Inflammatory theory of depression.

Abstract:

:Brain diseases are one of the most socially and economically burdening diseases in Europe. Among all brain diseases, more than 60% of social and economic costs are generated by mental disorders (mainly depressive disorders and anxiety disorders). Recurrent depressive disorders have been a significant civilizational problem in recent times. Among the biological and psychological theories explaining the causes of depression, the hypothesis involving an active inflammatory process taking place in a human organism is becoming increasingly important. The following are considered inflammation markers: inflammatory enzymes (e.g., manganese superoxide dismutase (MnSOD), myeloperoxidase (MPO), inducible nitric oxide synthase), proinflammatory and anti-inflammatory cytokines, and the phenomenon of oxidative stress. Through the kynurenine pathway, these factors lead to a deficit in serotonin and melatonin, which is considered one of the main reasons of depression. We can consider depression to be a chronic cold of the organism, which develops in response to the action of greater or smaller everyday stressors. This paper presents results of recent studies regarding this matter.

journal_name

Psychiatr Pol

journal_title

Psychiatria polska

authors

Gałecki P,Talarowska M

doi

10.12740/PP/76863

subject

Has Abstract

pub_date

2018-06-30 00:00:00

pages

437-447

issue

3

eissn

0033-2674

issn

2391-5854

pii

76863

journal_volume

52

pub_type

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