Abstract：
:An algorithm is presented for the analysis and quantification of the vascular structures of the human retina. Information about retinal blood vessel morphology is used in grading the severity and progression of a number of diseases. These disease processes are typically followed over relatively long time courses, and subjective analysis of the sequential images dictates the appropriate therapy for these patients. In this research, retinal fluorescein angiograms are acquired digitally in a 1024x1024 16-b image format and are processed using an automated vessel tracking program to identify and quantitate stenotic and/or tortuous vessel segments. The algorithm relies on a matched filtering approach coupled with a priori knowledge about retinal vessel properties to automatically detect the vessel boundaries, track the midline of the vessel, and extract useful parameters of clinical interest. By modeling the vessel profile using Gaussian functions, improved estimates of vessel diameters are obtained over previous algorithms. An adaptive densitometric tracking technique based on local neighborhood information is also used to improve computational performance in regions where the vessel is relatively straight.
journal_name
IEEE Trans Med Imagingjournal_title
IEEE transactions on medical imagingauthors
Zhou L,Rzeszotarski MS,Singerman LJ,Chokreff JMdoi
10.1109/42.363106subject
Has Abstractpub_date
1994-01-01 00:00:00pages
619-26issue
4eissn
0278-0062issn
1558-254Xjournal_volume
13pub_type
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