed registration method. First, a set of best-scale geometric features are selected for each point in the brain, in order to facilitate correspondence detection during th...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/tmi.2006.879320
更新日期：2006-09-01 00:00:00
abstract：:An electrical impedance tomography (EIT) system that uses the optimal current method to inject currents and the regularized Newton-Raphson algorithm to reconstruct an image of resistivity distribution is discussed. Iterative methods to derive the optimal current patterns through iterative physical measurements are dev...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/42.192684
更新日期：1992-01-01 00:00:00
abstract：:Three-dimensional (3-D) reconstructions of coronary bypass grafts performed from X-ray angiographic images may become increasingly important for the investigation of damaging mechanical stresses imposed to these vessels by the cyclic movement of the heart. Contrary to what we had experienced with coronary arteries, ap...
journal_title：IEEE transactions on medical imaging
pub_type： 信件
doi：10.1109/42.875203
更新日期：2000-07-01 00:00:00
abstract：:With each heartbeat, periodic variations in arterial blood pressure are transmitted along the vasculature, resulting in localized deformations of the arterial wall and its surrounding tissue. Quantification of such motions may help understand various cerebrovascular conditions, yet it has proven technically challengin...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2020.3012932
更新日期：2020-12-01 00:00:00
abstract：:Instrument detection, pose estimation, and tracking in surgical videos are an important vision component for computer-assisted interventions. While significant advances have been made in recent years, articulation detection is still a major challenge. In this paper, we propose a deep neural network for articulated mul...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2017.2787672
更新日期：2018-05-01 00:00:00
abstract：:We describe a nonparametric framework for incorporating information from co-registered anatomical images into positron emission tomographic (PET) image reconstruction through priors based on information theoretic similarity measures. We compare and evaluate the use of mutual information (MI) and joint entropy (JE) bet...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2010.2076827
更新日期：2011-03-01 00:00:00
abstract：:Magnetic nanoparticles can be caused to oscillate under the influence of an incident ultrasonic wave. If the particles are momentarily aligned with a magnetizing pulse creating a macroscopic magnetization, this oscillation will result in a time-varying magnetic moment which should be detectable as an induced voltage i...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2007.895476
更新日期：2007-05-01 00:00:00
abstract：:Kidney stone disease is a major health problem worldwide. Shockwave lithotripsy (SWL), which uses high-energy shockwave pulses to break up kidney stones, is extensively used in clinic. However, despite its noninvasiveness, SWL can produce cavitation in vivo. The rapid expansion and violent collapse of cavitation bubbl...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2019.2928740
更新日期：2020-02-01 00:00:00
abstract：:Accurate gain control of PET detectors is a prerequisite for quantitative accuracy. A shift in the 511 keV peak position can lead to errors in scatter correction, degrading quantitation. The PET detectors in a PET/MR scanner are subject to thermal transients due to eddy currents induced during gradient-intensive MRI s...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2020.3022321
更新日期：2021-01-01 00:00:00
abstract：:Microwave radar imaging is promising as a complementary medical imaging modality. However, the unique nature of the images means interpretation can be difficult. As a result, it is important to understand the sources of image differences, and how much variability is inherent in the imaging system itself. To address th...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2018.2806878
更新日期：2018-08-01 00:00:00
abstract：:Cervical cancer causes the fourth most cancer-related deaths of women worldwide. Early detection of cervical intraepithelial neoplasia (CIN) can significantly increase the survival rate of patients. In this paper, we propose a deep learning framework for the accurate identification of LSIL+ (including CIN and cervical...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2020.2994778
更新日期：2020-11-01 00:00:00
abstract：:An n-dimensional (n-D) filtered backprojection image reconstruction algorithm has been developed and used in the reconstruction of 4-D spectral-spatial magnetic resonance imaging (MRI) data. The algorithm uses n-1 successive stages of 2-D filtered backprojection to reconstruct an n-D image. This approach results in a ...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/42.387718
更新日期：1995-01-01 00:00:00
abstract：:The development and tests of an iterative reconstruction algorithm for emission tomography based on Bayesian statistical concepts are described. The algorithm uses the entropy of the generated image as a prior distribution, can be accelerated by the choice of an exponent, and converges uniformly to feasible images by ...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/42.56340
更新日期：1990-01-01 00:00:00
abstract：:Ultrasound molecular imaging (USMI) is accomplished by detecting microbubble (MB) contrast agents that have bound to specific biomarkers, and can be used for a variety of imaging applications, such as the early detection of cancer. USMI has been widely utilized in preclinical imaging in mice; however, USMI in humans c...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2017.2774814
更新日期：2018-01-01 00:00:00
abstract：:We have developed a method to study the statistical properties of the noise found in various medical images. The method is specifically designed for types of noise with uncorrelated fluctuations. Such signal fluctuations generally originate in the physical processes of imaging rather than in the tissue textures. Vario...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2004.832656
更新日期：2004-10-01 00:00:00
abstract：:Magnetic particle imaging allows to determine the spatial distribution of magnetic nanoparticles in vivo. The system matrix in magnetic particle imaging is commonly acquired in a tedious calibration scan and requires to measure the system response at numerous positions in the field-of-view. In this paper, we propose a...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2013.2258029
更新日期：2013-08-01 00:00:00
abstract：:A novel splat feature classification method is presented with application to retinal hemorrhage detection in fundus images. Reliable detection of retinal hemorrhages is important in the development of automated screening systems which can be translated into practice. Under our supervised approach, retinal color images...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2012.2227119
更新日期：2013-02-01 00:00:00
abstract：:It is well understood that binary classifiers have two implicit objective functions (sensitivity and specificity) describing their performance. Traditional methods of classifier training attempt to combine these two objective functions (or two analogous class performance measures) into one so that conventional scalar ...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/42.796281
更新日期：1999-08-01 00:00:00
abstract：:The point spread function (PSF) of a ring PET tomograph is known to be spatially variant and difficult to obtain because it must be reconstructed from projections. A mathematical model was developed to simulate the data acquisition from a point source and to reconstruct the PSF, taking into account weighting functions...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/42.158942
更新日期：1992-01-01 00:00:00
abstract：:Acoustic-resolution photoacoustic micro-scopy (AR-PAM) is an emerging biomedical imaging modality that combines superior optical sensitivity and fine ultrasonic resolution in an optical quasi-diffusive regime (~1-3 mm in tissues). AR-PAM has been explored for anatomical, functional, and molecular information in biolog...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2019.2938518
更新日期：2020-04-01 00:00:00
abstract：:Regularization is desirable for image reconstruction in emission tomography. A powerful regularization method is the penalized-likelihood (PL) reconstruction algorithm (or equivalently, maximum a posteriori reconstruction), where the sum of the likelihood and a noise suppressing penalty term (or Bayesian prior) is opt...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2003.816960
更新日期：2003-09-01 00:00:00
