Comparative bioavailability of diclofenac hydroxyethylpyrrolidine vs diclofenac sodium in man.

abstract：:Amitriptyline has clinically important interactions with ethanol. Five healthy volunteers received 25 mg of amitriptyline orally, preceded by one hour and followed for eight hours by oral ethanol (or juice), dosed to achieve and maintain blood ethanol concentrations of 800 mg/l. In the presence of ethanol, amitriptyli...

journal_title：European journal of clinical pharmacology

authors： Dorian P,Sellers EM,Reed KL,Warsh JJ,Hamilton C,Kaplan HL,Fan T

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:The study aimed to test the hypothesis that hospital electronic prescribing and medicine administration system (HEPMA) implementation impacted patient discharge letter quality, nature and frequency of prescribing errors. METHOD:A quasi experimental before and after retrospective case note review was conducted ...

journal_title：European journal of clinical pharmacology

authors： Mills PR,Weidmann AE,Stewart D

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:This study was performed to determine the oral pharmacokinetics (PK) of EV-077 and its effects on pharmacodynamic (PD) markers. EV-077 blocks prostanoid-induced and isoprostane-induced cellular activation, and is in development for the treatment of vascular inflammation and associated complications of type-2 di...

journal_title：European journal of clinical pharmacology

authors： Richardson A,Sakariassen KS,Meyer JP,Alberts P,Sorensen AS

更新日期：2013-03-01 00:00:00

abstract：:Oral and sublingual isoxsuprine 20 mg were compared with placebo in double blind randomised cross over trial in 7 patients with Raynaud's phenomenon. Skin thermography, plethysmography of the finger tips and direct temperature measurements showed that sublingual isoxsuprine was slightly but consistently superior to th...

journal_title：European journal of clinical pharmacology

authors： Wesseling H,den Heeten A,Wouda AA

更新日期：1981-01-01 00:00:00

abstract：:The effects of a beta-blocker, carvedilol, on peripheral hemodynamics and hemorheologic parameters were evaluated in 11 geriatric patients with essential hypertension [3 men and 8 women aged 62-79 years (mean, 68.6 years)]. Carvedilol was given orally after breakfast at a dose of 10 or 20 mg daily for 8 weeks. Periphe...

journal_title：European journal of clinical pharmacology

authors： Nagakawa Y,Akedo Y,Kaku S,Orimo H

更新日期：1990-01-01 00:00:00

abstract：:We have studied the antiaggregatory effect of fenflumizole, a new non-steroidal antiinflammatory imidazole derivative, in ten patients with unstable angina pectoris. We have measured the aggregation induced by arachidonic acid (AA), ADP, and collagen, and serum or plasma concentrations of beta-thromboglobulin (beta-TG...

journal_title：European journal of clinical pharmacology

authors： Grauholt AM,Grande P,Wadt J

更新日期：1987-01-01 00:00:00

abstract：:The effect of cimetidine and ranitidine on doxepin pharmacokinetics was studied in 6 healthy volunteers. Each subject completed 3 study phases: Treatment A, 9 consecutive doses of 50 mg doxepin (once daily); Treatment B, same as Treatment A but co-administration of cimetidine 600 mg b.i.d. starting after the sixth dox...

journal_title：European journal of clinical pharmacology

authors： Sutherland DL,Remillard AJ,Haight KR,Brown MA,Old L

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Many studies have indicated the adequate use of lipid-lowering drugs (LLDs) as a factor in reducing the risk of cardiovascular disease. However, in clinical practice, a very high percentage of patients are not adequately treated. OBJECTIVE:To analyze the management of hypercholesterolemia in a non-experimen...

journal_title：European journal of clinical pharmacology

authors： Di Martino M,Degli Esposti L,Ruffo P,Bustacchini S,Catte A,Sturani A,Degli Esposti E

更新日期：2005-05-01 00:00:00

abstract：:The use of cimetidine in general practice was studied in relation to the guidelines approved by the Dutch National Drug Regulatory Agency (DRA). National and regional figures showed that the frequency with which cimetidine was prescribed in general practice was greater than could be explained on the basis of approved ...

journal_title：European journal of clinical pharmacology

authors： Haayer FM,van der Werf GT,Wieringa NF,Wesseling H

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:Inconsistent results of lipid-lowering medications (LLMs) on improved cancer survival need more investigations. We tested the hypothesis that adherence to the drug would be associated with a lower cancer-specific mortality in a homogeneous population who has ever used the drug. METHODS:Utilising data from the ...

journal_title：European journal of clinical pharmacology

authors： Feng JL,Qin X

更新日期：2020-10-08 00:00:00

abstract：PURPOSE:Few data on the efficacy and safety of drugs in children are available as in the past, these children were not included in randomized controlled trials (RCTs). Data on the efficacy and safety of drugs in children are extrapolated from adults. The EMA recognizes the need for long-term safety studies on various d...

journal_title：European journal of clinical pharmacology

authors： Verhamme K,Sturkenboom M

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:Gefitinib is one of the standard treatments for non-small cell lung cancer (NSCLC) with epidermal growth factor receptor mutations. It has been reported that acid suppressants (AS) decrease the anti-tumor effect of gefitinib by reducing its solubility. AS is sometimes necessary in cancer patients; however, prev...

journal_title：European journal of clinical pharmacology

authors： Saito Y,Takekuma Y,Kobayashi M,Shinagawa N,Shimizu Y,Kinoshita I,Dosaka-Akita H,Iseki K,Sugawara M

更新日期：2020-10-07 00:00:00

abstract：:Factors which might affect paracetamol disposition have been studied in a heterogenous group of patients in need of mild analgesia in an intensive care unit. Following oral administration of 1 g of paracetamol, plasma and urinary concentrations of the parent compound and metabolites were assessed by HPLC. The renal cl...

journal_title：European journal of clinical pharmacology

authors： Kietzmann D,Bock KW,Krähmer B,Kettler D,Bircher J

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:The prevention of contrast-mediated nephropathy (CMN), which accounts for considerable morbidity and mortality, remains a vexing problem. Contrast induced renal vasoconstriction is believed to play a pivotal role in the CMN mechanism. The aim of this pilot study was to examine the safety and efficacy of two d...

journal_title：European journal of clinical pharmacology

authors： Spargias K,Adreanides E,Giamouzis G,Karagiannis S,Gouziouta A,Manginas A,Voudris V,Pavlides G,Cokkinos DV

更新日期：2006-08-01 00:00:00

abstract：:The pharmacokinetics of a single dose of netilmicin (NM) was studied in 6 healthy volunteers. Elimination of the drug was followed in serum and urine for 24 h and 72 h, respectively. NM concentrations were measured with a modified radioenzymatic assay. A three compartment open model was employed to calculate the pharm...

journal_title：European journal of clinical pharmacology

authors： Wenk M,Spring P,Vozeh S,Follath F

更新日期：1979-11-01 00:00:00

abstract：:Total beta-adrenoceptor density and beta 1- and beta 2-subtype distribution in right and left atria and in different ventricular regions from 14 failing and seven nonfailing human hearts have been compared. End-stage heart failure was due to idiopathic dilated cardiomyopathy (n = 8) or ischaemic cardiomyopathy (n = 6)...

journal_title：European journal of clinical pharmacology

authors： Steinfath M,Lavicky J,Schmitz W,Scholz H,Döring V,Kalmár P

更新日期：1992-01-01 00:00:00

abstract：:We have studied the pharmacodynamic effects of ramipril, propranolol, and their combination, as well as the effect of propranolol on the pharmacokinetics of ramipril in 12 healthy men (age 24 (SD 6) y, weight 72 (7) kg). Propranolol and placebo, ramipril and placebo, or propranolol and ramipril were given orally for f...

journal_title：European journal of clinical pharmacology

authors： van Griensven JM,Seibert-Grafe M,Schoemaker HC,Frölich M,Cohen AF

更新日期：1993-01-01 00:00:00

abstract：INTRODUCTION:Deoxycytidine kinase (DCK) is the rate-limiting enzyme of the intracellular phosphorylation of nucleoside anticancer drugs, including gemcitabine and beta-arabinofuranosylcytosine, to their active triphosphates. This study was performed to assess the occurrence and frequency of DCK polymorphisms in a predo...

journal_title：European journal of clinical pharmacology

authors： Joerger M,Bosch TM,Doodeman VD,Beijnen JH,Smits PH,Schellens JH

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:To analyse whether first-time use of antidepressants (incidence) and selection of TCAs (tricyclic antidepressants) versus new-generation drugs are associated with socio-economic status and psychiatric history. METHOD:We conducted a population-based cohort study using registry data covering Funen County, Denm...

journal_title：European journal of clinical pharmacology

authors： Hansen DG,Søndergaard J,Vach W,Gram LF,Rosholm JU,Mortensen PB,Kragstrup J

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:To investigate interindividual variability in response to pain treatment, we characterized postoperative patients for morphine metabolism and for COMT, OPRM1 and UGT2B7 polymorphisms. METHODS:A total of 109 patients treated with morphine were genotyped by DNA sequencing for 12 DNA polymorphisms of the COMT, OP...

journal_title：European journal of clinical pharmacology

authors： De Gregori M,Garbin G,De Gregori S,Minella CE,Bugada D,Lisa A,Govoni S,Regazzi M,Allegri M,Ranzani GN

更新日期：2013-09-01 00:00:00

abstract：:Ple 1053 (Azosemid) is a diuretic which resembles furosemide chemically and in its mode of action. When administered intravenously, Ple 1053 was approximately 5 times more potent on a weight basis than furosemide, its dose-response relationship was closer and the slope was steeper. After oral administration Ple 1053 a...

journal_title：European journal of clinical pharmacology

authors： Krück F,Bablok W,Besenfelder E,Betzien G,Kaufmann B

更新日期：1978-11-27 00:00:00

abstract：AIMS:Our objectives were to assess the detection and incidence of drug-induced agranulocytosis in two university hospitals using hematology laboratory data. METHODS:A prospective study was undertaken at Toulouse University Hospital (France) and Navarra University Hospital (Spain) for 1 year (from 1 May 2004 to 30 Apri...

journal_title：European journal of clinical pharmacology

authors： Tavassoli N,Duchayne E,Sadaba B,Desboeuf K,Sommet A,Lapeyre-Mestre M,Muoz MJ,Sie P,Honorato J,Montastruc JL,Bagheri H

更新日期：2007-03-01 00:00:00

abstract：:The confidence interval approach to bioavailability assessment depends first on selection of the confidence level, usually 95%, and then determination of the confidence limits for the expected bioavailability ratio AUC(Test)/AUC(Reference). In practice, however, it is sometimes of greater interest to know the probabil...

journal_title：European journal of clinical pharmacology

authors： Steinijans VW,Diletti E

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) is a delayed infrequent potentially life-threatening idiosyncratic drug reaction. Aromatic anticonvulsants and allopurinol are the most frequent causative agents. However, various reports of antibiotic-induced DRESS are available. In this...

journal_title：European journal of clinical pharmacology

authors： Sharifzadeh S,Mohammadpour AH,Tavanaee A,Elyasi S

更新日期：2020-10-06 00:00:00

abstract：:The cardiovascular and endocrine profile of cromakalim has been studied in 8 healthy men (age 25 +/- 2 years: means SEM) and its influence on renin release from cultured rat juxtaglomerular cells in vitro has also been examined. According to a double-blind, randomized sequence the subjects received placebo or cromakal...

journal_title：European journal of clinical pharmacology

authors： Ferrier CP,Kurtz A,Lehner P,Shaw SG,Pusterla C,Saxenhofer H,Weidmann P

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:The purpose of this study is to investigate whether there is an association between anticholinergic burden and mortality or rehospitalization in older adults discharged from hospital. METHODS:Prospective multicenter cohort study carried out with patients aged 65 and older discharged from seven acute care hospi...

journal_title：European journal of clinical pharmacology

authors： Gutiérrez-Valencia M,Martínez-Velilla N,Vetrano DL,Corsonello A,Lattanzio F,Ladrón-Arana S,Onder G

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:Gentamicin population pharmacokinetics in newborns were studied with special reference to possible gender effects. METHODS:Steady-state serum levels ( n=139) were obtained from 79 neonates with a mean birth weight of 2.1 kg, mean gestational age of 35.1 weeks and mean age at the time of sampling of 4.2 days....

journal_title：European journal of clinical pharmacology

authors： Botha JH,du Preez MJ,Adhikari M

更新日期：2003-12-01 00:00:00

abstract：:The pharmacokinetics of cefixime following a single oral dose of 200 mg have been investigated in 6 normal subjects and in 22 patients with various degrees of renal insufficiency. Serum and urine samples were collected between 0 and 72 h and were subjected to two methods of analysis: bioassay and HPLC. There was a lin...

journal_title：European journal of clinical pharmacology

authors： Dhib M,Moulin B,Leroy A,Hameau B,Godin M,Johannides R,Fillastre JP

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:We previously reported that chronic heart failure (CHF) treatments reduce the duration of hospitalisation, even in elderly patients. The present study aimed to determine whether CHF treatment also provides long-term benefits in terms of reduced mortality at 8 years. METHODS:A cohort of 281 patients who were ad...

journal_title：European journal of clinical pharmacology

authors： Maison P,Desamericq G,Hemery F,Elie N,Del'volgo A,Dubois-Randé JL,Hittinger L,Macquin-Mavier I

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Maintenance of the structural and functional integrity of the skeleton is a critical function of a continuous remodeling driven by highly associated processes of bone resorption and synthetic activities driven by osteoclasts and osteoblasts, respectively. Acceleration of bone turnover, accompanied with a dis...

journal_title：European journal of clinical pharmacology

authors： Leeming DJ,Alexandersen P,Karsdal MA,Qvist P,Schaller S,Tankó LB

更新日期：2006-10-01 00:00:00