Abstract:
:When more than two elemental materials are present in a given object, material quantification may not be robust and accurate when the routine two-material decomposition scheme in current dual energy CT imaging is employed. In this work, we present an innovative scheme to accomplish accurate three-material decomposition with measurements from a dual energy differential phase contrast CT (DE-DPC-CT) acquisition. A DE-DPC-CT system was constructed using a grating interferometer and a photon counting CT imaging system with two energy bins. The DE-DPC-CT system can simultaneously measure both the imaginary and the real part of the complex refractive index to enable a three-material decomposition. Physical phantom with 21 material inserts were constructed and measured using DE-DPC-CT system. Results demonstrated excellent accuracy in elemental material quantification. For example, relative root-mean-square errors of 4.5% for calcium and 5.2% for iodine were achieved using the proposed three-material decomposition scheme. Biological tissues with iodine inserts were used to demonstrate the potential utility of the proposed spectral CT imaging method. Experimental results showed that the proposed method correctly differentiates the bony structure, iodine, and the soft tissue in the biological specimen samples. A triple spectra CT scan was also performed to benchmark the performance of the DE-DPC-CT scan. Results demonstrated that the material decomposition from the DE-DPC-CT has a much lower quantification noise than that from the triple spectra CT scan.
journal_name
IEEE Trans Med Imagingjournal_title
IEEE transactions on medical imagingauthors
Ji X,Zhang R,Li K,Chen GHdoi
10.1109/TMI.2020.2990347subject
Has Abstractpub_date
2020-11-01 00:00:00pages
3278-3289issue
11eissn
0278-0062issn
1558-254Xjournal_volume
39pub_type
杂志文章abstract::Image acquisition techniques often suffer from low signal-to-noise ratio (SNR) and/or contrast-to-noise ratio (CNR). Although many acquisition techniques are available to minimize these, post acquisition filtering is a major off-line image processing technique commonly used to improve the SNR and CNR. A major drawback...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.963817
更新日期:2001-11-01 00:00:00
abstract::Bronchoscopy is a major step in lung cancer staging. To perform bronchoscopy, the physician uses a procedure plan, derived from a patient's 3D computed-tomography (CT) chest scan, to navigate the bronchoscope through the lung airways. Unfortunately, physicians vary greatly in their ability to perform bronchoscopy. As ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2013.2252361
更新日期:2013-08-01 00:00:00
abstract::Accurate gain control of PET detectors is a prerequisite for quantitative accuracy. A shift in the 511 keV peak position can lead to errors in scatter correction, degrading quantitation. The PET detectors in a PET/MR scanner are subject to thermal transients due to eddy currents induced during gradient-intensive MRI s...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2020.3022321
更新日期:2021-01-01 00:00:00
abstract::In this paper, we propose a new methodology for analysis of microarray images. First, a new gridding algorithm is proposed for determining the individual spots and their borders. Then, a Gaussian mixture model (GMM) approach is presented for the analysis of the individual spot images. The main advantages of the propos...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/tmi.2005.848358
更新日期:2005-07-01 00:00:00
abstract::While plane-wave imaging can improve the performance of power Doppler by enabling much longer ensembles than systems using focused beams, the long-ensemble averaging of the zero-lag autocorrelation R(0) estimates does not directly decrease the mean noise level, but only decreases its variance. Spatial variation of the...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2017.2699672
更新日期:2017-09-01 00:00:00
abstract::We propose a novel, physics-based method for detecting multi-scale tubular features in ultrasound images. The detector is based on a Hessian-matrix eigenvalue method, but unlike previous work, our detector is guided by an optimal model of vessel-like structures with respect to the ultrasound-image formation process. O...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2014.2340912
更新日期:2015-01-01 00:00:00
abstract::The most frequent extracranial solid tumors of childhood, named peripheral neuroblastic tumors (pNTs), are very challenging to diagnose due to their diversified categories and varying forms. Auxiliary diagnosis methods of such pediatric malignant cancers are highly needed to provide pathologists assistance and reduce ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2020.3027547
更新日期:2021-01-01 00:00:00
abstract::The continuous medial representation (cm-rep) is an approach that makes it possible to model, normalize, and analyze anatomical structures on the basis of medial geometry. Having recently presented a partial differential equation (PDE)-based approach for 3-D cm-rep modeling [1], here we present an equivalent 2-D appro...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2007.900322
更新日期:2007-09-01 00:00:00
abstract::Image interpolation is an important operation that is widely used in medical imaging, image processing, and computer graphics. A variety of interpolation methods are available in the literature. However, their systematic evaluation is lacking. In a previous paper, we presented a framework for the task-independent comp...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.759116
更新日期:1999-02-01 00:00:00
abstract::We describe a matched subspace detection algorithm to assist in the detection of small tumors in dynamic positron emission tomography (PET) images. The algorithm is designed to differentiate tumors from background using the time activity curves (TACs) that characterize the uptake of PET tracers. TACs are modeled using...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2008.929105
更新日期:2009-02-01 00:00:00
abstract::We express the performance of the N-class "guessing" observer in terms of the N2-N conditional probabilities which make up an N-class receiver operating characteristic (ROC) space, in a formulation in which sensitivities are eliminated in constructing the ROC space (equivalent to using false-negative fraction and fals...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/tmi.2004.841227
更新日期:2005-03-01 00:00:00
abstract::We present an integrated approach to probabilistic independent component analysis (ICA) for functional MRI (FMRI) data that allows for nonsquare mixing in the presence of Gaussian noise. In order to avoid overfitting, we employ objective estimation of the amount of Gaussian noise through Bayesian analysis of the true ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2003.822821
更新日期:2004-02-01 00:00:00
abstract::Deformable image registration is an important tool in medical image analysis. In the case of lung computed tomography (CT) registration there are three major challenges: large motion of small features, sliding motions between organs, and changing image contrast due to compression. Recently, Markov random field (MRF)-b...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2013.2246577
更新日期:2013-07-01 00:00:00
abstract::We propose a new method for deformable registration of pre-operative and post-recurrence brain MR scans of glioma patients. Performing this type of intra-subject registration is challenging as tumor, resection, recurrence, and edema cause large deformations, missing correspondences, and inconsistent intensity profiles...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2013.2293478
更新日期:2014-03-01 00:00:00
abstract::The maximum likelihood (ML) approach to estimating the radioactive distribution in the body cross section has become very popular among researchers in emission computed tomography (ECT) since it has been shown to provide very good images compared to those produced with the conventional filtered backprojection (FBP) al...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.538946
更新日期:1996-01-01 00:00:00
abstract::A fully automated, unsupervised lobe segmentation algorithm is presented based on a probabilistic segmentation of the fissures and the simultaneous construction of a populationmodel of the fissures. A two-class probabilistic segmentation segments the lung into candidate fissure voxels and the surrounding parenchyma. T...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2017.2688377
更新日期:2017-08-01 00:00:00
abstract::The segmentation of the human airway tree from volumetric computed tomography (CT) images builds an important step for many clinical applications and for physiological studies. Previously proposed algorithms suffer from one or several problems: leaking into the surrounding lung parenchyma, the need for the user to man...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2005.857654
更新日期:2005-12-01 00:00:00
abstract::Prostatic adenocarcinoma is the most commonly occurring cancer among men in the United States, second only to skin cancer. Currently, the only definitive method to ascertain the presence of prostatic cancer is by trans-rectal ultrasound (TRUS) directed biopsy. Owing to the poor image quality of ultrasound, the accurac...
journal_title:IEEE transactions on medical imaging
pub_type: 临床试验,杂志文章
doi:10.1109/TMI.2005.859208
更新日期:2005-12-01 00:00:00
abstract::High peak RF amplitude and excessive specific absorption rate (SAR) are two critical concerns for hardware implementation and patient safety in scientific and clinical research for high field MRI using parallel transmissions (pTX). In this paper, we introduce a squeezing strategy to reduce peak RF amplitude and integr...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2018.2828112
更新日期:2018-08-01 00:00:00
abstract::The purpose of this work is to study the architecture of the rearfoot using in vivo MR image data. Each data set used in this study is made of sixty sagittal slices of the foot acquired in a 1.5-T commercial GE MR system. We use the live-wire method to delineate boundaries and form the surfaces of the bones. In the fi...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.802753
更新日期:1999-09-01 00:00:00
abstract::Percutaneous coronary intervention (PCI) is the prevalent treatment for coronary artery disease, with hundreds of thousands of stents implanted annually. Computational studies have demonstrated the role of biomechanics in the failure of vascular stents, but clinical studies is this area are limited by a lack of unders...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2018.2870714
更新日期:2019-03-01 00:00:00
abstract::Multisource cone-beam computed tomography (CT) is an attractive approach of choice for superior temporal resolution, which is critically important for cardiac imaging and contrast enhanced studies. In this paper, we present a filtered-backprojection (FBP) algorithm for triple-source helical cone-beam CT. The algorithm...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2008.2004817
更新日期:2009-03-01 00:00:00
abstract::Cardiac resynchronization therapy (CRT) has been shown to improve cardiovascular function in specific patients suffering from heart failure. This procedure still needs to be optimized to overcome the high rate of implanted patients that do not respond to this therapy. We propose in this work a better characterization ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2014.2311694
更新日期:2014-06-01 00:00:00
abstract::This paper examines the use of the algebraic reconstruction technique (ART) and related techniques to reconstruct 3-D objects from a relatively sparse set of cone-beam projections. Although ART has been widely used for cone-beam reconstruction of high-contrast objects, e.g., in computed angiography, the work presented...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.781017
更新日期:1999-06-01 00:00:00
abstract::Magnetic nanoparticles can be caused to oscillate under the influence of an incident ultrasonic wave. If the particles are momentarily aligned with a magnetizing pulse creating a macroscopic magnetization, this oscillation will result in a time-varying magnetic moment which should be detectable as an induced voltage i...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2007.895476
更新日期:2007-05-01 00:00:00
abstract::Two methods of rejecting pileup events in 2-D array detectors used in positron emission tomography (PET) are investigated. Since the methods are based on different physical properties, they were investigated separately and in combination. Method one is based on the fact that valid events in the 2-D array detector occu...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.79481
更新日期:1991-01-01 00:00:00
abstract::Fast and accurate tissue elasticity imaging is essential in studying dynamic tissue mechanical properties. Various ultrasound shear elasticity imaging techniques have been developed in the last two decades. However, to reconstruct a full field-of-view 2-D shear elasticity map, multiple data acquisitions are typically ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2012.2205586
更新日期:2012-09-01 00:00:00
abstract::Ultrasound (US) imaging is the primary imaging modality for pediatric hydronephrosis, which manifests as the dilation of the renal collecting system (CS). In this paper, we present a new framework for the segmentation of renal structures, kidney and CS, from 3DUS scans. First, the kidney is segmented using an active s...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2016.2572641
更新日期:2016-11-01 00:00:00
abstract::Groupwise nonrigid image registration is a powerful tool to automatically establish correspondences across sets of images. Such correspondences are widely used for constructing statistical models of shape and appearance. As existing techniques usually treat registration as an optimization problem, a good initializatio...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2011.2169077
更新日期:2012-02-01 00:00:00
abstract::Tracing of left-ventricular epicardial and endocardial borders on echocardiographic sequences is essential for quantification of cardiac function. The authors designed a method based on an extension of active contour models to detect both epicardial and endocardial borders on short-axis cardiac sequences spanning the ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.500138
更新日期:1996-01-01 00:00:00