The effects on ventilation of ketorolac in comparison with morphine.

abstract：:Differences in the plasma concentrations of drugs after oral administration are caused by two main factors: variation in absorption ratios and in the distribution processes in the body. A new method for the dissection of both types of factors is discussed. The method uses a reference regression of the AUC-values to th...

journal_title：European journal of clinical pharmacology

authors： Betzien G,Kaufmann B,Schneider B

更新日期：1982-01-01 00:00:00

abstract：:The kinetics of mefloquine were studied in 12 healthy Thai male and 12 healthy Thai female volunteers. Mefloquine (MQ) was administered either alone (750 mg orally) or in combination (MSP) with sulphadoxine (1.5 g) and pyrimethamine (75 mg) to each of 6 male and 6 female subjects. Plasma concentrations of MQ were meas...

journal_title：European journal of clinical pharmacology

authors： Karbwang J,Bunnag D,Breckenridge AM,Back DJ

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of grapefruit juice (GJ) on the pharmacokinetics of orally administered verapamil in hypertensive patients. METHODS:Ten hypertensive patients on chronic verapamil treatment participated in a two-day study. On day 1 200 ml of water was given 1 hour before, and together with the morni...

journal_title：European journal of clinical pharmacology

authors： Zaidenstein R,Dishi V,Gips M,Soback S,Cohen N,Weissgarten J,Blatt A,Golik A

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:To test whether treatment with fenofibrate decreases asymmetric dimethylarginine (ADMA) level in hypertriglyceridemic individuals. METHODS:In the present study, 45 subjects with hypertriglyceridemia were recruited to receive treatment with fenofibrate (200 mg/d). Serum concentrations of ADMA, malondialdehyde...

journal_title：European journal of clinical pharmacology

authors： Yang TL,Chen MF,Xia X,Luo BL,Li YJ

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy of activated charcoal and gastric lavage in preventing the absorption of moclobemide, temazepam, and verapamil 30 min after drug ingestion. METHODS:In this randomized cross-over study with three phases, nine healthy volunteers received a single oral dose of 150 mg moclobemide, 10 mg t...

journal_title：European journal of clinical pharmacology

authors： Lapatto-Reiniluoto O,Kivistö KT,Neuvonen PJ

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:A four-drug cytochrome P450 (CYP) phenotyping cocktail was developed to rapidly and safely determine CYP2D6, CYP2C19, CYP2C9 and CYP1A2 enzyme activity and phenotype. METHODS:The cocktail consisted of the single CYP phenotyping probes of 50 mg tramadol (CYP2D6), 20 mg omeprazole (CYP2C19), 25 mg losartan (C...

journal_title：European journal of clinical pharmacology

authors： Pedersen RS,Damkier P,Christensen MM,Brosen K

更新日期：2013-12-01 00:00:00

abstract：:The plasma pharmacokinetics of adriamycin has been studied in 21 cancer patients (31-85 years old) without liver tumours after short (3.00 min) and prolonged (45 min-16 h) i.v. infusions. The area under the plasma concentration-time curve and the maximum plasma concentration compensated for dose variation showed a mor...

journal_title：European journal of clinical pharmacology

authors： Eksborg S,Strandler HS,Edsmyr F,Näslund I,Tahvanainen P

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:Drug-induced immune thrombocytopaenia is a rare, serious condition that can be triggered by numerous medications. To characterize the spectrum of drugs associated with immune thrombocytopaenia (ITP) in the Berlin Case-Control Surveillance Study (FAKOS). METHODS:Adult hospitalized patients with new onset idiopa...

journal_title：European journal of clinical pharmacology

authors： Garbe E,Andersohn F,Bronder E,Salama A,Klimpel A,Thomae M,Schrezenmeier H,Hildebrandt M,Späth-Schwalbe E,Grüneisen A,Meyer O,Kurtal H

更新日期：2012-05-01 00:00:00

abstract：:An aqueous solution of 35S-ampicillin and polyethylene glycol (PEG 4000, unabsorbable marker) was administered orally to 6 healthy subjects with gastrointestinal tubes. The minimal absorption of radioactive material, as shown by urinary excretion of label, differed markedly between subjects and averaged 44% (25-67). A...

journal_title：European journal of clinical pharmacology

authors： Swahn A

更新日期：1975-12-19 00:00:00

abstract：:The pharmacokinetics of cefoxitin was studied in 6 healthy volunteers and in 5 patients with a pleural effusion after administration of a single dose of 30 mg/kg i.v. infusion. The serum and pleural fluid concentrations of cefoxitin were determined microbiologically. The elimination half-life of the antibiotic from pl...

journal_title：European journal of clinical pharmacology

authors： Otero MJ,Garcia MJ,Barrueco M,Dominguez-Gil A,Gomez F,Portugal Alvarez J

更新日期：1984-01-01 00:00:00

abstract：:Ten normal adult tobacco smokers and 10 nonsmoking volunteers 20-31 years of age were the subjects of this study. The tobacco smokers all had a history of daily tobacco smoking. They were asked to stop smoking for 12 hours prior to testing. The Hoffmann (H) reflex and its recovery cycle were measured on different days...

journal_title：European journal of clinical pharmacology

authors： Domino EF,Kadoya C,Matsuoka S

更新日期：1994-01-01 00:00:00

abstract：:The function of the hepatic P450 enzyme system was evaluated by measuring the kinetics of antipyrine and serum sex hormone levels were determined in 12 male patients with epilepsy during carbamazepine medication, and two and six months after changing their medication to oxcarbazepine. Antipyrine t1/2 increased and ant...

journal_title：European journal of clinical pharmacology

authors： Isojärvi JI,Pakarinen AJ,Rautio A,Pelkonen O,Myllylä VV

更新日期：1995-01-01 00:00:00

abstract：:The effects of acute introduction and withdrawal of trimeprazine (Vallergan), an antihistaminic phenothiazine derivative with known sedative effects, were investigated by a single blind polygraphic study in 8 healthy volunteers. A baseline placebo was given on Nights 1-3, followed either by 10 mg or 20 mg of the drug ...

journal_title：European journal of clinical pharmacology

authors： Kayed K,Hansen T,Godtlibsen OB

更新日期：1977-03-11 00:00:00

abstract：:The time-courses of plasma carbamazepine concentrations were followed in six apparently healthy adult subjects who, at different times, took single oral drug doses of 200, 400, 500, 600, 700, 800 and 900 mg. There were some suggestions of impaired bioavailability of the drug when given in tablet form. The following va...

journal_title：European journal of clinical pharmacology

authors： Cotter LM,Eadie MJ,Hooper WD,Lander CM,Smith GA,Tyrer JH

更新日期：1977-12-28 00:00:00

abstract：:We have studied the pharmacokinetics of tulobuterol given transdermally or by aerosol inhalation in healthy male volunteers. Tulobuterol was rapidly absorbed after inhalation, with a tmax of 0.8-1.5 h. The Cmax and the AUC increased linearly with dose. Tulobuterol was well absorbed after transdermal administration, wi...

journal_title：European journal of clinical pharmacology

authors： Uematsu T,Nakano M,Kosuge K,Kanamaru M,Nakashima M

更新日期：1993-01-01 00:00:00

abstract：:Plasma concentrations of metoprolol, propranolol oxprenolol, acebutolol and its metabolite diacetolol were measured after single oral doses in young health volunteers. In order to assessed the inter- and intra-subject variability the following pharmacokinetic parameters were compared: AUC0(24), Cmax, tmax and t 1/2. T...

journal_title：European journal of clinical pharmacology

authors： Jack DB,Quarterman CP,Zaman R,Kendall MJ

更新日期：1982-01-01 00:00:00

abstract：:This study assessed the influence of acetylsalicylic acid (ASA, 1.0 g), ibuprofen (0.8 g) and paracetamol (1.0 g) on the single-dose kinetics of ethanol in 12 healthy volunteers ingesting the drug and a standardised 1840-kJ breakfast 1 h before intake of ethanol. It also assessed the influence of ethanol on the single...

journal_title：European journal of clinical pharmacology

authors： Melander O,Lidén A,Melander A

更新日期：1995-01-01 00:00:00

abstract：:We gave 24 healthy elderly volunteers with a perceived sleep onset of at least 30 minutes zolpidem 5 mg, zolpidem 10 mg, or placebo for 7 days in a double-blind, three-way, crossover study. The morning after nocturnal dosing, psychomotor performance and cognitive ability were measured using tests which are sensitive t...

journal_title：European journal of clinical pharmacology

authors： Fairweather DB,Kerr JS,Hindmarch I

更新日期：1992-01-01 00:00:00

abstract：:A phamacokinetic study in man has been made of a new dosage form of diclofenac hydroxyethylpyrrolidine (DIEP); soluble salt packed in sachets was compared with diclofenac sodium as enteric coated tablets. Oral DIEP 2 X 50 mg showed a significant difference in absorption kinetics (ka, lag time and tmax) as compared to ...

journal_title：European journal of clinical pharmacology

authors： Maggi CA,Lualdi P,Mautone G

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:To analyse reports of drug-induced myocardial infarction and chest pain sent to a national reporting centre. To review which drugs were suspected of exhibiting these adverse events and what mechanisms were involved. METHODS:During the 20-year period 1975 through 1994, a total of 19,141 reports on adverse re...

journal_title：European journal of clinical pharmacology

authors： Ottervanger JP,Wilson JH,Stricker BH

更新日期：1997-01-01 00:00:00

abstract：:In a double-blind, randomized study, the long-term effects of timolol and placebo on FEV1, PEFR, FVC, VC, respiratory rate and heart rate were compared in 32 patients surviving acute myocardial infarction, 17 on timolol and 15 on placebo. The patients were assessed before and after 1, 3 and 6 months of medication, and...

journal_title：European journal of clinical pharmacology

authors： Johansen S

更新日期：1985-01-01 00:00:00

abstract：:In a multicentre, double-blind, crossover, placebo-controlled study, the antihypertensive effect of labetalol 100 mg and chlorthalidone 10 mg, given alone or in combination, has been assessed in 32 hypertensive patients. The combination had a greater effect in reducing blood pressure than did its separate components. ...

journal_title：European journal of clinical pharmacology

authors： Lechi A,Pomari S,Berto R,Buniotto P,Parrinello A,Marini F,Cogo L,Tomasi A,Baretta G

更新日期：1982-01-01 00:00:00

abstract：:Encainide is a new anti-arrhythmic drug, which is highly effective against ventricular extrasystoles, both single and coupled, in the dose range of 80--140 mg i.v. Ventricular extrasystoles were abolished in 31 out of 33 cases treated. The drug is also relatively effective against supraventricular extrasystoles, but h...

journal_title：European journal of clinical pharmacology

authors： Kesteloot H,Stroobandt R

更新日期：1979-11-01 00:00:00

abstract：:Investigations were undertaken to evaluate which uraemic solutes decrease drug protein binding. This was done by performing HPLC-fractionation of uraemic biological fluids and studying the effect of addition of a lyophilisate of each fraction to normal plasma containing standard quantities of radiolabelled drugs. From...

journal_title：European journal of clinical pharmacology

authors： Vanholder R,De Smet R,Ringoir S

更新日期：1993-01-01 00:00:00

abstract：:The pharmacokinetics of a single 2 mg IV dose of chlordesmethyldiazepam has been studied in 11 patients with renal failure on regular haemodialysis and in 11 age-matched healthy controls. The kinetics was also examined after a single 2 mg oral dose in 6 of the 11 renal failure patients. After intravenous administratio...

journal_title：European journal of clinical pharmacology

authors： Sennesael J,Verbeelen D,Vanhaelst L,Pirola R,Bareggi SR

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) is a delayed infrequent potentially life-threatening idiosyncratic drug reaction. Aromatic anticonvulsants and allopurinol are the most frequent causative agents. However, various reports of antibiotic-induced DRESS are available. In this...

journal_title：European journal of clinical pharmacology

authors： Sharifzadeh S,Mohammadpour AH,Tavanaee A,Elyasi S

更新日期：2020-10-06 00:00:00

abstract：:The relation between plasma concentration of theophylline and number of apnea preterm infants was studied in six patients. The apnea frequency was monitored after cessation of theophylline treatment and plotted against the log plasma concentration of theophylline. It was calculated that at an average plasma concentrat...

journal_title：European journal of clinical pharmacology

authors： Lagercrantz H,Rane A,Tunell R

更新日期：1980-07-01 00:00:00

abstract：:The effect of long-term treatment on the absorption and disposition of metoprolol has been evaluated in 8 healthy, non-smoking, elderly individuals (mean age 74.5 years) and in a control group of 8 healthy, young individuals. Two trace doses of [3H]metoprolol were given i.v., first concomitantly with a single oral 50 ...

journal_title：European journal of clinical pharmacology

authors： Larsson M,Landahl S,Lundborg P,Regårdh CG

更新日期：1984-01-01 00:00:00

abstract：:Lorcainide is a promising antiarrhythmic agent that belongs to the class of local anesthetics. It was tested in 7 patients with malignant ventricular arrhythmias that were resistant to other antiarrhythmic agents. Lorcainide was effective in all cases (complete disappearance of arrhythmias in 6 cases and more than 50%...

journal_title：European journal of clinical pharmacology

authors： Cocco G,Strozzi C

更新日期：1978-11-16 00:00:00

abstract：:The kinetics of 14C-metformin have been studied in five healthy subjects after oral and intravenous administration. The intravenous dose was distributed to a small central compartment of 9.9 +/- 1.61 (X +/- SE), from which its elimination could be described using three-compartment open model. The elimination half-life...

journal_title：European journal of clinical pharmacology

authors： Pentikäinen PJ,Neuvonen PJ,Penttilä A

更新日期：1979-09-01 00:00:00