Effects of carvedilol on common carotid arterial flow, peripheral hemodynamics, and hemorheologic variables in hypertension.

abstract：:Influence of food on the serum concentration and kinetics ambenonium chloride (AMBC) has been examined in thirteen patients with myasthenia gravis (MG). Mean serum concentrations and Cmax during fasting were higher than those in the non-fasting state. The AUC (0-3 h) was also about four-times larger. The drug effects ...

journal_title：European journal of clinical pharmacology

authors： Ohtsubo K,Fujii N,Higuchi S,Aoyama T,Goto I,Tatsuhara T

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:The influence of nevirapine (NVP) on lopinavir (LPV) pharmacokinetics was investigated by a population analysis based on a non-linear mixed-effect modelling method. METHODS:In this analysis, 95 HIV-1 infected patients were studied [52 treated with LPV/ritonavir (400/100 mg twice a day) plus nucleoside revers...

journal_title：European journal of clinical pharmacology

authors： Dailly E,Reliquet V,Raffi F,Jolliet P

更新日期：2005-04-01 00:00:00

abstract：:Oral and sublingual isoxsuprine 20 mg were compared with placebo in double blind randomised cross over trial in 7 patients with Raynaud's phenomenon. Skin thermography, plethysmography of the finger tips and direct temperature measurements showed that sublingual isoxsuprine was slightly but consistently superior to th...

journal_title：European journal of clinical pharmacology

authors： Wesseling H,den Heeten A,Wouda AA

更新日期：1981-01-01 00:00:00

abstract：:The number of marketed non-steroidal anti-inflammatory agents varies widely from one European country to another, partly as a consequence of differing regulatory policies. During a four-year period, nine of 18 applications to market such drugs in the Netherlands failed; the remaining nine compounds were all licenced; ...

journal_title：European journal of clinical pharmacology

authors： Dukes MN,Lunde I

更新日期：1981-01-01 00:00:00

abstract：:The bioavailability of a new controlled release formulation of indomethacin lysine salt in tablets was tested in 6 healthy humans against a conventional indomethacin lysinate formulation in capsules. Both contained 100 mg of the drug, i.e. 70 mg indomethacin. Peak plasma levels were lower and more lasting and the AUC ...

journal_title：European journal of clinical pharmacology

authors： Marzo A,Reiner A,Arrigoni Martelli E,Conte U,Colombo P,La Manna A

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:The Drug Burden Index (DBI) is a tool to quantify the anticholinergic and sedative load of drugs. Establishing functional correlates of the DBI could optimize drug prescribing in patients with dementia. In this cross-sectional study, we determined the relationship between DBI and cognitive and physical function...

journal_title：European journal of clinical pharmacology

authors： Sanders LMJ,Hortobágyi T,van Staveren G,Taxis K,Boersma F,Klein HC,Bossers WJR,Blankevoort CG,Scherder EJA,Van der Zee EA,van Heuvelen MJG

更新日期：2017-12-01 00:00:00

abstract：:An expert meeting to discuss population pharmacokinetic/pharmacodynamic software was held in Brussels in November 1993 under the auspices of the European Co-operation in Science and Technology (COST), Medicine (B1) programme. Recently developed statistical methods offer the possibility of gaining integrated informatio...

journal_title：European journal of clinical pharmacology

authors： Aarons L,Balant LP,Mentré F,Morselli PL,Rowland M,Steimer JL,Vozeh S

更新日期：1994-01-01 00:00:00

abstract：:Right ventricular repolarisation and refractoriness after therapeutic doses of disopyramide have been studied in 10 patients with coronary artery disease by recording monophasic action potentials (MAP) during programmed stimulation. Using 2 catheters, with the tip of one in the apex and the other in the outflow tract ...

journal_title：European journal of clinical pharmacology

authors： Endresen K,Amlie JP,Forfang K

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Spontaneous reporting of adverse drug reactions (ADRs) is one approach to increasing our knowledge on the risks of drugs in clinical practice. Under-reporting is a shortcoming of this system. OBJECTIVES:To evaluate if repeated e-mails with attachments on ADR information can affect (1) the reporting of ADRs ...

journal_title：European journal of clinical pharmacology

authors： Johansson ML,Brunlöf G,Edward C,Wallerstedt SM

更新日期：2009-05-01 00:00:00

abstract：:Total beta-adrenoceptor density and beta 1- and beta 2-subtype distribution in right and left atria and in different ventricular regions from 14 failing and seven nonfailing human hearts have been compared. End-stage heart failure was due to idiopathic dilated cardiomyopathy (n = 8) or ischaemic cardiomyopathy (n = 6)...

journal_title：European journal of clinical pharmacology

authors： Steinfath M,Lavicky J,Schmitz W,Scholz H,Döring V,Kalmár P

更新日期：1992-01-01 00:00:00

abstract：:A four-period, two-panel, single-rising-dose study (0.1-100 mg) was conducted in healthy males to investigate the pharmacodynamics, tolerability and pharmacokinetics of MK-0434, a steroid 5 alpha-reductase inhibitor. MK-0434 was associated with a significant reduction in dihydrotestosterone, which was maximal at 24 h ...

journal_title：European journal of clinical pharmacology

authors： Van Hecken A,Depré M,Schwartz JI,Tjandramaga TB,Winchell GA,De Lepeleire I,Ng J,De Schepper PJ

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:Tigecycline is one of few antibiotics active against multidrug-resistant bacteria; however, the assessment of dosing strategies to optimize its activity is needed. The purpose was to use Monte Carlo Simulation (MCS) to determine if safe tigecycline dosing options attaining breakpoints for pharmacokinetic/pharma...

journal_title：European journal of clinical pharmacology

authors： Kispal B,Walker SAN

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:Thiopurine drugs are commonly used in pediatric patients for the treatment of acute leukemia, organ transplantation and inflammatory diseases. They are catabolized by the cytosolic thiopurine methyltransferase (TPMT), which is subject to a genetic polymorphism. In children, enzyme activities are immature at b...

journal_title：European journal of clinical pharmacology

authors： Ganiere-Monteil C,Medard Y,Lejus C,Bruneau B,Pineau A,Fenneteau O,Bourin M,Jacqz-Aigrain E

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:The existence of gender differences in the management of statin therapy among patients with chronic heart failure (HF) is still poorly investigated. We aimed at exploring the effect of gender on statin prescription rates and adequacy of dosing and on the association between statin therapy and all-cause 1-year m...

journal_title：European journal of clinical pharmacology

authors： Ballo P,Balzi D,Barchielli A,Turco L,Franconi F,Zuppiroli A

更新日期：2016-03-01 00:00:00

abstract：:A new device for IV admixtures has been developed in Israel, the Vialink minibag. It consists of a partly filled minibag, attached by rubber tubing to a sterile receptable into which various types of vials containing drugs can be firmly inserted. Time and motion studies were conducted to determine the time and cost as...

journal_title：European journal of clinical pharmacology

authors： Lustig A

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:The incidence of osteoporosis-related fractures will increase substantially over the coming decades as the population ages globally. This has important economic and public health implications, contributing substantially to morbidity and excess mortality in this population. METHODS:When prescribing for older pa...

journal_title：European journal of clinical pharmacology

authors： Brewer L,Williams D,Moore A

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:The aim of the study was to develop a European list of potentially inappropriate medications (PIM) for older people, which can be used for the analysis and comparison of prescribing patterns across European countries and for clinical practice. METHODS:A preliminary PIM list was developed, based on the German P...

journal_title：European journal of clinical pharmacology

authors： Renom-Guiteras A,Meyer G,Thürmann PA

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Databases of subjects receiving antidepressants provide evidence on the use of drugs in typical patients and settings under real-world conditions. This study analysed a general practice database to estimate the prevalence of antidepressant drug use, describe the use of these compounds by gender and age and es...

journal_title：European journal of clinical pharmacology

authors： Pietraru C,Barbui C,Poggio L,Tognoni G

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVES:Administration of fluvoxamine (FLV) with concomitant benzodiazepines is common in clinical situations. We studied the effects of the coadministration of FLV on plasma concentrations of alprazolam (ALP). We also studied the effects of CYP2C19(*)2 or CYP2C19(*)3 on these drug interactions. METHODS:The subject...

journal_title：European journal of clinical pharmacology

authors： Suzuki Y,Shioiri T,Muratake T,Kawashima Y,Sato S,Hagiwara M,Inoue Y,Shimoda K,Someya T

更新日期：2003-04-01 00:00:00

abstract：:The effect of a new dopamine receptor stimulating agent, piribedil (ET 495), was studied in 10 patients with Parkinson's syndrome, who had had no or a poor response to previous L-DOPA treatment, or had displayed marked side effects during L-DOPA administration. Piribedil produced significant improvement of the functio...

journal_title：European journal of clinical pharmacology

authors： Engel J,Granerus AK,Svanborg A

更新日期：1975-04-04 00:00:00

abstract：:In a double-blind, placebo-controlled cross-over study, the plasma atrial natriuretic peptide (ANP) levels of nine young and ten elderly hypertensive patients were compared after placebo and after treatment with 120 mg verapamil given three times daily over 4 weeks. During placebo, plasma ANP levels proved to be highe...

journal_title：European journal of clinical pharmacology

authors： Van Bortel LM,Schiffers PM,Böhm RO,Mooij JM,Rahn KH,Struyker Boudier HA

更新日期：1990-01-01 00:00:00

abstract：:The beta-adrenoceptor blocking activity of the new Class Ic-antiarrhythmic drug diprafenone has been determined in man in comparison with that of propranolol, using the standardized isoproterenol test. Following placebo, the dose of isoproterenol which increased the heart rate by 25 beats.min-1 (CD25) was 0.84 (0.1-2....

journal_title：European journal of clinical pharmacology

authors： Wagner F,Jähnchen E,Trenk D

更新日期：1989-01-01 00:00:00

abstract：:The effects of the beta-blocker atenolol on vigilance, concentration, and psychophysiological condition were determined by measuring visual reaction time and choice reaction time in volunteers subjected to combined physical and mental stress. Atenolol 50 mg or placebo were administered for three days in a double-blind...

journal_title：European journal of clinical pharmacology

authors： Harms D

更新日期：1985-01-01 00:00:00

abstract：:The effect of menstrual cycle on the pharmacokinetics of theophylline has been studied in 9 female asthmatic patients. At three different times during the cycle (first, tenth and twentieth days) each subject received an i.v. infusion of 240 mg theophylline. Significant changes were found in the kinetics of theophyllin...

journal_title：European journal of clinical pharmacology

authors： Bruguerolle B,Toumi M,Faraj F,Vervloet D,Razzouk H

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:Spontaneous reporting is the most common method used in pharmacovigilance and the best one to generate signals on new or rare adverse drug reactions (ADRs). Under-reporting is a major drawback of this system. The objective of this study was to quantify the extent of under-reporting in general practice and to ...

journal_title：European journal of clinical pharmacology

authors： Alvarez-Requejo A,Carvajal A,Bégaud B,Moride Y,Vega T,Arias LH

更新日期：1998-08-01 00:00:00

abstract：:The blood level versus time curve for unchanged cimetidine after a 200 mg oral dose has been determined in 20 apparently healthy subjects, ranging from 22 to 84 years of age. A significant relationship between the area under the curve (AUC) and age was found (r = 0.81; P less than 0.001). The peak concentrations of ci...

journal_title：European journal of clinical pharmacology

authors： Redolfi A,Borgogelli E,Lodola E

更新日期：1979-05-21 00:00:00

abstract：OBJECTIVE:Entacapone is a peripherally acting catechol O-methyltransferase (COMT) inhibitor used as an adjunct to each daily levodopa/dopa decarboxylase (DDC) inhibitor dose in the treatment of Parkinson's disease. Parkinsonian patients with advanced disease and motor fluctuations take several doses of levodopa daily, ...

journal_title：European journal of clinical pharmacology

authors： Rouru J,Gordin A,Huupponen R,Huhtala S,Savontaus E,Korpela K,Reinikainen K,Scheinin M

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:We investigated whether interindividual differences in the pharmacokinetic disposition of lansoprazole are attributed to the genetic polymorphism of CYP2C19 which occurred by two mutations. CYP2C19m1 and CYP2C19m2, in 20 Japanese subjects. METHODS:Polymerase chain reaction (PCR) restriction fragment length p...

journal_title：European journal of clinical pharmacology

authors： Katsuki H,Nakamura C,Arimori K,Fujiyama S,Nakano M

更新日期：1997-01-01 00:00:00

abstract：:We have shown that apparent nonlinearities in the pharmacokinetics of chloroquine and wide variability in reported kinetic values are possibly artefacts of experimental design. We have used simulated data based on linear equations to demonstrate that chloroquine kinetics may appear to be dose-dependent if samples are ...

journal_title：European journal of clinical pharmacology

authors： Tett SE,Cutler DJ

更新日期：1987-01-01 00:00:00

abstract：:The disposition of paracetamol following an oral dose of 1.0 g was compared in 10 healthy volunteers, 7 patients with moderate chronic renal failure and 6 patients with end stage renal failure on maintenance haemodialysis. Paracetamol absorption was normal in the patients with renal failure. The mean plasma half-life ...

journal_title：European journal of clinical pharmacology

authors： Prescott LF,Speirs GC,Critchley JA,Temple RM,Winney RJ

更新日期：1989-01-01 00:00:00