Abstract：
:Measures of vascular tortuosity-how curved and twisted a vessel is-are associated with a variety of vascular diseases. Consequently, measurements of vessel tortuosity that are accurate and comparable across modality, resolution, and size are greatly needed. Yet in practice, precise and consistent measurements are problematic-mismeasurements, inability to calculate, or contradictory and inconsistent measurements occur within and across studies. Here, we present a new method of measuring vessel tortuosity that ensures improved accuracy. Our method relies on numerical integration of the Frenet-Serret equations. By reconstructing the three-dimensional vessel coordinates from tortuosity measurements, we explain how to identify and use a minimally-sufficient sampling rate based on vessel radius while avoiding errors associated with oversampling and overfitting. Our work identifies a key failing in current practices of filtering asymptotic measurements and highlights inconsistencies and redundancies between existing tortuosity metrics. We demonstrate our method by applying it to manually constructed vessel phantoms with known measures of tortuousity, and 9,000 vessels from medical image data spanning human cerebral, coronary, and pulmonary vascular trees, and the carotid, abdominal, renal, and iliac arteries.
journal_name
IEEE Trans Med Imagingjournal_title
IEEE transactions on medical imagingauthors
Brummer AB,Hunt D,Savage Vdoi
10.1109/TMI.2020.3025467subject
Has Abstractpub_date
2021-01-01 00:00:00pages
297-309issue
1eissn
0278-0062issn
1558-254Xjournal_volume
40pub_type
杂志文章abstract：:Monte Carlo (MC) simulation provides a flexible and robust framework to efficiently evaluate and optimize image processing methods in emission tomography. In this work we present Brain-VISET (Voxel-based Iterative Simulation for Emission Tomography), a method that aims to simulate realistic [ (99m) Tc]-SPECT and [ (18...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2014.2326041
更新日期：2014-10-01 00:00:00
abstract：:Look-up tables (LUTs) are a common method for increasing the speed of many algorithms. Their use can be extended to the reconstruction of nonuniformly sampled k-space data using either a discrete Fourier transform (DFT) algorithm or a convolution-based gridding algorithm. A table for the DFT would be precalculated arr...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/42.918471
更新日期：2001-03-01 00:00:00
abstract：:With its single cell sensitivity over volumes as large as or larger than a mouse, cryo-imaging enables imaging of stem cell biodistribution, homing, engraftment, and molecular mechanisms. We developed and evaluated a highly automated software tool to detect fluorescently labeled stem cells within very large ( ∼ 200 GB...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2015.2497285
更新日期：2016-03-01 00:00:00
abstract：:An algorithm is developed that detects well-localized, unfragmented, thin edges in medical images based on optimization of edge configurations using a genetic algorithm (GA). Several enhancements were added to improve the performance of the algorithm over a traditional GA. The edge map is split into connected subregio...
journal_title：IEEE transactions on medical imaging
pub_type： 信件
doi：10.1109/42.712136
更新日期：1998-06-01 00:00:00
abstract：:We present an integrated approach to probabilistic independent component analysis (ICA) for functional MRI (FMRI) data that allows for nonsquare mixing in the presence of Gaussian noise. In order to avoid overfitting, we employ objective estimation of the amount of Gaussian noise through Bayesian analysis of the true ...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2003.822821
更新日期：2004-02-01 00:00:00
abstract：:Glaucoma is a chronic eye disease that leads to irreversible vision loss. The cup to disc ratio (CDR) plays an important role in the screening and diagnosis of glaucoma. Thus, the accurate and automatic segmentation of optic disc (OD) and optic cup (OC) from fundus images is a fundamental task. Most existing methods s...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2018.2791488
更新日期：2018-07-01 00:00:00
abstract：:When more than two elemental materials are present in a given object, material quantification may not be robust and accurate when the routine two-material decomposition scheme in current dual energy CT imaging is employed. In this work, we present an innovative scheme to accomplish accurate three-material decompositio...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2020.2990347
更新日期：2020-11-01 00:00:00
abstract：:Three-dimensional (3-D) ultrasound is a relatively new technique, which is well suited to imaging superficial blood vessels, and potentially provides a useful, noninvasive method for generating anatomically realistic 3-D models of the peripheral vasculature. Such models are essential for accurate simulation of blood f...
journal_title：IEEE transactions on medical imaging
pub_type： 临床试验,杂志文章
doi：10.1109/tmi.2004.825601
更新日期：2004-05-01 00:00:00
abstract：:Image guided interventions have seen growing interest in recent years. The use of X-rays for the procedure impels limiting the dose over time. Image sequences obtained thereby exhibit high levels of noise and very low contrasts. Hence, the development of efficient methods to enable optimal visualization of these seque...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2014.2349034
更新日期：2015-01-01 00:00:00
abstract：:The success of prostate brachytherapy critically depends on delivering adequate dose to the prostate gland. Intraoperative localization of the implanted seeds provides potential for dose evaluation and optimization during therapy. A reduced-dimensionality matching algorithm for prostate brachytherapy seed reconstructi...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2010.2059709
更新日期：2011-01-01 00:00:00
abstract：:This paper presents a novel image-guided robot-based system to assist orthopedic surgeons in performing distal locking of long bone intramedullary nails. The system consists of a bone-mounted miniature robot fitted with a drill guide that provides rigid mechanical guidance for hand-held drilling of the distal screws' ...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2005.844922
更新日期：2005-05-01 00:00:00
abstract：:It is known that when the maximum likelihood estimator (MLE) algorithm passes a certain point, it produces images that begin to deteriorate. We propose a quantitative criterion with a simple probabilistic interpretation that allows the user to stop the algorithm just before this effect begins. The MLE algorithm search...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.1987.4307849
更新日期：1987-01-01 00:00:00
abstract：:While many low rank and sparsity-based approaches have been developed for accelerated dynamic magnetic resonance imaging (dMRI), they all use low rankness or sparsity in input space, overlooking the intrinsic nonlinear correlation in most dMRI data. In this paper, we propose a kernel-based framework to allow nonlinear...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2017.2723871
更新日期：2017-11-01 00:00:00
abstract：:We propose an anatomy-based approach for an efficient construction of a three-dimensional human normal cerebral arterial model from segmented and skeletonized angiographic data. The centerline-based model is used for an accurate angiographic data representation. A vascular tree is represented by tubular segments and b...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/tmi.2005.845041
更新日期：2005-04-01 00:00:00
abstract：:This paper establishes for the first time that a coupled ultrasound (US) and electrical impedance tomography (EIT) system can serve as a non-invasive, spatially localized approach to extract clinically relevant muscle properties. The US/EIT system represents a potential enhancement to electrical impedance myography (E...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2018.2886152
更新日期：2019-06-01 00:00:00
abstract：:Ultrasonic imaging is the noninvasive clinical imaging modality of choice for diagnosing heart disease. At present, two-dimensional ultrasonic grayscale images provide a relatively cheap, fast, bedside method to study the morphology of the heart. Several methods have been proposed to assess myocardial function. These ...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2002.804440
更新日期：2002-09-01 00:00:00
abstract：:The three-dimensional cardiac electrical imaging (3DCEI) technique was previously developed to estimate the initiation site(s) of cardiac activation and activation sequence from the noninvasively measured body surface potential maps (BSPMs). The aim of this study was to develop and evaluate the capability of 3DCEI in ...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2012.2202914
更新日期：2012-09-01 00:00:00
abstract：:In this paper, we present a two-stage algorithm for mammogram registration, the geometrical alignment of mammogram sequences. The rationale behind this paper stems from the intrinsic difficulties in comparing mammogram sequences. Mammogram comparison is a valuable tool in national breast screening programs as well as ...
journal_title：IEEE transactions on medical imaging
pub_type： 临床试验,杂志文章
doi：10.1109/TMI.2005.848374
更新日期：2005-06-01 00:00:00
abstract：:We demonstrate three-dimensional intravascular flow imaging compatible with routine clinical image acquisition workflow by means of megahertz (MHz) intravascular Doppler Optical Coherence Tomography (OCT). The OCT system relies on a 1.1 mm diameter motorized imaging catheter and a 1.5 MHz Fourier Domain Mode Locked (F...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2019.2948258
更新日期：2020-05-01 00:00:00
abstract：:An algorithm is presented for the analysis and quantification of the vascular structures of the human retina. Information about retinal blood vessel morphology is used in grading the severity and progression of a number of diseases. These disease processes are typically followed over relatively long time courses, and ...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/42.363106
更新日期：1994-01-01 00:00:00
abstract：:Biomedical applications such as cell tracking and angiography require the detection of low concentrations of superparamagnetic iron oxide nanoparticles (SPIOs) for imaging purposes. Magnetic particle imaging (MPI) is a new technology which enables the quantitative and time-resolved localization of SPIO distributions. ...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2015.2501462
更新日期：2016-03-01 00:00:00
abstract：:Dynamic contrast-enhanced magnetic resonance (DCE-MR) imaging can be used to study microvascular structure in vivo by monitoring the abundance of an injected diffusible contrast agent over time. The resulting spatially resolved intensity-time curves are usually interpreted in terms of kinetic parameters obtained by fi...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2009.2019957
更新日期：2009-10-01 00:00:00
abstract：:Cerebral ischemic stroke causes injury to brain tissue characterized by a complex cascade of neuronal and vascular events. Imaging during the early stages of its development allows prediction of tissue infarction and penumbra so that optimal intervention can be determined in order to salvage brain function impairment....
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2019.2895779
更新日期：2019-06-01 00:00:00
abstract：:Spherically symmetric volume elements with smooth tapering of the values near their boundaries are alternatives to the more conventional voxels for the construction of volume images in the computer. Their use, instead of voxels, introduces additional parameters which enable the user to control the shape of the volume ...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/42.481442
更新日期：1996-01-01 00:00:00
abstract：:We present a method (DMESH) for nonrigid cyclic motion analysis using a series of velocity images covering the cycle acquired, for example, from phase-contrast magnetic resonance imaging. The method is based on fitting a dynamic finite-element mesh model to velocity samples of an extended region, at all time frames. T...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/42.790456
更新日期：1999-07-01 00:00:00
abstract：:A new postprocessing algorithm was developed for the diagnosis of breast cancer using electrical impedance scanning. This algorithm automatically recognizes bright focal spots in the conductivity map of the breast. Moreover, this algorithm discriminates between malignant and benign/normal tissues using two main predic...
journal_title：IEEE transactions on medical imaging
pub_type： 信件
doi：10.1109/TMI.2002.800605
更新日期：2002-06-01 00:00:00
abstract：:A technique determines the optimal window width for orbiting rod transmission studies in positron emission tomography (PET). Windowing reduces noise in orbiting rod transmission studies. Lines-of-response (LOR) which intersect the rods generate primarily true coincidence events. LOR which pass far from the rods genera...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/42.387708
更新日期：1995-01-01 00:00:00
abstract：:In this paper, we propose a new prostate computed tomography (CT) segmentation method for image guided radiation therapy. The main contributions of our method lie in the following aspects. 1) Instead of using voxel intensity information alone, patch-based representation in the discriminative feature space with logisti...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2012.2230018
更新日期：2013-02-01 00:00:00
abstract：:Our primary motivator is the need for screening HIV+ populations in resource-constrained regions for exposure to Tuberculosis, using posteroanterior chest radiographs (CXRs). The proposed method is motivated by the observation that radiological examinations routinely conduct bilateral comparisons of the lung field. In...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2017.2775636
更新日期：2018-05-01 00:00:00
abstract：:Image reconstruction in low-count PET is particularly challenging because gammas from natural radioactivity in Lu-based crystals cause high random fractions that lower the measurement signal-to-noise-ratio (SNR). In model-based image reconstruction (MBIR), using more iterations of an unregularized method may increase ...
journal_title：IEEE transactions on medical imaging
pub_type： 杂志文章
doi：10.1109/TMI.2020.2998480
更新日期：2020-11-01 00:00:00
