Abstract：
:The pharmacokinetics of isosorbide-5-mononitrate (IS-5-MN) has been studied in two groups of healthy volunteers after oral (n = 20) and intravenous (n = 11) administration of 20 mg, which had previously been proved to be as effective as 20 mg sustained-release isosorbide dinitrate (ISDN). IS-5-MN in serum was measured by gas chromatography using capillary columns. The kinetic calculations were carried out with a newly developed model, which assumes a virtual volume of distribution dependent on time. IS-5-MN is rapidly (invasion half-life 4.1 min) and completely absorbed from the gastro-intestinal tract without any first pass metabolism. The maximum concentration of 480 micrograms/l was reached 1.2 h after oral administration of 20 mg. The substance was distributed throughout the total body water (distribution coefficient: 0.62), and was eliminated with a terminal t1/2 of 4.1 and 4.6 h after oral and intravenous administration, respectively. Total body clearance was 115ml/min. Thus, IS-5-MN is unlike ISDN with respect to the absence of first-pass metabolism and an 8-times longer half-life. The consequences for therapy are discussed.
journal_name
Eur J Clin Pharmacoljournal_title
European journal of clinical pharmacologyauthors
Abshagen U,Betzien G,Endele R,Kaufmann Bdoi
10.1007/BF00618777subject
Has Abstractpub_date
1981-01-01 00:00:00pages
269-75issue
4eissn
0031-6970issn
1432-1041journal_volume
20pub_type
杂志文章abstract：OBJECTIVE:African populations, including the Sudanese, are underrepresented in warfarin pharmacogenetic studies. We designed a study to determine the associations between the polymorphisms and haplotype structures of CYP2C9 and VKORC1 and warfarin dose response in Sudanese patients, one of the most genetically diverse ...
journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/s00228-011-1060-1
更新日期：2011-11-01 00:00:00
abstract：:The pharmacokinetics of piretanide, a new loop diuretic, were studied in seven patients with severe liver disease before and after resolution of ascites. The time to maximum concentration was significantly prolonged by the presence of ascites. Tmax after relief of ascites was similar to that seen for normal volunteers...
journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00544070
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abstract：:The diabetogenic effect of deflazacort (DF), an oxazolinic synthetic corticosteroid, was studied in 12 healthy adult subjects with a positive family history of diabetes mellitus. Three oral glucose tests (oGTT) were performed at 9.00 a.m., after a 12 h fast, following randomized administration of Placebo (PL), or Defl...
journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00542555
更新日期：1982-01-01 00:00:00
abstract：:The effects of acute introduction and withdrawal of trimeprazine (Vallergan), an antihistaminic phenothiazine derivative with known sedative effects, were investigated by a single blind polygraphic study in 8 healthy volunteers. A baseline placebo was given on Nights 1-3, followed either by 10 mg or 20 mg of the drug ...
journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00606405
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abstract：:The effect of pentobarbital treatment in a mean dose of 30 mg/kg/day on the clearance of hexobarbital (Evipan) and dipyrone (Novalgin) has been evaluated in critical care patients receiving a large number of drugs as comedication. Eleven patients treated with pentobarbital showed a hexobarbital half-life of 2.79 h and...
journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/BF00607575
更新日期：1987-01-01 00:00:00
abstract：PURPOSE:To determine whether two of the major operational stressors associated with military missions in Afghanistan: dry heat and long durations of soldier patrol (SP), alter the pharmacokinetics of ibuprofen. METHODS:Thirteen healthy and physically fit participants (19-32 years) were randomized to a four-arm crossov...
journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00228-012-1307-5
更新日期：2013-01-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/BF00558135
更新日期：1989-01-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/s00228-006-0242-8
更新日期：2007-03-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00228-010-0938-7
更新日期：2011-01-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章
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更新日期：2012-04-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/s00228-003-0634-y
更新日期：2003-11-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1992-01-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/BF00279976
更新日期：1991-01-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章
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更新日期：1990-01-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/s00228-006-0206-z
更新日期：2007-01-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/BF01061375
更新日期：1982-01-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章,meta分析,评审
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更新日期：2011-08-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
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更新日期：1981-01-01 00:00:00
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journal_title：European journal of clinical pharmacology
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更新日期：2007-08-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章,多中心研究
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更新日期：2015-07-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/BF00560459
更新日期：1978-12-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00543787
更新日期：1983-01-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/BF00271367
更新日期：1993-01-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
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更新日期：2005-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2013-10-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00606628
更新日期：1987-01-01 00:00:00
abstract：:There is conflicting data in the literature as to whether subsensitivity of in-vivo beta 2-adrenoceptor (beta 2-AR) responses in patients with asthma is due to an endogenous defect of beta 2-AR or an effect of exogenous beta 2-agonist therapy. The purpose of the study was to compare in-vitro parameters of lymphocyte b...
journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/BF00315310
更新日期：1993-01-01 00:00:00
abstract：PURPOSE:Tacrolimus is a commonly used immunosuppressant in solid organ transplantation recipients, but it is characterized by a narrow therapeutic range and large inter-individual variability. The purpose of this study was to establish a population pharmacokinetic (PK) model of tacrolimus and evaluate the influence of ...
journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/s00228-012-1296-4
更新日期：2013-01-01 00:00:00
