Abstract:
:Cervical cancer causes the fourth most cancer-related deaths of women worldwide. Early detection of cervical intraepithelial neoplasia (CIN) can significantly increase the survival rate of patients. In this paper, we propose a deep learning framework for the accurate identification of LSIL+ (including CIN and cervical cancer) using time-lapsed colposcopic images. The proposed framework involves two main components, i.e., key-frame feature encoding networks and feature fusion network. The features of the original (pre-acetic-acid) image and the colposcopic images captured at around 60s, 90s, 120s and 150s during the acetic acid test are encoded by the feature encoding networks. Several fusion approaches are compared, all of which outperform the existing automated cervical cancer diagnosis systems using a single time slot. A graph convolutional network with edge features (E-GCN) is found to be the most suitable fusion approach in our study, due to its excellent explainability consistent with the clinical practice. A large-scale dataset, containing time-lapsed colposcopic images from 7,668 patients, is collected from the collaborative hospital to train and validate our deep learning framework. Colposcopists are invited to compete with our computer-aided diagnosis system. The proposed deep learning framework achieves a classification accuracy of 78.33%-comparable to that of an in-service colposcopist-which demonstrates its potential to provide assistance in the realistic clinical scenario.
journal_name
IEEE Trans Med Imagingjournal_title
IEEE transactions on medical imagingauthors
Li Y,Chen J,Xue P,Tang C,Chang J,Chu C,Ma K,Li Q,Zheng Y,Qiao Ydoi
10.1109/TMI.2020.2994778subject
Has Abstractpub_date
2020-11-01 00:00:00pages
3403-3415issue
11eissn
0278-0062issn
1558-254Xjournal_volume
39pub_type
杂志文章abstract::In this paper, we present a two-stage algorithm for mammogram registration, the geometrical alignment of mammogram sequences. The rationale behind this paper stems from the intrinsic difficulties in comparing mammogram sequences. Mammogram comparison is a valuable tool in national breast screening programs as well as ...
journal_title:IEEE transactions on medical imaging
pub_type: 临床试验,杂志文章
doi:10.1109/TMI.2005.848374
更新日期:2005-06-01 00:00:00
abstract::Certain diseases cause permanent changes to the shapes and densities of nailfold capillaries and, therefore, nailfold capillaroscopy is important as a tool for diagnosing and monitoring these diseases. The first aim of the project is to resolve differences in terminology that have developed over the years in previous ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.921482
更新日期:2001-04-01 00:00:00
abstract::Fast magnetic resonance imaging slice acquisition techniques such as single shot fast spin echo are routinely used in the presence of uncontrollable motion. These techniques are widely used for fetal magnetic resonance imaging (MRI) and MRI of moving subjects and organs. Although high-quality slices are frequently acq...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2010.2051680
更新日期:2010-10-01 00:00:00
abstract::A novel framework for the classification of acute rejection versus nonrejection status of renal transplants from 2-D dynamic contrast-enhanced magnetic resonance imaging is proposed. The framework consists of four steps. First, kidney objects are segmented from adjacent structures with a level set deformable boundary ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2013.2269139
更新日期:2013-10-01 00:00:00
abstract::The accuracy of in vivo dopamine D2 receptor quantification by positron emission tomography (PET) was determined for several models by means of singular-value decomposition, and some of the model assumptions were reviewed. These include steady-state, transient, double injection, and equilibrium approaches. All four mo...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.7783
更新日期:1988-01-01 00:00:00
abstract::An accurate diagnosis of burns and pressure ulcers in the early stages can be made by computerized image processing. This study describes a critical assessment of potential methodologies for noninvasive wound evaluation using a color imaging system. We also developed a method for quantifying histological readings and ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.552057
更新日期:1997-02-01 00:00:00
abstract::Myocardial tissue characterization using ultrasound is a growing area of investigation which attempts to evaluate the structure of the myocardium by analysis of ultrasound signals. Our laboratory has been exploring the use of texture analysis for the determination of myocardial tissue properties from two-dimensional e...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.1985.4307721
更新日期:1985-01-01 00:00:00
abstract::Lung cancer is the leading cause of cancer deaths worldwide and early diagnosis of lung nodule is of great importance for therapeutic treatment and saving lives. Automated lung nodule analysis requires both accurate lung nodule benign-malignant classification and attribute score regression. However, this is quite chal...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2019.2934577
更新日期:2020-03-01 00:00:00
abstract::The presence of high-density objects remains an open problem in medical CT imaging. Data of projections passing through objects of high density, such as metal implants, are dominated by noise and are highly affected by beam hardening and scatter. Reconstructed images become less diagnostically conclusive because of pr...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2015.2459764
更新日期:2016-01-01 00:00:00
abstract::A fully automated 2-D+time myocardial segmentation framework is proposed for cardiac magnetic resonance (CMR) blood-oxygen-level-dependent (BOLD) data sets. Ischemia detection with CINE BOLD CMR relies on spatio-temporal patterns in myocardial intensity, but these patterns also trouble supervised segmentation methods,...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2017.2726112
更新日期:2017-11-01 00:00:00
abstract::Magnetic resonance (MR) fingerprinting is a technique for acquiring and processing MR data that simultaneously provides quantitative maps of different tissue parameters through a pattern recognition algorithm. A predefined dictionary models the possible signal evolutions simulated using the Bloch equations with differ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2014.2337321
更新日期:2014-12-01 00:00:00
abstract::Thin, dense interslice septa have long been used to reduce the scattered radiation collected in positron emission tomography (PET). These septa prevent the acquisition of coincident gamma rays that are oblique to the scanning planes. Several volume imaging systems that acquire oblique rays have been built. The reasons...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.222675
更新日期:1993-01-01 00:00:00
abstract::A two-stage algorithm for extraction of the ventricular chambers (endocardial surfaces) in flow-enhanced magnetic resonance images is described. In the first stage, the approximate locations and sizes of the endocardial surfaces are determined by intensity thresholding. In the second stage, points on each approximated...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.370402
更新日期:1995-01-01 00:00:00
abstract::A computationally efficient mixed feature based neural network (MFNN) is proposed for the detection of microcalcification clusters (MCCs) in digitized mammograms. The MFNN employs features computed in both the spatial and spectral domain and uses spectral entropy as a decision parameter. Backpropagation with Kalman fi...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.538936
更新日期:1996-01-01 00:00:00
abstract::A major issue in telepathology is the extremely large and growing size of digitized "virtual" slides, which can require several gigabytes of storage and cause significant delays in data transmission for remote image interpretation and interactive visualization by pathologists. Compression can reduce this massive amoun...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2010.2077308
更新日期:2011-02-01 00:00:00
abstract::We are presenting data from the largest clinical trial on optical tomographic imaging of finger joints to date. Overall we evaluated 99 fingers of patients affected by rheumatoid arthritis (RA) and 120 fingers from healthy volunteers. Using frequency-domain imaging techniques we show that sensitivities and specificiti...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2011.2135374
更新日期:2011-10-01 00:00:00
abstract::Micro-computed tomography (micro-CT) has been widely used to generate high-resolution 3-D tissue images from small animals nondestructively, especially for mineralized skeletal tissues. However, its application to the analysis of soft cardiovascular tissues has been limited by poor inter-tissue contrast. Recent ex viv...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2012.2209183
更新日期:2013-01-01 00:00:00
abstract::It is well understood that binary classifiers have two implicit objective functions (sensitivity and specificity) describing their performance. Traditional methods of classifier training attempt to combine these two objective functions (or two analogous class performance measures) into one so that conventional scalar ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.796281
更新日期:1999-08-01 00:00:00
abstract::We describe a matched subspace detection algorithm to assist in the detection of small tumors in dynamic positron emission tomography (PET) images. The algorithm is designed to differentiate tumors from background using the time activity curves (TACs) that characterize the uptake of PET tracers. TACs are modeled using...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2008.929105
更新日期:2009-02-01 00:00:00
abstract::Hand-bone analysis with image processing techniques using a digital radiograph can be used to assess skeletal age. The analysis consists of two steps: phalangeal and carpal bone analysis. The carpal bone analysis is discussed. First, the carpal bone region of interest (CROI) is defined using a standard thresholding te...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.222665
更新日期:1993-01-01 00:00:00
abstract::Anisotropic multi-slice Cardiac Magnetic Resonance (CMR) Images are conventionally acquired in patient-specific short-axis (SAX) orientation. In specific cardiovascular diseases that affect right ventricular (RV) morphology, acquisitions in standard axial (AX) orientation are preferred by some investigators, due to po...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2021.3052972
更新日期:2021-01-20 00:00:00
abstract::Accurate gain control of PET detectors is a prerequisite for quantitative accuracy. A shift in the 511 keV peak position can lead to errors in scatter correction, degrading quantitation. The PET detectors in a PET/MR scanner are subject to thermal transients due to eddy currents induced during gradient-intensive MRI s...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2020.3022321
更新日期:2021-01-01 00:00:00
abstract::This paper presents two new methods for robust parameter estimation of mixtures in the context of magnetic resonance (MR) data segmentation. The head is constituted of different types of tissue that can be modeled by a finite mixture of multivariate Gaussian distributions. Our goal is to estimate accurately the statis...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.700730
更新日期:1998-04-01 00:00:00
abstract::Although Blood Oxygenation Level Dependent (BOLD) functional MRI (fMRI) is widely used to examine brain function in adults, the need for general anesthesia limits its practical utility in infants and small children. Functional Near-Infrared Spectroscopy - Diffuse Optical Tomography (fNIRS-DOT) imaging promises to be a...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2020.2990823
更新日期:2020-11-01 00:00:00
abstract::Since the invention of diffusion magnetic resonance imaging (dMRI), currently the only established method for studying white matter connectivity in a clinical environment, there has been a great deal of interest in the effects of various pathologies on the connectivity of the brain. As methods for in vivo tractography...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2007.905826
更新日期:2007-11-01 00:00:00
abstract::Two-dimensional ultrasound sector scans of the left ventricle (LV) are commonly used to diagnose cardiac mechanical function. Present quantification procedures of wall motion by this technique entail inaccuracies, mainly due to relatively poor image quality and the absence of a definition of the relative position of t...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.1987.4307836
更新日期:1987-01-01 00:00:00
abstract::Radio-frequency current density imaging (RF-CDI) is an imaging technique that noninvasively measures current density distribution at the Larmor frequency utilizing magnetic resonance imaging (MRI). Previously implemented RF-CDI techniques were only able to image a single slice transverse to the static magnetic field B...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2008.2012161
更新日期:2009-07-01 00:00:00
abstract::Segmentation of the wrist bones in CT images has been frequently used in different clinical applications including arthritis evaluation, bone age assessment and image-guided interventions. The major challenges include non-uniformity and spongy textures of the bone tissue as well as narrow inter-bone spaces. In this wo...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2016.2529500
更新日期:2016-08-01 00:00:00
abstract::We propose a method that incorporates the time-frequency characteristics of neural sources into magnetoencephalographic (MEG) source estimation. The method is based on the multiple-signal-classification (MUSIC) algorithm and it calculates a time--frequency matrix in which diagonal and off-diagonal terms are the auto a...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.750262
更新日期:1999-01-01 00:00:00
abstract::Optical coherence tomography (OCT) uses retroreflected light to provide micrometer-resolution, cross-sectional scans of biological tissues. OCT's first application was in ophthalmic imaging where it has proven particularly useful in diagnosing, monitoring, and studying glaucoma. Diagnosing glaucoma is difficult and it...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2006.871417
更新日期:2006-05-01 00:00:00