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Frequency-domain optical tomographic imaging of arthritic finger joints.

Abstract：

:We are presenting data from the largest clinical trial on optical tomographic imaging of finger joints to date. Overall we evaluated 99 fingers of patients affected by rheumatoid arthritis (RA) and 120 fingers from healthy volunteers. Using frequency-domain imaging techniques we show that sensitivities and specificities of 0.85 and higher can be achieved in detecting RA. This is accomplished by deriving multiple optical parameters from the optical tomographic images and combining them for the statistical analysis. Parameters derived from the scattering coefficient perform slightly better than absorption derived parameters. Furthermore we found that data obtained at 600 MHz leads to better classification results than data obtained at 0 or 300 MHz.

journal_name

IEEE Trans Med Imaging

journal_title

IEEE transactions on medical imaging

authors

Hielscher AH,Kim HK,Montejo LD,Blaschke S,Netz UJ,Zwaka PA,Illing G,Muller GA,Beuthan J

doi

10.1109/TMI.2011.2135374

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

1725-36

issue

10

eissn

0278-0062

issn

1558-254X

journal_volume

30

pub_type

杂志文章

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