Anticholinergic burden and health outcomes among older adults discharged from hospital: results from the CRIME study.

abstract：:The metabolism of hydralazine in a group of slow acetylator patients with the drug-induced lupus syndrome was compared with the metabolism in asymptomatic control subjects. There were no toxicologically significant difference in metabolite excretion between the groups which reached statistical significance, although t...

journal_title：European journal of clinical pharmacology

authors： Timbrell JA,Facchini V,Harland SJ,Mansilla-Tinoco R

更新日期：1984-01-01 00:00:00

abstract：:The effects of guar gum (GG) and microcrystalline cellulose (MC) on metabolic control and serum lipids were compared in a double-blind, cross-over trial in 18 poorly controlled Type 2 diabetic patients. There were two 12 week treatment periods separated by a 4 week wash-out period. A significant reduction in fasting B...

journal_title：European journal of clinical pharmacology

authors： Niemi MK,Keinänen-Kiukaanniemi SM,Salmela PI

更新日期：1988-01-01 00:00:00

abstract：:The role of acetylator phenotype in determining the response to hydralazine when it was added to diuretic and beta-blocker at doses not exceeding 200 mg daily was examined in 57 hypertensive patients. 81% of rapid acetylators needed 200 mg hydralazine daily compared to 38% of slow acetylators (p less than 0.01). Despi...

journal_title：European journal of clinical pharmacology

authors： Ramsay LE,Silas JH,Ollerenshaw JD,Tucker GT,Phillips FC,Freestone S

更新日期：1984-01-01 00:00:00

abstract：:The maternofetal transfer of the beta 1-selective adrenergic antagonist celiprolol has been studied in four hypertensive pregnant women. Fetal plasma concentrations were about 25-50% of the levels found on the maternal side. There was no significant difference between the plasma concentrations of the two enantiomers i...

journal_title：European journal of clinical pharmacology

authors： Kofahl B,Henke D,Hettenbach A,Mutschler E

更新日期：1993-01-01 00:00:00

abstract：:A randomised, placebo controlled clinical trial was conducted to examine the efficacy of a homeopathic after-bite gel in the symptomatic relief of mosquito bites. Sixty eight healthy volunteers were bitten under laboratory conditions by Aedes aegypti mosquitoes at three spots, on the ventral aspect of the forearm. One...

journal_title：European journal of clinical pharmacology

authors： Hill N,Stam C,Tuinder S,van Haselen RA

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To investigate adherence to prescription in a female population aged 35-65 years. DESIGN:Postal questionnaire study of 2991 randomly sampled 35- to 64-year-old women in seven provinces of central Sweden. METHODS:The study was performed in 1995 as a cross-sectional postal questionnaire study in seven countie...

journal_title：European journal of clinical pharmacology

authors： Bardel A,Wallander MA,Svärdsudd K

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:We previously reported that chronic heart failure (CHF) treatments reduce the duration of hospitalisation, even in elderly patients. The present study aimed to determine whether CHF treatment also provides long-term benefits in terms of reduced mortality at 8 years. METHODS:A cohort of 281 patients who were ad...

journal_title：European journal of clinical pharmacology

authors： Maison P,Desamericq G,Hemery F,Elie N,Del'volgo A,Dubois-Randé JL,Hittinger L,Macquin-Mavier I

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:Gentamicin population pharmacokinetics in newborns were studied with special reference to possible gender effects. METHODS:Steady-state serum levels ( n=139) were obtained from 79 neonates with a mean birth weight of 2.1 kg, mean gestational age of 35.1 weeks and mean age at the time of sampling of 4.2 days....

journal_title：European journal of clinical pharmacology

authors： Botha JH,du Preez MJ,Adhikari M

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Laryngoscopy and tracheal intubation are associated with hemodynamic responses that might increase morbidity and mortality in some patients. Lornoxicam is a nonsteroidal anti-inflammatory drug, which, when added to fentanyl, successfully attenuated the pressor response of intubation. The aim o...

journal_title：European journal of clinical pharmacology

authors： Daabiss M,Hashish M

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:To investigate the usefulness of the 3-hydroxylation of quinine as a biomarker reaction for the activity of CYP3A4 in man and to study the interindividual variation in the metabolic ratio (MR), i.e. quinine/3-hydroxyquinine. METHODS:Data from a previous study (A) was used for determination of the MR of quini...

journal_title：European journal of clinical pharmacology

authors： Mirghani RA,Ericsson O,Tybring G,Gustafsson LL,Bertilsson L

更新日期：2003-05-01 00:00:00

abstract：:Blood ciclosporin (Cs) metabolite pattern in 58 liver grafted patients was routinely monitored by HPLC from the first Cs dose after transplantation until discharge from hospital. Eighteen patients with normal kidney function were allocated to Group I and 14 patients in Group II suffered Cs nephrotoxicity during their ...

journal_title：European journal of clinical pharmacology

authors： Christians U,Kohlhaw K,Budniak J,Bleck JS,Schottmann R,Schlitt HJ,Almeida VM,Deters M,Wonigeit K,Pichlmayr R

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:We proposed a statistical criterion to detect drug-drug interactions causing adverse drug reactions in spontaneous reporting systems. METHODS:The used criterion quantitatively measures the discrepancy between the observed and expected number of adverse events via chi-square statistics. We compared the performa...

journal_title：European journal of clinical pharmacology

authors： Gosho M,Maruo K,Tada K,Hirakawa A

更新日期：2017-06-01 00:00:00

abstract：:The pharmacokinetics of isosorbide-5-mononitrate (IS-5-MN) has been studied in two groups of healthy volunteers after oral (n = 20) and intravenous (n = 11) administration of 20 mg, which had previously been proved to be as effective as 20 mg sustained-release isosorbide dinitrate (ISDN). IS-5-MN in serum was measured...

journal_title：European journal of clinical pharmacology

authors： Abshagen U,Betzien G,Endele R,Kaufmann B

更新日期：1981-01-01 00:00:00

abstract：INTRODUCTION:This study compared the characteristics of new human drugs approved by the Food and Drug Administration (FDA), the European Medicine Agency (EMA), and Swissmedic (SMC) in the period 2007 to 2016. METHODS:The list of new drugs and therapeutic biologics approved by the FDA, the EMA, and SMC in the period 20...

journal_title：European journal of clinical pharmacology

authors： Zeukeng MJ,Seoane-Vazquez E,Bonnabry P

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:Neuroblastoma is the most common extracranial solid tumour in childhood. It accounts for 15% of all paediatric oncology deaths. In the last few decades, improvement in treatment outcome for high-risk patients has not occurred, with an overall survival rate <30-40%. Many reasons may account for such a low surviv...

journal_title：European journal of clinical pharmacology

authors： Bellanti F,Kågedal B,Della Pasqua O

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:To investigate the influence of concomitant administration of roxithromycin on the plasma pharmacokinetics of lovastatin. METHODS:In an open, randomized, crossover study, 12 healthy volunteers received 80 mg lovastatin orally either alone or concomitantly with 300 mg roxithromycin after 5-day pretreatment wi...

journal_title：European journal of clinical pharmacology

authors： Bucher M,Mair G,Kees F

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:To investigate pharmacokinetics (PK) of encapsulated CPT-11, released CPT-11 and the active metabolite SN-38 following administration of IHL-305 and to identify factors that may influence IHL-305 PK. METHODS:Plasma samples from 39 patients with solid tumors were collected in a phase I study. IHL-305 was admini...

journal_title：European journal of clinical pharmacology

authors： Wu H,Infante JR,Keedy VL,Jones SF,Chan E,Bendell JC,Lee W,Zamboni BA,Ikeda S,Kodaira H,Rothenberg ML,Burris HA 3rd,Zamboni WC

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:NXY-059 is a nitrone-based, free-radical trapping agent being developed for the treatment of acute ischaemic stroke. Elimination of NXY-059 is primarily renal. The objective of the study was to investigate the pharmacokinetics of NXY-059 in subjects with renal impairment. METHODS:Twenty-four subjects with a ...

journal_title：European journal of clinical pharmacology

authors： Strid S,Borgå O,Edenius C,Jostell KG,Odergren T,Weil A

更新日期：2002-09-01 00:00:00

abstract：:A one-compartment model with first-order absorption has provided good fits to five sets of indomethacin data and four sets of ketoprofen data taken at different times of day. There was substantial variation in the model parameters with time of administration and most of the features of this variation applied equally t...

journal_title：European journal of clinical pharmacology

authors： Aronson JK,Chappell MJ,Godfrey KR,Yew MK

更新日期：1993-01-01 00:00:00

abstract：:Thirty-eight severely hypertensive patients were treated with oral clonidine. Each patient received a "loading" dose of 0.2 mg clonidine, followed by 0.1 mg hourly until the blood pressure was substantially reduced, or until a total dose of 0.8 mg has been administered. Thirty-five (82.1%) patients responded favourabl...

journal_title：European journal of clinical pharmacology

authors： Karachalios GN

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:After liver transplantation (LT), genotypic differences between the recipient and the transplanted liver, medications and post-LT complications may all affect drug metabolism. We have studied the effect of two CYP2D6 mutations in the donor and the recipient on post-LT CYP2D6 phenotype. METHOD:The CYP2D6 phen...

journal_title：European journal of clinical pharmacology

authors： Monek O,Paintaud G,Bechtel Y,Miguet JP,Mantion G,Bechtel PR

更新日期：1998-03-01 00:00:00

abstract：PURPOSE:It is well known that CPT-11 (irinotecan) is biotransformed to its active metabolite, SN-38, by carboxylesterase in the liver and other tissues. However, little is known about its pharmacokinetics (PK) when administered intraperitoneally. The aim of our study was to develop a population pharmacokinetic model fo...

journal_title：European journal of clinical pharmacology

authors： Ahn BJ,Choi MK,Park YS,Lee J,Park SH,Park JO,Lim HY,Kang WK,Ko JW,Yim DS

更新日期：2010-12-01 00:00:00

abstract：:Plasma aspirin, salicylate and salicyluric acid concentrations were monitored in young, elderly and alcoholic subjects after ingestion of a single 1.2 g dose of soluble aspirin. The plasma aspirin, salicylate and unbound salicylate concentration-time profiles varied considerably between individual subjects. Most of th...

journal_title：European journal of clinical pharmacology

authors： Roberts MS,Rumble RH,Wanwimolruk S,Thomas D,Brooks PM

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVES:An increased risk of all-cause and cardiovascular mortality in users of anxiolytic-hypnotic drugs (AHD) has been reported, and use of analgesics may be an additional factor. Therefore, we examined the association of AHD and analgesic use, alone and in combination, with all-cause and ischaemic heart disease (...

journal_title：European journal of clinical pharmacology

authors： Merlo J,Hedblad B,Ogren M,Ranstam J,Ostergren PO,Ekedahl A,Hanson BS,Isacsson SO,Liedholm H,Melander A

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Triptans are contraindicated in patients with known or suspected coronary artery disease (CAD); however, few studies have evaluated triptans in patients with obstructive CAD to quantify the vasoconstrictive effect on diseased coronary vessels. METHODS:Patients undergoing percutaneous transluminal coronary a...

journal_title：European journal of clinical pharmacology

authors： Newman CM,Starkey I,Buller N,Seabra-Gomes R,Kirby S,Hettiarachchi J,Cumberland D,Hillis WS

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:In elderly patients, both falls and impaired memory are considerable medical problems. Hypnotics, which are frequently administered to this patient group for the treatment of insomnia, should ideally not impair equilibrium or memory functions. This double-blind, randomised, four-way, cross-over study investig...

journal_title：European journal of clinical pharmacology

authors： Allain H,Bentué-Ferrer D,Tarral A,Gandon JM

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:To analyse the contribution of adverse drug reactions (ADR) to hospital readmissions. METHODS:This was a case-control study in which unscheduled admissions of patients who had been admitted to the hospital during the two previous months were assessed during a 21-month period. The patient was considered a cas...

journal_title：European journal of clinical pharmacology

authors： Ruiz B,García M,Aguirre U,Aguirre C

更新日期：2008-07-01 00:00:00

abstract：:17 patients with severe digoxin intoxication were successfully treated with 320 to 480 mg Fab fragments of digoxin-specific IgG from sheep. The infusion period ranged between 0.5 and 7 h. Serum and urine concentrations of digoxin bound to Fab fragments, and in 11 cases unbound Fab fragments in serum, were determined d...

journal_title：European journal of clinical pharmacology

authors： Schaumann W,Kaufmann B,Neubert P,Smolarz A

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:Inhaled corticosteroids (ICS) are widely used in the treatment of asthma. We studied the suspected adverse drug reactions (sADRs) reported during the use of ICS in the Netherlands. METHODS:In the Netherlands, health professionals and patients can report suspected ADRs to the Pharmacovigilance Centre Lareb. ...

journal_title：European journal of clinical pharmacology

authors： de Vries TW,de Langen-Wouterse JJ,van Puijenbroek E,Duiverman EJ,de Jong-Van den Berg LT

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Tamoxifen is one of the cornerstones of endocrine therapy for breast cancer. Recently, the decreased activity CYP3A4*22 allele and the loss of function CYP3A5*3 allele have been described as potential factors that could help to explain the inter-patient variability in tamoxifen metabolism. The aim of this st...

journal_title：European journal of clinical pharmacology

authors： Sanchez Spitman AB,Moes DJAR,Gelderblom H,Dezentje VO,Swen JJ,Guchelaar HJ

更新日期：2017-12-01 00:00:00