Abstract：
:Synthesizing a CT image from an available MR image has recently emerged as a key goal in radiotherapy treatment planning for cancer patients. CycleGANs have achieved promising results on unsupervised MR-to-CT image synthesis; however, because they have no direct constraints between input and synthetic images, cycleGANs do not guarantee structural consistency between these two images. This means that anatomical geometry can be shifted in the synthetic CT images, clearly a highly undesirable outcome in the given application. In this paper, we propose a structure-constrained cycleGAN for unsupervised MR-to-CT synthesis by defining an extra structure-consistency loss based on the modality independent neighborhood descriptor. We also utilize a spectral normalization technique to stabilize the training process and a self-attention module to model the long-range spatial dependencies in the synthetic images. Results on unpaired brain and abdomen MR-to-CT image synthesis show that our method produces better synthetic CT images in both accuracy and visual quality as compared to other unsupervised synthesis methods. We also show that an approximate affine pre-registration for unpaired training data can improve synthesis results.
journal_name
IEEE Trans Med Imagingjournal_title
IEEE transactions on medical imagingauthors
Yang H,Sun J,Carass A,Zhao C,Lee J,Prince JL,Xu Zdoi
10.1109/TMI.2020.3015379subject
Has Abstractpub_date
2020-12-01 00:00:00pages
4249-4261issue
12eissn
0278-0062issn
1558-254Xjournal_volume
39pub_type
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